AB hydrolase-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Alpha/beta hydrolase family, putative

Species:

Leishmania mexicana

UniProt:

E9AW15_LEIMU

TriTrypDb:

LmxM.23.0140

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AW15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW15

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	1
GO:0006644	phospholipid metabolic process	4	1
GO:0006650	glycerophospholipid metabolic process	5	1
GO:0006654	phosphatidic acid biosynthetic process	6	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0008610	lipid biosynthetic process	4	1
GO:0008654	phospholipid biosynthetic process	5	1
GO:0009058	biosynthetic process	2	1
GO:0009987	cellular process	1	1
GO:0019637	organophosphate metabolic process	3	1
GO:0042592	homeostatic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044255	cellular lipid metabolic process	3	1
GO:0045017	glycerolipid biosynthetic process	4	1
GO:0046473	phosphatidic acid metabolic process	6	1
GO:0046474	glycerophospholipid biosynthetic process	5	1
GO:0046486	glycerolipid metabolic process	4	1
GO:0048878	chemical homeostasis	4	1
GO:0055088	lipid homeostasis	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016740	transferase activity	2	1
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0016787	hydrolase activity	2	2
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0042171	lysophosphatidic acid acyltransferase activity	6	1
GO:0052689	carboxylic ester hydrolase activity	4	1
GO:0071617	lysophospholipid acyltransferase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	325	329	PF00656	0.232
CLV_C14_Caspase3-7	372	376	PF00656	0.329
CLV_NRD_NRD_1	163	165	PF00675	0.385
CLV_NRD_NRD_1	23	25	PF00675	0.620
CLV_NRD_NRD_1	273	275	PF00675	0.322
CLV_NRD_NRD_1	28	30	PF00675	0.558
CLV_PCSK_KEX2_1	163	165	PF00082	0.385
CLV_PCSK_KEX2_1	23	25	PF00082	0.561
CLV_PCSK_KEX2_1	273	275	PF00082	0.322
CLV_PCSK_KEX2_1	28	30	PF00082	0.580
CLV_PCSK_PC7_1	24	30	PF00082	0.437
CLV_PCSK_SKI1_1	220	224	PF00082	0.462
CLV_PCSK_SKI1_1	246	250	PF00082	0.280
CLV_PCSK_SKI1_1	282	286	PF00082	0.165
CLV_PCSK_SKI1_1	310	314	PF00082	0.283
CLV_PCSK_SKI1_1	48	52	PF00082	0.450
DEG_MDM2_SWIB_1	279	287	PF02201	0.236
DEG_Nend_Nbox_1	1	3	PF02207	0.521
DOC_CKS1_1	350	355	PF01111	0.232
DOC_CYCLIN_yCln2_LP_2	224	230	PF00134	0.246
DOC_MAPK_gen_1	237	247	PF00069	0.251
DOC_MAPK_gen_1	363	371	PF00069	0.283
DOC_MAPK_MEF2A_6	239	247	PF00069	0.321
DOC_MAPK_MEF2A_6	336	344	PF00069	0.249
DOC_MAPK_MEF2A_6	363	371	PF00069	0.283
DOC_PP1_RVXF_1	186	192	PF00149	0.296
DOC_PP1_RVXF_1	280	287	PF00149	0.154
DOC_PP4_FxxP_1	153	156	PF00568	0.449
DOC_PP4_FxxP_1	191	194	PF00568	0.253
DOC_USP7_MATH_1	11	15	PF00917	0.456
DOC_USP7_MATH_1	322	326	PF00917	0.154
DOC_WW_Pin1_4	102	107	PF00397	0.706
DOC_WW_Pin1_4	288	293	PF00397	0.290
DOC_WW_Pin1_4	349	354	PF00397	0.232
LIG_14-3-3_CanoR_1	142	151	PF00244	0.329
LIG_14-3-3_CanoR_1	163	172	PF00244	0.407
LIG_14-3-3_CanoR_1	282	287	PF00244	0.337
LIG_Actin_WH2_2	248	264	PF00022	0.296
LIG_BIR_III_2	328	332	PF00653	0.232
LIG_BRCT_BRCA1_1	139	143	PF00533	0.296
LIG_deltaCOP1_diTrp_1	280	286	PF00928	0.369
LIG_FHA_1	102	108	PF00498	0.745
LIG_FHA_1	44	50	PF00498	0.381
LIG_FHA_1	67	73	PF00498	0.438
LIG_LIR_Apic_2	190	194	PF02991	0.259
LIG_LIR_Gen_1	280	290	PF02991	0.343
LIG_LIR_Gen_1	291	302	PF02991	0.268
LIG_LIR_Nem_3	140	144	PF02991	0.273
LIG_LIR_Nem_3	145	151	PF02991	0.269
LIG_LIR_Nem_3	176	181	PF02991	0.399
LIG_LIR_Nem_3	201	205	PF02991	0.271
LIG_LIR_Nem_3	280	286	PF02991	0.294
LIG_LIR_Nem_3	291	297	PF02991	0.307
LIG_NRBOX	357	363	PF00104	0.283
LIG_PALB2_WD40_1	181	189	PF16756	0.369
LIG_PDZ_Class_2	405	410	PF00595	0.531
LIG_Pex14_2	279	283	PF04695	0.236
LIG_PTB_Apo_2	251	258	PF02174	0.193
LIG_SH2_CRK	294	298	PF00017	0.404
LIG_SH2_NCK_1	16	20	PF00017	0.445
LIG_SH2_SRC	16	19	PF00017	0.447
LIG_SH2_SRC	296	299	PF00017	0.369
LIG_SH2_STAP1	151	155	PF00017	0.259
LIG_SH2_STAP1	294	298	PF00017	0.236
LIG_SH2_STAP1	318	322	PF00017	0.283
LIG_SH2_STAP1	33	37	PF00017	0.587
LIG_SH2_STAT5	177	180	PF00017	0.343
LIG_SH2_STAT5	181	184	PF00017	0.319
LIG_SH2_STAT5	296	299	PF00017	0.236
LIG_SH3_3	103	109	PF00018	0.671
LIG_SH3_3	263	269	PF00018	0.253
LIG_SH3_3	350	356	PF00018	0.232
LIG_SH3_5	292	296	PF00018	0.337
LIG_SUMO_SIM_anti_2	122	128	PF11976	0.236
LIG_SUMO_SIM_par_1	220	226	PF11976	0.269
LIG_WW_3	25	29	PF00397	0.567
MOD_CK1_1	108	114	PF00069	0.535
MOD_CK1_1	166	172	PF00069	0.271
MOD_CK1_1	401	407	PF00069	0.387
MOD_CK1_1	86	92	PF00069	0.515
MOD_CK2_1	167	173	PF00069	0.334
MOD_GlcNHglycan	85	88	PF01048	0.637
MOD_GSK3_1	101	108	PF00069	0.494
MOD_GSK3_1	163	170	PF00069	0.350
MOD_GSK3_1	31	38	PF00069	0.568
MOD_GSK3_1	330	337	PF00069	0.335
MOD_GSK3_1	345	352	PF00069	0.334
MOD_GSK3_1	395	402	PF00069	0.345
MOD_GSK3_1	86	93	PF00069	0.523
MOD_N-GLC_1	83	88	PF02516	0.652
MOD_NEK2_1	198	203	PF00069	0.331
MOD_NEK2_1	205	210	PF00069	0.331
MOD_NEK2_1	334	339	PF00069	0.216
MOD_NEK2_2	215	220	PF00069	0.271
MOD_PIKK_1	11	17	PF00454	0.585
MOD_PIKK_1	38	44	PF00454	0.567
MOD_PKA_1	163	169	PF00069	0.322
MOD_PKA_2	163	169	PF00069	0.396
MOD_PKB_1	368	376	PF00069	0.283
MOD_Plk_1	334	340	PF00069	0.154
MOD_Plk_1	38	44	PF00069	0.435
MOD_Plk_4	282	288	PF00069	0.439
MOD_Plk_4	31	37	PF00069	0.638
MOD_Plk_4	322	328	PF00069	0.390
MOD_ProDKin_1	102	108	PF00069	0.705
MOD_ProDKin_1	288	294	PF00069	0.290
MOD_ProDKin_1	349	355	PF00069	0.232
TRG_DiLeu_BaEn_1	217	222	PF01217	0.271
TRG_DiLeu_BaEn_1	357	362	PF01217	0.283
TRG_ENDOCYTIC_2	294	297	PF00928	0.404
TRG_ENDOCYTIC_2	33	36	PF00928	0.628
TRG_ER_diArg_1	22	24	PF00400	0.637
TRG_ER_diArg_1	27	29	PF00400	0.595
TRG_ER_diArg_1	272	274	PF00400	0.322
TRG_ER_diArg_1	367	370	PF00400	0.283
TRG_ER_diArg_1	94	97	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	142	146	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P520	Leptomonas seymouri	57%	100%
A0A0S4JMK2	Bodo saltans	33%	81%
A0A1X0NG89	Trypanosomatidae	41%	100%
A0A3S7WXG3	Leishmania donovani	89%	100%
A0A422NW44	Trypanosoma rangeli	42%	99%
A4HCM8	Leishmania braziliensis	74%	100%
A4I052	Leishmania infantum	89%	100%
O02218	Caenorhabditis elegans	27%	100%
O22975	Arabidopsis thaliana	24%	98%
P53264	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	21%	92%
P91143	Caenorhabditis elegans	30%	100%
Q0J0A4	Oryza sativa subsp. japonica	23%	99%
Q4QBG1	Leishmania major	79%	100%
Q5EA59	Bos taurus	32%	100%
Q5EE05	Sus scrofa	27%	100%
Q6QA69	Rattus norvegicus	28%	100%
Q8TB40	Homo sapiens	31%	100%
Q8VD66	Mus musculus	31%	100%
Q8WTS1	Homo sapiens	28%	100%
V5B077	Trypanosoma cruzi	43%	100%