Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW24_LEIMU

TriTrypDb:

LmxM.23.0223

Length:

152

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

E9AW24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.575
CLV_PCSK_KEX2_1	126	128	PF00082	0.667
CLV_PCSK_KEX2_1	2	4	PF00082	0.575
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.667
DEG_Nend_UBRbox_1	1	4	PF02207	0.692
DEG_SPOP_SBC_1	47	51	PF00917	0.628
DOC_CKS1_1	67	72	PF01111	0.690
DOC_CKS1_1	84	89	PF01111	0.598
DOC_PP4_FxxP_1	109	112	PF00568	0.412
DOC_USP7_MATH_1	143	147	PF00917	0.412
DOC_USP7_MATH_1	20	24	PF00917	0.708
DOC_WW_Pin1_4	66	71	PF00397	0.660
DOC_WW_Pin1_4	83	88	PF00397	0.715
LIG_14-3-3_CanoR_1	2	6	PF00244	0.584
LIG_14-3-3_CanoR_1	25	31	PF00244	0.700
LIG_14-3-3_CanoR_1	60	67	PF00244	0.664
LIG_BRCT_BRCA1_1	44	48	PF00533	0.684
LIG_FHA_2	84	90	PF00498	0.679
LIG_PDZ_Class_3	147	152	PF00595	0.472
LIG_RPA_C_Fungi	55	67	PF08784	0.515
LIG_SH2_STAP1	61	65	PF00017	0.435
LIG_SH2_STAT5	116	119	PF00017	0.538
LIG_SH3_3	64	70	PF00018	0.558
LIG_SH3_3	81	87	PF00018	0.525
LIG_SUMO_SIM_anti_2	102	108	PF11976	0.444
MOD_CDK_SPxK_1	66	72	PF00069	0.605
MOD_CK1_1	36	42	PF00069	0.488
MOD_CK1_1	52	58	PF00069	0.689
MOD_CK2_1	141	147	PF00069	0.687
MOD_CK2_1	83	89	PF00069	0.591
MOD_CK2_1	92	98	PF00069	0.483
MOD_GlcNHglycan	118	121	PF01048	0.420
MOD_GlcNHglycan	17	20	PF01048	0.606
MOD_GlcNHglycan	36	39	PF01048	0.584
MOD_GlcNHglycan	57	60	PF01048	0.614
MOD_GlcNHglycan	98	102	PF01048	0.415
MOD_GSK3_1	20	27	PF00069	0.589
MOD_GSK3_1	36	43	PF00069	0.687
MOD_GSK3_1	46	53	PF00069	0.613
MOD_GSK3_1	92	99	PF00069	0.565
MOD_NEK2_1	1	6	PF00069	0.532
MOD_NEK2_1	33	38	PF00069	0.548
MOD_NEK2_1	40	45	PF00069	0.558
MOD_NEK2_1	48	53	PF00069	0.502
MOD_NEK2_2	20	25	PF00069	0.591
MOD_PIKK_1	42	48	PF00454	0.455
MOD_PKA_2	1	7	PF00069	0.460
MOD_PKA_2	24	30	PF00069	0.585
MOD_PKA_2	92	98	PF00069	0.617
MOD_Plk_4	99	105	PF00069	0.462
MOD_ProDKin_1	66	72	PF00069	0.564
MOD_ProDKin_1	83	89	PF00069	0.646
MOD_SUMO_rev_2	119	128	PF00179	0.570
TRG_ER_diArg_1	1	3	PF00400	0.738
TRG_ER_diArg_1	80	83	PF00400	0.647

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IFQ1	Leishmania donovani	86%	100%
A4HCN6	Leishmania braziliensis	66%	100%
A4I061	Leishmania infantum	86%	100%
E9ACS2	Leishmania major	84%	100%