TMhelix containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW26_LEIMU

TriTrypDb:

LmxM.23.0230

Length:

190

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AW26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	186	190	PF00656	0.601
CLV_C14_Caspase3-7	25	29	PF00656	0.344
CLV_NRD_NRD_1	105	107	PF00675	0.318
CLV_NRD_NRD_1	109	111	PF00675	0.334
CLV_NRD_NRD_1	15	17	PF00675	0.609
CLV_NRD_NRD_1	186	188	PF00675	0.466
CLV_NRD_NRD_1	43	45	PF00675	0.585
CLV_PCSK_KEX2_1	105	107	PF00082	0.355
CLV_PCSK_KEX2_1	109	111	PF00082	0.363
CLV_PCSK_KEX2_1	130	132	PF00082	0.385
CLV_PCSK_KEX2_1	15	17	PF00082	0.611
CLV_PCSK_PC1ET2_1	130	132	PF00082	0.385
CLV_PCSK_PC7_1	105	111	PF00082	0.338
CLV_PCSK_PC7_1	11	17	PF00082	0.615
CLV_PCSK_SKI1_1	136	140	PF00082	0.396
CLV_PCSK_SKI1_1	149	153	PF00082	0.404
DEG_APCC_DBOX_1	66	74	PF00400	0.377
DOC_MAPK_gen_1	15	22	PF00069	0.431
DOC_MAPK_MEF2A_6	15	22	PF00069	0.445
DOC_MAPK_NFAT4_5	15	23	PF00069	0.446
DOC_PP1_RVXF_1	78	85	PF00149	0.294
DOC_USP7_MATH_1	26	30	PF00917	0.350
DOC_USP7_UBL2_3	45	49	PF12436	0.329
LIG_14-3-3_CanoR_1	11	15	PF00244	0.414
LIG_BIR_II_1	1	5	PF00653	0.412
LIG_FHA_1	31	37	PF00498	0.505
LIG_FHA_1	5	11	PF00498	0.405
LIG_FHA_1	94	100	PF00498	0.340
LIG_FHA_2	184	190	PF00498	0.577
LIG_Integrin_RGD_1	106	108	PF01839	0.288
LIG_LIR_Gen_1	17	26	PF02991	0.316
LIG_LIR_Gen_1	85	94	PF02991	0.387
LIG_LIR_Nem_3	17	22	PF02991	0.326
LIG_LIR_Nem_3	85	89	PF02991	0.385
LIG_Pex14_2	93	97	PF04695	0.420
LIG_SH2_STAT5	19	22	PF00017	0.501
LIG_TRAF2_1	116	119	PF00917	0.616
LIG_WRC_WIRS_1	94	99	PF05994	0.383
MOD_CK1_1	4	10	PF00069	0.417
MOD_CK2_1	151	157	PF00069	0.483
MOD_CK2_1	40	46	PF00069	0.420
MOD_GlcNHglycan	1	4	PF01048	0.627
MOD_GlcNHglycan	139	142	PF01048	0.329
MOD_GlcNHglycan	24	27	PF01048	0.557
MOD_GlcNHglycan	59	62	PF01048	0.631
MOD_GSK3_1	10	17	PF00069	0.399
MOD_GSK3_1	147	154	PF00069	0.475
MOD_GSK3_1	22	29	PF00069	0.418
MOD_N-GLC_1	30	35	PF02516	0.706
MOD_NEK2_1	1	6	PF00069	0.366
MOD_NEK2_1	20	25	PF00069	0.437
MOD_NEK2_1	40	45	PF00069	0.478
MOD_NEK2_1	57	62	PF00069	0.433
MOD_NEK2_1	82	87	PF00069	0.481
MOD_NEK2_1	93	98	PF00069	0.360
MOD_NEK2_2	14	19	PF00069	0.304
MOD_PKA_2	10	16	PF00069	0.419
MOD_PKA_2	26	32	PF00069	0.353
MOD_PKA_2	66	72	PF00069	0.377
MOD_Plk_4	1	7	PF00069	0.365
MOD_Plk_4	147	153	PF00069	0.578
MOD_Plk_4	93	99	PF00069	0.331
MOD_SUMO_rev_2	135	141	PF00179	0.519
TRG_ENDOCYTIC_2	19	22	PF00928	0.449
TRG_ER_diArg_1	104	106	PF00400	0.522
TRG_ER_diArg_1	14	16	PF00400	0.413
TRG_Pf-PMV_PEXEL_1	153	157	PF00026	0.428
TRG_PTS2	1	40	PF00400	0.420

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y2	Leptomonas seymouri	49%	100%
A0A0S4JFQ3	Bodo saltans	34%	100%
A0A3S7WXI2	Leishmania donovani	81%	100%
A4HCN8	Leishmania braziliensis	68%	100%
A4I063	Leishmania infantum	82%	100%
Q4QBF1	Leishmania major	82%	100%