LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein
Species:
Leishmania mexicana
UniProt:
E9AW39_LEIMU
TriTrypDb:
LmxM.23.0355
Length:
366

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW39
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW39

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 232 236 PF00656 0.681
CLV_NRD_NRD_1 60 62 PF00675 0.730
CLV_NRD_NRD_1 73 75 PF00675 0.335
CLV_PCSK_KEX2_1 60 62 PF00082 0.652
CLV_PCSK_KEX2_1 73 75 PF00082 0.442
CLV_PCSK_SKI1_1 279 283 PF00082 0.424
CLV_PCSK_SKI1_1 60 64 PF00082 0.571
DEG_SPOP_SBC_1 145 149 PF00917 0.683
DOC_CKS1_1 280 285 PF01111 0.732
DOC_CKS1_1 4 9 PF01111 0.485
DOC_MAPK_gen_1 57 67 PF00069 0.675
DOC_MAPK_MEF2A_6 128 135 PF00069 0.638
DOC_PP4_FxxP_1 280 283 PF00568 0.720
DOC_USP7_MATH_1 145 149 PF00917 0.686
DOC_USP7_MATH_1 188 192 PF00917 0.772
DOC_USP7_MATH_1 320 324 PF00917 0.729
DOC_USP7_MATH_1 355 359 PF00917 0.736
DOC_WW_Pin1_4 147 152 PF00397 0.775
DOC_WW_Pin1_4 263 268 PF00397 0.601
DOC_WW_Pin1_4 279 284 PF00397 0.665
DOC_WW_Pin1_4 28 33 PF00397 0.678
DOC_WW_Pin1_4 290 295 PF00397 0.589
DOC_WW_Pin1_4 3 8 PF00397 0.490
DOC_WW_Pin1_4 321 326 PF00397 0.707
LIG_14-3-3_CanoR_1 160 164 PF00244 0.632
LIG_14-3-3_CanoR_1 187 196 PF00244 0.763
LIG_14-3-3_CanoR_1 23 29 PF00244 0.639
LIG_14-3-3_CanoR_1 230 240 PF00244 0.685
LIG_Actin_WH2_2 41 59 PF00022 0.394
LIG_Actin_WH2_2 9 25 PF00022 0.590
LIG_BIR_II_1 1 5 PF00653 0.709
LIG_FHA_1 217 223 PF00498 0.579
LIG_FHA_1 23 29 PF00498 0.496
LIG_FHA_1 345 351 PF00498 0.725
LIG_FHA_2 108 114 PF00498 0.443
LIG_FHA_2 230 236 PF00498 0.591
LIG_GBD_Chelix_1 16 24 PF00786 0.504
LIG_LIR_Gen_1 110 119 PF02991 0.539
LIG_LIR_Gen_1 161 172 PF02991 0.622
LIG_LIR_Gen_1 274 284 PF02991 0.494
LIG_LIR_Gen_1 358 365 PF02991 0.602
LIG_LIR_Nem_3 110 115 PF02991 0.625
LIG_LIR_Nem_3 161 167 PF02991 0.639
LIG_LIR_Nem_3 169 174 PF02991 0.584
LIG_LIR_Nem_3 274 280 PF02991 0.477
LIG_LIR_Nem_3 358 364 PF02991 0.598
LIG_SH2_CRK 112 116 PF00017 0.726
LIG_SH2_CRK 45 49 PF00017 0.537
LIG_SH2_NCK_1 317 321 PF00017 0.716
LIG_SH2_SRC 317 320 PF00017 0.711
LIG_SH2_STAP1 35 39 PF00017 0.520
LIG_SH2_STAP1 45 49 PF00017 0.620
LIG_SH2_STAT3 35 38 PF00017 0.371
LIG_SH2_STAT5 179 182 PF00017 0.582
LIG_SH3_3 1 7 PF00018 0.530
LIG_SH3_3 116 122 PF00018 0.641
LIG_SUMO_SIM_anti_2 12 17 PF11976 0.630
LIG_SUMO_SIM_par_1 131 137 PF11976 0.480
LIG_TYR_ITIM 43 48 PF00017 0.541
LIG_TYR_ITSM 108 115 PF00017 0.519
MOD_CDK_SPK_2 28 33 PF00069 0.678
MOD_CDK_SPxxK_3 321 328 PF00069 0.718
MOD_CK1_1 150 156 PF00069 0.717
MOD_CK1_1 159 165 PF00069 0.571
MOD_CK1_1 195 201 PF00069 0.593
MOD_CK1_1 229 235 PF00069 0.711
MOD_CK1_1 293 299 PF00069 0.622
MOD_CK1_1 86 92 PF00069 0.666
MOD_CK1_1 93 99 PF00069 0.650
MOD_CK2_1 268 274 PF00069 0.468
MOD_CMANNOS 255 258 PF00535 0.479
MOD_GlcNHglycan 142 145 PF01048 0.668
MOD_GlcNHglycan 168 171 PF01048 0.593
MOD_GlcNHglycan 190 193 PF01048 0.774
MOD_GlcNHglycan 235 239 PF01048 0.772
MOD_GlcNHglycan 244 247 PF01048 0.573
MOD_GlcNHglycan 91 95 PF01048 0.559
MOD_GlcNHglycan 98 101 PF01048 0.621
MOD_GSK3_1 140 147 PF00069 0.712
MOD_GSK3_1 158 165 PF00069 0.528
MOD_GSK3_1 188 195 PF00069 0.648
MOD_GSK3_1 202 209 PF00069 0.575
MOD_GSK3_1 226 233 PF00069 0.619
MOD_GSK3_1 24 31 PF00069 0.500
MOD_GSK3_1 242 249 PF00069 0.613
MOD_GSK3_1 344 351 PF00069 0.629
MOD_GSK3_1 86 93 PF00069 0.619
MOD_GSK3_1 95 102 PF00069 0.779
MOD_NEK2_1 202 207 PF00069 0.550
MOD_NEK2_1 22 27 PF00069 0.546
MOD_NEK2_1 51 56 PF00069 0.570
MOD_NEK2_1 83 88 PF00069 0.546
MOD_NEK2_2 107 112 PF00069 0.444
MOD_PIKK_1 51 57 PF00454 0.586
MOD_PKA_2 159 165 PF00069 0.628
MOD_PKA_2 186 192 PF00069 0.774
MOD_PKA_2 216 222 PF00069 0.581
MOD_PKA_2 22 28 PF00069 0.550
MOD_PKA_2 229 235 PF00069 0.673
MOD_Plk_4 107 113 PF00069 0.594
MOD_Plk_4 159 165 PF00069 0.705
MOD_Plk_4 202 208 PF00069 0.602
MOD_Plk_4 246 252 PF00069 0.510
MOD_Plk_4 293 299 PF00069 0.486
MOD_ProDKin_1 147 153 PF00069 0.774
MOD_ProDKin_1 263 269 PF00069 0.592
MOD_ProDKin_1 279 285 PF00069 0.671
MOD_ProDKin_1 28 34 PF00069 0.674
MOD_ProDKin_1 290 296 PF00069 0.581
MOD_ProDKin_1 3 9 PF00069 0.488
MOD_ProDKin_1 321 327 PF00069 0.708
TRG_DiLeu_BaEn_1 12 17 PF01217 0.628
TRG_ENDOCYTIC_2 112 115 PF00928 0.614
TRG_ENDOCYTIC_2 45 48 PF00928 0.517
TRG_ER_diArg_1 72 74 PF00400 0.574
TRG_Pf-PMV_PEXEL_1 303 307 PF00026 0.650

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P5J7 Leptomonas seymouri 39% 94%
A0A3Q8IFQ9 Leishmania donovani 83% 100%
E9ACS3 Leishmania major 83% 98%
E9AH10 Leishmania infantum 84% 100%
E9AIQ8 Leishmania braziliensis 68% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS