Peroxidoxin (Tryparedoxin peroxidase)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

tryparedoxin peroxidase

Species:

Leishmania mexicana

UniProt:

E9AW04_LEIMU

TriTrypDb:

LmxM.23.0040

Length:

226

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0005829	cytosol	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9AW04

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW04

PDB structure(s): 4kb3_A , 4kb3_B , 4kb3_C , 4kb3_D , 4kb3_E , 4kb3_F , 4kb3_G , 4kb3_H , 4kb3_I , 4kb3_J , 4kce_A , 4kce_B , 6e0f_A , 6e0f_B , 6e0f_C , 6e0f_D , 6e0f_E , 6e0f_F , 6e0f_G , 6e0f_H , 6e0f_I , 6e0f_J , 6e0g_A , 6e0g_B , 6e0g_C , 6e0g_D , 6e0g_E , 6e0g_F , 6e0g_G , 6e0g_H , 6e0g_I , 6e0g_J

Function

Biological processes
Term	Name	Level	Count
GO:0009987	cellular process	1	1
GO:0019725	cellular homeostasis	2	1
GO:0042592	homeostatic process	3	1
GO:0045454	cell redox homeostasis	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004601	peroxidase activity	2	12
GO:0016209	antioxidant activity	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	12
GO:0051920	peroxiredoxin activity	3	12
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	197	201	PF00656	0.355
CLV_NRD_NRD_1	120	122	PF00675	0.305
CLV_NRD_NRD_1	3	5	PF00675	0.529
CLV_PCSK_KEX2_1	12	14	PF00082	0.481
CLV_PCSK_KEX2_1	3	5	PF00082	0.546
CLV_PCSK_KEX2_1	97	99	PF00082	0.191
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.533
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.191
CLV_PCSK_SKI1_1	157	161	PF00082	0.294
CLV_PCSK_SKI1_1	165	169	PF00082	0.297
CLV_PCSK_SKI1_1	34	38	PF00082	0.415
DEG_Nend_Nbox_1	1	3	PF02207	0.556
DOC_CKS1_1	117	122	PF01111	0.305
DOC_CYCLIN_RxL_1	154	163	PF00134	0.349
DOC_MAPK_FxFP_2	71	74	PF00069	0.384
DOC_MAPK_gen_1	64	72	PF00069	0.290
DOC_MAPK_gen_1	97	105	PF00069	0.191
DOC_MAPK_MEF2A_6	64	72	PF00069	0.290
DOC_PP4_FxxP_1	71	74	PF00568	0.316
DOC_PP4_FxxP_1	79	82	PF00568	0.263
DOC_USP7_MATH_1	135	139	PF00917	0.419
DOC_WW_Pin1_4	116	121	PF00397	0.290
DOC_WW_Pin1_4	20	25	PF00397	0.641
LIG_14-3-3_CanoR_1	3	11	PF00244	0.507
LIG_14-3-3_CanoR_1	34	39	PF00244	0.525
LIG_14-3-3_CanoR_1	98	105	PF00244	0.300
LIG_Actin_WH2_2	155	171	PF00022	0.290
LIG_BIR_III_2	200	204	PF00653	0.355
LIG_Clathr_ClatBox_1	159	163	PF01394	0.290
LIG_Clathr_ClatBox_1	25	29	PF01394	0.495
LIG_FHA_1	20	26	PF00498	0.548
LIG_FHA_1	33	39	PF00498	0.431
LIG_FHA_1	81	87	PF00498	0.438
LIG_FHA_1	98	104	PF00498	0.233
LIG_FHA_2	170	176	PF00498	0.372
LIG_FHA_2	35	41	PF00498	0.305
LIG_LIR_Apic_2	76	82	PF02991	0.290
LIG_LIR_Gen_1	108	117	PF02991	0.290
LIG_LIR_Gen_1	76	85	PF02991	0.304
LIG_LIR_Nem_3	108	114	PF02991	0.290
LIG_LIR_Nem_3	144	148	PF02991	0.293
LIG_LIR_Nem_3	29	33	PF02991	0.495
LIG_LIR_Nem_3	76	80	PF02991	0.304
LIG_OCRL_FandH_1	87	99	PF00620	0.311
LIG_PTB_Apo_2	24	31	PF02174	0.513
LIG_PTB_Phospho_1	24	30	PF10480	0.501
LIG_REV1ctd_RIR_1	219	226	PF16727	0.526
LIG_SH2_CRK	145	149	PF00017	0.290
LIG_SH2_PTP2	67	70	PF00017	0.305
LIG_SH2_STAP1	111	115	PF00017	0.349
LIG_SH2_STAT5	67	70	PF00017	0.305
LIG_SH3_3	114	120	PF00018	0.349
LIG_SH3_3	205	211	PF00018	0.324
LIG_SUMO_SIM_par_1	100	106	PF11976	0.305
LIG_UBA3_1	159	165	PF00899	0.290
MOD_CDK_SPK_2	116	121	PF00069	0.290
MOD_CDK_SPxK_1	116	122	PF00069	0.305
MOD_CDK_SPxxK_3	116	123	PF00069	0.290
MOD_CK1_1	106	112	PF00069	0.317
MOD_CK2_1	34	40	PF00069	0.401
MOD_GlcNHglycan	150	154	PF01048	0.355
MOD_GlcNHglycan	45	48	PF01048	0.464
MOD_GSK3_1	209	216	PF00069	0.440
MOD_NEK2_1	19	24	PF00069	0.517
MOD_NEK2_1	213	218	PF00069	0.311
MOD_NEK2_1	32	37	PF00069	0.575
MOD_NEK2_1	5	10	PF00069	0.492
MOD_NEK2_1	75	80	PF00069	0.296
MOD_PIKK_1	97	103	PF00454	0.290
MOD_PKA_1	3	9	PF00069	0.523
MOD_PKA_1	97	103	PF00069	0.191
MOD_PKA_2	3	9	PF00069	0.576
MOD_PKA_2	97	103	PF00069	0.191
MOD_Plk_1	135	141	PF00069	0.465
MOD_Plk_1	75	81	PF00069	0.290
MOD_Plk_4	106	112	PF00069	0.396
MOD_ProDKin_1	116	122	PF00069	0.290
MOD_ProDKin_1	20	26	PF00069	0.643
TRG_DiLeu_BaLyEn_6	21	26	PF01217	0.530
TRG_ENDOCYTIC_2	111	114	PF00928	0.349
TRG_ENDOCYTIC_2	145	148	PF00928	0.290
TRG_ENDOCYTIC_2	67	70	PF00928	0.305
TRG_ER_diArg_1	2	4	PF00400	0.551
TRG_NLS_MonoExtN_4	120	125	PF00514	0.305

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0K3AUJ9	Caenorhabditis elegans	61%	100%
A0A0N1PB76	Leptomonas seymouri	81%	100%
A0A0S4J2M3	Bodo saltans	69%	99%
A0A1X0NCW4	Trypanosomatidae	55%	100%
A0A1X0NUK9	Trypanosomatidae	55%	100%
A0A1X0NXA0	Trypanosomatidae	71%	100%
A0A2Z5VKM8	Chattonella marina var. antiqua	53%	100%
A0A3Q8IFP4	Leishmania donovani	96%	100%
A0A3R7K6K7	Trypanosoma rangeli	73%	100%
A0A3S7WTJ2	Leishmania donovani	56%	100%
A0A3S7WTK5	Leishmania donovani	56%	100%
A0A422N179	Trypanosoma rangeli	59%	100%
A0A422NRB2	Trypanosoma rangeli	59%	100%
A0A6L0X3Y6	Leishmania infantum	56%	100%
A0A6L0XFC6	Leishmania infantum	96%	100%
A0R1V9	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	36%	100%
A2SZW8	Zea mays	30%	99%
A4H877	Leishmania braziliensis	55%	100%
A4H879	Leishmania braziliensis	56%	100%
A4HCL7	Leishmania braziliensis	88%	100%
A4HWK2	Leishmania infantum	56%	100%
A4HWK3	Leishmania infantum	55%	100%
A5IIX7	Thermotoga petrophila (strain ATCC BAA-488 / DSM 13995 / JCM 10881 / RKU-1)	43%	100%
B6DTL8	Bodo saltans	57%	86%
C9ZUX7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
C9ZXT5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	56%	100%
E9AQA3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	58%	100%
E9AQA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	59%	100%
K0J4Q8	Amphibacillus xylanus (strain ATCC 51415 / DSM 6626 / JCM 7361 / LMG 17667 / NBRC 15112 / Ep01)	38%	100%
O04005	Arabidopsis thaliana	31%	100%
O08709	Mus musculus	32%	100%
O08807	Mus musculus	58%	82%
O17433	Dirofilaria immitis	34%	96%
O24364	Spinacia oleracea	54%	85%
O26262	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	30%	100%
O29969	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	37%	100%
O34564	Bacillus subtilis (strain 168)	52%	100%
O35244	Rattus norvegicus	33%	100%
O58966	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	35%	100%
O67024	Aquifex aeolicus (strain VF5)	42%	100%
O74887	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	60%	100%
O77834	Bos taurus	33%	100%
P0A0B5	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P0A0B6	Staphylococcus aureus (strain MW2)	36%	100%
P0A0B7	Staphylococcus aureus (strain NCTC 8325 / PS 47)	36%	100%
P0A251	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	33%	100%
P0A252	Salmonella typhi	33%	100%
P0AE08	Escherichia coli (strain K12)	34%	100%
P0AE09	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	34%	100%
P0AE10	Escherichia coli O157:H7	34%	100%
P0AE11	Shigella flexneri	34%	100%
P0C5C8	Oryza sativa subsp. indica	32%	100%
P0C5C9	Oryza sativa subsp. japonica	31%	100%
P0C5D0	Oryza sativa subsp. indica	30%	100%
P0C5D1	Oryza sativa subsp. japonica	29%	100%
P0C5D4	Oryza sativa subsp. indica	26%	100%
P0C5D5	Oryza sativa subsp. japonica	26%	100%
P0CB50	Gallus gallus	58%	100%
P0CU34	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	100%
P19476	Entamoeba histolytica	44%	97%
P20108	Mus musculus	58%	88%
P21762	Helicobacter pylori (strain ATCC 700392 / 26695)	47%	100%
P23161	Clostridium pasteurianum	49%	100%
P26830	Ferdinandcohnia aciditolerans (strain JCM 32973 / CCTCC AB 2017280 / YN-1)	35%	100%
P30041	Homo sapiens	32%	100%
P30048	Homo sapiens	58%	88%
P32119	Homo sapiens	59%	100%
P34227	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	87%
P34760	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	60%	100%
P35700	Mus musculus	57%	100%
P35704	Rattus norvegicus	59%	100%
P35705	Bos taurus	58%	88%
P48822	Brugia malayi	52%	99%
P49537	Trieres chinensis	44%	100%
P51272	Porphyra purpurea	50%	100%
P52570	Onchocerca volvulus	33%	97%
P52571	Bromus secalinus	29%	100%
P52572	Hordeum vulgare	30%	100%
P52574	Syntrichia ruralis	27%	100%
P55979	Helicobacter pylori (strain ATCC 700392 / 26695)	31%	100%
P56876	Helicobacter pylori (strain J99 / ATCC 700824)	47%	100%
P57279	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	41%	100%
P80239	Bacillus subtilis (strain 168)	35%	100%
P80602	Triticum aestivum	53%	100%
P91883	Fasciola hepatica	56%	100%
P99074	Staphylococcus aureus (strain N315)	36%	100%
P9WQB6	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	43%	100%
P9WQB7	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	43%	100%
Q02UU0	Pseudomonas aeruginosa (strain UCBPP-PA14)	37%	100%
Q04120	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	57%	100%
Q06830	Homo sapiens	58%	100%
Q13162	Homo sapiens	57%	83%
Q17172	Brugia malayi	58%	100%
Q1XDL4	Neopyropia yezoensis	52%	100%
Q21824	Caenorhabditis elegans	56%	100%
Q26695	Trypanosoma brucei rhodesiense	56%	100%
Q2FJN4	Staphylococcus aureus (strain USA300)	36%	100%
Q2PFL9	Macaca fascicularis	32%	100%
Q2PFZ3	Macaca fascicularis	59%	100%
Q2YVK2	Staphylococcus aureus (strain bovine RF122 / ET3-1)	36%	100%
Q49UT8	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	33%	100%
Q4L376	Staphylococcus haemolyticus (strain JCSC1435)	35%	100%
Q4QBH2	Leishmania major	96%	100%
Q4QF68	Leishmania major	56%	100%
Q4QF74	Leishmania major	55%	100%
Q4QF76	Leishmania major	56%	100%
Q4QF80	Leishmania major	56%	100%
Q54SE2	Dictyostelium discoideum	30%	94%
Q555L5	Dictyostelium discoideum	54%	87%
Q55624	Synechocystis sp. (strain PCC 6803 / Kazusa)	49%	100%
Q58146	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	41%	100%
Q5E947	Bos taurus	59%	100%
Q5HIR5	Staphylococcus aureus (strain COL)	36%	100%
Q5HRY1	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	36%	100%
Q5JF30	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	37%	100%
Q5R7E0	Pongo abelii	32%	100%
Q5RC63	Pongo abelii	62%	100%
Q5REY3	Pongo abelii	57%	88%
Q5ZJF4	Gallus gallus	33%	100%
Q61171	Mus musculus	59%	100%
Q63716	Rattus norvegicus	58%	100%
Q6B4U9	Myotis lucifugus	58%	100%
Q6DV14	Gekko japonicus	59%	100%
Q6E2Z6	Medicago truncatula	30%	100%
Q6ER94	Oryza sativa subsp. japonica	54%	87%
Q6GC91	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GJR7	Staphylococcus aureus (strain MRSA252)	36%	100%
Q6L140	Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828)	39%	100%
Q6W8Q2	Triticum aestivum	29%	100%
Q89AS1	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	43%	100%
Q8CMQ2	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	37%	100%
Q8K3U7	Cricetulus griseus	58%	100%
Q8K9W0	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	43%	100%
Q8PYP6	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	36%	100%
Q8R844	Caldanaerobacter subterraneus subsp. tengcongensis (strain DSM 15242 / JCM 11007 / NBRC 100824 / MB4)	42%	100%
Q8SS85	Encephalitozoon cuniculi (strain GB-M1)	46%	100%
Q8T6C4	Echinococcus granulosus	62%	100%
Q8U218	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	36%	100%
Q90384	Cynops pyrrhogaster	58%	100%
Q91191	Oncorhynchus mykiss	56%	100%
Q96291	Arabidopsis thaliana	56%	85%
Q96468	Hordeum vulgare	53%	100%
Q979N7	Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1)	39%	100%
Q9BGI2	Bos taurus	58%	82%
Q9BGI3	Bos taurus	62%	100%
Q9C5R8	Arabidopsis thaliana	54%	83%
Q9HJL3	Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)	39%	100%
Q9JKY1	Cricetulus griseus	57%	100%
Q9L3Q5	Peptoclostridium acidaminophilum	39%	100%
Q9LU86	Arabidopsis thaliana	31%	100%
Q9NL98	Ascaris suum	59%	100%
Q9TSX9	Sus scrofa	33%	100%
Q9UZV4	Pyrococcus abyssi (strain GE5 / Orsay)	35%	100%
Q9V3P0	Drosophila melanogaster	64%	100%
Q9WZR4	Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)	42%	100%
Q9Y7F0	Candida albicans (strain SC5314 / ATCC MYA-2876)	51%	100%
Q9Y9L0	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	37%	90%
Q9Z0V5	Rattus norvegicus	58%	83%
Q9Z0V6	Rattus norvegicus	58%	88%
Q9ZMU4	Helicobacter pylori (strain J99 / ATCC 700824)	32%	100%
R4QWJ8	Leishmania donovani	56%	100%
V5ALW5	Trypanosoma cruzi	71%	69%