Metallo-beta-lactamase family protein-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase family protein-like protein

Species:

Leishmania mexicana

UniProt:

E9AW68_LEIMU

TriTrypDb:

LmxM.23.1660

Length:

380

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW68

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	168	172	PF00656	0.432
CLV_NRD_NRD_1	351	353	PF00675	0.392
CLV_NRD_NRD_1	363	365	PF00675	0.406
CLV_NRD_NRD_1	62	64	PF00675	0.514
CLV_NRD_NRD_1	99	101	PF00675	0.473
CLV_PCSK_FUR_1	349	353	PF00082	0.393
CLV_PCSK_KEX2_1	351	353	PF00082	0.411
CLV_PCSK_KEX2_1	363	365	PF00082	0.423
CLV_PCSK_KEX2_1	62	64	PF00082	0.488
CLV_PCSK_SKI1_1	295	299	PF00082	0.266
DEG_APCC_DBOX_1	186	194	PF00400	0.505
DEG_Nend_Nbox_1	1	3	PF02207	0.574
DEG_SCF_FBW7_1	277	283	PF00400	0.360
DOC_CKS1_1	277	282	PF01111	0.360
DOC_CYCLIN_RxL_1	292	301	PF00134	0.286
DOC_MAPK_DCC_7	62	70	PF00069	0.335
DOC_MAPK_gen_1	62	70	PF00069	0.571
DOC_MAPK_gen_1	98	106	PF00069	0.312
DOC_PP1_RVXF_1	293	299	PF00149	0.266
DOC_PP2B_LxvP_1	289	292	PF13499	0.266
DOC_USP7_MATH_1	165	169	PF00917	0.412
DOC_USP7_MATH_1	314	318	PF00917	0.411
DOC_USP7_MATH_1	58	62	PF00917	0.432
DOC_USP7_UBL2_3	47	51	PF12436	0.509
DOC_WW_Pin1_4	236	241	PF00397	0.613
DOC_WW_Pin1_4	276	281	PF00397	0.266
DOC_WW_Pin1_4	71	76	PF00397	0.357
LIG_14-3-3_CanoR_1	249	255	PF00244	0.410
LIG_14-3-3_CanoR_1	25	29	PF00244	0.418
LIG_14-3-3_CanoR_1	261	266	PF00244	0.310
LIG_14-3-3_CanoR_1	343	348	PF00244	0.359
LIG_Actin_WH2_2	113	128	PF00022	0.462
LIG_Actin_WH2_2	32	49	PF00022	0.449
LIG_APCC_ABBAyCdc20_2	101	107	PF00400	0.442
LIG_BIR_III_2	171	175	PF00653	0.404
LIG_BRCT_BRCA1_1	261	265	PF00533	0.467
LIG_Clathr_ClatBox_1	325	329	PF01394	0.411
LIG_deltaCOP1_diTrp_1	110	119	PF00928	0.304
LIG_deltaCOP1_diTrp_1	166	173	PF00928	0.309
LIG_FHA_1	120	126	PF00498	0.395
LIG_FHA_1	19	25	PF00498	0.521
LIG_FHA_1	202	208	PF00498	0.321
LIG_FHA_1	297	303	PF00498	0.322
LIG_FHA_1	333	339	PF00498	0.266
LIG_FHA_1	34	40	PF00498	0.376
LIG_FHA_1	72	78	PF00498	0.423
LIG_FHA_2	146	152	PF00498	0.213
LIG_LIR_Gen_1	114	121	PF02991	0.315
LIG_LIR_Gen_1	43	53	PF02991	0.547
LIG_LIR_Nem_3	114	119	PF02991	0.316
LIG_LIR_Nem_3	178	183	PF02991	0.313
LIG_LIR_Nem_3	196	201	PF02991	0.550
LIG_LIR_Nem_3	262	268	PF02991	0.356
LIG_LIR_Nem_3	43	48	PF02991	0.535
LIG_PCNA_PIPBox_1	194	203	PF02747	0.410
LIG_PCNA_yPIPBox_3	349	361	PF02747	0.428
LIG_Pex14_1	169	173	PF04695	0.311
LIG_PTB_Apo_2	192	199	PF02174	0.504
LIG_PTB_Phospho_1	192	198	PF10480	0.502
LIG_SH2_CRK	305	309	PF00017	0.300
LIG_SH2_GRB2like	84	87	PF00017	0.459
LIG_SH2_NCK_1	305	309	PF00017	0.262
LIG_SH2_SRC	84	87	PF00017	0.459
LIG_SH2_STAP1	203	207	PF00017	0.568
LIG_SH2_STAP1	361	365	PF00017	0.521
LIG_SH2_STAT3	203	206	PF00017	0.499
LIG_SH2_STAT5	201	204	PF00017	0.458
LIG_SH2_STAT5	276	279	PF00017	0.281
LIG_SH3_2	240	245	PF14604	0.558
LIG_SH3_3	237	243	PF00018	0.612
LIG_SH3_3	274	280	PF00018	0.411
LIG_SH3_3	308	314	PF00018	0.298
LIG_SH3_3	333	339	PF00018	0.275
LIG_SH3_CIN85_PxpxPR_1	240	245	PF14604	0.558
LIG_SUMO_SIM_par_1	323	329	PF11976	0.411
LIG_TYR_ITIM	303	308	PF00017	0.300
LIG_WW_3	242	246	PF00397	0.539
MOD_CDK_SPK_2	236	241	PF00069	0.580
MOD_CK1_1	196	202	PF00069	0.492
MOD_CK1_1	256	262	PF00069	0.380
MOD_CK1_1	324	330	PF00069	0.411
MOD_CK2_1	145	151	PF00069	0.207
MOD_GlcNHglycan	122	125	PF01048	0.429
MOD_GlcNHglycan	231	234	PF01048	0.548
MOD_GlcNHglycan	236	239	PF01048	0.529
MOD_GlcNHglycan	256	259	PF01048	0.456
MOD_GlcNHglycan	316	319	PF01048	0.399
MOD_GSK3_1	115	122	PF00069	0.353
MOD_GSK3_1	256	263	PF00069	0.376
MOD_GSK3_1	276	283	PF00069	0.302
MOD_LATS_1	341	347	PF00433	0.356
MOD_N-GLC_1	259	264	PF02516	0.512
MOD_N-GLC_1	30	35	PF02516	0.379
MOD_NEK2_1	119	124	PF00069	0.340
MOD_NEK2_1	130	135	PF00069	0.260
MOD_NEK2_1	193	198	PF00069	0.445
MOD_NEK2_1	254	259	PF00069	0.389
MOD_NEK2_1	304	309	PF00069	0.257
MOD_NEK2_1	321	326	PF00069	0.271
MOD_PK_1	66	72	PF00069	0.375
MOD_PKA_2	125	131	PF00069	0.389
MOD_PKA_2	18	24	PF00069	0.486
MOD_PKA_2	248	254	PF00069	0.354
MOD_PKA_2	260	266	PF00069	0.310
MOD_PKA_2	342	348	PF00069	0.356
MOD_PKA_2	58	64	PF00069	0.441
MOD_Plk_1	165	171	PF00069	0.458
MOD_Plk_1	30	36	PF00069	0.382
MOD_Plk_1	332	338	PF00069	0.266
MOD_Plk_4	115	121	PF00069	0.456
MOD_Plk_4	145	151	PF00069	0.327
MOD_Plk_4	165	171	PF00069	0.458
MOD_Plk_4	193	199	PF00069	0.537
MOD_Plk_4	261	267	PF00069	0.367
MOD_Plk_4	269	275	PF00069	0.341
MOD_Plk_4	321	327	PF00069	0.318
MOD_Plk_4	332	338	PF00069	0.218
MOD_ProDKin_1	236	242	PF00069	0.610
MOD_ProDKin_1	276	282	PF00069	0.266
MOD_ProDKin_1	71	77	PF00069	0.350
TRG_DiLeu_BaEn_1	73	78	PF01217	0.474
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.411
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.724
TRG_ENDOCYTIC_2	180	183	PF00928	0.345
TRG_ENDOCYTIC_2	305	308	PF00928	0.300
TRG_ER_diArg_1	210	213	PF00400	0.539
TRG_ER_diArg_1	4	7	PF00400	0.628
TRG_NES_CRM1_1	138	151	PF08389	0.353
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	358	362	PF00026	0.472

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I936	Leptomonas seymouri	79%	98%
A0A0S4IRF9	Bodo saltans	43%	100%
A0A1X0NXH8	Trypanosomatidae	49%	100%
A0A3Q8ICH4	Leishmania donovani	95%	100%
A0A422MYI7	Trypanosoma rangeli	50%	100%
A4HCS9	Leishmania braziliensis	85%	96%
A4I0A3	Leishmania infantum	95%	100%
C9ZV29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
Q4QBB0	Leishmania major	94%	100%
V5BFN3	Trypanosoma cruzi	51%	100%