Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania mexicana

UniProt:

E9AW61_LEIMU

TriTrypDb:

LmxM.23.1590

Length:

465

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW61

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW61

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	21
GO:0005488	binding	1	21
GO:0036094	small molecule binding	2	21
GO:0097159	organic cyclic compound binding	2	21
GO:1901265	nucleoside phosphate binding	3	21
GO:1901363	heterocyclic compound binding	2	21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	395	399	PF00656	0.546
CLV_MEL_PAP_1	72	78	PF00089	0.174
CLV_NRD_NRD_1	1	3	PF00675	0.640
CLV_NRD_NRD_1	17	19	PF00675	0.267
CLV_NRD_NRD_1	265	267	PF00675	0.537
CLV_NRD_NRD_1	59	61	PF00675	0.249
CLV_PCSK_KEX2_1	265	267	PF00082	0.537
CLV_PCSK_KEX2_1	99	101	PF00082	0.408
CLV_PCSK_PC1ET2_1	99	101	PF00082	0.408
CLV_PCSK_SKI1_1	138	142	PF00082	0.354
CLV_PCSK_SKI1_1	207	211	PF00082	0.334
CLV_PCSK_SKI1_1	347	351	PF00082	0.406
DEG_APCC_DBOX_1	206	214	PF00400	0.345
DEG_Nend_UBRbox_1	1	4	PF02207	0.610
DEG_SPOP_SBC_1	389	393	PF00917	0.445
DOC_CKS1_1	268	273	PF01111	0.412
DOC_CYCLIN_yClb1_LxF_4	136	141	PF00134	0.299
DOC_CYCLIN_yCln2_LP_2	163	169	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	191	197	PF00134	0.255
DOC_MAPK_gen_1	18	24	PF00069	0.277
DOC_MAPK_gen_1	2	10	PF00069	0.319
DOC_MAPK_gen_1	99	106	PF00069	0.408
DOC_MAPK_MEF2A_6	2	10	PF00069	0.319
DOC_MAPK_MEF2A_6	250	259	PF00069	0.525
DOC_PP1_RVXF_1	136	142	PF00149	0.441
DOC_PP1_RVXF_1	5	11	PF00149	0.393
DOC_PP4_FxxP_1	215	218	PF00568	0.388
DOC_PP4_FxxP_1	285	288	PF00568	0.514
DOC_PP4_FxxP_1	71	74	PF00568	0.408
DOC_USP7_MATH_1	120	124	PF00917	0.275
DOC_USP7_MATH_1	171	175	PF00917	0.408
DOC_USP7_MATH_1	290	294	PF00917	0.641
DOC_USP7_MATH_1	356	360	PF00917	0.517
DOC_USP7_MATH_2	394	400	PF00917	0.390
DOC_WW_Pin1_4	175	180	PF00397	0.549
DOC_WW_Pin1_4	267	272	PF00397	0.673
DOC_WW_Pin1_4	390	395	PF00397	0.523
LIG_14-3-3_CanoR_1	224	232	PF00244	0.540
LIG_14-3-3_CanoR_1	347	355	PF00244	0.456
LIG_BRCT_BRCA1_1	177	181	PF00533	0.417
LIG_Clathr_ClatBox_1	139	143	PF01394	0.354
LIG_deltaCOP1_diTrp_1	200	208	PF00928	0.336
LIG_FHA_1	320	326	PF00498	0.430
LIG_FHA_1	329	335	PF00498	0.405
LIG_FHA_1	438	444	PF00498	0.380
LIG_FHA_2	224	230	PF00498	0.470
LIG_FHA_2	275	281	PF00498	0.472
LIG_FHA_2	339	345	PF00498	0.505
LIG_FHA_2	390	396	PF00498	0.578
LIG_LIR_Apic_2	214	218	PF02991	0.430
LIG_LIR_Apic_2	284	288	PF02991	0.518
LIG_LIR_Apic_2	291	297	PF02991	0.657
LIG_LIR_Gen_1	434	444	PF02991	0.379
LIG_LIR_Gen_1	78	85	PF02991	0.319
LIG_LIR_Gen_1	89	96	PF02991	0.302
LIG_LIR_Nem_3	193	198	PF02991	0.339
LIG_LIR_Nem_3	200	206	PF02991	0.327
LIG_LIR_Nem_3	373	379	PF02991	0.547
LIG_LIR_Nem_3	404	410	PF02991	0.418
LIG_LIR_Nem_3	434	439	PF02991	0.458
LIG_LIR_Nem_3	78	82	PF02991	0.319
LIG_LIR_Nem_3	89	95	PF02991	0.302
LIG_MYND_1	190	194	PF01753	0.414
LIG_Pex14_2	311	315	PF04695	0.426
LIG_SH2_CRK	195	199	PF00017	0.226
LIG_SH2_PTP2	294	297	PF00017	0.418
LIG_SH2_PTP2	92	95	PF00017	0.306
LIG_SH2_STAT3	438	441	PF00017	0.314
LIG_SH2_STAT5	204	207	PF00017	0.313
LIG_SH2_STAT5	294	297	PF00017	0.430
LIG_SH2_STAT5	438	441	PF00017	0.314
LIG_SH2_STAT5	92	95	PF00017	0.306
LIG_SH3_1	265	271	PF00018	0.474
LIG_SH3_3	173	179	PF00018	0.326
LIG_SH3_3	265	271	PF00018	0.474
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.361
LIG_TRAF2_1	393	396	PF00917	0.421
LIG_TYR_ITIM	90	95	PF00017	0.312
MOD_CK1_1	94	100	PF00069	0.329
MOD_CK2_1	120	126	PF00069	0.374
MOD_CK2_1	274	280	PF00069	0.486
MOD_CK2_1	389	395	PF00069	0.691
MOD_GlcNHglycan	122	125	PF01048	0.353
MOD_GlcNHglycan	358	361	PF01048	0.720
MOD_GlcNHglycan	365	370	PF01048	0.676
MOD_GlcNHglycan	398	401	PF01048	0.513
MOD_GlcNHglycan	461	464	PF01048	0.661
MOD_GSK3_1	171	178	PF00069	0.438
MOD_GSK3_1	303	310	PF00069	0.505
MOD_GSK3_1	390	397	PF00069	0.530
MOD_GSK3_1	91	98	PF00069	0.426
MOD_N-GLC_1	242	247	PF02516	0.492
MOD_N-GLC_1	328	333	PF02516	0.295
MOD_N-GLC_1	370	375	PF02516	0.435
MOD_N-GLC_1	56	61	PF02516	0.400
MOD_NEK2_1	11	16	PF00069	0.317
MOD_NEK2_1	142	147	PF00069	0.402
MOD_NEK2_1	283	288	PF00069	0.477
MOD_NEK2_2	330	335	PF00069	0.261
MOD_PIKK_1	147	153	PF00454	0.325
MOD_PIKK_1	347	353	PF00454	0.345
MOD_PIKK_1	437	443	PF00454	0.351
MOD_PKA_1	431	437	PF00069	0.475
MOD_PKA_2	223	229	PF00069	0.506
MOD_PKA_2	29	35	PF00069	0.370
MOD_PKB_1	345	353	PF00069	0.349
MOD_Plk_1	283	289	PF00069	0.451
MOD_Plk_1	319	325	PF00069	0.419
MOD_Plk_1	444	450	PF00069	0.429
MOD_Plk_4	177	183	PF00069	0.505
MOD_Plk_4	290	296	PF00069	0.444
MOD_Plk_4	410	416	PF00069	0.432
MOD_Plk_4	75	81	PF00069	0.358
MOD_ProDKin_1	175	181	PF00069	0.543
MOD_ProDKin_1	267	273	PF00069	0.663
MOD_ProDKin_1	390	396	PF00069	0.515
MOD_SUMO_rev_2	52	59	PF00179	0.409
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.316
TRG_DiLeu_BaLyEn_6	187	192	PF01217	0.340
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.549
TRG_ENDOCYTIC_2	195	198	PF00928	0.227
TRG_ENDOCYTIC_2	379	382	PF00928	0.585
TRG_ENDOCYTIC_2	79	82	PF00928	0.319
TRG_ENDOCYTIC_2	92	95	PF00928	0.294
TRG_ER_diArg_1	345	348	PF00400	0.551
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.376
TRG_Pf-PMV_PEXEL_1	347	351	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	43	47	PF00026	0.198

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P740	Leptomonas seymouri	63%	100%
A0A0N1I5Z7	Leptomonas seymouri	31%	100%
A0A0N1I7E8	Leptomonas seymouri	32%	100%
A0A1X0NX10	Trypanosomatidae	32%	100%
A0A1X0NX22	Trypanosomatidae	37%	100%
A0A1X0NXP4	Trypanosomatidae	29%	100%
A0A3Q8IM07	Leishmania donovani	31%	100%
A0A3S7WXP2	Leishmania donovani	92%	100%
A0A3S7WXT7	Leishmania donovani	32%	100%
A4HCS3	Leishmania braziliensis	79%	100%
A4I097	Leishmania infantum	92%	100%
A4I0B8	Leishmania infantum	32%	100%
E9AH12	Leishmania infantum	31%	100%
E9AW62	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AW82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
Q4QBB6	Leishmania major	31%	82%
Q4QBB7	Leishmania major	90%	100%
Q9U0V7	Leishmania major	32%	82%
V5BB31	Trypanosoma cruzi	24%	100%
V5BH08	Trypanosoma cruzi	36%	100%