Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW06_LEIMU

TriTrypDb:

LmxM.23.0060

Length:

175

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	106	108	PF00675	0.565
CLV_NRD_NRD_1	114	116	PF00675	0.570
CLV_NRD_NRD_1	138	140	PF00675	0.648
CLV_NRD_NRD_1	7	9	PF00675	0.609
CLV_NRD_NRD_1	78	80	PF00675	0.453
CLV_NRD_NRD_1	82	84	PF00675	0.491
CLV_PCSK_FUR_1	76	80	PF00082	0.451
CLV_PCSK_KEX2_1	113	115	PF00082	0.517
CLV_PCSK_KEX2_1	138	140	PF00082	0.648
CLV_PCSK_KEX2_1	7	9	PF00082	0.609
CLV_PCSK_KEX2_1	78	80	PF00082	0.406
CLV_PCSK_KEX2_1	82	84	PF00082	0.426
CLV_PCSK_PC1ET2_1	113	115	PF00082	0.517
CLV_PCSK_PC7_1	3	9	PF00082	0.505
CLV_PCSK_PC7_1	78	84	PF00082	0.415
CLV_PCSK_SKI1_1	14	18	PF00082	0.596
CLV_PCSK_SKI1_1	19	23	PF00082	0.448
CLV_PCSK_SKI1_1	83	87	PF00082	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.595
DOC_MAPK_gen_1	14	22	PF00069	0.409
DOC_MAPK_MEF2A_6	165	172	PF00069	0.669
DOC_MAPK_NFAT4_5	165	173	PF00069	0.571
DOC_USP7_MATH_1	149	153	PF00917	0.566
DOC_USP7_MATH_1	45	49	PF00917	0.527
DOC_USP7_MATH_1	52	56	PF00917	0.431
DOC_WW_Pin1_4	127	132	PF00397	0.652
DOC_WW_Pin1_4	137	142	PF00397	0.571
LIG_Actin_WH2_2	13	28	PF00022	0.415
LIG_Actin_WH2_2	64	80	PF00022	0.515
LIG_BRCT_BRCA1_1	152	156	PF00533	0.647
LIG_CtBP_PxDLS_1	126	130	PF00389	0.572
LIG_FHA_1	152	158	PF00498	0.631
LIG_SUMO_SIM_par_1	125	130	PF11976	0.672
LIG_UBA3_1	21	29	PF00899	0.412
MOD_CK2_1	127	133	PF00069	0.572
MOD_Cter_Amidation	172	175	PF01082	0.585
MOD_GlcNHglycan	120	123	PF01048	0.610
MOD_GlcNHglycan	47	50	PF01048	0.543
MOD_NEK2_1	25	30	PF00069	0.595
MOD_PKA_2	103	109	PF00069	0.494
MOD_PKA_2	25	31	PF00069	0.425
MOD_PKA_2	45	51	PF00069	0.496
MOD_ProDKin_1	127	133	PF00069	0.659
MOD_ProDKin_1	137	143	PF00069	0.570
TRG_ER_diArg_1	7	9	PF00400	0.659
TRG_ER_diArg_1	76	79	PF00400	0.427
TRG_NES_CRM1_1	12	23	PF08389	0.297
TRG_NLS_MonoExtN_4	111	117	PF00514	0.568
TRG_Pf-PMV_PEXEL_1	7	12	PF00026	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N3	Leptomonas seymouri	74%	100%
A0A0S4J210	Bodo saltans	35%	79%
A0A1X0NYR9	Trypanosomatidae	45%	94%
A0A3S7WXG0	Leishmania donovani	90%	100%
A4HCL9	Leishmania braziliensis	83%	99%
A4I043	Leishmania infantum	89%	100%
C9ZUX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	94%
Q4QBH0	Leishmania major	93%	99%