Centrosomal protein of 104 kDa

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW60_LEIMU

TriTrypDb:

LmxM.23.0547

Length:

907

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 4

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW60

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	207	211	PF00656	0.442
CLV_C14_Caspase3-7	51	55	PF00656	0.488
CLV_MEL_PAP_1	116	122	PF00089	0.536
CLV_NRD_NRD_1	29	31	PF00675	0.502
CLV_NRD_NRD_1	372	374	PF00675	0.606
CLV_NRD_NRD_1	72	74	PF00675	0.470
CLV_NRD_NRD_1	777	779	PF00675	0.774
CLV_NRD_NRD_1	84	86	PF00675	0.497
CLV_PCSK_KEX2_1	372	374	PF00082	0.606
CLV_PCSK_KEX2_1	72	74	PF00082	0.472
CLV_PCSK_KEX2_1	777	779	PF00082	0.774
CLV_PCSK_PC1ET2_1	372	374	PF00082	0.529
CLV_PCSK_SKI1_1	241	245	PF00082	0.568
CLV_PCSK_SKI1_1	338	342	PF00082	0.555
CLV_PCSK_SKI1_1	72	76	PF00082	0.605
DEG_SPOP_SBC_1	528	532	PF00917	0.747
DOC_CKS1_1	136	141	PF01111	0.509
DOC_CKS1_1	440	445	PF01111	0.696
DOC_CKS1_1	515	520	PF01111	0.731
DOC_CYCLIN_yClb3_PxF_3	770	778	PF00134	0.784
DOC_MAPK_gen_1	70	77	PF00069	0.511
DOC_MAPK_MEF2A_6	19	27	PF00069	0.466
DOC_MAPK_MEF2A_6	798	806	PF00069	0.627
DOC_MAPK_MEF2A_6	880	889	PF00069	0.629
DOC_PP1_RVXF_1	112	119	PF00149	0.527
DOC_PP1_RVXF_1	429	436	PF00149	0.742
DOC_PP1_RVXF_1	71	78	PF00149	0.498
DOC_PP4_FxxP_1	479	482	PF00568	0.570
DOC_PP4_FxxP_1	498	501	PF00568	0.518
DOC_PP4_FxxP_1	66	69	PF00568	0.548
DOC_PP4_FxxP_1	94	97	PF00568	0.505
DOC_USP7_MATH_1	106	110	PF00917	0.529
DOC_USP7_MATH_1	333	337	PF00917	0.587
DOC_USP7_MATH_1	465	469	PF00917	0.598
DOC_USP7_MATH_1	499	503	PF00917	0.800
DOC_USP7_MATH_1	524	528	PF00917	0.843
DOC_USP7_MATH_1	535	539	PF00917	0.814
DOC_USP7_MATH_1	548	552	PF00917	0.559
DOC_USP7_MATH_1	675	679	PF00917	0.721
DOC_USP7_MATH_1	704	708	PF00917	0.727
DOC_USP7_MATH_1	730	734	PF00917	0.559
DOC_USP7_MATH_1	879	883	PF00917	0.694
DOC_USP7_UBL2_3	280	284	PF12436	0.566
DOC_USP7_UBL2_3	387	391	PF12436	0.696
DOC_USP7_UBL2_3	86	90	PF12436	0.547
DOC_WW_Pin1_4	135	140	PF00397	0.501
DOC_WW_Pin1_4	149	154	PF00397	0.589
DOC_WW_Pin1_4	364	369	PF00397	0.476
DOC_WW_Pin1_4	439	444	PF00397	0.685
DOC_WW_Pin1_4	497	502	PF00397	0.525
DOC_WW_Pin1_4	514	519	PF00397	0.723
DOC_WW_Pin1_4	529	534	PF00397	0.714
DOC_WW_Pin1_4	577	582	PF00397	0.653
DOC_WW_Pin1_4	604	609	PF00397	0.755
DOC_WW_Pin1_4	613	618	PF00397	0.676
DOC_WW_Pin1_4	619	624	PF00397	0.678
DOC_WW_Pin1_4	643	648	PF00397	0.672
DOC_WW_Pin1_4	65	70	PF00397	0.517
DOC_WW_Pin1_4	807	812	PF00397	0.429
DOC_WW_Pin1_4	838	843	PF00397	0.758
DOC_WW_Pin1_4	896	901	PF00397	0.613
LIG_14-3-3_CanoR_1	225	229	PF00244	0.534
LIG_14-3-3_CanoR_1	634	642	PF00244	0.754
LIG_14-3-3_CanoR_1	669	674	PF00244	0.575
LIG_14-3-3_CanoR_1	72	78	PF00244	0.345
LIG_14-3-3_CanoR_1	85	94	PF00244	0.383
LIG_14-3-3_CanoR_1	867	874	PF00244	0.636
LIG_14-3-3_CterR_2	904	907	PF00244	0.626
LIG_APCC_ABBA_1	802	807	PF00400	0.657
LIG_APCC_ABBA_1	890	895	PF00400	0.573
LIG_BIR_III_4	469	473	PF00653	0.829
LIG_BRCT_BRCA1_1	608	612	PF00533	0.562
LIG_CSL_BTD_1	859	862	PF09270	0.627
LIG_FHA_1	224	230	PF00498	0.535
LIG_FHA_1	242	248	PF00498	0.567
LIG_FHA_1	298	304	PF00498	0.522
LIG_FHA_1	321	327	PF00498	0.370
LIG_FHA_1	354	360	PF00498	0.560
LIG_FHA_1	397	403	PF00498	0.585
LIG_FHA_1	469	475	PF00498	0.728
LIG_FHA_1	869	875	PF00498	0.515
LIG_FHA_2	232	238	PF00498	0.556
LIG_FHA_2	504	510	PF00498	0.738
LIG_FHA_2	586	592	PF00498	0.718
LIG_FHA_2	627	633	PF00498	0.567
LIG_FHA_2	90	96	PF00498	0.508
LIG_KLC1_Yacidic_2	803	807	PF13176	0.666
LIG_LIR_Apic_2	476	482	PF02991	0.566
LIG_LIR_Apic_2	495	501	PF02991	0.655
LIG_LIR_Apic_2	506	511	PF02991	0.772
LIG_LIR_Apic_2	63	69	PF02991	0.535
LIG_LIR_Apic_2	788	794	PF02991	0.637
LIG_LIR_Apic_2	92	97	PF02991	0.505
LIG_LIR_Gen_1	22	28	PF02991	0.406
LIG_LIR_Gen_1	383	393	PF02991	0.606
LIG_LIR_Gen_1	47	56	PF02991	0.353
LIG_LIR_Gen_1	824	832	PF02991	0.614
LIG_LIR_Nem_3	22	27	PF02991	0.406
LIG_LIR_Nem_3	383	388	PF02991	0.551
LIG_LIR_Nem_3	47	53	PF02991	0.348
LIG_LIR_Nem_3	76	80	PF02991	0.331
LIG_LIR_Nem_3	784	790	PF02991	0.666
LIG_LIR_Nem_3	895	901	PF02991	0.620
LIG_PDZ_Class_2	902	907	PF00595	0.618
LIG_Pex14_2	62	66	PF04695	0.504
LIG_Pex14_2	901	905	PF04695	0.607
LIG_PTAP_UEV_1	541	546	PF05743	0.568
LIG_PTAP_UEV_1	574	579	PF05743	0.541
LIG_PTB_Apo_2	819	826	PF02174	0.621
LIG_PTB_Phospho_1	819	825	PF10480	0.618
LIG_SH2_CRK	791	795	PF00017	0.629
LIG_SH2_PTP2	24	27	PF00017	0.398
LIG_SH2_SRC	508	511	PF00017	0.796
LIG_SH2_SRC	805	808	PF00017	0.696
LIG_SH2_STAP1	252	256	PF00017	0.605
LIG_SH2_STAP1	4	8	PF00017	0.440
LIG_SH2_STAT3	252	255	PF00017	0.598
LIG_SH2_STAT3	718	721	PF00017	0.703
LIG_SH2_STAT3	729	732	PF00017	0.597
LIG_SH2_STAT3	742	745	PF00017	0.573
LIG_SH2_STAT3	749	752	PF00017	0.502
LIG_SH2_STAT3	757	760	PF00017	0.534
LIG_SH2_STAT5	16	19	PF00017	0.414
LIG_SH2_STAT5	24	27	PF00017	0.378
LIG_SH2_STAT5	313	316	PF00017	0.546
LIG_SH2_STAT5	417	420	PF00017	0.671
LIG_SH2_STAT5	787	790	PF00017	0.631
LIG_SH2_STAT5	805	808	PF00017	0.404
LIG_SH2_STAT5	891	894	PF00017	0.593
LIG_SH2_STAT5	898	901	PF00017	0.490
LIG_SH3_3	133	139	PF00018	0.480
LIG_SH3_3	225	231	PF00018	0.520
LIG_SH3_3	434	440	PF00018	0.485
LIG_SH3_3	516	522	PF00018	0.829
LIG_SH3_3	539	545	PF00018	0.603
LIG_SH3_3	569	575	PF00018	0.843
LIG_SH3_3	653	659	PF00018	0.705
LIG_SH3_3	662	668	PF00018	0.701
LIG_SH3_3	724	730	PF00018	0.686
LIG_SH3_3	767	773	PF00018	0.823
LIG_SH3_3	873	879	PF00018	0.677
LIG_SUMO_SIM_par_1	24	29	PF11976	0.395
LIG_SUMO_SIM_par_1	355	360	PF11976	0.583
LIG_SUMO_SIM_par_1	568	573	PF11976	0.562
LIG_TRAF2_1	781	784	PF00917	0.780
LIG_UBA3_1	357	362	PF00899	0.611
LIG_WRC_WIRS_1	74	79	PF05994	0.299
MOD_CDC14_SPxK_1	810	813	PF00782	0.395
MOD_CDK_SPK_2	65	70	PF00069	0.548
MOD_CDK_SPxK_1	807	813	PF00069	0.420
MOD_CDK_SPxxK_3	65	72	PF00069	0.516
MOD_CK1_1	121	127	PF00069	0.619
MOD_CK1_1	164	170	PF00069	0.777
MOD_CK1_1	172	178	PF00069	0.690
MOD_CK1_1	266	272	PF00069	0.597
MOD_CK1_1	40	46	PF00069	0.335
MOD_CK1_1	451	457	PF00069	0.709
MOD_CK1_1	468	474	PF00069	0.531
MOD_CK1_1	527	533	PF00069	0.724
MOD_CK1_1	573	579	PF00069	0.824
MOD_CK1_1	65	71	PF00069	0.543
MOD_CK1_1	707	713	PF00069	0.581
MOD_CK1_1	846	852	PF00069	0.717
MOD_CK1_1	866	872	PF00069	0.311
MOD_CK2_1	106	112	PF00069	0.482
MOD_CK2_1	231	237	PF00069	0.555
MOD_CK2_1	394	400	PF00069	0.579
MOD_CK2_1	41	47	PF00069	0.561
MOD_CK2_1	503	509	PF00069	0.744
MOD_CK2_1	585	591	PF00069	0.717
MOD_CK2_1	626	632	PF00069	0.619
MOD_CK2_1	675	681	PF00069	0.749
MOD_CK2_1	778	784	PF00069	0.780
MOD_CK2_1	89	95	PF00069	0.514
MOD_GlcNHglycan	120	123	PF01048	0.545
MOD_GlcNHglycan	166	169	PF01048	0.737
MOD_GlcNHglycan	174	177	PF01048	0.676
MOD_GlcNHglycan	265	268	PF01048	0.586
MOD_GlcNHglycan	287	292	PF01048	0.661
MOD_GlcNHglycan	522	525	PF01048	0.797
MOD_GlcNHglycan	526	529	PF01048	0.798
MOD_GlcNHglycan	57	60	PF01048	0.642
MOD_GlcNHglycan	572	575	PF01048	0.760
MOD_GlcNHglycan	643	646	PF01048	0.705
MOD_GlcNHglycan	693	696	PF01048	0.584
MOD_GlcNHglycan	845	848	PF01048	0.744
MOD_GlcNHglycan	87	90	PF01048	0.469
MOD_GSK3_1	114	121	PF00069	0.532
MOD_GSK3_1	360	367	PF00069	0.425
MOD_GSK3_1	37	44	PF00069	0.617
MOD_GSK3_1	497	504	PF00069	0.802
MOD_GSK3_1	520	527	PF00069	0.797
MOD_GSK3_1	573	580	PF00069	0.624
MOD_GSK3_1	626	633	PF00069	0.692
MOD_GSK3_1	641	648	PF00069	0.812
MOD_GSK3_1	669	676	PF00069	0.747
MOD_GSK3_1	691	698	PF00069	0.650
MOD_GSK3_1	85	92	PF00069	0.469
MOD_GSK3_1	899	906	PF00069	0.616
MOD_N-GLC_1	619	624	PF02516	0.828
MOD_NEK2_1	11	16	PF00069	0.495
MOD_NEK2_1	118	123	PF00069	0.540
MOD_NEK2_1	185	190	PF00069	0.480
MOD_NEK2_1	402	407	PF00069	0.574
MOD_NEK2_1	425	430	PF00069	0.665
MOD_NEK2_1	503	508	PF00069	0.812
MOD_NEK2_1	570	575	PF00069	0.554
MOD_NEK2_1	585	590	PF00069	0.534
MOD_NEK2_1	62	67	PF00069	0.516
MOD_PIKK_1	307	313	PF00454	0.715
MOD_PIKK_1	535	541	PF00454	0.842
MOD_PIKK_1	548	554	PF00454	0.588
MOD_PIKK_1	606	612	PF00454	0.564
MOD_PIKK_1	673	679	PF00454	0.757
MOD_PIKK_1	695	701	PF00454	0.627
MOD_PIKK_1	728	734	PF00454	0.561
MOD_PIKK_1	849	855	PF00454	0.719
MOD_PK_1	19	25	PF00069	0.473
MOD_PK_1	669	675	PF00069	0.574
MOD_PK_1	880	886	PF00069	0.651
MOD_PKA_1	85	91	PF00069	0.477
MOD_PKA_2	118	124	PF00069	0.539
MOD_PKA_2	186	192	PF00069	0.618
MOD_PKA_2	224	230	PF00069	0.657
MOD_PKA_2	633	639	PF00069	0.702
MOD_PKA_2	812	818	PF00069	0.622
MOD_PKA_2	866	872	PF00069	0.636
MOD_PKA_2	879	885	PF00069	0.458
MOD_Plk_1	62	68	PF00069	0.521
MOD_Plk_1	626	632	PF00069	0.665
MOD_Plk_1	815	821	PF00069	0.601
MOD_Plk_2-3	327	333	PF00069	0.552
MOD_Plk_2-3	394	400	PF00069	0.579
MOD_Plk_4	100	106	PF00069	0.541
MOD_Plk_4	19	25	PF00069	0.473
MOD_Plk_4	224	230	PF00069	0.626
MOD_Plk_4	353	359	PF00069	0.530
MOD_Plk_4	402	408	PF00069	0.598
MOD_Plk_4	652	658	PF00069	0.631
MOD_Plk_4	815	821	PF00069	0.601
MOD_Plk_4	880	886	PF00069	0.651
MOD_ProDKin_1	135	141	PF00069	0.498
MOD_ProDKin_1	149	155	PF00069	0.591
MOD_ProDKin_1	364	370	PF00069	0.483
MOD_ProDKin_1	439	445	PF00069	0.688
MOD_ProDKin_1	497	503	PF00069	0.527
MOD_ProDKin_1	514	520	PF00069	0.728
MOD_ProDKin_1	529	535	PF00069	0.713
MOD_ProDKin_1	577	583	PF00069	0.654
MOD_ProDKin_1	604	610	PF00069	0.755
MOD_ProDKin_1	613	619	PF00069	0.674
MOD_ProDKin_1	643	649	PF00069	0.667
MOD_ProDKin_1	65	71	PF00069	0.512
MOD_ProDKin_1	807	813	PF00069	0.420
MOD_ProDKin_1	838	844	PF00069	0.762
MOD_ProDKin_1	896	902	PF00069	0.614
MOD_SUMO_for_1	361	364	PF00179	0.676
MOD_SUMO_for_1	834	837	PF00179	0.650
MOD_SUMO_rev_2	108	116	PF00179	0.510
MOD_SUMO_rev_2	281	291	PF00179	0.641
MOD_SUMO_rev_2	803	811	PF00179	0.688
TRG_DiLeu_BaLyEn_6	343	348	PF01217	0.642
TRG_ENDOCYTIC_2	24	27	PF00928	0.398
TRG_ENDOCYTIC_2	787	790	PF00928	0.631
TRG_ENDOCYTIC_2	825	828	PF00928	0.611
TRG_ENDOCYTIC_2	898	901	PF00928	0.604
TRG_ER_diArg_1	72	74	PF00400	0.554
TRG_ER_diArg_1	777	779	PF00400	0.774
TRG_Pf-PMV_PEXEL_1	241	246	PF00026	0.667
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.538

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRN9	Leptomonas seymouri	60%	100%
A0A3S7WXK3	Leishmania donovani	83%	100%
A4I096	Leishmania infantum	83%	100%
Q4QBB8	Leishmania major	80%	94%