Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW47_LEIMU

TriTrypDb:

LmxM.23.0440

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW47

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.449
CLV_C14_Caspase3-7	55	59	PF00656	0.469
CLV_NRD_NRD_1	10	12	PF00675	0.483
CLV_NRD_NRD_1	163	165	PF00675	0.676
CLV_NRD_NRD_1	92	94	PF00675	0.548
CLV_PCSK_KEX2_1	163	165	PF00082	0.448
CLV_PCSK_KEX2_1	187	189	PF00082	0.633
CLV_PCSK_KEX2_1	91	93	PF00082	0.600
CLV_PCSK_PC1ET2_1	187	189	PF00082	0.498
CLV_PCSK_SKI1_1	272	276	PF00082	0.588
CLV_PCSK_SKI1_1	65	69	PF00082	0.559
DEG_APCC_DBOX_1	31	39	PF00400	0.313
DEG_Nend_UBRbox_3	1	3	PF02207	0.292
DEG_SPOP_SBC_1	79	83	PF00917	0.454
DOC_CYCLIN_yCln2_LP_2	205	211	PF00134	0.487
DOC_MAPK_DCC_7	91	101	PF00069	0.311
DOC_MAPK_gen_1	11	19	PF00069	0.274
DOC_MAPK_gen_1	187	194	PF00069	0.488
DOC_MAPK_gen_1	91	98	PF00069	0.395
DOC_MAPK_MEF2A_6	187	196	PF00069	0.511
DOC_MAPK_MEF2A_6	92	101	PF00069	0.526
DOC_PP2B_LxvP_1	156	159	PF13499	0.431
DOC_PP2B_LxvP_1	205	208	PF13499	0.497
DOC_PP4_FxxP_1	222	225	PF00568	0.300
DOC_USP7_MATH_1	179	183	PF00917	0.579
DOC_USP7_MATH_1	292	296	PF00917	0.558
DOC_USP7_MATH_1	79	83	PF00917	0.593
DOC_USP7_UBL2_3	183	187	PF12436	0.545
DOC_WW_Pin1_4	134	139	PF00397	0.451
DOC_WW_Pin1_4	309	314	PF00397	0.430
DOC_WW_Pin1_4	75	80	PF00397	0.530
DOC_WW_Pin1_4	81	86	PF00397	0.666
LIG_14-3-3_CanoR_1	125	129	PF00244	0.417
LIG_14-3-3_CanoR_1	151	157	PF00244	0.455
LIG_14-3-3_CanoR_1	272	281	PF00244	0.369
LIG_Actin_WH2_2	50	67	PF00022	0.284
LIG_APCC_ABBA_1	108	113	PF00400	0.449
LIG_CtBP_PxDLS_1	227	231	PF00389	0.250
LIG_FHA_1	14	20	PF00498	0.330
LIG_FHA_1	169	175	PF00498	0.551
LIG_FHA_2	195	201	PF00498	0.369
LIG_FHA_2	260	266	PF00498	0.432
LIG_LIR_Apic_2	133	138	PF02991	0.435
LIG_LIR_Gen_1	218	228	PF02991	0.468
LIG_LIR_Gen_1	254	263	PF02991	0.443
LIG_LIR_Gen_1	58	68	PF02991	0.390
LIG_LIR_Nem_3	218	223	PF02991	0.454
LIG_LIR_Nem_3	254	259	PF02991	0.447
LIG_LIR_Nem_3	5	10	PF02991	0.298
LIG_LIR_Nem_3	58	63	PF02991	0.337
LIG_PCNA_PIPBox_1	1	10	PF02747	0.305
LIG_PTB_Apo_2	67	74	PF02174	0.523
LIG_SH2_GRB2like	117	120	PF00017	0.458
LIG_SH2_STAP1	111	115	PF00017	0.293
LIG_SH2_STAP1	117	121	PF00017	0.321
LIG_SH2_STAP1	60	64	PF00017	0.389
LIG_SH2_STAT3	117	120	PF00017	0.465
LIG_SH2_STAT5	135	138	PF00017	0.354
LIG_SH2_STAT5	256	259	PF00017	0.428
LIG_SH2_STAT5	34	37	PF00017	0.333
LIG_SH2_STAT5	7	10	PF00017	0.318
LIG_SH3_3	218	224	PF00018	0.375
LIG_SH3_3	231	237	PF00018	0.352
LIG_SH3_3	307	313	PF00018	0.314
LIG_SH3_3	94	100	PF00018	0.476
LIG_TYR_ITSM	3	10	PF00017	0.308
LIG_WW_3	157	161	PF00397	0.395
MOD_CK1_1	77	83	PF00069	0.650
MOD_CK2_1	194	200	PF00069	0.380
MOD_DYRK1A_RPxSP_1	309	313	PF00069	0.329
MOD_GlcNHglycan	105	108	PF01048	0.343
MOD_GlcNHglycan	143	146	PF01048	0.523
MOD_GlcNHglycan	183	186	PF01048	0.720
MOD_GlcNHglycan	253	256	PF01048	0.511
MOD_GlcNHglycan	86	89	PF01048	0.663
MOD_GSK3_1	120	127	PF00069	0.496
MOD_GSK3_1	194	201	PF00069	0.337
MOD_GSK3_1	226	233	PF00069	0.394
MOD_GSK3_1	251	258	PF00069	0.416
MOD_GSK3_1	309	316	PF00069	0.474
MOD_GSK3_1	74	81	PF00069	0.654
MOD_N-GLC_1	74	79	PF02516	0.640
MOD_NEK2_1	141	146	PF00069	0.476
MOD_NEK2_1	150	155	PF00069	0.435
MOD_NEK2_1	194	199	PF00069	0.366
MOD_NEK2_1	230	235	PF00069	0.397
MOD_NEK2_1	251	256	PF00069	0.419
MOD_NEK2_2	46	51	PF00069	0.376
MOD_PKA_2	124	130	PF00069	0.377
MOD_PKA_2	150	156	PF00069	0.553
MOD_PKA_2	213	219	PF00069	0.349
MOD_Plk_1	284	290	PF00069	0.460
MOD_Plk_4	124	130	PF00069	0.399
MOD_Plk_4	226	232	PF00069	0.386
MOD_Plk_4	3	9	PF00069	0.317
MOD_ProDKin_1	134	140	PF00069	0.454
MOD_ProDKin_1	309	315	PF00069	0.438
MOD_ProDKin_1	75	81	PF00069	0.540
TRG_ENDOCYTIC_2	111	114	PF00928	0.325
TRG_ENDOCYTIC_2	256	259	PF00928	0.371
TRG_ENDOCYTIC_2	60	63	PF00928	0.335
TRG_ENDOCYTIC_2	7	10	PF00928	0.318
TRG_ER_diArg_1	91	93	PF00400	0.605

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5K0	Leptomonas seymouri	57%	100%
A0A0S4JDC4	Bodo saltans	36%	100%
A0A1X0NXD8	Trypanosomatidae	43%	100%
A0A3R7MEG1	Trypanosoma rangeli	44%	100%
A0A3S5H7B7	Leishmania donovani	91%	100%
A4HCQ8	Leishmania braziliensis	79%	100%
A4I083	Leishmania infantum	91%	100%
C9ZV00	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
Q4QBD0	Leishmania major	91%	100%
V5ASF5	Trypanosoma cruzi	43%	100%