Poly(A)-specific ribonuclease PARN

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW65_LEIMU

TriTrypDb:

LmxM.23.1630

Length:

596

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 23
NetGPI	no	yes: 0, no: 23

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	3
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9AW65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	24
GO:0005488	binding	1	24
GO:0097159	organic cyclic compound binding	2	24
GO:1901363	heterocyclic compound binding	2	24
GO:0000175	3'-5'-RNA exonuclease activity	7	4
GO:0003824	catalytic activity	1	4
GO:0004518	nuclease activity	4	4
GO:0004527	exonuclease activity	5	4
GO:0004532	RNA exonuclease activity	5	4
GO:0004535	poly(A)-specific ribonuclease activity	8	1
GO:0004540	RNA nuclease activity	4	4
GO:0008408	3'-5' exonuclease activity	6	4
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	4
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	4
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	4
GO:0140098	catalytic activity, acting on RNA	3	4
GO:0140640	catalytic activity, acting on a nucleic acid	2	4
GO:0003723	RNA binding	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	328	332	PF00656	0.420
CLV_C14_Caspase3-7	506	510	PF00656	0.372
CLV_NRD_NRD_1	130	132	PF00675	0.263
CLV_NRD_NRD_1	195	197	PF00675	0.258
CLV_NRD_NRD_1	260	262	PF00675	0.231
CLV_NRD_NRD_1	285	287	PF00675	0.347
CLV_NRD_NRD_1	291	293	PF00675	0.339
CLV_NRD_NRD_1	310	312	PF00675	0.361
CLV_NRD_NRD_1	361	363	PF00675	0.377
CLV_NRD_NRD_1	4	6	PF00675	0.316
CLV_NRD_NRD_1	528	530	PF00675	0.553
CLV_NRD_NRD_1	584	586	PF00675	0.686
CLV_NRD_NRD_1	594	596	PF00675	0.686
CLV_NRD_NRD_1	72	74	PF00675	0.327
CLV_PCSK_FUR_1	258	262	PF00082	0.332
CLV_PCSK_FUR_1	592	596	PF00082	0.529
CLV_PCSK_KEX2_1	130	132	PF00082	0.256
CLV_PCSK_KEX2_1	195	197	PF00082	0.258
CLV_PCSK_KEX2_1	260	262	PF00082	0.242
CLV_PCSK_KEX2_1	285	287	PF00082	0.311
CLV_PCSK_KEX2_1	291	293	PF00082	0.300
CLV_PCSK_KEX2_1	361	363	PF00082	0.377
CLV_PCSK_KEX2_1	4	6	PF00082	0.310
CLV_PCSK_KEX2_1	528	530	PF00082	0.511
CLV_PCSK_KEX2_1	54	56	PF00082	0.265
CLV_PCSK_KEX2_1	584	586	PF00082	0.686
CLV_PCSK_KEX2_1	594	596	PF00082	0.686
CLV_PCSK_KEX2_1	72	74	PF00082	0.204
CLV_PCSK_PC1ET2_1	54	56	PF00082	0.272
CLV_PCSK_SKI1_1	292	296	PF00082	0.273
CLV_PCSK_SKI1_1	301	305	PF00082	0.212
CLV_PCSK_SKI1_1	346	350	PF00082	0.317
CLV_PCSK_SKI1_1	362	366	PF00082	0.177
CLV_PCSK_SKI1_1	449	453	PF00082	0.332
CLV_PCSK_SKI1_1	558	562	PF00082	0.468
CLV_Separin_Metazoa	17	21	PF03568	0.400
DEG_APCC_DBOX_1	291	299	PF00400	0.532
DEG_COP1_1	28	39	PF00400	0.498
DEG_Nend_UBRbox_3	1	3	PF02207	0.336
DOC_CKS1_1	85	90	PF01111	0.513
DOC_MAPK_gen_1	130	136	PF00069	0.442
DOC_MAPK_gen_1	209	218	PF00069	0.520
DOC_MAPK_gen_1	238	248	PF00069	0.535
DOC_MAPK_MEF2A_6	241	248	PF00069	0.515
DOC_MAPK_MEF2A_6	250	257	PF00069	0.469
DOC_MAPK_MEF2A_6	60	68	PF00069	0.474
DOC_MAPK_NFAT4_5	241	249	PF00069	0.532
DOC_PP1_RVXF_1	213	219	PF00149	0.492
DOC_PP1_RVXF_1	299	305	PF00149	0.458
DOC_PP4_FxxP_1	568	571	PF00568	0.699
DOC_USP7_MATH_1	162	166	PF00917	0.572
DOC_USP7_MATH_1	203	207	PF00917	0.528
DOC_USP7_MATH_1	253	257	PF00917	0.344
DOC_USP7_MATH_1	553	557	PF00917	0.705
DOC_USP7_MATH_1	563	567	PF00917	0.645
DOC_USP7_MATH_1	75	79	PF00917	0.479
DOC_WW_Pin1_4	119	124	PF00397	0.450
DOC_WW_Pin1_4	272	277	PF00397	0.532
DOC_WW_Pin1_4	383	388	PF00397	0.471
DOC_WW_Pin1_4	549	554	PF00397	0.631
DOC_WW_Pin1_4	84	89	PF00397	0.431
LIG_14-3-3_CanoR_1	187	194	PF00244	0.562
LIG_14-3-3_CanoR_1	215	219	PF00244	0.489
LIG_14-3-3_CanoR_1	558	565	PF00244	0.709
LIG_14-3-3_CanoR_1	584	588	PF00244	0.688
LIG_Actin_WH2_2	523	541	PF00022	0.355
LIG_deltaCOP1_diTrp_1	322	325	PF00928	0.532
LIG_eIF4E_1	400	406	PF01652	0.532
LIG_eIF4E_1	96	102	PF01652	0.532
LIG_FHA_1	268	274	PF00498	0.478
LIG_FHA_1	303	309	PF00498	0.532
LIG_FHA_1	353	359	PF00498	0.427
LIG_FHA_1	38	44	PF00498	0.446
LIG_FHA_1	388	394	PF00498	0.451
LIG_FHA_1	422	428	PF00498	0.438
LIG_FHA_1	494	500	PF00498	0.529
LIG_FHA_1	510	516	PF00498	0.354
LIG_FHA_2	109	115	PF00498	0.473
LIG_FHA_2	167	173	PF00498	0.452
LIG_FHA_2	174	180	PF00498	0.434
LIG_FHA_2	463	469	PF00498	0.524
LIG_LIR_Apic_2	566	571	PF02991	0.700
LIG_LIR_Gen_1	322	330	PF02991	0.545
LIG_LIR_Gen_1	416	427	PF02991	0.442
LIG_LIR_Gen_1	59	68	PF02991	0.458
LIG_LIR_Nem_3	21	27	PF02991	0.454
LIG_LIR_Nem_3	297	303	PF02991	0.472
LIG_LIR_Nem_3	322	326	PF02991	0.540
LIG_LIR_Nem_3	398	403	PF02991	0.504
LIG_LIR_Nem_3	416	422	PF02991	0.446
LIG_LIR_Nem_3	59	64	PF02991	0.454
LIG_LIR_Nem_3	6	11	PF02991	0.452
LIG_NRBOX	427	433	PF00104	0.476
LIG_Pex14_1	353	357	PF04695	0.532
LIG_Pex14_2	300	304	PF04695	0.442
LIG_Pex14_2	349	353	PF04695	0.464
LIG_RPA_C_Fungi	182	194	PF08784	0.466
LIG_SH2_CRK	400	404	PF00017	0.351
LIG_SH2_CRK	419	423	PF00017	0.276
LIG_SH2_CRK	61	65	PF00017	0.331
LIG_SH2_NCK_1	400	404	PF00017	0.436
LIG_SH2_NCK_1	61	65	PF00017	0.331
LIG_SH2_PTP2	543	546	PF00017	0.357
LIG_SH2_SRC	400	403	PF00017	0.255
LIG_SH2_SRC	543	546	PF00017	0.521
LIG_SH2_STAP1	419	423	PF00017	0.289
LIG_SH2_STAP1	457	461	PF00017	0.407
LIG_SH2_STAT5	110	113	PF00017	0.356
LIG_SH2_STAT5	267	270	PF00017	0.447
LIG_SH2_STAT5	357	360	PF00017	0.277
LIG_SH2_STAT5	382	385	PF00017	0.288
LIG_SH2_STAT5	437	440	PF00017	0.454
LIG_SH2_STAT5	543	546	PF00017	0.492
LIG_SH3_1	539	545	PF00018	0.346
LIG_SH3_3	117	123	PF00018	0.326
LIG_SH3_3	270	276	PF00018	0.363
LIG_SH3_3	388	394	PF00018	0.285
LIG_SH3_3	539	545	PF00018	0.476
LIG_SH3_3	82	88	PF00018	0.321
LIG_SUMO_SIM_anti_2	270	275	PF11976	0.411
LIG_SUMO_SIM_anti_2	401	407	PF11976	0.255
LIG_SUMO_SIM_par_1	269	275	PF11976	0.395
LIG_SUMO_SIM_par_1	475	480	PF11976	0.326
LIG_TRAF2_1	111	114	PF00917	0.363
LIG_TRAF2_1	275	278	PF00917	0.369
LIG_TRFH_1	100	104	PF08558	0.304
LIG_WRC_WIRS_1	490	495	PF05994	0.240
MOD_CK1_1	167	173	PF00069	0.359
MOD_CK1_1	256	262	PF00069	0.345
MOD_CK1_1	503	509	PF00069	0.463
MOD_CK1_1	556	562	PF00069	0.710
MOD_CK1_1	59	65	PF00069	0.397
MOD_CK1_1	78	84	PF00069	0.256
MOD_CK2_1	108	114	PF00069	0.329
MOD_CK2_1	162	168	PF00069	0.400
MOD_CK2_1	173	179	PF00069	0.269
MOD_CK2_1	272	278	PF00069	0.411
MOD_CK2_1	462	468	PF00069	0.516
MOD_GlcNHglycan	123	126	PF01048	0.374
MOD_GlcNHglycan	264	267	PF01048	0.330
MOD_GlcNHglycan	327	330	PF01048	0.255
MOD_GlcNHglycan	375	378	PF01048	0.260
MOD_GlcNHglycan	521	524	PF01048	0.494
MOD_GlcNHglycan	555	558	PF01048	0.510
MOD_GlcNHglycan	77	80	PF01048	0.393
MOD_GSK3_1	162	169	PF00069	0.377
MOD_GSK3_1	214	221	PF00069	0.415
MOD_GSK3_1	369	376	PF00069	0.391
MOD_GSK3_1	37	44	PF00069	0.274
MOD_GSK3_1	383	390	PF00069	0.416
MOD_GSK3_1	489	496	PF00069	0.427
MOD_GSK3_1	505	512	PF00069	0.456
MOD_GSK3_1	549	556	PF00069	0.618
MOD_GSK3_1	74	81	PF00069	0.312
MOD_N-GLC_1	532	537	PF02516	0.503
MOD_NEK2_1	218	223	PF00069	0.411
MOD_NEK2_1	294	299	PF00069	0.372
MOD_NEK2_1	307	312	PF00069	0.319
MOD_NEK2_1	325	330	PF00069	0.260
MOD_NEK2_1	352	357	PF00069	0.407
MOD_NEK2_1	423	428	PF00069	0.285
MOD_NEK2_1	452	457	PF00069	0.407
MOD_NEK2_1	56	61	PF00069	0.329
MOD_NEK2_1	583	588	PF00069	0.657
MOD_NEK2_2	253	258	PF00069	0.411
MOD_PIKK_1	162	168	PF00454	0.394
MOD_PIKK_1	444	450	PF00454	0.286
MOD_PIKK_1	493	499	PF00454	0.309
MOD_PK_1	369	375	PF00069	0.295
MOD_PKA_2	186	192	PF00069	0.475
MOD_PKA_2	214	220	PF00069	0.183
MOD_PKA_2	259	265	PF00069	0.343
MOD_PKA_2	583	589	PF00069	0.690
MOD_PKA_2	59	65	PF00069	0.347
MOD_Plk_1	500	506	PF00069	0.500
MOD_Plk_1	532	538	PF00069	0.442
MOD_Plk_4	214	220	PF00069	0.385
MOD_Plk_4	401	407	PF00069	0.417
MOD_Plk_4	423	429	PF00069	0.263
MOD_Plk_4	489	495	PF00069	0.503
MOD_Plk_4	500	506	PF00069	0.469
MOD_Plk_4	59	65	PF00069	0.401
MOD_ProDKin_1	119	125	PF00069	0.296
MOD_ProDKin_1	272	278	PF00069	0.411
MOD_ProDKin_1	383	389	PF00069	0.326
MOD_ProDKin_1	549	555	PF00069	0.635
MOD_ProDKin_1	84	90	PF00069	0.270
TRG_DiLeu_BaEn_1	290	295	PF01217	0.255
TRG_DiLeu_BaLyEn_6	533	538	PF01217	0.514
TRG_ENDOCYTIC_2	141	144	PF00928	0.285
TRG_ENDOCYTIC_2	400	403	PF00928	0.285
TRG_ENDOCYTIC_2	419	422	PF00928	0.272
TRG_ENDOCYTIC_2	61	64	PF00928	0.311
TRG_ER_diArg_1	129	131	PF00400	0.304
TRG_ER_diArg_1	155	158	PF00400	0.329
TRG_ER_diArg_1	194	196	PF00400	0.308
TRG_ER_diArg_1	257	260	PF00400	0.292
TRG_ER_diArg_1	284	286	PF00400	0.380
TRG_ER_diArg_1	3	5	PF00400	0.389
TRG_ER_diArg_1	528	530	PF00400	0.555
TRG_ER_diArg_1	583	585	PF00400	0.681
TRG_ER_diArg_1	591	594	PF00400	0.634
TRG_ER_diArg_1	71	73	PF00400	0.392
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.346
TRG_Pf-PMV_PEXEL_1	528	532	PF00026	0.524

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P603	Leptomonas seymouri	27%	100%
A0A0N1ILJ1	Leptomonas seymouri	67%	98%
A0A0S4J225	Bodo saltans	28%	82%
A0A1X0NLC6	Trypanosomatidae	25%	100%
A0A1X0NXI3	Trypanosomatidae	43%	99%
A0A3Q8ICI3	Leishmania donovani	92%	99%
A0A3R7K5K5	Trypanosoma rangeli	26%	100%
A0A3S7X9D8	Leishmania donovani	27%	88%
A0A3S7XC77	Leishmania donovani	27%	100%
A0A422N5N5	Trypanosoma rangeli	50%	100%
A4HCS6	Leishmania braziliensis	90%	99%
A4HQF5	Leishmania braziliensis	27%	100%
A4I0A0	Leishmania infantum	92%	99%
A4IBC6	Leishmania infantum	27%	88%
A4IC91	Leishmania infantum	27%	100%
B2RXZ1	Mus musculus	25%	100%
C9ZV58	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
D0A3T2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AF58	Leishmania major	26%	88%
E9AU71	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	97%
H9JAQ7	Bombyx mori	24%	100%
O95453	Homo sapiens	22%	93%
P69341	Bos taurus	23%	93%
Q4Q0C3	Leishmania major	26%	100%
Q4QBB3	Leishmania major	94%	100%
Q5R6R6	Pongo abelii	23%	100%
Q5RC51	Pongo abelii	22%	93%
Q8NA58	Homo sapiens	23%	100%
Q8VDG3	Mus musculus	24%	96%
Q90ZA1	Xenopus laevis	24%	94%
Q9LG26	Arabidopsis thaliana	23%	87%
V5ASU9	Trypanosoma cruzi	26%	100%
V5BCG2	Trypanosoma cruzi	47%	100%