DUF1767 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF1767), putative

Species:

Leishmania mexicana

UniProt:

E9AW09_LEIMU

TriTrypDb:

LmxM.23.0090

Length:

346

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AW09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	181	183	PF00675	0.691
CLV_NRD_NRD_1	302	304	PF00675	0.669
CLV_PCSK_KEX2_1	107	109	PF00082	0.357
CLV_PCSK_KEX2_1	180	182	PF00082	0.678
CLV_PCSK_KEX2_1	302	304	PF00082	0.669
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.357
CLV_PCSK_PC7_1	103	109	PF00082	0.357
CLV_PCSK_SKI1_1	107	111	PF00082	0.357
CLV_PCSK_SKI1_1	78	82	PF00082	0.409
DOC_CKS1_1	135	140	PF01111	0.557
DOC_MAPK_gen_1	107	114	PF00069	0.557
DOC_MAPK_gen_1	9	16	PF00069	0.420
DOC_MAPK_MEF2A_6	107	114	PF00069	0.557
DOC_MAPK_NFAT4_5	107	115	PF00069	0.557
DOC_USP7_MATH_1	27	31	PF00917	0.520
DOC_USP7_MATH_1	60	64	PF00917	0.520
DOC_WW_Pin1_4	134	139	PF00397	0.557
LIG_14-3-3_CanoR_1	103	110	PF00244	0.557
LIG_14-3-3_CanoR_1	111	121	PF00244	0.494
LIG_14-3-3_CanoR_1	207	213	PF00244	0.616
LIG_14-3-3_CanoR_1	9	15	PF00244	0.282
LIG_APCC_ABBA_1	142	147	PF00400	0.511
LIG_APCC_ABBAyCdc20_2	141	147	PF00400	0.511
LIG_CtBP_PxDLS_1	218	222	PF00389	0.499
LIG_FHA_1	126	132	PF00498	0.547
LIG_FHA_1	49	55	PF00498	0.520
LIG_FHA_1	79	85	PF00498	0.557
LIG_FHA_2	135	141	PF00498	0.557
LIG_FHA_2	30	36	PF00498	0.590
LIG_LIR_Gen_1	40	48	PF02991	0.520
LIG_LIR_Nem_3	220	226	PF02991	0.506
LIG_LIR_Nem_3	332	337	PF02991	0.666
LIG_LIR_Nem_3	339	345	PF02991	0.576
LIG_LIR_Nem_3	40	45	PF02991	0.520
LIG_PTB_Apo_2	95	102	PF02174	0.520
LIG_SH2_CRK	223	227	PF00017	0.512
LIG_SH2_STAP1	12	16	PF00017	0.557
LIG_SH2_STAT5	20	23	PF00017	0.557
LIG_SH3_3	223	229	PF00018	0.505
LIG_SH3_3	80	86	PF00018	0.557
LIG_SUMO_SIM_anti_2	158	166	PF11976	0.547
LIG_TRAF2_1	91	94	PF00917	0.499
MOD_CDK_SPxxK_3	134	141	PF00069	0.557
MOD_CK1_1	15	21	PF00069	0.549
MOD_CK1_1	160	166	PF00069	0.550
MOD_CK1_1	30	36	PF00069	0.625
MOD_CK1_1	308	314	PF00069	0.534
MOD_CK2_1	134	140	PF00069	0.522
MOD_CK2_1	29	35	PF00069	0.590
MOD_CK2_1	37	43	PF00069	0.557
MOD_CK2_1	88	94	PF00069	0.555
MOD_Cter_Amidation	300	303	PF01082	0.644
MOD_GlcNHglycan	214	217	PF01048	0.693
MOD_GlcNHglycan	244	247	PF01048	0.640
MOD_GlcNHglycan	263	266	PF01048	0.664
MOD_GlcNHglycan	277	280	PF01048	0.573
MOD_GlcNHglycan	329	332	PF01048	0.508
MOD_GlcNHglycan	62	65	PF01048	0.357
MOD_GSK3_1	10	17	PF00069	0.466
MOD_GSK3_1	208	215	PF00069	0.682
MOD_GSK3_1	74	81	PF00069	0.557
MOD_N-GLC_1	103	108	PF02516	0.357
MOD_N-GLC_1	160	165	PF02516	0.311
MOD_N-GLC_1	74	79	PF02516	0.357
MOD_N-GLC_2	152	154	PF02516	0.357
MOD_N-GLC_2	241	243	PF02516	0.585
MOD_NEK2_1	157	162	PF00069	0.511
MOD_PIKK_1	78	84	PF00454	0.557
MOD_PKA_2	102	108	PF00069	0.557
MOD_PKA_2	275	281	PF00069	0.629
MOD_Plk_1	124	130	PF00069	0.545
MOD_Plk_1	160	166	PF00069	0.511
MOD_Plk_1	281	287	PF00069	0.597
MOD_Plk_4	160	166	PF00069	0.557
MOD_Plk_4	208	214	PF00069	0.497
MOD_Plk_4	37	43	PF00069	0.553
MOD_Plk_4	49	55	PF00069	0.485
MOD_ProDKin_1	134	140	PF00069	0.557
TRG_DiLeu_BaLyEn_6	105	110	PF01217	0.557
TRG_ENDOCYTIC_2	223	226	PF00928	0.512
TRG_ER_diArg_1	180	182	PF00400	0.678
TRG_ER_diArg_1	312	315	PF00400	0.565
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	39	43	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WXE9	Leishmania donovani	84%	100%
A4HCM2	Leishmania braziliensis	76%	99%
A4I046	Leishmania infantum	85%	100%
Q4QBG7	Leishmania major	84%	100%