CST complex subunit CTC1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AW00_LEIMU

TriTrypDb:

LmxM.23.0010

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AW00

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AW00

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.599
CLV_C14_Caspase3-7	252	256	PF00656	0.594
CLV_C14_Caspase3-7	444	448	PF00656	0.600
CLV_NRD_NRD_1	146	148	PF00675	0.581
CLV_PCSK_KEX2_1	146	148	PF00082	0.581
CLV_PCSK_SKI1_1	137	141	PF00082	0.339
CLV_PCSK_SKI1_1	33	37	PF00082	0.689
CLV_PCSK_SKI1_1	433	437	PF00082	0.300
CLV_PCSK_SKI1_1	56	60	PF00082	0.377
CLV_PCSK_SKI1_1	599	603	PF00082	0.489
DEG_Nend_Nbox_1	1	3	PF02207	0.615
DOC_AGCK_PIF_1	495	500	PF00069	0.574
DOC_CYCLIN_RxL_1	427	440	PF00134	0.336
DOC_CYCLIN_yCln2_LP_2	149	155	PF00134	0.696
DOC_CYCLIN_yCln2_LP_2	363	369	PF00134	0.546
DOC_CYCLIN_yCln2_LP_2	556	562	PF00134	0.364
DOC_MAPK_gen_1	212	222	PF00069	0.643
DOC_MAPK_gen_1	303	313	PF00069	0.713
DOC_MAPK_gen_1	38	46	PF00069	0.460
DOC_PP1_RVXF_1	431	438	PF00149	0.319
DOC_PP1_RVXF_1	50	56	PF00149	0.713
DOC_PP1_RVXF_1	597	603	PF00149	0.485
DOC_PP2B_LxvP_1	149	152	PF13499	0.525
DOC_PP2B_LxvP_1	58	61	PF13499	0.368
DOC_PP4_FxxP_1	423	426	PF00568	0.587
DOC_USP7_MATH_1	153	157	PF00917	0.566
DOC_USP7_MATH_1	318	322	PF00917	0.653
DOC_USP7_MATH_1	445	449	PF00917	0.564
DOC_USP7_MATH_1	54	58	PF00917	0.607
DOC_WW_Pin1_4	332	337	PF00397	0.426
DOC_WW_Pin1_4	372	377	PF00397	0.489
DOC_WW_Pin1_4	426	431	PF00397	0.362
DOC_WW_Pin1_4	476	481	PF00397	0.495
DOC_WW_Pin1_4	503	508	PF00397	0.551
LIG_14-3-3_CanoR_1	146	150	PF00244	0.508
LIG_14-3-3_CanoR_1	217	223	PF00244	0.619
LIG_14-3-3_CanoR_1	441	450	PF00244	0.515
LIG_14-3-3_CanoR_1	45	49	PF00244	0.465
LIG_14-3-3_CanoR_1	466	472	PF00244	0.487
LIG_BIR_III_2	554	558	PF00653	0.583
LIG_BRCT_BRCA1_1	163	167	PF00533	0.675
LIG_BRCT_BRCA1_1	472	476	PF00533	0.632
LIG_BRCT_BRCA1_1	498	502	PF00533	0.564
LIG_Clathr_ClatBox_1	579	583	PF01394	0.527
LIG_eIF4E_1	565	571	PF01652	0.352
LIG_FAT_LD_1	582	590	PF03623	0.358
LIG_FHA_1	155	161	PF00498	0.594
LIG_FHA_1	171	177	PF00498	0.720
LIG_FHA_1	297	303	PF00498	0.659
LIG_FHA_1	385	391	PF00498	0.515
LIG_FHA_1	477	483	PF00498	0.586
LIG_FHA_1	503	509	PF00498	0.598
LIG_FHA_1	517	523	PF00498	0.555
LIG_FHA_1	529	535	PF00498	0.503
LIG_FHA_1	551	557	PF00498	0.488
LIG_FHA_1	565	571	PF00498	0.475
LIG_FHA_1	574	580	PF00498	0.439
LIG_FHA_2	250	256	PF00498	0.677
LIG_FHA_2	325	331	PF00498	0.423
LIG_FHA_2	524	530	PF00498	0.501
LIG_FHA_2	88	94	PF00498	0.506
LIG_Integrin_RGD_1	117	119	PF01839	0.449
LIG_LIR_Gen_1	100	109	PF02991	0.404
LIG_LIR_Gen_1	138	145	PF02991	0.546
LIG_LIR_Gen_1	164	169	PF02991	0.684
LIG_LIR_Gen_1	216	225	PF02991	0.545
LIG_LIR_Gen_1	349	359	PF02991	0.430
LIG_LIR_Gen_1	590	600	PF02991	0.575
LIG_LIR_Nem_3	100	105	PF02991	0.489
LIG_LIR_Nem_3	138	143	PF02991	0.441
LIG_LIR_Nem_3	164	168	PF02991	0.674
LIG_LIR_Nem_3	216	222	PF02991	0.551
LIG_LIR_Nem_3	26	30	PF02991	0.587
LIG_LIR_Nem_3	349	354	PF02991	0.427
LIG_LIR_Nem_3	540	544	PF02991	0.671
LIG_LIR_Nem_3	590	595	PF02991	0.554
LIG_PDZ_Class_2	608	613	PF00595	0.476
LIG_Pex14_2	481	485	PF04695	0.559
LIG_Pex14_2	498	502	PF04695	0.286
LIG_REV1ctd_RIR_1	165	174	PF16727	0.443
LIG_REV1ctd_RIR_1	533	542	PF16727	0.637
LIG_SH2_GRB2like	71	74	PF00017	0.406
LIG_SH2_STAP1	102	106	PF00017	0.417
LIG_SH2_STAP1	135	139	PF00017	0.559
LIG_SH2_STAP1	67	71	PF00017	0.664
LIG_SH2_STAT3	274	277	PF00017	0.568
LIG_SH2_STAT3	7	10	PF00017	0.757
LIG_SH2_STAT5	135	138	PF00017	0.630
LIG_SH2_STAT5	30	33	PF00017	0.613
LIG_SH2_STAT5	350	353	PF00017	0.595
LIG_SH2_STAT5	478	481	PF00017	0.575
LIG_SH2_STAT5	551	554	PF00017	0.585
LIG_SH2_STAT5	67	70	PF00017	0.496
LIG_SH2_STAT5	7	10	PF00017	0.757
LIG_SH3_3	19	25	PF00018	0.709
LIG_SH3_3	462	468	PF00018	0.490
LIG_SUMO_SIM_par_1	156	161	PF11976	0.662
LIG_SUMO_SIM_par_1	365	370	PF11976	0.483
LIG_SUMO_SIM_par_1	593	598	PF11976	0.590
LIG_WRC_WIRS_1	24	29	PF05994	0.747
LIG_WW_3	402	406	PF00397	0.385
MOD_CDK_SPxxK_3	426	433	PF00069	0.360
MOD_CK1_1	100	106	PF00069	0.521
MOD_CK1_1	130	136	PF00069	0.474
MOD_CK1_1	154	160	PF00069	0.457
MOD_CK1_1	17	23	PF00069	0.631
MOD_CK1_1	278	284	PF00069	0.710
MOD_CK1_1	346	352	PF00069	0.499
MOD_CK1_1	501	507	PF00069	0.451
MOD_CK1_1	523	529	PF00069	0.573
MOD_CK2_1	221	227	PF00069	0.458
MOD_CK2_1	23	29	PF00069	0.754
MOD_CK2_1	346	352	PF00069	0.569
MOD_GlcNHglycan	209	212	PF01048	0.678
MOD_GlcNHglycan	223	226	PF01048	0.618
MOD_GlcNHglycan	235	238	PF01048	0.505
MOD_GlcNHglycan	345	348	PF01048	0.562
MOD_GlcNHglycan	443	446	PF01048	0.609
MOD_GlcNHglycan	447	450	PF01048	0.574
MOD_GlcNHglycan	587	592	PF01048	0.338
MOD_GSK3_1	127	134	PF00069	0.408
MOD_GSK3_1	14	21	PF00069	0.665
MOD_GSK3_1	197	204	PF00069	0.659
MOD_GSK3_1	207	214	PF00069	0.575
MOD_GSK3_1	278	285	PF00069	0.526
MOD_GSK3_1	334	341	PF00069	0.554
MOD_GSK3_1	342	349	PF00069	0.651
MOD_GSK3_1	435	442	PF00069	0.596
MOD_GSK3_1	467	474	PF00069	0.682
MOD_GSK3_1	498	505	PF00069	0.468
MOD_GSK3_1	516	523	PF00069	0.402
MOD_GSK3_1	561	568	PF00069	0.465
MOD_GSK3_1	93	100	PF00069	0.482
MOD_N-GLC_1	458	463	PF02516	0.656
MOD_NEK2_1	145	150	PF00069	0.524
MOD_NEK2_1	201	206	PF00069	0.561
MOD_NEK2_1	260	265	PF00069	0.395
MOD_NEK2_1	280	285	PF00069	0.524
MOD_NEK2_1	338	343	PF00069	0.611
MOD_NEK2_1	367	372	PF00069	0.580
MOD_NEK2_1	44	49	PF00069	0.517
MOD_NEK2_1	471	476	PF00069	0.489
MOD_NEK2_1	498	503	PF00069	0.537
MOD_NEK2_1	593	598	PF00069	0.516
MOD_NEK2_2	261	266	PF00069	0.468
MOD_NEK2_2	267	272	PF00069	0.498
MOD_NEK2_2	530	535	PF00069	0.400
MOD_NEK2_2	542	547	PF00069	0.350
MOD_NEK2_2	573	578	PF00069	0.525
MOD_PK_1	127	133	PF00069	0.535
MOD_PK_1	97	103	PF00069	0.586
MOD_PKA_2	145	151	PF00069	0.378
MOD_PKA_2	161	167	PF00069	0.691
MOD_PKA_2	211	217	PF00069	0.668
MOD_PKA_2	302	308	PF00069	0.705
MOD_PKA_2	44	50	PF00069	0.455
MOD_Plk_1	127	133	PF00069	0.675
MOD_Plk_1	17	23	PF00069	0.585
MOD_Plk_1	281	287	PF00069	0.727
MOD_Plk_1	324	330	PF00069	0.455
MOD_Plk_1	439	445	PF00069	0.613
MOD_Plk_1	587	593	PF00069	0.528
MOD_Plk_4	154	160	PF00069	0.588
MOD_Plk_4	18	24	PF00069	0.627
MOD_Plk_4	261	267	PF00069	0.474
MOD_Plk_4	3	9	PF00069	0.752
MOD_Plk_4	334	340	PF00069	0.529
MOD_Plk_4	346	352	PF00069	0.428
MOD_Plk_4	384	390	PF00069	0.530
MOD_Plk_4	471	477	PF00069	0.581
MOD_Plk_4	530	536	PF00069	0.453
MOD_Plk_4	566	572	PF00069	0.587
MOD_Plk_4	581	587	PF00069	0.430
MOD_Plk_4	97	103	PF00069	0.502
MOD_ProDKin_1	332	338	PF00069	0.419
MOD_ProDKin_1	372	378	PF00069	0.486
MOD_ProDKin_1	426	432	PF00069	0.364
MOD_ProDKin_1	476	482	PF00069	0.498
MOD_ProDKin_1	503	509	PF00069	0.546
MOD_SUMO_for_1	37	40	PF00179	0.529
TRG_AP2beta_CARGO_1	138	147	PF09066	0.347
TRG_DiLeu_BaEn_2	587	593	PF01217	0.610
TRG_DiLeu_BaEn_2	605	611	PF01217	0.435
TRG_DiLeu_BaLyEn_6	363	368	PF01217	0.483
TRG_DiLeu_BaLyEn_6	504	509	PF01217	0.602
TRG_DiLeu_BaLyEn_6	575	580	PF01217	0.537
TRG_ENDOCYTIC_2	102	105	PF00928	0.427
TRG_ENDOCYTIC_2	350	353	PF00928	0.504
TRG_ENDOCYTIC_2	478	481	PF00928	0.448
TRG_ENDOCYTIC_2	541	544	PF00928	0.663
TRG_ENDOCYTIC_2	549	552	PF00928	0.337
TRG_ER_diArg_1	145	147	PF00400	0.577
TRG_ER_diArg_1	298	301	PF00400	0.720
TRG_Pf-PMV_PEXEL_1	251	255	PF00026	0.681

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8ICD4	Leishmania donovani	80%	100%
A4HCL3	Leishmania braziliensis	60%	100%
A4I037	Leishmania infantum	80%	100%
Q4QBH6	Leishmania major	78%	100%