AMPKBI domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

5'-AMP-activated protein kinase subunit beta, putative

Species:

Leishmania mexicana

UniProt:

E9AW52_LEIMU

TriTrypDb:

LmxM.23.0490

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0031588	nucleotide-activated protein kinase complex	3	12
GO:0032991	protein-containing complex	1	12
GO:0061695	transferase complex, transferring phosphorus-containing groups	4	12
GO:0110165	cellular anatomical entity	1	12
GO:0140535	intracellular protein-containing complex	2	12
GO:1902494	catalytic complex	2	12
GO:1902911	protein kinase complex	5	12
GO:1990234	transferase complex	3	12
GO:0005634	nucleus	5	1
GO:0005777	peroxisome	6	1
GO:0005929	cilium	4	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0120025	plasma membrane bounded cell projection	3	1

Expansion

Sequence features

E9AW52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW52

Function

Biological processes
Term	Name	Level	Count
GO:0001932	regulation of protein phosphorylation	7	12
GO:0007165	signal transduction	2	12
GO:0009987	cellular process	1	12
GO:0019220	regulation of phosphate metabolic process	6	12
GO:0019222	regulation of metabolic process	3	12
GO:0031323	regulation of cellular metabolic process	4	12
GO:0031399	regulation of protein modification process	6	12
GO:0042325	regulation of phosphorylation	7	12
GO:0043549	regulation of kinase activity	5	12
GO:0045859	regulation of protein kinase activity	6	12
GO:0050789	regulation of biological process	2	12
GO:0050790	regulation of catalytic activity	3	12
GO:0050794	regulation of cellular process	3	12
GO:0051171	regulation of nitrogen compound metabolic process	4	12
GO:0051174	regulation of phosphorus metabolic process	5	12
GO:0051246	regulation of protein metabolic process	5	12
GO:0051338	regulation of transferase activity	4	12
GO:0060255	regulation of macromolecule metabolic process	4	12
GO:0065007	biological regulation	1	12
GO:0065009	regulation of molecular function	2	12
GO:0080090	regulation of primary metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0019899	enzyme binding	3	1
GO:0019900	kinase binding	4	1
GO:0019901	protein kinase binding	5	1
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.579
CLV_C14_Caspase3-7	73	77	PF00656	0.320
CLV_NRD_NRD_1	156	158	PF00675	0.443
CLV_NRD_NRD_1	220	222	PF00675	0.263
CLV_NRD_NRD_1	27	29	PF00675	0.417
CLV_PCSK_KEX2_1	220	222	PF00082	0.286
DEG_SCF_FBW7_1	167	174	PF00400	0.248
DOC_CKS1_1	172	177	PF01111	0.261
DOC_CKS1_1	44	49	PF01111	0.342
DOC_CKS1_1	80	85	PF01111	0.225
DOC_CYCLIN_yCln2_LP_2	109	115	PF00134	0.480
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.248
DOC_MAPK_DCC_7	157	165	PF00069	0.271
DOC_MAPK_gen_1	116	126	PF00069	0.522
DOC_MAPK_gen_1	157	165	PF00069	0.282
DOC_MAPK_gen_1	180	189	PF00069	0.391
DOC_MAPK_gen_1	28	35	PF00069	0.285
DOC_MAPK_MEF2A_6	157	165	PF00069	0.296
DOC_MAPK_MEF2A_6	28	35	PF00069	0.266
DOC_PP2B_LxvP_1	205	208	PF13499	0.248
DOC_PP2B_LxvP_1	56	59	PF13499	0.342
DOC_PP4_FxxP_1	198	201	PF00568	0.143
DOC_SPAK_OSR1_1	66	70	PF12202	0.263
DOC_USP7_MATH_1	194	198	PF00917	0.324
DOC_WW_Pin1_4	167	172	PF00397	0.274
DOC_WW_Pin1_4	43	48	PF00397	0.317
DOC_WW_Pin1_4	79	84	PF00397	0.330
LIG_deltaCOP1_diTrp_1	144	153	PF00928	0.516
LIG_FHA_1	104	110	PF00498	0.707
LIG_FHA_1	121	127	PF00498	0.337
LIG_FHA_1	236	242	PF00498	0.308
LIG_FHA_1	7	13	PF00498	0.492
LIG_FHA_1	76	82	PF00498	0.303
LIG_FHA_2	130	136	PF00498	0.480
LIG_FHA_2	21	27	PF00498	0.384
LIG_LIR_Apic_2	195	201	PF02991	0.143
LIG_LIR_Gen_1	50	60	PF02991	0.248
LIG_LIR_Nem_3	156	162	PF02991	0.274
LIG_LIR_Nem_3	50	56	PF02991	0.305
LIG_LIR_Nem_3	9	13	PF02991	0.406
LIG_LYPXL_yS_3	159	162	PF13949	0.263
LIG_PDZ_Class_2	254	259	PF00595	0.637
LIG_SH2_CRK	169	173	PF00017	0.248
LIG_SH2_CRK	237	241	PF00017	0.289
LIG_SH2_CRK	65	69	PF00017	0.308
LIG_SH2_PTP2	32	35	PF00017	0.282
LIG_SH2_STAP1	237	241	PF00017	0.282
LIG_SH2_STAT3	16	19	PF00017	0.494
LIG_SH2_STAT5	169	172	PF00017	0.248
LIG_SH2_STAT5	217	220	PF00017	0.248
LIG_SH2_STAT5	233	236	PF00017	0.263
LIG_SH2_STAT5	237	240	PF00017	0.263
LIG_SH2_STAT5	32	35	PF00017	0.282
LIG_SH3_1	158	164	PF00018	0.263
LIG_SH3_3	102	108	PF00018	0.674
LIG_SH3_3	158	164	PF00018	0.288
LIG_SH3_3	2	8	PF00018	0.578
LIG_SH3_3	244	250	PF00018	0.545
LIG_SH3_3	41	47	PF00018	0.350
LIG_SH3_3	77	83	PF00018	0.341
LIG_SH3_3	88	94	PF00018	0.675
LIG_SUMO_SIM_par_1	207	212	PF11976	0.330
LIG_TYR_ITAM	50	68	PF00017	0.342
LIG_TYR_ITIM	167	172	PF00017	0.248
LIG_TYR_ITIM	241	246	PF00017	0.391
MOD_CK1_1	48	54	PF00069	0.263
MOD_CK2_1	129	135	PF00069	0.544
MOD_CK2_1	20	26	PF00069	0.491
MOD_GlcNHglycan	191	195	PF01048	0.232
MOD_GlcNHglycan	47	50	PF01048	0.276
MOD_GSK3_1	167	174	PF00069	0.263
MOD_GSK3_1	190	197	PF00069	0.280
MOD_GSK3_1	20	27	PF00069	0.478
MOD_GSK3_1	75	82	PF00069	0.379
MOD_NEK2_1	103	108	PF00069	0.587
MOD_NEK2_1	153	158	PF00069	0.459
MOD_NEK2_1	209	214	PF00069	0.248
MOD_NEK2_1	227	232	PF00069	0.282
MOD_NEK2_1	24	29	PF00069	0.391
MOD_NEK2_2	120	125	PF00069	0.494
MOD_NEK2_2	194	199	PF00069	0.143
MOD_NEK2_2	253	258	PF00069	0.458
MOD_PIKK_1	103	109	PF00454	0.692
MOD_PIKK_1	75	81	PF00454	0.263
MOD_PKA_2	179	185	PF00069	0.303
MOD_Plk_1	194	200	PF00069	0.191
MOD_Plk_2-3	20	26	PF00069	0.382
MOD_Plk_4	120	126	PF00069	0.494
MOD_Plk_4	174	180	PF00069	0.391
MOD_Plk_4	236	242	PF00069	0.311
MOD_Plk_4	48	54	PF00069	0.263
MOD_ProDKin_1	167	173	PF00069	0.274
MOD_ProDKin_1	43	49	PF00069	0.317
MOD_ProDKin_1	79	85	PF00069	0.330
TRG_ENDOCYTIC_2	159	162	PF00928	0.256
TRG_ENDOCYTIC_2	169	172	PF00928	0.236
TRG_ENDOCYTIC_2	237	240	PF00928	0.257
TRG_ENDOCYTIC_2	243	246	PF00928	0.349
TRG_ENDOCYTIC_2	32	35	PF00928	0.282
TRG_ENDOCYTIC_2	53	56	PF00928	0.249
TRG_ENDOCYTIC_2	65	68	PF00928	0.250
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9V7	Leptomonas seymouri	81%	77%
A0A0S4IRW9	Bodo saltans	43%	70%
A0A1X0NX44	Trypanosomatidae	56%	77%
A0A3Q8ICH1	Leishmania donovani	95%	77%
A0A3R7K3F4	Trypanosoma rangeli	56%	87%
A4HCR3	Leishmania braziliensis	91%	100%
A4I088	Leishmania infantum	95%	77%
C9ZV05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	84%
P80386	Rattus norvegicus	26%	96%
Q4QBC5	Leishmania major	96%	100%
Q5BIS9	Bos taurus	27%	96%
Q5R801	Pongo abelii	26%	96%
Q9R078	Mus musculus	27%	96%
Q9Y478	Homo sapiens	26%	96%
V5ASF8	Trypanosoma cruzi	55%	85%