Acetyl-coenzyme A synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acetyl-CoA synthetase, putative

Species:

Leishmania mexicana

UniProt:

E9AW57_LEIMU

TriTrypDb:

LmxM.23.0540

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 21

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 10

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0016020	membrane	2	5
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	7

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Expansion

Sequence features

E9AW57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW57

Function

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Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	17
GO:0006083	acetate metabolic process	7	17
GO:0006084	acetyl-CoA metabolic process	5	17
GO:0006085	acetyl-CoA biosynthetic process	6	17
GO:0006139	nucleobase-containing compound metabolic process	3	17
GO:0006163	purine nucleotide metabolic process	5	17
GO:0006164	purine nucleotide biosynthetic process	6	17
GO:0006637	acyl-CoA metabolic process	4	17
GO:0006725	cellular aromatic compound metabolic process	3	17
GO:0006753	nucleoside phosphate metabolic process	4	17

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0003987	acetate-CoA ligase activity	5	17
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016208	AMP binding	4	17
GO:0016405	CoA-ligase activity	4	17
GO:0016874	ligase activity	2	17
GO:0016877	ligase activity, forming carbon-sulfur bonds	3	17
GO:0016878	acid-thiol ligase activity	4	17

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	45	49	PF00656	0.675
CLV_NRD_NRD_1	563	565	PF00675	0.493
CLV_NRD_NRD_1	58	60	PF00675	0.324
CLV_NRD_NRD_1	643	645	PF00675	0.561
CLV_NRD_NRD_1	673	675	PF00675	0.559
CLV_NRD_NRD_1	676	678	PF00675	0.551
CLV_NRD_NRD_1	91	93	PF00675	0.362
CLV_PCSK_KEX2_1	563	565	PF00082	0.493
CLV_PCSK_KEX2_1	673	675	PF00082	0.559
CLV_PCSK_KEX2_1	91	93	PF00082	0.362

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0G2K047	Rattus norvegicus	32%	100%
A0A0H2ZF83	Pseudomonas aeruginosa (strain UCBPP-PA14)	25%	100%
A0A0S4J3H6	Bodo saltans	24%	100%
A0A0S4JQ01	Bodo saltans	61%	100%
A0A0S4KJT4	Bodo saltans	34%	100%
A0A1X0NYC1	Trypanosomatidae	65%	100%
A0A1X0NYG3	Trypanosomatidae	66%	100%
A0A2H5AIX5	Narcissus pseudonarcissus	23%	100%
A0A2H5AIY4	Narcissus pseudonarcissus	21%	100%
A0A3Q8IBG6	Leishmania donovani	92%	100%

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