Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Kinetoplastid kinetochore protein 25, putative

Species:

Leishmania mexicana

UniProt:

E9AW63_LEIMU

TriTrypDb:

LmxM.23.1610

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW63

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.486
CLV_NRD_NRD_1	217	219	PF00675	0.592
CLV_NRD_NRD_1	357	359	PF00675	0.582
CLV_PCSK_KEX2_1	103	105	PF00082	0.486
CLV_PCSK_KEX2_1	170	172	PF00082	0.585
CLV_PCSK_KEX2_1	219	221	PF00082	0.607
CLV_PCSK_KEX2_1	344	346	PF00082	0.585
CLV_PCSK_KEX2_1	357	359	PF00082	0.424
CLV_PCSK_PC1ET2_1	170	172	PF00082	0.557
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.607
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.571
CLV_PCSK_SKI1_1	347	351	PF00082	0.444
CLV_PCSK_SKI1_1	357	361	PF00082	0.521
DEG_APCC_KENBOX_2	260	264	PF00400	0.518
DEG_SCF_FBW7_1	131	136	PF00400	0.642
DEG_SPOP_SBC_1	285	289	PF00917	0.648
DOC_CKS1_1	139	144	PF01111	0.592
DOC_CKS1_1	27	32	PF01111	0.594
DOC_CYCLIN_RxL_1	205	217	PF00134	0.616
DOC_CYCLIN_RxL_1	355	365	PF00134	0.488
DOC_PP1_RVXF_1	302	309	PF00149	0.662
DOC_PP1_RVXF_1	355	362	PF00149	0.468
DOC_PP1_RVXF_1	81	88	PF00149	0.525
DOC_PP4_FxxP_1	87	90	PF00568	0.533
DOC_USP7_MATH_1	110	114	PF00917	0.539
DOC_USP7_MATH_1	213	217	PF00917	0.641
DOC_USP7_MATH_1	230	234	PF00917	0.564
DOC_USP7_MATH_1	285	289	PF00917	0.520
DOC_USP7_MATH_1	302	306	PF00917	0.649
DOC_USP7_MATH_1	4	8	PF00917	0.611
DOC_USP7_MATH_2	221	227	PF00917	0.696
DOC_USP7_UBL2_3	120	124	PF12436	0.589
DOC_WW_Pin1_4	129	134	PF00397	0.610
DOC_WW_Pin1_4	138	143	PF00397	0.628
DOC_WW_Pin1_4	162	167	PF00397	0.618
DOC_WW_Pin1_4	190	195	PF00397	0.542
DOC_WW_Pin1_4	26	31	PF00397	0.603
DOC_WW_Pin1_4	86	91	PF00397	0.500
LIG_14-3-3_CanoR_1	358	366	PF00244	0.583
LIG_APCC_ABBA_1	308	313	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.563
LIG_BIR_III_4	224	228	PF00653	0.609
LIG_BIR_III_4	75	79	PF00653	0.477
LIG_BRCT_BRCA1_1	304	308	PF00533	0.583
LIG_BRCT_BRCA1_1	44	48	PF00533	0.562
LIG_FHA_1	139	145	PF00498	0.576
LIG_FHA_1	156	162	PF00498	0.735
LIG_FHA_1	348	354	PF00498	0.454
LIG_FHA_1	35	41	PF00498	0.454
LIG_FHA_1	361	367	PF00498	0.536
LIG_FHA_2	226	232	PF00498	0.664
LIG_FHA_2	289	295	PF00498	0.650
LIG_FHA_2	322	328	PF00498	0.469
LIG_FHA_2	335	341	PF00498	0.423
LIG_FHA_2	360	366	PF00498	0.597
LIG_FHA_2	56	62	PF00498	0.442
LIG_LIR_Gen_1	113	122	PF02991	0.616
LIG_LIR_Gen_1	319	328	PF02991	0.519
LIG_LIR_Nem_3	113	117	PF02991	0.587
LIG_LIR_Nem_3	305	311	PF02991	0.578
LIG_LIR_Nem_3	319	325	PF02991	0.592
LIG_LIR_Nem_3	45	51	PF02991	0.513
LIG_PTAP_UEV_1	271	276	PF05743	0.505
LIG_SH2_PTP2	322	325	PF00017	0.486
LIG_SH2_STAT5	100	103	PF00017	0.438
LIG_SH2_STAT5	114	117	PF00017	0.513
LIG_SH2_STAT5	322	325	PF00017	0.486
LIG_SH3_3	128	134	PF00018	0.584
LIG_SH3_3	136	142	PF00018	0.608
LIG_SH3_3	269	275	PF00018	0.505
LIG_SH3_3	27	33	PF00018	0.651
LIG_SH3_5	196	200	PF00018	0.567
LIG_SUMO_SIM_par_1	273	279	PF11976	0.573
LIG_TRAF2_1	336	339	PF00917	0.568
LIG_WRC_WIRS_1	114	119	PF05994	0.726
MOD_CDK_SPxxK_3	190	197	PF00069	0.552
MOD_CK1_1	113	119	PF00069	0.526
MOD_CK1_1	15	21	PF00069	0.623
MOD_CK1_1	187	193	PF00069	0.524
MOD_CK1_1	2	8	PF00069	0.552
MOD_CK1_1	206	212	PF00069	0.653
MOD_CK1_1	233	239	PF00069	0.672
MOD_CK1_1	254	260	PF00069	0.696
MOD_CK1_1	279	285	PF00069	0.602
MOD_CK1_1	288	294	PF00069	0.697
MOD_CK1_1	316	322	PF00069	0.612
MOD_CK1_1	55	61	PF00069	0.436
MOD_CK2_1	225	231	PF00069	0.618
MOD_CK2_1	288	294	PF00069	0.622
MOD_CK2_1	334	340	PF00069	0.495
MOD_CK2_1	359	365	PF00069	0.584
MOD_CK2_1	67	73	PF00069	0.426
MOD_GlcNHglycan	14	17	PF01048	0.624
MOD_GlcNHglycan	150	153	PF01048	0.671
MOD_GlcNHglycan	186	189	PF01048	0.628
MOD_GlcNHglycan	223	228	PF01048	0.642
MOD_GlcNHglycan	231	235	PF01048	0.675
MOD_GlcNHglycan	254	257	PF01048	0.655
MOD_GlcNHglycan	272	275	PF01048	0.553
MOD_GlcNHglycan	278	281	PF01048	0.755
MOD_GlcNHglycan	354	357	PF01048	0.528
MOD_GlcNHglycan	6	9	PF01048	0.558
MOD_GlcNHglycan	95	98	PF01048	0.487
MOD_GSK3_1	129	136	PF00069	0.640
MOD_GSK3_1	184	191	PF00069	0.620
MOD_GSK3_1	22	29	PF00069	0.645
MOD_GSK3_1	236	243	PF00069	0.627
MOD_GSK3_1	266	273	PF00069	0.669
MOD_GSK3_1	276	283	PF00069	0.804
MOD_GSK3_1	284	291	PF00069	0.587
MOD_N-GLC_1	21	26	PF02516	0.642
MOD_N-GLC_1	66	71	PF02516	0.413
MOD_NEK2_1	276	281	PF00069	0.636
MOD_NEK2_1	66	71	PF00069	0.428
MOD_NEK2_2	302	307	PF00069	0.674
MOD_PIKK_1	133	139	PF00454	0.519
MOD_PIKK_1	236	242	PF00454	0.664
MOD_PIKK_1	286	292	PF00454	0.518
MOD_PIKK_1	334	340	PF00454	0.597
MOD_PKA_2	204	210	PF00069	0.638
MOD_Plk_1	203	209	PF00069	0.592
MOD_Plk_1	21	27	PF00069	0.716
MOD_Plk_1	293	299	PF00069	0.637
MOD_Plk_1	66	72	PF00069	0.429
MOD_Plk_2-3	294	300	PF00069	0.639
MOD_Plk_4	110	116	PF00069	0.619
MOD_Plk_4	22	28	PF00069	0.682
MOD_Plk_4	318	324	PF00069	0.540
MOD_Plk_4	34	40	PF00069	0.403
MOD_Plk_4	67	73	PF00069	0.426
MOD_ProDKin_1	129	135	PF00069	0.611
MOD_ProDKin_1	138	144	PF00069	0.626
MOD_ProDKin_1	162	168	PF00069	0.618
MOD_ProDKin_1	190	196	PF00069	0.538
MOD_ProDKin_1	26	32	PF00069	0.597
MOD_ProDKin_1	86	92	PF00069	0.494
MOD_SUMO_rev_2	215	221	PF00179	0.688
TRG_ENDOCYTIC_2	114	117	PF00928	0.588
TRG_ENDOCYTIC_2	322	325	PF00928	0.523
TRG_ER_diArg_1	218	221	PF00400	0.687
TRG_ER_diArg_1	357	359	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE95	Leptomonas seymouri	48%	94%
A0A3S5H7B8	Leishmania donovani	85%	100%
A4HCS4	Leishmania braziliensis	78%	100%
A4I098	Leishmania infantum	85%	80%
Q4QBB5	Leishmania major	90%	100%