Dolichyldiphosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

PAP2 superfamily, putative

Species:

Leishmania mexicana

UniProt:

E9AW69_LEIMU

TriTrypDb:

LmxM.23.1665

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

E9AW69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW69

Function

Biological processes
Term	Name	Level	Count
GO:0006486	protein glycosylation	4	5
GO:0006487	protein N-linked glycosylation	5	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0043413	macromolecule glycosylation	3	5
GO:0044238	primary metabolic process	2	5
GO:0070085	glycosylation	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5
GO:0006629	lipid metabolic process	3	1
GO:0008610	lipid biosynthetic process	4	1
GO:0009058	biosynthetic process	2	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016462	pyrophosphatase activity	5	5
GO:0016787	hydrolase activity	2	5
GO:0016817	hydrolase activity, acting on acid anhydrides	3	5
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	5
GO:0047874	dolichyldiphosphatase activity	6	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	236	238	PF00675	0.400
CLV_PCSK_FUR_1	234	238	PF00082	0.361
CLV_PCSK_KEX2_1	236	238	PF00082	0.400
CLV_PCSK_KEX2_1	57	59	PF00082	0.359
CLV_PCSK_PC1ET2_1	57	59	PF00082	0.359
CLV_PCSK_SKI1_1	193	197	PF00082	0.413
CLV_PCSK_SKI1_1	54	58	PF00082	0.301
DEG_Nend_Nbox_1	1	3	PF02207	0.599
DOC_CKS1_1	112	117	PF01111	0.274
DOC_MAPK_DCC_7	35	44	PF00069	0.242
DOC_MAPK_MEF2A_6	35	44	PF00069	0.265
DOC_PP2B_LxvP_1	120	123	PF13499	0.250
DOC_PP2B_LxvP_1	188	191	PF13499	0.337
DOC_PP4_FxxP_1	112	115	PF00568	0.284
DOC_USP7_MATH_1	116	120	PF00917	0.250
DOC_USP7_MATH_1	165	169	PF00917	0.254
DOC_USP7_MATH_1	171	175	PF00917	0.313
DOC_USP7_MATH_1	207	211	PF00917	0.381
DOC_USP7_MATH_1	215	219	PF00917	0.667
DOC_USP7_MATH_1	221	225	PF00917	0.614
DOC_USP7_UBL2_3	57	61	PF12436	0.576
DOC_WW_Pin1_4	111	116	PF00397	0.358
DOC_WW_Pin1_4	69	74	PF00397	0.506
DOC_WW_Pin1_4	98	103	PF00397	0.193
LIG_14-3-3_CanoR_1	126	132	PF00244	0.188
LIG_14-3-3_CanoR_1	219	228	PF00244	0.628
LIG_14-3-3_CanoR_1	96	102	PF00244	0.274
LIG_Actin_WH2_2	127	145	PF00022	0.293
LIG_Actin_WH2_2	41	59	PF00022	0.307
LIG_BRCT_BRCA1_1	81	85	PF00533	0.316
LIG_FHA_1	112	118	PF00498	0.274
LIG_FHA_1	161	167	PF00498	0.282
LIG_FHA_1	34	40	PF00498	0.347
LIG_FHA_1	47	53	PF00498	0.245
LIG_FHA_1	88	94	PF00498	0.378
LIG_FHA_1	99	105	PF00498	0.268
LIG_LIR_Apic_2	110	115	PF02991	0.274
LIG_LIR_Gen_1	82	93	PF02991	0.288
LIG_LIR_Nem_3	82	88	PF02991	0.339
LIG_SH2_PTP2	124	127	PF00017	0.222
LIG_SH2_STAP1	135	139	PF00017	0.329
LIG_SH2_STAT3	28	31	PF00017	0.395
LIG_SH2_STAT3	92	95	PF00017	0.316
LIG_SH2_STAT5	124	127	PF00017	0.400
LIG_SH2_STAT5	158	161	PF00017	0.383
LIG_SH2_STAT5	176	179	PF00017	0.404
LIG_SH2_STAT5	2	5	PF00017	0.626
LIG_SH2_STAT5	28	31	PF00017	0.505
LIG_SH2_STAT5	9	12	PF00017	0.567
LIG_SH2_STAT5	92	95	PF00017	0.343
LIG_SH3_1	70	76	PF00018	0.484
LIG_SH3_3	112	118	PF00018	0.284
LIG_SH3_3	60	66	PF00018	0.614
LIG_SH3_3	70	76	PF00018	0.448
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.213
LIG_SUMO_SIM_anti_2	20	26	PF11976	0.307
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.282
LIG_SUMO_SIM_par_1	130	136	PF11976	0.329
LIG_WW_2	115	118	PF00397	0.250
MOD_CK1_1	174	180	PF00069	0.369
MOD_CK1_1	84	90	PF00069	0.319
MOD_GlcNHglycan	173	176	PF01048	0.549
MOD_GlcNHglycan	19	22	PF01048	0.260
MOD_GlcNHglycan	203	206	PF01048	0.389
MOD_GlcNHglycan	223	226	PF01048	0.476
MOD_GSK3_1	107	114	PF00069	0.278
MOD_GSK3_1	133	140	PF00069	0.390
MOD_GSK3_1	197	204	PF00069	0.389
MOD_GSK3_1	46	53	PF00069	0.314
MOD_GSK3_1	74	81	PF00069	0.526
MOD_N-GLC_1	107	112	PF02516	0.474
MOD_N-GLC_1	171	176	PF02516	0.539
MOD_NEK2_1	1	6	PF00069	0.618
MOD_NEK2_1	160	165	PF00069	0.353
MOD_NEK2_1	197	202	PF00069	0.316
MOD_NEK2_2	107	112	PF00069	0.250
MOD_NEK2_2	133	138	PF00069	0.316
MOD_PKA_2	215	221	PF00069	0.547
MOD_Plk_1	107	113	PF00069	0.274
MOD_Plk_4	107	113	PF00069	0.346
MOD_Plk_4	127	133	PF00069	0.339
MOD_Plk_4	81	87	PF00069	0.360
MOD_ProDKin_1	111	117	PF00069	0.358
MOD_ProDKin_1	69	75	PF00069	0.506
MOD_ProDKin_1	98	104	PF00069	0.193
TRG_DiLeu_BaEn_1	192	197	PF01217	0.249
TRG_Pf-PMV_PEXEL_1	58	62	PF00026	0.365

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7E3	Leptomonas seymouri	49%	100%
A0A0S4JMP4	Bodo saltans	28%	95%
A0A3S7WXN1	Leishmania donovani	90%	100%
A4HCT0	Leishmania braziliensis	75%	100%
A4I0A4	Leishmania infantum	90%	100%
Q4QBA9	Leishmania major	88%	100%