Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW18_LEIMU

TriTrypDb:

LmxM.23.0170

Length:

227

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AW18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.614
CLV_NRD_NRD_1	131	133	PF00675	0.600
CLV_NRD_NRD_1	187	189	PF00675	0.371
CLV_PCSK_KEX2_1	131	133	PF00082	0.571
CLV_PCSK_SKI1_1	153	157	PF00082	0.560
CLV_Separin_Metazoa	41	45	PF03568	0.571
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.555
DOC_PP2B_LxvP_1	195	198	PF13499	0.557
DOC_WW_Pin1_4	10	15	PF00397	0.698
LIG_14-3-3_CanoR_1	104	110	PF00244	0.460
LIG_14-3-3_CanoR_1	144	149	PF00244	0.371
LIG_14-3-3_CanoR_1	150	156	PF00244	0.398
LIG_Actin_WH2_2	173	190	PF00022	0.319
LIG_FHA_1	182	188	PF00498	0.618
LIG_FHA_1	66	72	PF00498	0.419
LIG_FHA_2	90	96	PF00498	0.443
LIG_LIR_Nem_3	193	197	PF02991	0.608
LIG_LIR_Nem_3	58	63	PF02991	0.281
LIG_SH2_SRC	63	66	PF00017	0.466
LIG_SH2_STAT5	167	170	PF00017	0.367
LIG_SH2_STAT5	63	66	PF00017	0.379
LIG_SUMO_SIM_par_1	210	217	PF11976	0.554
LIG_TRAF2_1	73	76	PF00917	0.314
MOD_CK1_1	105	111	PF00069	0.394
MOD_CK1_1	154	160	PF00069	0.436
MOD_CK2_1	197	203	PF00069	0.726
MOD_CK2_1	35	41	PF00069	0.619
MOD_GlcNHglycan	159	162	PF01048	0.655
MOD_GlcNHglycan	209	212	PF01048	0.486
MOD_GlcNHglycan	57	60	PF01048	0.366
MOD_GSK3_1	151	158	PF00069	0.420
MOD_GSK3_1	3	10	PF00069	0.694
MOD_N-GLC_1	102	107	PF02516	0.609
MOD_N-GLC_1	144	149	PF02516	0.596
MOD_NEK2_1	134	139	PF00069	0.367
MOD_NEK2_1	155	160	PF00069	0.379
MOD_NEK2_1	34	39	PF00069	0.617
MOD_NEK2_1	89	94	PF00069	0.414
MOD_NMyristoyl	1	7	PF02799	0.647
MOD_PIKK_1	35	41	PF00454	0.577
MOD_PK_1	144	150	PF00069	0.413
MOD_PKA_2	66	72	PF00069	0.405
MOD_PKA_2	90	96	PF00069	0.300
MOD_PKB_1	142	150	PF00069	0.360
MOD_Plk_1	102	108	PF00069	0.408
MOD_Plk_1	144	150	PF00069	0.408
MOD_ProDKin_1	10	16	PF00069	0.691
TRG_DiLeu_BaEn_1	102	107	PF01217	0.409
TRG_DiLeu_BaEn_4	75	81	PF01217	0.276
TRG_ENDOCYTIC_2	167	170	PF00928	0.385
TRG_ER_diArg_1	141	144	PF00400	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU2	Leptomonas seymouri	55%	100%
A0A1X0NGY8	Trypanosomatidae	27%	100%
A0A3S7WXJ0	Leishmania donovani	90%	100%
A4HCN1	Leishmania braziliensis	78%	100%
A4I055	Leishmania infantum	89%	100%
Q4QBF8	Leishmania major	89%	100%
V5B4L7	Trypanosoma cruzi	30%	95%