WGS project CAEQ00000000 data, annotated contig

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW02_LEIMU

TriTrypDb:

LmxM.23.0025

Length:

292

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW02

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	78	82	PF00656	0.582
CLV_NRD_NRD_1	131	133	PF00675	0.495
CLV_NRD_NRD_1	260	262	PF00675	0.457
CLV_PCSK_KEX2_1	131	133	PF00082	0.616
CLV_PCSK_KEX2_1	260	262	PF00082	0.432
CLV_PCSK_SKI1_1	73	77	PF00082	0.284
DOC_MAPK_gen_1	102	111	PF00069	0.606
DOC_MAPK_gen_1	131	137	PF00069	0.473
DOC_MAPK_gen_1	191	199	PF00069	0.487
DOC_PP1_RVXF_1	3	9	PF00149	0.679
DOC_PP4_FxxP_1	93	96	PF00568	0.549
DOC_USP7_MATH_1	136	140	PF00917	0.528
DOC_USP7_MATH_1	166	170	PF00917	0.586
DOC_USP7_MATH_1	241	245	PF00917	0.511
DOC_USP7_MATH_1	249	253	PF00917	0.452
DOC_USP7_MATH_1	85	89	PF00917	0.554
DOC_WW_Pin1_4	126	131	PF00397	0.509
LIG_14-3-3_CanoR_1	191	199	PF00244	0.532
LIG_14-3-3_CanoR_1	283	292	PF00244	0.479
LIG_14-3-3_CanoR_1	71	76	PF00244	0.497
LIG_Actin_WH2_2	29	47	PF00022	0.626
LIG_AP2alpha_2	212	214	PF02296	0.489
LIG_BRCT_BRCA1_1	58	62	PF00533	0.539
LIG_FHA_1	27	33	PF00498	0.714
LIG_FHA_1	275	281	PF00498	0.503
LIG_FHA_1	285	291	PF00498	0.490
LIG_FHA_2	266	272	PF00498	0.525
LIG_LIR_Gen_1	138	147	PF02991	0.524
LIG_LIR_Gen_1	7	16	PF02991	0.598
LIG_LIR_Gen_1	74	83	PF02991	0.457
LIG_LIR_Nem_3	138	143	PF02991	0.474
LIG_LIR_Nem_3	7	11	PF02991	0.536
LIG_LIR_Nem_3	74	79	PF02991	0.440
LIG_NRBOX	178	184	PF00104	0.465
LIG_PDZ_Class_2	287	292	PF00595	0.394
LIG_Rb_LxCxE_1	12	31	PF01857	0.513
LIG_SH3_3	108	114	PF00018	0.408
LIG_SH3_3	160	166	PF00018	0.482
LIG_SUMO_SIM_anti_2	221	227	PF11976	0.397
LIG_SUMO_SIM_anti_2	234	240	PF11976	0.424
LIG_SUMO_SIM_par_1	234	240	PF11976	0.502
LIG_TYR_ITIM	225	230	PF00017	0.391
MOD_CDC14_SPxK_1	129	132	PF00782	0.362
MOD_CDK_SPK_2	126	131	PF00069	0.420
MOD_CDK_SPxK_1	126	132	PF00069	0.432
MOD_CK2_1	242	248	PF00069	0.478
MOD_CK2_1	71	77	PF00069	0.541
MOD_CK2_1	83	89	PF00069	0.545
MOD_GlcNHglycan	244	247	PF01048	0.663
MOD_GlcNHglycan	36	39	PF01048	0.645
MOD_GlcNHglycan	83	86	PF01048	0.571
MOD_GSK3_1	26	33	PF00069	0.621
MOD_GSK3_1	67	74	PF00069	0.512
MOD_GSK3_1	81	88	PF00069	0.350
MOD_N-GLC_2	17	19	PF02516	0.627
MOD_NEK2_1	10	15	PF00069	0.592
MOD_NEK2_1	284	289	PF00069	0.486
MOD_NEK2_1	32	37	PF00069	0.565
MOD_NEK2_1	62	67	PF00069	0.510
MOD_NEK2_1	83	88	PF00069	0.599
MOD_OFUCOSY	189	196	PF10250	0.451
MOD_PIKK_1	218	224	PF00454	0.474
MOD_PIKK_1	284	290	PF00454	0.449
MOD_PK_1	71	77	PF00069	0.566
MOD_PKA_2	249	255	PF00069	0.519
MOD_PKA_2	282	288	PF00069	0.481
MOD_Plk_2-3	265	271	PF00069	0.535
MOD_Plk_4	136	142	PF00069	0.573
MOD_Plk_4	204	210	PF00069	0.480
MOD_Plk_4	249	255	PF00069	0.598
MOD_Plk_4	265	271	PF00069	0.433
MOD_ProDKin_1	126	132	PF00069	0.521
MOD_SUMO_rev_2	265	275	PF00179	0.505
TRG_ENDOCYTIC_2	227	230	PF00928	0.393
TRG_ER_diArg_1	130	132	PF00400	0.465
TRG_ER_diArg_1	259	261	PF00400	0.463
TRG_NES_CRM1_1	173	188	PF08389	0.539

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJU6	Leptomonas seymouri	38%	100%
A0A1X0NX74	Trypanosomatidae	30%	97%
A0A3Q8IAU7	Leishmania donovani	88%	100%
A0A3R7KT29	Trypanosoma rangeli	23%	93%
A4HCL5	Leishmania braziliensis	76%	100%
A4I039	Leishmania infantum	88%	100%
C9ZUX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	96%
Q4QBH4	Leishmania major	89%	100%
V5B6S5	Trypanosoma cruzi	27%	92%