DUF4208 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW38_LEIMU

TriTrypDb:

LmxM.23.0350

Length:

294

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW38

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.657
CLV_NRD_NRD_1	138	140	PF00675	0.530
CLV_NRD_NRD_1	14	16	PF00675	0.709
CLV_NRD_NRD_1	23	25	PF00675	0.758
CLV_NRD_NRD_1	270	272	PF00675	0.635
CLV_PCSK_FUR_1	21	25	PF00082	0.496
CLV_PCSK_KEX2_1	138	140	PF00082	0.567
CLV_PCSK_KEX2_1	154	156	PF00082	0.431
CLV_PCSK_KEX2_1	205	207	PF00082	0.589
CLV_PCSK_KEX2_1	23	25	PF00082	0.757
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.559
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.556
CLV_PCSK_PC1ET2_1	205	207	PF00082	0.687
CLV_PCSK_PC7_1	134	140	PF00082	0.553
CLV_PCSK_PC7_1	19	25	PF00082	0.710
CLV_PCSK_SKI1_1	125	129	PF00082	0.575
CLV_PCSK_SKI1_1	142	146	PF00082	0.571
CLV_PCSK_SKI1_1	171	175	PF00082	0.685
CLV_PCSK_SKI1_1	176	180	PF00082	0.664
CLV_PCSK_SKI1_1	247	251	PF00082	0.666
CLV_PCSK_SKI1_1	57	61	PF00082	0.669
CLV_PCSK_SKI1_1	90	94	PF00082	0.537
DEG_SPOP_SBC_1	58	62	PF00917	0.570
DOC_MAPK_gen_1	138	146	PF00069	0.547
DOC_MAPK_gen_1	201	210	PF00069	0.602
DOC_MAPK_MEF2A_6	204	212	PF00069	0.737
DOC_PP1_RVXF_1	110	116	PF00149	0.463
DOC_PP1_RVXF_1	169	175	PF00149	0.571
DOC_PP4_FxxP_1	72	75	PF00568	0.462
DOC_USP7_MATH_1	228	232	PF00917	0.674
DOC_USP7_MATH_1	9	13	PF00917	0.664
DOC_USP7_UBL2_3	138	142	PF12436	0.547
DOC_USP7_UBL2_3	201	205	PF12436	0.668
DOC_USP7_UBL2_3	272	276	PF12436	0.610
DOC_WW_Pin1_4	125	130	PF00397	0.488
DOC_WW_Pin1_4	212	217	PF00397	0.767
DOC_WW_Pin1_4	218	223	PF00397	0.783
LIG_14-3-3_CanoR_1	57	66	PF00244	0.626
LIG_Actin_WH2_2	77	95	PF00022	0.486
LIG_BRCT_BRCA1_1	60	64	PF00533	0.585
LIG_FHA_1	58	64	PF00498	0.575
LIG_FHA_2	182	188	PF00498	0.603
LIG_FHA_2	192	198	PF00498	0.514
LIG_FHA_2	256	262	PF00498	0.643
LIG_LIR_Apic_2	48	54	PF02991	0.686
LIG_LIR_Gen_1	280	289	PF02991	0.720
LIG_LIR_Nem_3	148	152	PF02991	0.479
LIG_LIR_Nem_3	280	286	PF02991	0.668
LIG_LIR_Nem_3	287	292	PF02991	0.629
LIG_Pex14_1	141	145	PF04695	0.452
LIG_SH2_GRB2like	105	108	PF00017	0.486
LIG_SH2_STAT5	152	155	PF00017	0.534
LIG_SH2_STAT5	257	260	PF00017	0.683
LIG_SH3_3	219	225	PF00018	0.571
LIG_TRAF2_1	194	197	PF00917	0.589
MOD_CK1_1	221	227	PF00069	0.682
MOD_CK1_1	36	42	PF00069	0.665
MOD_CK2_1	130	136	PF00069	0.478
MOD_CK2_1	181	187	PF00069	0.583
MOD_CK2_1	191	197	PF00069	0.539
MOD_Cter_Amidation	136	139	PF01082	0.514
MOD_Cter_Amidation	21	24	PF01082	0.676
MOD_GSK3_1	217	224	PF00069	0.552
MOD_GSK3_1	253	260	PF00069	0.716
MOD_GSK3_1	277	284	PF00069	0.724
MOD_GSK3_1	35	42	PF00069	0.710
MOD_GSK3_1	92	99	PF00069	0.567
MOD_LATS_1	275	281	PF00433	0.729
MOD_NEK2_1	59	64	PF00069	0.529
MOD_NEK2_1	92	97	PF00069	0.480
MOD_PIKK_1	36	42	PF00454	0.690
MOD_PKA_2	281	287	PF00069	0.711
MOD_Plk_1	191	197	PF00069	0.627
MOD_Plk_1	36	42	PF00069	0.562
MOD_Plk_4	127	133	PF00069	0.645
MOD_Plk_4	59	65	PF00069	0.541
MOD_ProDKin_1	125	131	PF00069	0.487
MOD_ProDKin_1	212	218	PF00069	0.769
MOD_ProDKin_1	221	227	PF00069	0.794
MOD_SUMO_for_1	249	252	PF00179	0.444
MOD_SUMO_rev_2	47	54	PF00179	0.539
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.508
TRG_ER_diArg_1	21	24	PF00400	0.598
TRG_NLS_Bipartite_1	124	142	PF00514	0.591
TRG_NLS_MonoExtC_3	137	142	PF00514	0.550
TRG_NLS_MonoExtC_3	14	19	PF00514	0.703
TRG_NLS_MonoExtN_4	13	20	PF00514	0.716
TRG_NLS_MonoExtN_4	201	208	PF00514	0.679
TRG_Pf-PMV_PEXEL_1	90	94	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P555	Leptomonas seymouri	52%	84%
A0A0S4IRA8	Bodo saltans	27%	93%
A0A1X0NX54	Trypanosomatidae	42%	100%
A0A3Q8IAW9	Leishmania donovani	88%	100%
A0A422NW66	Trypanosoma rangeli	41%	100%
A4HCP9	Leishmania braziliensis	69%	100%
A4I075	Leishmania infantum	88%	100%
C9ZUZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4QBD9	Leishmania major	86%	100%
V5B5B0	Trypanosoma cruzi	38%	100%