DEK_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW20_LEIMU

TriTrypDb:

LmxM.23.0190

Length:

125

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	74	78	PF00656	0.578
CLV_NRD_NRD_1	43	45	PF00675	0.466
CLV_NRD_NRD_1	67	69	PF00675	0.455
CLV_NRD_NRD_1	87	89	PF00675	0.514
CLV_NRD_NRD_1	90	92	PF00675	0.494
CLV_PCSK_FUR_1	68	72	PF00082	0.562
CLV_PCSK_FUR_1	85	89	PF00082	0.331
CLV_PCSK_KEX2_1	42	44	PF00082	0.488
CLV_PCSK_KEX2_1	67	69	PF00082	0.471
CLV_PCSK_KEX2_1	70	72	PF00082	0.491
CLV_PCSK_KEX2_1	87	89	PF00082	0.388
CLV_PCSK_KEX2_1	90	92	PF00082	0.324
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.556
CLV_PCSK_PC1ET2_1	87	89	PF00082	0.399
CLV_PCSK_PC7_1	83	89	PF00082	0.530
CLV_PCSK_SKI1_1	24	28	PF00082	0.470
CLV_PCSK_SKI1_1	46	50	PF00082	0.493
DEG_ODPH_VHL_1	14	27	PF01847	0.526
DOC_USP7_MATH_1	96	100	PF00917	0.615
LIG_Actin_WH2_2	38	53	PF00022	0.531
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_Clathr_ClatBox_1	101	105	PF01394	0.668
LIG_FHA_1	2	8	PF00498	0.703
LIG_FHA_2	116	122	PF00498	0.718
LIG_SUMO_SIM_anti_2	19	24	PF11976	0.530
LIG_SUMO_SIM_par_1	25	31	PF11976	0.436
LIG_SUMO_SIM_par_1	99	105	PF11976	0.659
LIG_TRAF2_1	117	120	PF00917	0.744
LIG_TRAF2_1	16	19	PF00917	0.495
LIG_TRAF2_1	79	82	PF00917	0.592
MOD_CK1_1	112	118	PF00069	0.739
MOD_CK1_1	3	9	PF00069	0.518
MOD_CK1_1	53	59	PF00069	0.532
MOD_CK2_1	114	120	PF00069	0.771
MOD_CK2_1	76	82	PF00069	0.581
MOD_Cter_Amidation	68	71	PF01082	0.563
MOD_GlcNHglycan	107	110	PF01048	0.621
MOD_GlcNHglycan	113	117	PF01048	0.658
MOD_GSK3_1	105	112	PF00069	0.654
MOD_GSK3_1	49	56	PF00069	0.524
MOD_Plk_2-3	28	34	PF00069	0.532
TRG_DiLeu_BaEn_4	81	87	PF01217	0.496
TRG_DiLeu_BaLyEn_6	97	102	PF01217	0.397
TRG_ER_diArg_1	41	44	PF00400	0.469
TRG_ER_diArg_1	66	68	PF00400	0.471
TRG_ER_diArg_1	83	86	PF00400	0.337
TRG_ER_diArg_1	88	91	PF00400	0.505
TRG_NLS_Bipartite_1	70	91	PF00514	0.563
TRG_NLS_MonoCore_2	86	91	PF00514	0.555
TRG_NLS_MonoExtC_3	38	43	PF00514	0.515
TRG_NLS_MonoExtC_3	86	91	PF00514	0.555
TRG_NLS_MonoExtN_4	85	91	PF00514	0.560
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV53	Leptomonas seymouri	78%	98%
A0A1X0NGK1	Trypanosomatidae	51%	100%
A0A3R7MXM6	Trypanosoma rangeli	46%	100%
A0A3S7WXL7	Leishmania donovani	93%	100%
A4HCN3	Leishmania braziliensis	83%	100%
A4I057	Leishmania infantum	93%	100%
Q4QBF6	Leishmania major	92%	100%