Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW36_LEIMU

TriTrypDb:

LmxM.23.0330

Length:

220

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AW36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	144	146	PF00675	0.466
CLV_NRD_NRD_1	95	97	PF00675	0.493
CLV_PCSK_FUR_1	142	146	PF00082	0.461
CLV_PCSK_KEX2_1	144	146	PF00082	0.466
CLV_PCSK_KEX2_1	95	97	PF00082	0.467
CLV_PCSK_SKI1_1	119	123	PF00082	0.525
CLV_PCSK_SKI1_1	216	220	PF00082	0.607
CLV_PCSK_SKI1_1	40	44	PF00082	0.461
CLV_PCSK_SKI1_1	95	99	PF00082	0.443
DEG_Nend_UBRbox_2	1	3	PF02207	0.732
DOC_CYCLIN_RxL_1	90	102	PF00134	0.715
DOC_PP1_RVXF_1	214	220	PF00149	0.603
DOC_USP7_MATH_1	121	125	PF00917	0.630
DOC_USP7_MATH_1	182	186	PF00917	0.734
DOC_USP7_UBL2_3	177	181	PF12436	0.721
LIG_FHA_1	11	17	PF00498	0.664
LIG_FHA_1	155	161	PF00498	0.646
LIG_FHA_2	150	156	PF00498	0.705
LIG_FHA_2	36	42	PF00498	0.660
LIG_LIR_Apic_2	133	138	PF02991	0.718
LIG_LIR_Apic_2	43	48	PF02991	0.667
LIG_LIR_Gen_1	211	219	PF02991	0.396
LIG_LIR_Nem_3	111	116	PF02991	0.627
LIG_LIR_Nem_3	178	183	PF02991	0.675
LIG_LIR_Nem_3	211	215	PF02991	0.361
LIG_MYND_2	23	27	PF01753	0.713
LIG_PCNA_yPIPBox_3	90	98	PF02747	0.622
LIG_Pex14_2	208	212	PF04695	0.404
LIG_Pex14_2	215	219	PF04695	0.524
LIG_REV1ctd_RIR_1	98	104	PF16727	0.685
LIG_SH2_CRK	128	132	PF00017	0.650
LIG_SH2_CRK	135	139	PF00017	0.642
LIG_SH2_CRK	166	170	PF00017	0.632
LIG_SH2_CRK	180	184	PF00017	0.617
LIG_SH2_SRC	135	138	PF00017	0.737
LIG_SH2_STAT5	170	173	PF00017	0.649
LIG_SH2_STAT5	55	58	PF00017	0.632
LIG_SH3_1	135	141	PF00018	0.738
LIG_SH3_3	135	141	PF00018	0.663
LIG_SH3_3	156	162	PF00018	0.684
LIG_SH3_3	18	24	PF00018	0.545
LIG_TRAF2_1	184	187	PF00917	0.705
LIG_WW_3	22	26	PF00397	0.735
MOD_CK1_1	3	9	PF00069	0.774
MOD_CK2_1	149	155	PF00069	0.747
MOD_CK2_1	35	41	PF00069	0.642
MOD_GlcNHglycan	202	205	PF01048	0.455
MOD_GlcNHglycan	7	10	PF01048	0.468
MOD_GlcNHglycan	84	87	PF01048	0.501
MOD_GSK3_1	149	156	PF00069	0.749
MOD_NEK2_1	10	15	PF00069	0.670
MOD_NEK2_1	200	205	PF00069	0.346
MOD_NEK2_1	208	213	PF00069	0.311
MOD_NEK2_1	26	31	PF00069	0.664
MOD_NEK2_2	99	104	PF00069	0.684
MOD_Plk_1	154	160	PF00069	0.747
MOD_Plk_1	40	46	PF00069	0.646
MOD_Plk_4	208	214	PF00069	0.302
MOD_Plk_4	26	32	PF00069	0.699
MOD_Plk_4	40	46	PF00069	0.590
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.738
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.685
TRG_ENDOCYTIC_2	128	131	PF00928	0.652
TRG_ENDOCYTIC_2	180	183	PF00928	0.662
TRG_ER_diArg_1	141	144	PF00400	0.654
TRG_ER_diArg_1	94	96	PF00400	0.698
TRG_NES_CRM1_1	120	136	PF08389	0.702
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	71	75	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCU7	Leptomonas seymouri	76%	100%
A0A0S4JC90	Bodo saltans	46%	99%
A0A1X0NX56	Trypanosomatidae	63%	100%
A0A3R7NYD4	Trypanosoma rangeli	63%	77%
A0A3S7WXL9	Leishmania donovani	95%	100%
A4HCP7	Leishmania braziliensis	90%	100%
A4I073	Leishmania infantum	95%	100%
C9ZUY7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	61%	100%
Q4QBE1	Leishmania major	94%	100%
V5AKG4	Trypanosoma cruzi	60%	77%