LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9AW54_LEIMU
TriTrypDb:
LmxM.23.0510
Length:
98

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW54
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW54

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_FUR_1 36 40 PF00082 0.569
CLV_PCSK_KEX2_1 38 40 PF00082 0.595
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.573
CLV_PCSK_SKI1_1 5 9 PF00082 0.626
CLV_PCSK_SKI1_1 50 54 PF00082 0.524
CLV_PCSK_SKI1_1 64 68 PF00082 0.566
DOC_MAPK_gen_1 36 46 PF00069 0.601
DOC_MAPK_gen_1 70 79 PF00069 0.403
DOC_PP1_RVXF_1 48 54 PF00149 0.454
DOC_USP7_MATH_1 58 62 PF00917 0.389
LIG_FHA_1 79 85 PF00498 0.650
LIG_FHA_2 7 13 PF00498 0.605
LIG_LIR_Gen_1 73 79 PF02991 0.476
LIG_LIR_Nem_3 73 77 PF02991 0.371
LIG_LIR_Nem_3 93 98 PF02991 0.588
LIG_SH2_NCK_1 74 78 PF00017 0.546
LIG_SH2_SRC 22 25 PF00017 0.517
LIG_SH2_STAP1 62 66 PF00017 0.562
LIG_SH2_STAT5 78 81 PF00017 0.616
MOD_CK1_1 30 36 PF00069 0.556
MOD_CK1_1 83 89 PF00069 0.672
MOD_CK2_1 6 12 PF00069 0.614
MOD_GSK3_1 79 86 PF00069 0.681
MOD_NEK2_1 27 32 PF00069 0.633
MOD_PKA_2 27 33 PF00069 0.659
MOD_SUMO_rev_2 86 93 PF00179 0.431
TRG_ENDOCYTIC_2 74 77 PF00928 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZM7 Leptomonas seymouri 64% 100%
A0A3S7WXN8 Leishmania donovani 90% 100%
A4HCR5 Leishmania braziliensis 71% 100%
A4I090 Leishmania infantum 90% 100%
C9ZV07 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 48% 100%
Q4QBC3 Leishmania major 86% 100%
V5D8H0 Trypanosoma cruzi 56% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS