Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW35_LEIMU

TriTrypDb:

LmxM.23.0320

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW35

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW35

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.602
CLV_NRD_NRD_1	176	178	PF00675	0.713
CLV_NRD_NRD_1	243	245	PF00675	0.545
CLV_NRD_NRD_1	44	46	PF00675	0.607
CLV_PCSK_KEX2_1	156	158	PF00082	0.573
CLV_PCSK_KEX2_1	176	178	PF00082	0.713
CLV_PCSK_KEX2_1	243	245	PF00082	0.545
CLV_PCSK_KEX2_1	44	46	PF00082	0.609
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.573
DEG_SCF_FBW7_1	8	14	PF00400	0.459
DOC_CKS1_1	197	202	PF01111	0.626
DOC_CKS1_1	5	10	PF01111	0.667
DOC_CYCLIN_yCln2_LP_2	261	267	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.667
DOC_MAPK_DCC_7	218	226	PF00069	0.572
DOC_MAPK_MEF2A_6	218	226	PF00069	0.572
DOC_PP2B_LxvP_1	74	77	PF13499	0.477
DOC_USP7_MATH_1	104	108	PF00917	0.750
DOC_USP7_MATH_1	112	116	PF00917	0.707
DOC_USP7_MATH_1	142	146	PF00917	0.588
DOC_USP7_MATH_1	150	154	PF00917	0.451
DOC_USP7_MATH_1	64	68	PF00917	0.505
DOC_USP7_UBL2_3	152	156	PF12436	0.561
DOC_WW_Pin1_4	167	172	PF00397	0.723
DOC_WW_Pin1_4	196	201	PF00397	0.650
DOC_WW_Pin1_4	4	9	PF00397	0.668
LIG_14-3-3_CanoR_1	165	169	PF00244	0.727
LIG_14-3-3_CanoR_1	218	222	PF00244	0.580
LIG_14-3-3_CanoR_1	44	50	PF00244	0.669
LIG_BIR_II_1	1	5	PF00653	0.722
LIG_eIF4E_1	234	240	PF01652	0.611
LIG_FHA_1	208	214	PF00498	0.470
LIG_FHA_2	129	135	PF00498	0.411
LIG_FHA_2	57	63	PF00498	0.571
LIG_Integrin_isoDGR_2	163	165	PF01839	0.435
LIG_Integrin_RGD_1	244	246	PF01839	0.596
LIG_LIR_Apic_2	194	200	PF02991	0.676
LIG_LIR_Apic_2	252	258	PF02991	0.575
LIG_LIR_Gen_1	67	77	PF02991	0.540
LIG_LIR_Nem_3	67	72	PF02991	0.532
LIG_NRP_CendR_1	271	273	PF00754	0.534
LIG_SH2_CRK	197	201	PF00017	0.643
LIG_SH2_CRK	69	73	PF00017	0.512
LIG_SH2_GRB2like	13	16	PF00017	0.463
LIG_SH2_NCK_1	255	259	PF00017	0.542
LIG_SH2_STAT5	69	72	PF00017	0.550
LIG_SH3_3	114	120	PF00018	0.557
LIG_SH3_3	5	11	PF00018	0.707
LIG_SH3_3	76	82	PF00018	0.432
LIG_SH3_3	84	90	PF00018	0.697
MOD_CK1_1	107	113	PF00069	0.713
MOD_CK1_1	185	191	PF00069	0.615
MOD_CK2_1	112	118	PF00069	0.702
MOD_CK2_1	128	134	PF00069	0.392
MOD_Cter_Amidation	174	177	PF01082	0.677
MOD_GlcNHglycan	1	4	PF01048	0.741
MOD_GlcNHglycan	15	18	PF01048	0.595
MOD_GlcNHglycan	236	239	PF01048	0.436
MOD_GSK3_1	104	111	PF00069	0.767
MOD_GSK3_1	207	214	PF00069	0.522
MOD_GSK3_1	265	272	PF00069	0.517
MOD_GSK3_1	64	71	PF00069	0.479
MOD_GSK3_1	7	14	PF00069	0.725
MOD_NEK2_1	108	113	PF00069	0.712
MOD_NEK2_1	209	214	PF00069	0.494
MOD_PKA_2	164	170	PF00069	0.466
MOD_PKA_2	217	223	PF00069	0.586
MOD_PKA_2	43	49	PF00069	0.709
MOD_Plk_1	128	134	PF00069	0.515
MOD_Plk_4	112	118	PF00069	0.503
MOD_Plk_4	128	134	PF00069	0.450
MOD_Plk_4	217	223	PF00069	0.544
MOD_Plk_4	68	74	PF00069	0.525
MOD_ProDKin_1	167	173	PF00069	0.724
MOD_ProDKin_1	196	202	PF00069	0.634
MOD_ProDKin_1	4	10	PF00069	0.668
MOD_SUMO_rev_2	148	158	PF00179	0.549
MOD_SUMO_rev_2	182	188	PF00179	0.584
TRG_ENDOCYTIC_2	69	72	PF00928	0.531
TRG_ER_diArg_1	242	244	PF00400	0.510
TRG_ER_diArg_1	43	45	PF00400	0.595

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2Y3	Leptomonas seymouri	49%	93%
A0A1X0NXL5	Trypanosomatidae	35%	100%
A0A3Q8ICG3	Leishmania donovani	88%	100%
A0A422NW27	Trypanosoma rangeli	26%	100%
A4HCP6	Leishmania braziliensis	72%	98%
A4I072	Leishmania infantum	87%	100%
C9ZUY6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4QBE2	Leishmania major	87%	100%