Putative trypanothione synthetase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

trypanothione synthetase, putative

Species:

Leishmania mexicana

UniProt:

E9AW49_LEIMU

TriTrypDb:

LmxM.23.0460

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW49

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016874	ligase activity	2	7
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	7
GO:0016880	acid-ammonia (or amide) ligase activity	4	7
GO:0047479	trypanothione synthase activity	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	181	185	PF00656	0.212
CLV_NRD_NRD_1	123	125	PF00675	0.442
CLV_NRD_NRD_1	136	138	PF00675	0.440
CLV_PCSK_KEX2_1	123	125	PF00082	0.442
CLV_PCSK_SKI1_1	131	135	PF00082	0.472
CLV_PCSK_SKI1_1	192	196	PF00082	0.456
DEG_MDM2_SWIB_1	121	128	PF02201	0.320
DEG_SPOP_SBC_1	14	18	PF00917	0.553
DEG_SPOP_SBC_1	67	71	PF00917	0.686
DOC_CYCLIN_RxL_1	128	136	PF00134	0.253
DOC_CYCLIN_yCln2_LP_2	277	283	PF00134	0.281
DOC_PP2B_LxvP_1	132	135	PF13499	0.240
DOC_SPAK_OSR1_1	263	267	PF12202	0.334
DOC_USP7_MATH_1	14	18	PF00917	0.644
DOC_USP7_MATH_1	67	71	PF00917	0.637
DOC_USP7_UBL2_3	188	192	PF12436	0.292
DOC_WW_Pin1_4	154	159	PF00397	0.248
DOC_WW_Pin1_4	213	218	PF00397	0.330
DOC_WW_Pin1_4	58	63	PF00397	0.677
LIG_14-3-3_CanoR_1	68	76	PF00244	0.525
LIG_BRCT_BRCA1_1	251	255	PF00533	0.294
LIG_deltaCOP1_diTrp_1	184	193	PF00928	0.320
LIG_FHA_1	127	133	PF00498	0.334
LIG_FHA_2	223	229	PF00498	0.355
LIG_LIR_Apic_2	213	217	PF02991	0.334
LIG_LIR_Gen_1	184	194	PF02991	0.320
LIG_LIR_Nem_3	108	114	PF02991	0.362
LIG_LIR_Nem_3	184	189	PF02991	0.320
LIG_LIR_Nem_3	216	221	PF02991	0.298
LIG_PDZ_Class_2	294	299	PF00595	0.429
LIG_Pex14_1	246	250	PF04695	0.254
LIG_Pex14_2	121	125	PF04695	0.240
LIG_SH2_GRB2like	92	95	PF00017	0.371
LIG_SH2_STAP1	148	152	PF00017	0.303
LIG_SH2_STAT3	114	117	PF00017	0.240
LIG_SH2_STAT5	141	144	PF00017	0.355
LIG_SH2_STAT5	235	238	PF00017	0.288
LIG_SH2_STAT5	242	245	PF00017	0.421
LIG_SH2_STAT5	265	268	PF00017	0.335
LIG_SH2_STAT5	84	87	PF00017	0.489
LIG_SH3_3	19	25	PF00018	0.574
LIG_SH3_3	8	14	PF00018	0.507
MOD_CK1_1	157	163	PF00069	0.315
MOD_CK1_1	213	219	PF00069	0.332
MOD_CK1_1	71	77	PF00069	0.582
MOD_CK1_1	93	99	PF00069	0.426
MOD_CK2_1	2	8	PF00069	0.612
MOD_GlcNHglycan	17	20	PF01048	0.651
MOD_GlcNHglycan	251	254	PF01048	0.331
MOD_GlcNHglycan	5	8	PF01048	0.608
MOD_GlcNHglycan	73	76	PF01048	0.354
MOD_GSK3_1	63	70	PF00069	0.668
MOD_GSK3_1	90	97	PF00069	0.496
MOD_N-GLC_1	93	98	PF02516	0.436
MOD_NEK2_1	1	6	PF00069	0.657
MOD_NEK2_1	126	131	PF00069	0.345
MOD_NEK2_1	32	37	PF00069	0.552
MOD_NMyristoyl	1	7	PF02799	0.608
MOD_OFUCOSY	139	146	PF10250	0.535
MOD_PIKK_1	157	163	PF00454	0.257
MOD_PKA_2	67	73	PF00069	0.555
MOD_Plk_4	203	209	PF00069	0.273
MOD_ProDKin_1	154	160	PF00069	0.248
MOD_ProDKin_1	213	219	PF00069	0.330
MOD_ProDKin_1	58	64	PF00069	0.676
MOD_SPalmitoyl_4	1	7	PF01529	0.546
MOD_SUMO_rev_2	5	11	PF00179	0.610
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.334
TRG_ER_diArg_1	123	125	PF00400	0.241
TRG_Pf-PMV_PEXEL_1	131	136	PF00026	0.485

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II02	Leptomonas seymouri	58%	100%
A0A0S4IVA9	Bodo saltans	38%	98%
A0A3S7WXK4	Leishmania donovani	81%	92%
A0A422N6B5	Trypanosoma rangeli	41%	100%
A4HCR0	Leishmania braziliensis	68%	100%
A4I085	Leishmania infantum	80%	92%
C9ZV01	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QBC8	Leishmania major	74%	100%
V5BCE6	Trypanosoma cruzi	42%	100%