EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9AW58_LEIMU

TriTrypDb:

LmxM.23.0542

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW58

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005509	calcium ion binding	5	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	137	141	PF00656	0.510
CLV_C14_Caspase3-7	235	239	PF00656	0.468
CLV_NRD_NRD_1	13	15	PF00675	0.641
CLV_PCSK_KEX2_1	13	15	PF00082	0.645
CLV_PCSK_SKI1_1	303	307	PF00082	0.523
CLV_Separin_Metazoa	72	76	PF03568	0.695
DOC_CDC14_PxL_1	198	206	PF14671	0.514
DOC_CDC14_PxL_1	48	56	PF14671	0.633
DOC_CKS1_1	61	66	PF01111	0.642
DOC_CYCLIN_yCln2_LP_2	171	177	PF00134	0.715
DOC_MAPK_MEF2A_6	223	230	PF00069	0.691
DOC_PP2B_LxvP_1	171	174	PF13499	0.713
DOC_PP4_FxxP_1	165	168	PF00568	0.492
DOC_USP7_MATH_1	141	145	PF00917	0.735
DOC_USP7_MATH_1	221	225	PF00917	0.664
DOC_USP7_MATH_1	40	44	PF00917	0.726
DOC_USP7_MATH_1	91	95	PF00917	0.590
DOC_USP7_UBL2_3	135	139	PF12436	0.802
DOC_WW_Pin1_4	106	111	PF00397	0.624
DOC_WW_Pin1_4	166	171	PF00397	0.678
DOC_WW_Pin1_4	213	218	PF00397	0.499
DOC_WW_Pin1_4	60	65	PF00397	0.657
DOC_WW_Pin1_4	98	103	PF00397	0.835
LIG_14-3-3_CanoR_1	108	116	PF00244	0.599
LIG_14-3-3_CanoR_1	14	22	PF00244	0.721
LIG_APCC_ABBA_1	198	203	PF00400	0.607
LIG_BIR_II_1	1	5	PF00653	0.657
LIG_BIR_III_2	37	41	PF00653	0.721
LIG_BIR_III_4	240	244	PF00653	0.631
LIG_eIF4E_1	16	22	PF01652	0.717
LIG_FHA_1	16	22	PF00498	0.703
LIG_FHA_2	296	302	PF00498	0.490
LIG_FHA_2	5	11	PF00498	0.647
LIG_Integrin_RGD_1	35	37	PF01839	0.605
LIG_LIR_Apic_2	162	168	PF02991	0.501
LIG_LIR_Gen_1	192	202	PF02991	0.595
LIG_LIR_Gen_1	232	241	PF02991	0.559
LIG_LIR_Gen_1	45	54	PF02991	0.731
LIG_LIR_Nem_3	192	197	PF02991	0.526
LIG_LIR_Nem_3	232	237	PF02991	0.500
LIG_LIR_Nem_3	45	51	PF02991	0.747
LIG_LYPXL_S_1	200	204	PF13949	0.506
LIG_LYPXL_yS_3	201	204	PF13949	0.506
LIG_PCNA_yPIPBox_3	60	74	PF02747	0.703
LIG_SH2_STAT5	16	19	PF00017	0.626
LIG_SH2_STAT5	196	199	PF00017	0.511
LIG_SH3_3	174	180	PF00018	0.749
LIG_SH3_3	225	231	PF00018	0.673
LIG_SUMO_SIM_anti_2	69	75	PF11976	0.488
LIG_SUMO_SIM_par_1	294	301	PF11976	0.517
LIG_TRAF2_1	7	10	PF00917	0.714
LIG_TYR_ITIM	199	204	PF00017	0.509
MOD_CDK_SPxxK_3	98	105	PF00069	0.834
MOD_CK1_1	109	115	PF00069	0.590
MOD_CK1_1	160	166	PF00069	0.784
MOD_CK1_1	182	188	PF00069	0.587
MOD_CK1_1	92	98	PF00069	0.717
MOD_CK2_1	4	10	PF00069	0.649
MOD_CK2_1	40	46	PF00069	0.695
MOD_GlcNHglycan	159	162	PF01048	0.783
MOD_GlcNHglycan	181	184	PF01048	0.554
MOD_GlcNHglycan	191	194	PF01048	0.529
MOD_GlcNHglycan	208	211	PF01048	0.456
MOD_GlcNHglycan	223	226	PF01048	0.509
MOD_GlcNHglycan	245	248	PF01048	0.350
MOD_GlcNHglycan	42	45	PF01048	0.629
MOD_GlcNHglycan	78	81	PF01048	0.606
MOD_GlcNHglycan	93	97	PF01048	0.740
MOD_GSK3_1	111	118	PF00069	0.819
MOD_GSK3_1	129	136	PF00069	0.634
MOD_GSK3_1	202	209	PF00069	0.582
MOD_GSK3_1	91	98	PF00069	0.669
MOD_N-GLC_1	189	194	PF02516	0.462
MOD_NEK2_1	189	194	PF00069	0.569
MOD_NEK2_1	28	33	PF00069	0.676
MOD_NEK2_1	76	81	PF00069	0.596
MOD_PIKK_1	115	121	PF00454	0.821
MOD_PIKK_1	202	208	PF00454	0.467
MOD_PIKK_1	63	69	PF00454	0.601
MOD_PIKK_1	95	101	PF00454	0.627
MOD_PKA_2	206	212	PF00069	0.719
MOD_Plk_1	142	148	PF00069	0.525
MOD_Plk_1	189	195	PF00069	0.556
MOD_Plk_2-3	232	238	PF00069	0.311
MOD_ProDKin_1	106	112	PF00069	0.626
MOD_ProDKin_1	166	172	PF00069	0.679
MOD_ProDKin_1	213	219	PF00069	0.500
MOD_ProDKin_1	60	66	PF00069	0.649
MOD_ProDKin_1	98	104	PF00069	0.835
TRG_DiLeu_BaEn_1	260	265	PF01217	0.683
TRG_ENDOCYTIC_2	196	199	PF00928	0.511
TRG_ENDOCYTIC_2	201	204	PF00928	0.506
TRG_ER_diArg_1	13	15	PF00400	0.645
TRG_NLS_MonoExtN_4	124	130	PF00514	0.752

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYT7	Leptomonas seymouri	37%	94%
A0A3Q8IEH7	Leishmania donovani	86%	100%
A4HCS0	Leishmania braziliensis	68%	100%
A4I094	Leishmania infantum	86%	100%
E9ACS4	Leishmania major	83%	99%