Transmembrane protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW53_LEIMU

TriTrypDb:

LmxM.23.0500

Length:

284

Annotations

LeishMANIAdb annotations

An absolutely unique fold restricted to kinetoplastids. most predictions are too weak to assume any secure topology.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 2, no: 5
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AW53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	226	230	PF00656	0.472
CLV_NRD_NRD_1	142	144	PF00675	0.473
CLV_NRD_NRD_1	260	262	PF00675	0.415
CLV_NRD_NRD_1	94	96	PF00675	0.540
CLV_PCSK_KEX2_1	260	262	PF00082	0.415
DEG_Nend_UBRbox_1	1	4	PF02207	0.570
DEG_ODPH_VHL_1	76	89	PF01847	0.351
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.596
DOC_MAPK_MEF2A_6	2	10	PF00069	0.567
DOC_MAPK_NFAT4_5	2	10	PF00069	0.567
DOC_MAPK_RevD_3	245	261	PF00069	0.369
DOC_USP7_MATH_1	25	29	PF00917	0.564
DOC_USP7_MATH_1	266	270	PF00917	0.692
DOC_USP7_MATH_1	99	103	PF00917	0.546
DOC_WW_Pin1_4	267	272	PF00397	0.701
LIG_14-3-3_CanoR_1	149	159	PF00244	0.487
LIG_14-3-3_CanoR_1	19	24	PF00244	0.400
LIG_14-3-3_CanoR_1	49	58	PF00244	0.484
LIG_FHA_1	171	177	PF00498	0.381
LIG_FHA_1	215	221	PF00498	0.460
LIG_FHA_1	226	232	PF00498	0.385
LIG_FHA_1	31	37	PF00498	0.357
LIG_FHA_2	51	57	PF00498	0.534
LIG_LIR_Gen_1	213	224	PF02991	0.380
LIG_LIR_Gen_1	238	248	PF02991	0.320
LIG_LIR_Nem_3	213	219	PF02991	0.380
LIG_LIR_Nem_3	238	243	PF02991	0.456
LIG_MAD2	64	72	PF02301	0.433
LIG_MYND_1	207	211	PF01753	0.380
LIG_Pex14_1	223	227	PF04695	0.596
LIG_RPA_C_Fungi	46	58	PF08784	0.576
LIG_SH2_CRK	216	220	PF00017	0.201
LIG_SH2_SRC	188	191	PF00017	0.223
LIG_SH2_STAP1	216	220	PF00017	0.380
LIG_SH2_STAT5	180	183	PF00017	0.494
LIG_SH2_STAT5	188	191	PF00017	0.272
LIG_SH2_STAT5	201	204	PF00017	0.320
LIG_SH2_STAT5	216	219	PF00017	0.320
LIG_SH3_1	64	70	PF00018	0.515
LIG_SH3_3	184	190	PF00018	0.491
LIG_SH3_3	204	210	PF00018	0.381
LIG_SH3_3	265	271	PF00018	0.663
LIG_SH3_3	64	70	PF00018	0.459
LIG_SH3_3	91	97	PF00018	0.617
LIG_Sin3_3	158	165	PF02671	0.297
LIG_SUMO_SIM_anti_2	127	132	PF11976	0.380
LIG_SUMO_SIM_anti_2	3	9	PF11976	0.398
LIG_SUMO_SIM_par_1	12	17	PF11976	0.335
LIG_SUMO_SIM_par_1	158	164	PF11976	0.361
LIG_TYR_ITIM	178	183	PF00017	0.543
MOD_CK1_1	28	34	PF00069	0.729
MOD_CK2_1	267	273	PF00069	0.637
MOD_GlcNHglycan	101	104	PF01048	0.652
MOD_GlcNHglycan	212	215	PF01048	0.380
MOD_GlcNHglycan	231	234	PF01048	0.582
MOD_GlcNHglycan	257	260	PF01048	0.573
MOD_GlcNHglycan	43	46	PF01048	0.616
MOD_GSK3_1	14	21	PF00069	0.558
MOD_GSK3_1	210	217	PF00069	0.380
MOD_GSK3_1	225	232	PF00069	0.558
MOD_GSK3_1	24	31	PF00069	0.475
MOD_NEK2_1	110	115	PF00069	0.546
MOD_NEK2_1	150	155	PF00069	0.380
MOD_NEK2_1	170	175	PF00069	0.290
MOD_NEK2_1	181	186	PF00069	0.401
MOD_NEK2_1	253	258	PF00069	0.398
MOD_PIKK_1	182	188	PF00454	0.598
MOD_PKA_2	18	24	PF00069	0.458
MOD_PKA_2	50	56	PF00069	0.555
MOD_Plk_1	171	177	PF00069	0.493
MOD_Plk_2-3	273	279	PF00069	0.639
MOD_Plk_4	171	177	PF00069	0.458
MOD_Plk_4	19	25	PF00069	0.383
MOD_Plk_4	196	202	PF00069	0.381
MOD_Plk_4	83	89	PF00069	0.444
MOD_ProDKin_1	267	273	PF00069	0.633
TRG_ENDOCYTIC_2	180	183	PF00928	0.552
TRG_ENDOCYTIC_2	216	219	PF00928	0.380
TRG_NLS_MonoExtN_4	140	147	PF00514	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P307	Leptomonas seymouri	60%	100%
A0A3Q8ICG4	Leishmania donovani	93%	100%
A4HCR4	Leishmania braziliensis	81%	100%
A4I089	Leishmania infantum	93%	100%
C9ZV06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
Q4QBC4	Leishmania major	92%	100%