Methyltransf_25 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative methyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9AW10_LEIMU

TriTrypDb:

LmxM.23.0100

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW10

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	3
GO:0032259	methylation	2	3

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0008168	methyltransferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0016741	transferase activity, transferring one-carbon groups	3	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	26	28	PF00675	0.479
CLV_PCSK_SKI1_1	105	109	PF00082	0.386
CLV_PCSK_SKI1_1	201	205	PF00082	0.446
CLV_PCSK_SKI1_1	28	32	PF00082	0.323
CLV_PCSK_SKI1_1	57	61	PF00082	0.551
CLV_PCSK_SKI1_1	8	12	PF00082	0.572
DOC_CKS1_1	43	48	PF01111	0.530
DOC_CKS1_1	63	68	PF01111	0.447
DOC_CYCLIN_RxL_1	24	33	PF00134	0.313
DOC_MAPK_MEF2A_6	35	43	PF00069	0.503
DOC_PP4_FxxP_1	43	46	PF00568	0.527
DOC_WW_Pin1_4	131	136	PF00397	0.406
DOC_WW_Pin1_4	42	47	PF00397	0.524
DOC_WW_Pin1_4	62	67	PF00397	0.533
LIG_Actin_WH2_2	179	196	PF00022	0.350
LIG_AP2alpha_2	247	249	PF02296	0.509
LIG_BIR_II_1	1	5	PF00653	0.469
LIG_BRCT_BRCA1_1	183	187	PF00533	0.314
LIG_BRCT_BRCA1_1	98	102	PF00533	0.406
LIG_Clathr_ClatBox_1	29	33	PF01394	0.485
LIG_CtBP_PxDLS_1	135	139	PF00389	0.432
LIG_FHA_1	210	216	PF00498	0.258
LIG_HCF-1_HBM_1	17	20	PF13415	0.469
LIG_LIR_Apic_2	40	46	PF02991	0.492
LIG_LIR_Gen_1	17	26	PF02991	0.461
LIG_LIR_Gen_1	176	186	PF02991	0.350
LIG_LIR_Gen_1	33	43	PF02991	0.282
LIG_LIR_Nem_3	17	23	PF02991	0.471
LIG_LIR_Nem_3	176	181	PF02991	0.350
LIG_LIR_Nem_3	247	252	PF02991	0.405
LIG_LIR_Nem_3	33	39	PF02991	0.269
LIG_NRBOX	70	76	PF00104	0.492
LIG_Pex14_1	85	89	PF04695	0.369
LIG_SH2_GRB2like	20	23	PF00017	0.500
LIG_SH2_NCK_1	20	24	PF00017	0.503
LIG_SH2_PTP2	83	86	PF00017	0.406
LIG_SH2_SRC	20	23	PF00017	0.500
LIG_SH2_STAT5	150	153	PF00017	0.273
LIG_SH2_STAT5	188	191	PF00017	0.314
LIG_SH2_STAT5	252	255	PF00017	0.432
LIG_SH2_STAT5	83	86	PF00017	0.361
LIG_SH3_3	242	248	PF00018	0.515
LIG_SH3_3	36	42	PF00018	0.492
LIG_SH3_3	60	66	PF00018	0.541
LIG_SUMO_SIM_anti_2	137	144	PF11976	0.432
LIG_SUMO_SIM_anti_2	154	159	PF11976	0.273
LIG_SUMO_SIM_anti_2	70	79	PF11976	0.511
LIG_SUMO_SIM_par_1	28	33	PF11976	0.383
LIG_SUMO_SIM_par_1	70	79	PF11976	0.282
LIG_TRAF2_1	233	236	PF00917	0.466
LIG_WRC_WIRS_1	175	180	PF05994	0.406
MOD_CDK_SPxxK_3	42	49	PF00069	0.524
MOD_CK1_1	134	140	PF00069	0.350
MOD_CK1_1	44	50	PF00069	0.609
MOD_CK1_1	76	82	PF00069	0.210
MOD_CK2_1	61	67	PF00069	0.602
MOD_GlcNHglycan	201	204	PF01048	0.510
MOD_GlcNHglycan	46	49	PF01048	0.549
MOD_GSK3_1	215	222	PF00069	0.378
MOD_GSK3_1	57	64	PF00069	0.607
MOD_N-GLC_1	209	214	PF02516	0.298
MOD_NEK2_1	117	122	PF00069	0.432
MOD_NEK2_1	187	192	PF00069	0.359
MOD_NEK2_1	215	220	PF00069	0.363
MOD_NEK2_1	240	245	PF00069	0.442
MOD_PKB_1	55	63	PF00069	0.542
MOD_Plk_1	209	215	PF00069	0.365
MOD_Plk_4	209	215	PF00069	0.335
MOD_Plk_4	240	246	PF00069	0.444
MOD_ProDKin_1	131	137	PF00069	0.406
MOD_ProDKin_1	42	48	PF00069	0.523
MOD_ProDKin_1	62	68	PF00069	0.523
MOD_SUMO_for_1	169	172	PF00179	0.432
TRG_DiLeu_BaEn_1	67	72	PF01217	0.620
TRG_DiLeu_BaEn_4	235	241	PF01217	0.263
TRG_ENDOCYTIC_2	20	23	PF00928	0.474
TRG_ENDOCYTIC_2	36	39	PF00928	0.454
TRG_NES_CRM1_1	223	236	PF08389	0.462

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I266	Leptomonas seymouri	55%	100%
A0A0S4J1S6	Bodo saltans	40%	84%
A0A1X0NX63	Trypanosomatidae	44%	100%
A0A3S7WXK7	Leishmania donovani	93%	100%
A4HCM3	Leishmania braziliensis	79%	100%
A4I047	Leishmania infantum	92%	100%
Q4QBG6	Leishmania major	92%	100%