Agmatinase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

agmatinase-like protein

Species:

Leishmania mexicana

UniProt:

E9AW07_LEIMU

TriTrypDb:

LmxM.23.0070

Length:

332

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW07

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006520	amino acid metabolic process	3	1
GO:0006525	arginine metabolic process	6	1
GO:0006576	biogenic amine metabolic process	5	1
GO:0006595	polyamine metabolic process	6	1
GO:0006596	polyamine biosynthetic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009058	biosynthetic process	2	1
GO:0009064	glutamine family amino acid metabolic process	5	1
GO:0009308	amine metabolic process	4	1
GO:0009309	amine biosynthetic process	5	1
GO:0009445	putrescine metabolic process	7	1
GO:0009446	putrescine biosynthetic process	8	1
GO:0009987	cellular process	1	1
GO:0019752	carboxylic acid metabolic process	5	1
GO:0033388	putrescine biosynthetic process from arginine	7	1
GO:0033389	putrescine biosynthetic process from arginine, using agmatinase	8	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042401	biogenic amine biosynthetic process	6	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901605	alpha-amino acid metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	10
GO:0008783	agmatinase activity	5	6
GO:0016787	hydrolase activity	2	7
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	7
GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	4	7
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0004053	arginase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	323	327	PF00656	0.660
CLV_NRD_NRD_1	186	188	PF00675	0.273
CLV_NRD_NRD_1	189	191	PF00675	0.303
CLV_PCSK_KEX2_1	136	138	PF00082	0.269
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.269
CLV_PCSK_SKI1_1	136	140	PF00082	0.269
CLV_PCSK_SKI1_1	152	156	PF00082	0.269
CLV_PCSK_SKI1_1	163	167	PF00082	0.283
CLV_PCSK_SKI1_1	168	172	PF00082	0.289
CLV_PCSK_SKI1_1	206	210	PF00082	0.269
CLV_PCSK_SKI1_1	248	252	PF00082	0.269
CLV_PCSK_SKI1_1	291	295	PF00082	0.331
DEG_APCC_DBOX_1	247	255	PF00400	0.469
DEG_Nend_Nbox_1	1	3	PF02207	0.397
DOC_CYCLIN_RxL_1	133	143	PF00134	0.469
DOC_CYCLIN_RxL_1	157	169	PF00134	0.493
DOC_CYCLIN_RxL_1	203	213	PF00134	0.473
DOC_MAPK_gen_1	136	147	PF00069	0.468
DOC_MAPK_gen_1	212	222	PF00069	0.469
DOC_MAPK_gen_1	258	267	PF00069	0.469
DOC_MAPK_MEF2A_6	157	166	PF00069	0.517
DOC_MAPK_MEF2A_6	215	224	PF00069	0.469
DOC_PP4_FxxP_1	61	64	PF00568	0.524
DOC_USP7_MATH_1	35	39	PF00917	0.481
DOC_USP7_UBL2_3	168	172	PF12436	0.469
DOC_WW_Pin1_4	236	241	PF00397	0.494
DOC_WW_Pin1_4	46	51	PF00397	0.376
LIG_14-3-3_CanoR_1	137	147	PF00244	0.606
LIG_14-3-3_CanoR_1	180	189	PF00244	0.469
LIG_Actin_WH2_2	158	174	PF00022	0.502
LIG_Actin_WH2_2	280	296	PF00022	0.375
LIG_FHA_1	106	112	PF00498	0.469
LIG_FHA_1	245	251	PF00498	0.477
LIG_FHA_1	288	294	PF00498	0.480
LIG_FHA_1	38	44	PF00498	0.452
LIG_FHA_2	305	311	PF00498	0.494
LIG_FHA_2	321	327	PF00498	0.613
LIG_FHA_2	58	64	PF00498	0.416
LIG_FHA_2	94	100	PF00498	0.278
LIG_IBAR_NPY_1	327	329	PF08397	0.487
LIG_LIR_Apic_2	58	64	PF02991	0.488
LIG_LIR_Gen_1	54	64	PF02991	0.414
LIG_LIR_Gen_1	98	107	PF02991	0.515
LIG_LIR_Nem_3	113	119	PF02991	0.477
LIG_LIR_Nem_3	133	138	PF02991	0.382
LIG_LIR_Nem_3	217	221	PF02991	0.469
LIG_LIR_Nem_3	326	332	PF02991	0.464
LIG_LIR_Nem_3	54	59	PF02991	0.411
LIG_LIR_Nem_3	73	79	PF02991	0.379
LIG_PCNA_yPIPBox_3	286	299	PF02747	0.384
LIG_PTB_Apo_2	41	48	PF02174	0.443
LIG_PTB_Phospho_1	41	47	PF10480	0.437
LIG_SH2_CRK	135	139	PF00017	0.469
LIG_SH2_CRK	47	51	PF00017	0.447
LIG_SH2_PTP2	116	119	PF00017	0.474
LIG_SH2_SRC	116	119	PF00017	0.469
LIG_SH2_STAT5	101	104	PF00017	0.497
LIG_SH2_STAT5	116	119	PF00017	0.426
LIG_SH2_STAT5	301	304	PF00017	0.446
LIG_SH2_STAT5	47	50	PF00017	0.427
LIG_SH3_3	225	231	PF00018	0.477
LIG_SH3_3	234	240	PF00018	0.494
LIG_SH3_3	64	70	PF00018	0.519
LIG_SH3_5	328	332	PF00018	0.469
LIG_SUMO_SIM_anti_2	141	148	PF11976	0.469
LIG_TRAF2_1	307	310	PF00917	0.524
LIG_UBA3_1	253	261	PF00899	0.362
LIG_WW_3	12	16	PF00397	0.453
MOD_CDK_SPK_2	46	51	PF00069	0.410
MOD_CK1_1	304	310	PF00069	0.472
MOD_CK1_1	90	96	PF00069	0.490
MOD_CK2_1	304	310	PF00069	0.474
MOD_CK2_1	57	63	PF00069	0.502
MOD_GlcNHglycan	119	122	PF01048	0.313
MOD_GlcNHglycan	124	128	PF01048	0.322
MOD_GlcNHglycan	149	152	PF01048	0.327
MOD_GlcNHglycan	15	18	PF01048	0.535
MOD_GlcNHglycan	183	186	PF01048	0.368
MOD_GlcNHglycan	31	34	PF01048	0.494
MOD_GSK3_1	102	109	PF00069	0.325
MOD_N-GLC_2	179	181	PF02516	0.420
MOD_NEK2_1	287	292	PF00069	0.476
MOD_NEK2_1	29	34	PF00069	0.482
MOD_NEK2_1	293	298	PF00069	0.469
MOD_NEK2_1	37	42	PF00069	0.502
MOD_NEK2_2	57	62	PF00069	0.376
MOD_PIKK_1	282	288	PF00454	0.382
MOD_PIKK_1	302	308	PF00454	0.304
MOD_PKA_2	139	145	PF00069	0.481
MOD_Plk_1	57	63	PF00069	0.386
MOD_Plk_4	293	299	PF00069	0.447
MOD_Plk_4	70	76	PF00069	0.418
MOD_ProDKin_1	236	242	PF00069	0.339
MOD_ProDKin_1	46	52	PF00069	0.380
MOD_SUMO_rev_2	183	189	PF00179	0.304
MOD_SUMO_rev_2	84	90	PF00179	0.320
TRG_DiLeu_BaEn_1	313	318	PF01217	0.515
TRG_ENDOCYTIC_2	101	104	PF00928	0.441
TRG_ENDOCYTIC_2	116	119	PF00928	0.234
TRG_ENDOCYTIC_2	135	138	PF00928	0.212
TRG_ENDOCYTIC_2	197	200	PF00928	0.303
TRG_ENDOCYTIC_2	218	221	PF00928	0.327
TRG_ENDOCYTIC_2	56	59	PF00928	0.391
TRG_ER_diArg_1	314	317	PF00400	0.602
TRG_Pf-PMV_PEXEL_1	163	167	PF00026	0.303
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA1	Leptomonas seymouri	80%	100%
A0A1X0NYK7	Trypanosomatidae	67%	100%
A0A3Q8IBD4	Leishmania donovani	97%	100%
A4HCM0	Leishmania braziliensis	89%	100%
A4I044	Leishmania infantum	97%	100%
A8GIX7	Serratia proteamaculans (strain 568)	23%	100%
A9N3R6	Salmonella paratyphi B (strain ATCC BAA-1250 / SPB7)	23%	100%
B4T5I5	Salmonella newport (strain SL254)	23%	100%
B4THG3	Salmonella heidelberg (strain SL476)	23%	100%
B4TV53	Salmonella schwarzengrund (strain CVM19633)	23%	100%
B5BFP3	Salmonella paratyphi A (strain AKU_12601)	23%	100%
B5F5K3	Salmonella agona (strain SL483)	23%	100%
C0PY54	Salmonella paratyphi C (strain RKS4594)	23%	100%
C9ZUY0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
P0DJQ3	Streptomyces clavuligerus	26%	100%
P60655	Salmonella typhi	23%	100%
P60656	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	23%	100%
Q4QBG9	Leishmania major	95%	100%
Q57K36	Salmonella choleraesuis (strain SC-B67)	23%	100%
Q5PJH7	Salmonella paratyphi A (strain ATCC 9150 / SARB42)	23%	100%
Q9K6B9	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	23%	100%
Q9ZPF5	Arabidopsis thaliana	26%	97%
V5BBD2	Trypanosoma cruzi	67%	100%