Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW50_LEIMU

TriTrypDb:

LmxM.23.0470

Length:

350

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW50

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW50

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.800
CLV_C14_Caspase3-7	336	340	PF00656	0.715
CLV_NRD_NRD_1	135	137	PF00675	0.747
CLV_NRD_NRD_1	89	91	PF00675	0.690
CLV_PCSK_KEX2_1	135	137	PF00082	0.747
CLV_PCSK_KEX2_1	240	242	PF00082	0.718
CLV_PCSK_KEX2_1	89	91	PF00082	0.695
CLV_PCSK_PC1ET2_1	240	242	PF00082	0.718
CLV_PCSK_SKI1_1	116	120	PF00082	0.788
CLV_PCSK_SKI1_1	185	189	PF00082	0.621
CLV_Separin_Metazoa	216	220	PF03568	0.364
DEG_SPOP_SBC_1	141	145	PF00917	0.554
DOC_ANK_TNKS_1	320	327	PF00023	0.551
DOC_CYCLIN_RxL_1	237	248	PF00134	0.527
DOC_MAPK_gen_1	89	95	PF00069	0.717
DOC_PP2B_LxvP_1	158	161	PF13499	0.655
DOC_USP7_MATH_1	127	131	PF00917	0.749
DOC_USP7_MATH_1	263	267	PF00917	0.795
DOC_USP7_MATH_1	331	335	PF00917	0.777
DOC_USP7_MATH_1	340	344	PF00917	0.643
DOC_USP7_MATH_1	42	46	PF00917	0.529
DOC_USP7_MATH_1	99	103	PF00917	0.742
DOC_WW_Pin1_4	286	291	PF00397	0.753
DOC_WW_Pin1_4	313	318	PF00397	0.551
LIG_14-3-3_CanoR_1	116	121	PF00244	0.787
LIG_14-3-3_CanoR_1	20	28	PF00244	0.643
LIG_14-3-3_CanoR_1	272	281	PF00244	0.688
LIG_14-3-3_CanoR_1	54	58	PF00244	0.811
LIG_Actin_WH2_2	197	214	PF00022	0.499
LIG_BIR_II_1	1	5	PF00653	0.791
LIG_EVH1_1	158	162	PF00568	0.650
LIG_FHA_1	106	112	PF00498	0.778
LIG_FHA_1	121	127	PF00498	0.480
LIG_FHA_1	143	149	PF00498	0.531
LIG_FHA_1	199	205	PF00498	0.541
LIG_FHA_1	226	232	PF00498	0.746
LIG_FHA_1	287	293	PF00498	0.796
LIG_FHA_1	307	313	PF00498	0.619
LIG_FHA_1	38	44	PF00498	0.738
LIG_FHA_1	99	105	PF00498	0.757
LIG_LIR_Apic_2	123	127	PF02991	0.799
LIG_MYND_1	163	167	PF01753	0.725
LIG_PDZ_Class_2	345	350	PF00595	0.679
LIG_SH2_PTP2	82	85	PF00017	0.611
LIG_SH2_SRC	82	85	PF00017	0.633
LIG_SH2_STAP1	33	37	PF00017	0.709
LIG_SH2_STAT5	213	216	PF00017	0.566
LIG_SH2_STAT5	82	85	PF00017	0.611
LIG_SH3_3	154	160	PF00018	0.727
LIG_SH3_3	16	22	PF00018	0.660
LIG_SH3_3	164	170	PF00018	0.557
LIG_SH3_3	299	305	PF00018	0.754
LIG_SH3_3	314	320	PF00018	0.590
LIG_SH3_3	78	84	PF00018	0.671
LIG_SUMO_SIM_par_1	178	184	PF11976	0.619
LIG_TRAF2_1	181	184	PF00917	0.485
MOD_CK1_1	11	17	PF00069	0.780
MOD_CK1_1	285	291	PF00069	0.545
MOD_CK1_1	31	37	PF00069	0.468
MOD_CK1_1	334	340	PF00069	0.607
MOD_CK1_1	59	65	PF00069	0.775
MOD_CK2_1	223	229	PF00069	0.686
MOD_CK2_1	313	319	PF00069	0.552
MOD_GlcNHglycan	100	104	PF01048	0.742
MOD_GlcNHglycan	129	132	PF01048	0.675
MOD_GlcNHglycan	137	140	PF01048	0.673
MOD_GlcNHglycan	23	26	PF01048	0.824
MOD_GlcNHglycan	233	236	PF01048	0.710
MOD_GlcNHglycan	257	260	PF01048	0.818
MOD_GlcNHglycan	265	268	PF01048	0.675
MOD_GlcNHglycan	274	277	PF01048	0.504
MOD_GlcNHglycan	58	61	PF01048	0.712
MOD_GSK3_1	116	123	PF00069	0.692
MOD_GSK3_1	221	228	PF00069	0.451
MOD_GSK3_1	247	254	PF00069	0.804
MOD_GSK3_1	263	270	PF00069	0.798
MOD_GSK3_1	282	289	PF00069	0.492
MOD_GSK3_1	95	102	PF00069	0.663
MOD_N-GLC_1	272	277	PF02516	0.709
MOD_NEK2_1	193	198	PF00069	0.594
MOD_NEK2_1	282	287	PF00069	0.786
MOD_NEK2_1	37	42	PF00069	0.584
MOD_NEK2_1	88	93	PF00069	0.676
MOD_NEK2_2	151	156	PF00069	0.737
MOD_PIKK_1	105	111	PF00454	0.818
MOD_PIKK_1	116	122	PF00454	0.753
MOD_PIKK_1	193	199	PF00454	0.498
MOD_PIKK_1	26	32	PF00454	0.657
MOD_PIKK_1	267	273	PF00454	0.794
MOD_PIKK_1	306	312	PF00454	0.535
MOD_PIKK_1	331	337	PF00454	0.737
MOD_PIKK_1	37	43	PF00454	0.695
MOD_PIKK_1	44	50	PF00454	0.689
MOD_PIKK_1	8	14	PF00454	0.705
MOD_PKA_1	135	141	PF00069	0.532
MOD_PKA_2	134	140	PF00069	0.751
MOD_PKA_2	53	59	PF00069	0.811
MOD_PKA_2	88	94	PF00069	0.673
MOD_Plk_1	151	157	PF00069	0.733
MOD_ProDKin_1	286	292	PF00069	0.755
MOD_ProDKin_1	313	319	PF00069	0.552
TRG_DiLeu_BaEn_2	343	349	PF01217	0.683
TRG_DiLeu_BaLyEn_6	277	282	PF01217	0.791
TRG_ER_diArg_1	241	244	PF00400	0.795
TRG_ER_diArg_1	88	90	PF00400	0.682
TRG_NLS_MonoExtC_3	239	245	PF00514	0.733
TRG_NLS_MonoExtN_4	238	244	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.721
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.786

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9J6	Leptomonas seymouri	33%	100%
A0A3S7WXL1	Leishmania donovani	84%	100%
A4HCR1	Leishmania braziliensis	64%	98%
A4I086	Leishmania infantum	84%	100%
Q4QBC7	Leishmania major	84%	100%