Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AW62_LEIMU

TriTrypDb:

LmxM.23.1600

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW62

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW62

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	20
GO:0005488	binding	1	20
GO:0036094	small molecule binding	2	20
GO:0097159	organic cyclic compound binding	2	20
GO:1901265	nucleoside phosphate binding	3	20
GO:1901363	heterocyclic compound binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	155	157	PF00675	0.336
CLV_NRD_NRD_1	348	350	PF00675	0.369
CLV_NRD_NRD_1	59	61	PF00675	0.248
CLV_PCSK_KEX2_1	155	157	PF00082	0.374
CLV_PCSK_KEX2_1	330	332	PF00082	0.410
CLV_PCSK_PC1ET2_1	330	332	PF00082	0.309
CLV_PCSK_PC7_1	326	332	PF00082	0.312
CLV_PCSK_SKI1_1	125	129	PF00082	0.315
CLV_PCSK_SKI1_1	155	159	PF00082	0.450
CLV_PCSK_SKI1_1	195	199	PF00082	0.331
CLV_PCSK_SKI1_1	283	287	PF00082	0.360
DEG_APCC_DBOX_1	194	202	PF00400	0.342
DOC_PP4_FxxP_1	203	206	PF00568	0.390
DOC_PP4_FxxP_1	289	292	PF00568	0.398
DOC_USP7_MATH_1	193	197	PF00917	0.161
DOC_USP7_MATH_1	221	225	PF00917	0.301
DOC_USP7_MATH_1	252	256	PF00917	0.254
DOC_USP7_MATH_1	348	352	PF00917	0.479
DOC_WW_Pin1_4	108	113	PF00397	0.392
DOC_WW_Pin1_4	163	168	PF00397	0.508
DOC_WW_Pin1_4	248	253	PF00397	0.413
LIG_14-3-3_CanoR_1	155	160	PF00244	0.419
LIG_14-3-3_CanoR_1	349	353	PF00244	0.402
LIG_APCC_ABBAyCdc20_2	125	131	PF00400	0.246
LIG_BIR_II_1	1	5	PF00653	0.521
LIG_Clathr_ClatBox_1	127	131	PF01394	0.308
LIG_deltaCOP1_diTrp_1	188	197	PF00928	0.337
LIG_deltaCOP1_diTrp_1	346	352	PF00928	0.457
LIG_FHA_1	269	275	PF00498	0.401
LIG_FHA_1	3	9	PF00498	0.502
LIG_FHA_1	352	358	PF00498	0.373
LIG_FHA_2	64	70	PF00498	0.281
LIG_FHA_2	85	91	PF00498	0.319
LIG_GBD_Chelix_1	209	217	PF00786	0.325
LIG_IRF3_LxIS_1	51	57	PF10401	0.155
LIG_LIR_Apic_2	288	292	PF02991	0.352
LIG_LIR_Gen_1	196	205	PF02991	0.369
LIG_LIR_Gen_1	66	71	PF02991	0.317
LIG_LIR_Gen_1	77	85	PF02991	0.296
LIG_LIR_Nem_3	188	194	PF02991	0.317
LIG_LIR_Nem_3	319	325	PF02991	0.397
LIG_LIR_Nem_3	66	70	PF02991	0.317
LIG_LIR_Nem_3	77	83	PF02991	0.296
LIG_MYND_1	178	182	PF01753	0.415
LIG_Pex14_2	159	163	PF04695	0.274
LIG_Pex14_2	244	248	PF04695	0.391
LIG_SH2_PTP2	80	83	PF00017	0.295
LIG_SH2_SRC	67	70	PF00017	0.235
LIG_SH2_STAP1	241	245	PF00017	0.464
LIG_SH2_STAP1	67	71	PF00017	0.267
LIG_SH2_STAT5	140	143	PF00017	0.428
LIG_SH2_STAT5	243	246	PF00017	0.364
LIG_SH2_STAT5	80	83	PF00017	0.295
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.356
LIG_TYR_ITIM	78	83	PF00017	0.308
LIG_WRC_WIRS_1	160	165	PF05994	0.290
LIG_WRC_WIRS_1	194	199	PF05994	0.382
LIG_WRC_WIRS_1	222	227	PF05994	0.390
LIG_WRC_WIRS_1	245	250	PF05994	0.315
MOD_CDC14_SPxK_1	166	169	PF00782	0.338
MOD_CDK_SPxK_1	163	169	PF00069	0.324
MOD_CK1_1	2	8	PF00069	0.471
MOD_CK1_1	247	253	PF00069	0.295
MOD_CK1_1	351	357	PF00069	0.417
MOD_CK2_1	107	113	PF00069	0.384
MOD_CK2_1	114	120	PF00069	0.372
MOD_CK2_1	63	69	PF00069	0.315
MOD_CK2_1	84	90	PF00069	0.377
MOD_GlcNHglycan	122	125	PF01048	0.378
MOD_GlcNHglycan	258	261	PF01048	0.373
MOD_GlcNHglycan	289	292	PF01048	0.622
MOD_GlcNHglycan	332	336	PF01048	0.511
MOD_GlcNHglycan	363	366	PF01048	0.411
MOD_GSK3_1	155	162	PF00069	0.402
MOD_GSK3_1	201	208	PF00069	0.266
MOD_GSK3_1	244	251	PF00069	0.359
MOD_GSK3_1	252	259	PF00069	0.318
MOD_GSK3_1	268	275	PF00069	0.337
MOD_GSK3_1	30	37	PF00069	0.289
MOD_GSK3_1	50	57	PF00069	0.139
MOD_GSK3_1	79	86	PF00069	0.376
MOD_N-GLC_1	302	307	PF02516	0.402
MOD_NEK2_1	11	16	PF00069	0.366
MOD_NEK2_1	130	135	PF00069	0.336
MOD_NEK2_1	159	164	PF00069	0.400
MOD_NEK2_1	244	249	PF00069	0.349
MOD_NEK2_1	256	261	PF00069	0.370
MOD_NEK2_1	30	35	PF00069	0.332
MOD_NEK2_1	316	321	PF00069	0.324
MOD_NEK2_1	361	366	PF00069	0.370
MOD_NEK2_2	221	226	PF00069	0.445
MOD_NEK2_2	50	55	PF00069	0.169
MOD_PIKK_1	316	322	PF00454	0.461
MOD_PKA_1	155	161	PF00069	0.418
MOD_PKA_2	155	161	PF00069	0.418
MOD_PKA_2	348	354	PF00069	0.374
MOD_Plk_1	227	233	PF00069	0.423
MOD_Plk_1	296	302	PF00069	0.556
MOD_Plk_4	114	120	PF00069	0.286
MOD_Plk_4	130	136	PF00069	0.287
MOD_Plk_4	155	161	PF00069	0.431
MOD_Plk_4	244	250	PF00069	0.319
MOD_Plk_4	252	258	PF00069	0.365
MOD_Plk_4	30	36	PF00069	0.294
MOD_Plk_4	348	354	PF00069	0.392
MOD_ProDKin_1	108	114	PF00069	0.392
MOD_ProDKin_1	163	169	PF00069	0.509
MOD_ProDKin_1	248	254	PF00069	0.409
MOD_SUMO_for_1	225	228	PF00179	0.463
MOD_SUMO_rev_2	53	63	PF00179	0.411
TRG_DiLeu_BaEn_1	333	338	PF01217	0.361
TRG_DiLeu_LyEn_5	333	338	PF01217	0.361
TRG_ENDOCYTIC_2	241	244	PF00928	0.395
TRG_ENDOCYTIC_2	245	248	PF00928	0.328
TRG_ENDOCYTIC_2	67	70	PF00928	0.317
TRG_ENDOCYTIC_2	80	83	PF00928	0.288
TRG_ER_diArg_1	154	156	PF00400	0.346
TRG_Pf-PMV_PEXEL_1	212	216	PF00026	0.518
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	28%	80%
A0A0N1I5Z7	Leptomonas seymouri	69%	100%
A0A0N1I7E8	Leptomonas seymouri	38%	98%
A0A0S4IRH3	Bodo saltans	39%	100%
A0A0S4JVB2	Bodo saltans	24%	90%
A0A1X0NWZ0	Trypanosomatidae	27%	76%
A0A1X0NX10	Trypanosomatidae	43%	99%
A0A1X0NX22	Trypanosomatidae	41%	79%
A0A1X0NXP4	Trypanosomatidae	49%	100%
A0A3Q8IM07	Leishmania donovani	94%	100%
A0A3S7WXP2	Leishmania donovani	38%	79%
A0A3S7WXT7	Leishmania donovani	38%	98%
A4HCS3	Leishmania braziliensis	30%	100%
A4I097	Leishmania infantum	38%	79%
A4I0B8	Leishmania infantum	38%	98%
D4GP30	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	27%	100%
E9AH12	Leishmania infantum	94%	85%
E9AW61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	98%
O32223	Bacillus subtilis (strain 168)	26%	100%
P49305	Rhizobium meliloti	25%	100%
Q148L6	Bos taurus	25%	100%
Q4QBB6	Leishmania major	93%	100%
Q4QBB7	Leishmania major	30%	100%
Q7JK39	Macaca fuscata fuscata	25%	100%
Q9ALN5	Saccharopolyspora spinosa	27%	100%
Q9DBB8	Mus musculus	25%	100%
Q9SZ83	Arabidopsis thaliana	30%	100%
Q9TQS6	Macaca fascicularis	25%	100%
Q9TV69	Sus scrofa	23%	100%
Q9U0V7	Leishmania major	38%	100%
Q9UQ10	Homo sapiens	26%	100%
V5BB31	Trypanosoma cruzi	26%	84%
V5BH08	Trypanosoma cruzi	41%	92%