Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW25_LEIMU

TriTrypDb:

LmxM.23.0225

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9AW25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	89	93	PF00656	0.690
CLV_NRD_NRD_1	2	4	PF00675	0.416
CLV_NRD_NRD_1	76	78	PF00675	0.471
CLV_PCSK_KEX2_1	2	4	PF00082	0.416
CLV_PCSK_KEX2_1	76	78	PF00082	0.471
CLV_PCSK_SKI1_1	165	169	PF00082	0.399
CLV_PCSK_SKI1_1	95	99	PF00082	0.435
DEG_Nend_UBRbox_1	1	4	PF02207	0.704
DEG_SCF_FBW7_1	44	51	PF00400	0.626
DEG_SPOP_SBC_1	31	35	PF00917	0.625
DOC_CKS1_1	181	186	PF01111	0.574
DOC_CKS1_1	45	50	PF01111	0.627
DOC_PP2B_LxvP_1	97	100	PF13499	0.671
DOC_PP4_FxxP_1	124	127	PF00568	0.741
DOC_PP4_MxPP_1	134	137	PF00568	0.724
DOC_WW_Pin1_4	180	185	PF00397	0.583
DOC_WW_Pin1_4	44	49	PF00397	0.616
DOC_WW_Pin1_4	55	60	PF00397	0.623
LIG_14-3-3_CanoR_1	165	170	PF00244	0.618
LIG_deltaCOP1_diTrp_1	204	214	PF00928	0.543
LIG_FHA_1	32	38	PF00498	0.680
LIG_FHA_1	39	45	PF00498	0.634
LIG_FHA_2	49	55	PF00498	0.573
LIG_FHA_2	87	93	PF00498	0.680
LIG_LIR_Apic_2	80	86	PF02991	0.618
LIG_LIR_Gen_1	205	216	PF02991	0.543
LIG_LIR_Nem_3	204	210	PF02991	0.543
LIG_LIR_Nem_3	213	217	PF02991	0.417
LIG_Pex14_2	214	218	PF04695	0.417
LIG_SH2_CRK	196	200	PF00017	0.718
LIG_SH2_STAT3	120	123	PF00017	0.711
LIG_SH2_STAT3	46	49	PF00017	0.668
LIG_SH2_STAT5	40	43	PF00017	0.660
LIG_SH2_STAT5	46	49	PF00017	0.604
LIG_SH2_STAT5	55	58	PF00017	0.571
LIG_SH3_1	42	48	PF00018	0.586
LIG_SH3_3	179	185	PF00018	0.662
LIG_SH3_3	42	48	PF00018	0.596
LIG_SH3_3	93	99	PF00018	0.642
LIG_UBA3_1	217	226	PF00899	0.417
LIG_WRC_WIRS_1	211	216	PF05994	0.372
LIG_WW_1	117	120	PF00397	0.711
MOD_CDK_SPK_2	55	60	PF00069	0.675
MOD_CK2_1	170	176	PF00069	0.651
MOD_GlcNHglycan	109	112	PF01048	0.445
MOD_GSK3_1	44	51	PF00069	0.616
MOD_N-GLC_1	31	36	PF02516	0.457
MOD_NEK2_1	203	208	PF00069	0.608
MOD_NEK2_1	210	215	PF00069	0.366
MOD_PKA_2	107	113	PF00069	0.620
MOD_PKB_1	163	171	PF00069	0.612
MOD_Plk_1	203	209	PF00069	0.524
MOD_Plk_4	203	209	PF00069	0.513
MOD_ProDKin_1	180	186	PF00069	0.580
MOD_ProDKin_1	44	50	PF00069	0.616
MOD_ProDKin_1	55	61	PF00069	0.621
TRG_ER_diArg_1	1	3	PF00400	0.639
TRG_ER_diArg_1	163	166	PF00400	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHG6	Leptomonas seymouri	60%	100%
A0A0S4JGN0	Bodo saltans	36%	90%
A0A1X0NGS3	Trypanosomatidae	40%	100%
A0A3Q8ICE4	Leishmania donovani	93%	100%
A0A3S7WXM6	Leishmania donovani	90%	100%
A4HCN7	Leishmania braziliensis	77%	100%
A4I062	Leishmania infantum	93%	100%
Q4QBF2	Leishmania major	92%	100%
V5B7Q1	Trypanosoma cruzi	43%	93%