LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania mexicana
UniProt:
E9AW45_LEIMU
TriTrypDb:
LmxM.23.0420
Length:
140

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW45
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW45

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 46 48 PF00675 0.767
CLV_PCSK_KEX2_1 46 48 PF00082 0.767
DOC_PP4_FxxP_1 59 62 PF00568 0.644
DOC_SPAK_OSR1_1 58 62 PF12202 0.604
DOC_USP7_MATH_1 133 137 PF00917 0.681
DOC_USP7_MATH_1 36 40 PF00917 0.695
DOC_USP7_MATH_1 76 80 PF00917 0.541
DOC_WW_Pin1_4 32 37 PF00397 0.629
LIG_14-3-3_CanoR_1 92 99 PF00244 0.704
LIG_Actin_WH2_2 76 94 PF00022 0.690
LIG_BRCT_BRCA1_1 36 40 PF00533 0.481
LIG_FHA_2 9 15 PF00498 0.581
LIG_FHA_2 92 98 PF00498 0.700
LIG_GBD_Chelix_1 83 91 PF00786 0.668
LIG_LIR_Nem_3 94 99 PF02991 0.509
LIG_NRBOX 86 92 PF00104 0.674
LIG_SH2_CRK 49 53 PF00017 0.512
LIG_SH2_STAT3 99 102 PF00017 0.704
LIG_SH2_STAT5 10 13 PF00017 0.685
LIG_SH3_1 49 55 PF00018 0.460
LIG_SH3_3 49 55 PF00018 0.715
LIG_SH3_3 58 64 PF00018 0.684
LIG_SUMO_SIM_anti_2 86 92 PF11976 0.461
MOD_CK1_1 16 22 PF00069 0.566
MOD_CK1_1 24 30 PF00069 0.615
MOD_CK1_1 32 38 PF00069 0.596
MOD_CK1_1 8 14 PF00069 0.691
MOD_GlcNHglycan 20 23 PF01048 0.775
MOD_GlcNHglycan 40 43 PF01048 0.768
MOD_GlcNHglycan 72 75 PF01048 0.473
MOD_GSK3_1 1 8 PF00069 0.763
MOD_GSK3_1 21 28 PF00069 0.754
MOD_GSK3_1 30 37 PF00069 0.703
MOD_NEK2_1 1 6 PF00069 0.644
MOD_NEK2_1 40 45 PF00069 0.762
MOD_PK_1 13 19 PF00069 0.691
MOD_PKA_2 91 97 PF00069 0.695
MOD_Plk_1 120 126 PF00069 0.661
MOD_Plk_1 13 19 PF00069 0.673
MOD_Plk_4 1 7 PF00069 0.601
MOD_ProDKin_1 32 38 PF00069 0.629
TRG_DiLeu_BaEn_1 86 91 PF01217 0.456
TRG_NES_CRM1_1 107 121 PF08389 0.658
TRG_Pf-PMV_PEXEL_1 65 69 PF00026 0.656

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILZ4 Leishmania donovani 89% 91%
A4HCQ6 Leishmania braziliensis 65% 99%
A4I081 Leishmania infantum 88% 91%
Q4QBD2 Leishmania major 88% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS