Cyclic nucleotide-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW17_LEIMU

TriTrypDb:

LmxM.23.0160

Length:

526

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	7
GO:0042995	cell projection	2	7
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0110165	cellular anatomical entity	1	8
GO:0120025	plasma membrane bounded cell projection	3	7
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9AW17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	415	419	PF00656	0.590
CLV_C14_Caspase3-7	432	436	PF00656	0.377
CLV_NRD_NRD_1	248	250	PF00675	0.447
CLV_NRD_NRD_1	466	468	PF00675	0.432
CLV_PCSK_KEX2_1	468	470	PF00082	0.459
CLV_PCSK_PC1ET2_1	468	470	PF00082	0.541
CLV_PCSK_SKI1_1	105	109	PF00082	0.361
CLV_PCSK_SKI1_1	259	263	PF00082	0.478
CLV_PCSK_SKI1_1	27	31	PF00082	0.452
CLV_PCSK_SKI1_1	450	454	PF00082	0.508
CLV_PCSK_SKI1_1	481	485	PF00082	0.531
CLV_PCSK_SKI1_1	503	507	PF00082	0.445
CLV_PCSK_SKI1_1	94	98	PF00082	0.616
CLV_Separin_Metazoa	21	25	PF03568	0.527
DEG_APCC_DBOX_1	104	112	PF00400	0.382
DEG_APCC_DBOX_1	26	34	PF00400	0.479
DOC_CDC14_PxL_1	241	249	PF14671	0.552
DOC_CYCLIN_RxL_1	253	266	PF00134	0.576
DOC_MAPK_DCC_7	105	113	PF00069	0.453
DOC_MAPK_DCC_7	94	102	PF00069	0.612
DOC_MAPK_gen_1	160	169	PF00069	0.494
DOC_MAPK_gen_1	24	32	PF00069	0.450
DOC_MAPK_gen_1	467	475	PF00069	0.446
DOC_MAPK_gen_1	500	509	PF00069	0.513
DOC_MAPK_gen_1	72	80	PF00069	0.494
DOC_MAPK_HePTP_8	497	509	PF00069	0.548
DOC_MAPK_MEF2A_6	105	113	PF00069	0.406
DOC_MAPK_MEF2A_6	233	241	PF00069	0.501
DOC_MAPK_MEF2A_6	500	509	PF00069	0.557
DOC_PP1_RVXF_1	158	164	PF00149	0.465
DOC_SPAK_OSR1_1	455	459	PF12202	0.360
DOC_USP7_MATH_1	138	142	PF00917	0.526
DOC_USP7_MATH_1	173	177	PF00917	0.559
DOC_USP7_MATH_1	2	6	PF00917	0.538
DOC_USP7_MATH_1	359	363	PF00917	0.461
DOC_USP7_MATH_1	463	467	PF00917	0.426
DOC_USP7_UBL2_3	229	233	PF12436	0.501
DOC_WW_Pin1_4	95	100	PF00397	0.571
LIG_14-3-3_CanoR_1	162	168	PF00244	0.439
LIG_14-3-3_CanoR_1	249	253	PF00244	0.466
LIG_14-3-3_CanoR_1	259	268	PF00244	0.378
LIG_14-3-3_CanoR_1	27	33	PF00244	0.505
LIG_14-3-3_CanoR_1	285	294	PF00244	0.420
LIG_14-3-3_CanoR_1	317	326	PF00244	0.492
LIG_14-3-3_CanoR_1	397	405	PF00244	0.432
LIG_14-3-3_CanoR_1	447	453	PF00244	0.569
LIG_14-3-3_CanoR_1	467	475	PF00244	0.258
LIG_14-3-3_CanoR_1	511	516	PF00244	0.438
LIG_APCC_ABBA_1	316	321	PF00400	0.551
LIG_BIR_III_4	435	439	PF00653	0.349
LIG_BRCT_BRCA1_1	335	339	PF00533	0.276
LIG_CaM_NSCaTE_8	370	377	PF13499	0.456
LIG_EH1_1	458	466	PF00400	0.513
LIG_FHA_1	120	126	PF00498	0.525
LIG_FHA_1	164	170	PF00498	0.450
LIG_FHA_1	197	203	PF00498	0.559
LIG_FHA_1	226	232	PF00498	0.633
LIG_FHA_1	267	273	PF00498	0.447
LIG_FHA_1	281	287	PF00498	0.453
LIG_FHA_1	313	319	PF00498	0.527
LIG_FHA_1	362	368	PF00498	0.497
LIG_FHA_1	444	450	PF00498	0.340
LIG_FHA_1	485	491	PF00498	0.498
LIG_FHA_1	83	89	PF00498	0.487
LIG_FHA_2	198	204	PF00498	0.529
LIG_FHA_2	211	217	PF00498	0.501
LIG_FHA_2	249	255	PF00498	0.487
LIG_FHA_2	271	277	PF00498	0.581
LIG_FHA_2	318	324	PF00498	0.457
LIG_FHA_2	398	404	PF00498	0.487
LIG_FHA_2	410	416	PF00498	0.504
LIG_FHA_2	452	458	PF00498	0.488
LIG_FXI_DFP_1	194	198	PF00024	0.267
LIG_GBD_Chelix_1	150	158	PF00786	0.487
LIG_Integrin_RGD_1	302	304	PF01839	0.396
LIG_Integrin_RGD_1	329	331	PF01839	0.393
LIG_LIR_Gen_1	336	347	PF02991	0.305
LIG_LIR_Gen_1	428	436	PF02991	0.456
LIG_LIR_Gen_1	451	461	PF02991	0.487
LIG_LIR_Gen_1	50	58	PF02991	0.326
LIG_LIR_LC3C_4	487	490	PF02991	0.403
LIG_LIR_Nem_3	335	340	PF02991	0.432
LIG_LIR_Nem_3	428	434	PF02991	0.404
LIG_LIR_Nem_3	451	456	PF02991	0.501
LIG_LIR_Nem_3	482	488	PF02991	0.435
LIG_LIR_Nem_3	50	55	PF02991	0.326
LIG_LYPXL_yS_3	337	340	PF13949	0.569
LIG_MAD2	496	504	PF02301	0.443
LIG_NRBOX	257	263	PF00104	0.577
LIG_PCNA_PIPBox_1	6	15	PF02747	0.393
LIG_PCNA_yPIPBox_3	249	262	PF02747	0.467
LIG_PCNA_yPIPBox_3	6	16	PF02747	0.423
LIG_PTB_Apo_2	131	138	PF02174	0.660
LIG_SH2_CRK	356	360	PF00017	0.405
LIG_SH2_CRK	485	489	PF00017	0.413
LIG_SH2_GRB2like	132	135	PF00017	0.611
LIG_SH2_PTP2	52	55	PF00017	0.330
LIG_SH2_SRC	235	238	PF00017	0.560
LIG_SH2_SRC	356	359	PF00017	0.476
LIG_SH2_STAT5	101	104	PF00017	0.510
LIG_SH2_STAT5	13	16	PF00017	0.485
LIG_SH2_STAT5	240	243	PF00017	0.536
LIG_SH2_STAT5	319	322	PF00017	0.524
LIG_SH2_STAT5	332	335	PF00017	0.363
LIG_SH2_STAT5	424	427	PF00017	0.466
LIG_SH2_STAT5	52	55	PF00017	0.460
LIG_SH3_1	220	226	PF00018	0.587
LIG_SH3_3	19	25	PF00018	0.485
LIG_SH3_3	220	226	PF00018	0.580
LIG_SH3_3	337	343	PF00018	0.575
LIG_SUMO_SIM_par_1	121	126	PF11976	0.468
LIG_SUMO_SIM_par_1	165	170	PF11976	0.329
LIG_TRFH_1	339	343	PF08558	0.284
LIG_TYR_ITIM	483	488	PF00017	0.445
LIG_UBA3_1	308	312	PF00899	0.429
MOD_CK1_1	141	147	PF00069	0.456
MOD_CK1_1	263	269	PF00069	0.520
MOD_CK1_1	270	276	PF00069	0.519
MOD_CK1_1	362	368	PF00069	0.415
MOD_CK1_1	448	454	PF00069	0.533
MOD_CK2_1	210	216	PF00069	0.544
MOD_CK2_1	248	254	PF00069	0.480
MOD_CK2_1	270	276	PF00069	0.511
MOD_CK2_1	285	291	PF00069	0.352
MOD_CK2_1	317	323	PF00069	0.505
MOD_CK2_1	342	348	PF00069	0.533
MOD_CK2_1	36	42	PF00069	0.593
MOD_CK2_1	397	403	PF00069	0.480
MOD_CK2_1	409	415	PF00069	0.535
MOD_CK2_1	511	517	PF00069	0.471
MOD_GlcNHglycan	145	148	PF01048	0.506
MOD_GlcNHglycan	168	172	PF01048	0.257
MOD_GlcNHglycan	269	272	PF01048	0.470
MOD_GlcNHglycan	276	280	PF01048	0.429
MOD_GlcNHglycan	312	315	PF01048	0.389
MOD_GlcNHglycan	431	434	PF01048	0.503
MOD_GSK3_1	119	126	PF00069	0.391
MOD_GSK3_1	133	140	PF00069	0.429
MOD_GSK3_1	163	170	PF00069	0.238
MOD_GSK3_1	260	267	PF00069	0.507
MOD_N-GLC_1	133	138	PF02516	0.669
MOD_NEK2_1	137	142	PF00069	0.674
MOD_NEK2_1	167	172	PF00069	0.381
MOD_NEK2_1	182	187	PF00069	0.478
MOD_NEK2_1	197	202	PF00069	0.488
MOD_NEK2_1	280	285	PF00069	0.454
MOD_NEK2_1	325	330	PF00069	0.432
MOD_NEK2_1	333	338	PF00069	0.401
MOD_NEK2_1	360	365	PF00069	0.474
MOD_NEK2_1	484	489	PF00069	0.462
MOD_OFUCOSY	395	401	PF10250	0.426
MOD_PIKK_1	138	144	PF00454	0.705
MOD_PIKK_1	2	8	PF00454	0.531
MOD_PIKK_1	79	85	PF00454	0.575
MOD_PK_1	469	475	PF00069	0.472
MOD_PKA_1	468	474	PF00069	0.407
MOD_PKA_2	248	254	PF00069	0.466
MOD_PKA_2	468	474	PF00069	0.465
MOD_PKB_1	467	475	PF00069	0.484
MOD_Plk_1	133	139	PF00069	0.603
MOD_Plk_1	263	269	PF00069	0.408
MOD_Plk_2-3	248	254	PF00069	0.491
MOD_Plk_4	127	133	PF00069	0.454
MOD_Plk_4	188	194	PF00069	0.557
MOD_Plk_4	28	34	PF00069	0.499
MOD_Plk_4	362	368	PF00069	0.524
MOD_Plk_4	409	415	PF00069	0.535
MOD_ProDKin_1	95	101	PF00069	0.564
MOD_SUMO_rev_2	402	412	PF00179	0.452
TRG_ENDOCYTIC_2	319	322	PF00928	0.550
TRG_ENDOCYTIC_2	337	340	PF00928	0.303
TRG_ENDOCYTIC_2	485	488	PF00928	0.451
TRG_ENDOCYTIC_2	52	55	PF00928	0.330
TRG_ER_diArg_1	159	162	PF00400	0.546
TRG_ER_diArg_1	219	222	PF00400	0.675
TRG_ER_FFAT_2	263	273	PF00635	0.470
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.425
TRG_Pf-PMV_PEXEL_1	496	501	PF00026	0.501

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4S8	Leptomonas seymouri	57%	94%
A0A0S4JG45	Bodo saltans	29%	86%
A0A1X0NG29	Trypanosomatidae	37%	96%
A0A3S5H7B5	Leishmania donovani	91%	100%
A0A422NVZ8	Trypanosoma rangeli	40%	100%
A4HCN0	Leishmania braziliensis	79%	100%
A4I054	Leishmania infantum	91%	100%
Q4QBF9	Leishmania major	92%	100%