RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVZ9_LEIMU

TriTrypDb:

LmxM.22.1670

Length:

918

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVZ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVZ9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	9
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	833	837	PF00656	0.321
CLV_NRD_NRD_1	11	13	PF00675	0.709
CLV_NRD_NRD_1	180	182	PF00675	0.455
CLV_NRD_NRD_1	256	258	PF00675	0.438
CLV_NRD_NRD_1	532	534	PF00675	0.554
CLV_NRD_NRD_1	658	660	PF00675	0.520
CLV_NRD_NRD_1	855	857	PF00675	0.510
CLV_PCSK_FUR_1	9	13	PF00082	0.699
CLV_PCSK_KEX2_1	11	13	PF00082	0.711
CLV_PCSK_KEX2_1	180	182	PF00082	0.455
CLV_PCSK_KEX2_1	256	258	PF00082	0.438
CLV_PCSK_KEX2_1	526	528	PF00082	0.507
CLV_PCSK_KEX2_1	658	660	PF00082	0.548
CLV_PCSK_KEX2_1	855	857	PF00082	0.510
CLV_PCSK_PC1ET2_1	526	528	PF00082	0.560
CLV_PCSK_SKI1_1	107	111	PF00082	0.718
CLV_PCSK_SKI1_1	11	15	PF00082	0.729
CLV_PCSK_SKI1_1	150	154	PF00082	0.607
CLV_PCSK_SKI1_1	175	179	PF00082	0.532
CLV_PCSK_SKI1_1	202	206	PF00082	0.454
CLV_PCSK_SKI1_1	333	337	PF00082	0.554
CLV_PCSK_SKI1_1	369	373	PF00082	0.501
CLV_PCSK_SKI1_1	41	45	PF00082	0.716
CLV_PCSK_SKI1_1	477	481	PF00082	0.549
CLV_PCSK_SKI1_1	71	75	PF00082	0.640
CLV_PCSK_SKI1_1	713	717	PF00082	0.586
DEG_APCC_DBOX_1	113	121	PF00400	0.712
DEG_APCC_DBOX_1	149	157	PF00400	0.565
DEG_APCC_DBOX_1	704	712	PF00400	0.592
DEG_Nend_UBRbox_1	1	4	PF02207	0.694
DOC_CYCLIN_RxL_1	147	155	PF00134	0.474
DOC_CYCLIN_RxL_1	175	186	PF00134	0.543
DOC_CYCLIN_RxL_1	474	482	PF00134	0.558
DOC_CYCLIN_RxL_1	68	79	PF00134	0.608
DOC_CYCLIN_RxL_1	709	719	PF00134	0.633
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.588
DOC_CYCLIN_yCln2_LP_2	66	72	PF00134	0.602
DOC_CYCLIN_yCln2_LP_2	880	886	PF00134	0.234
DOC_MAPK_gen_1	180	187	PF00069	0.511
DOC_MAPK_gen_1	481	490	PF00069	0.567
DOC_MAPK_gen_1	655	665	PF00069	0.567
DOC_MAPK_MEF2A_6	180	187	PF00069	0.516
DOC_MAPK_MEF2A_6	658	667	PF00069	0.561
DOC_MAPK_NFAT4_5	180	188	PF00069	0.318
DOC_PP1_RVXF_1	662	668	PF00149	0.516
DOC_PP2B_LxvP_1	143	146	PF13499	0.622
DOC_PP2B_LxvP_1	192	195	PF13499	0.516
DOC_PP2B_LxvP_1	419	422	PF13499	0.484
DOC_PP2B_LxvP_1	66	69	PF13499	0.604
DOC_PP4_FxxP_1	20	23	PF00568	0.608
DOC_PP4_FxxP_1	805	808	PF00568	0.495
DOC_USP7_MATH_1	167	171	PF00917	0.359
DOC_USP7_MATH_1	414	418	PF00917	0.485
DOC_USP7_MATH_1	522	526	PF00917	0.569
DOC_USP7_MATH_1	568	572	PF00917	0.521
DOC_USP7_MATH_1	704	708	PF00917	0.483
DOC_USP7_MATH_1	765	769	PF00917	0.541
DOC_USP7_MATH_1	908	912	PF00917	0.511
DOC_USP7_UBL2_3	549	553	PF12436	0.523
DOC_WW_Pin1_4	163	168	PF00397	0.610
DOC_WW_Pin1_4	18	23	PF00397	0.670
DOC_WW_Pin1_4	33	38	PF00397	0.757
DOC_WW_Pin1_4	372	377	PF00397	0.285
DOC_WW_Pin1_4	741	746	PF00397	0.531
LIG_14-3-3_CanoR_1	238	244	PF00244	0.431
LIG_14-3-3_CanoR_1	271	276	PF00244	0.552
LIG_14-3-3_CanoR_1	341	346	PF00244	0.538
LIG_14-3-3_CanoR_1	429	435	PF00244	0.450
LIG_14-3-3_CanoR_1	46	52	PF00244	0.716
LIG_14-3-3_CanoR_1	474	480	PF00244	0.531
LIG_14-3-3_CanoR_1	652	660	PF00244	0.363
LIG_14-3-3_CanoR_1	664	668	PF00244	0.609
LIG_14-3-3_CanoR_1	705	709	PF00244	0.476
LIG_14-3-3_CanoR_1	713	719	PF00244	0.507
LIG_Actin_WH2_2	187	204	PF00022	0.562
LIG_Actin_WH2_2	356	371	PF00022	0.479
LIG_BRCT_BRCA1_1	16	20	PF00533	0.721
LIG_BRCT_BRCA1_1	263	267	PF00533	0.566
LIG_BRCT_BRCA1_1	439	443	PF00533	0.455
LIG_BRCT_BRCA1_1	743	747	PF00533	0.614
LIG_BRCT_BRCA1_1	765	769	PF00533	0.618
LIG_CaM_NSCaTE_8	364	371	PF13499	0.487
LIG_Clathr_ClatBox_1	715	719	PF01394	0.646
LIG_CtBP_PxDLS_1	357	361	PF00389	0.566
LIG_FHA_1	26	32	PF00498	0.754
LIG_FHA_1	423	429	PF00498	0.462
LIG_FHA_1	48	54	PF00498	0.673
LIG_FHA_1	902	908	PF00498	0.598
LIG_FHA_2	785	791	PF00498	0.499
LIG_FHA_2	874	880	PF00498	0.280
LIG_LIR_Apic_2	17	23	PF02991	0.608
LIG_LIR_Apic_2	538	542	PF02991	0.476
LIG_LIR_Gen_1	237	247	PF02991	0.411
LIG_LIR_Gen_1	263	270	PF02991	0.464
LIG_LIR_Gen_1	313	323	PF02991	0.474
LIG_LIR_Gen_1	430	435	PF02991	0.454
LIG_LIR_Gen_1	440	450	PF02991	0.374
LIG_LIR_Gen_1	696	704	PF02991	0.503
LIG_LIR_Gen_1	790	798	PF02991	0.510
LIG_LIR_Gen_1	91	101	PF02991	0.600
LIG_LIR_Nem_3	126	132	PF02991	0.587
LIG_LIR_Nem_3	263	268	PF02991	0.461
LIG_LIR_Nem_3	313	318	PF02991	0.483
LIG_LIR_Nem_3	430	434	PF02991	0.425
LIG_LIR_Nem_3	440	446	PF02991	0.423
LIG_LIR_Nem_3	696	700	PF02991	0.493
LIG_LIR_Nem_3	790	794	PF02991	0.539
LIG_LIR_Nem_3	825	831	PF02991	0.491
LIG_LIR_Nem_3	91	97	PF02991	0.624
LIG_NRBOX	295	301	PF00104	0.548
LIG_NRBOX	318	324	PF00104	0.460
LIG_NRBOX	475	481	PF00104	0.492
LIG_PDZ_Class_2	913	918	PF00595	0.522
LIG_Pex14_1	279	283	PF04695	0.483
LIG_PTB_Apo_2	228	235	PF02174	0.438
LIG_REV1ctd_RIR_1	232	242	PF16727	0.535
LIG_SH2_CRK	697	701	PF00017	0.278
LIG_SH2_NCK_1	697	701	PF00017	0.569
LIG_SH2_PTP2	315	318	PF00017	0.480
LIG_SH2_STAP1	912	916	PF00017	0.569
LIG_SH2_STAT3	798	801	PF00017	0.541
LIG_SH2_STAT5	160	163	PF00017	0.541
LIG_SH2_STAT5	315	318	PF00017	0.384
LIG_SH2_STAT5	633	636	PF00017	0.465
LIG_SH2_STAT5	697	700	PF00017	0.473
LIG_SH2_STAT5	782	785	PF00017	0.537
LIG_SH2_STAT5	791	794	PF00017	0.572
LIG_SH3_3	192	198	PF00018	0.457
LIG_SH3_3	2	8	PF00018	0.700
LIG_SH3_3	213	219	PF00018	0.431
LIG_SH3_3	247	253	PF00018	0.501
LIG_SH3_CIN85_PxpxPR_1	4	9	PF14604	0.696
LIG_SUMO_SIM_anti_2	82	88	PF11976	0.372
LIG_SUMO_SIM_par_1	714	719	PF11976	0.643
LIG_SUMO_SIM_par_1	82	88	PF11976	0.640
LIG_TRAF2_1	376	379	PF00917	0.391
LIG_WRC_WIRS_1	428	433	PF05994	0.497
MOD_CK1_1	236	242	PF00069	0.541
MOD_CK1_1	430	436	PF00069	0.526
MOD_CK1_1	52	58	PF00069	0.546
MOD_CK1_1	535	541	PF00069	0.512
MOD_CK1_1	600	606	PF00069	0.559
MOD_CK1_1	646	652	PF00069	0.472
MOD_CK1_1	653	659	PF00069	0.492
MOD_CK1_1	707	713	PF00069	0.558
MOD_CK1_1	761	767	PF00069	0.554
MOD_CK1_1	85	91	PF00069	0.660
MOD_CK2_1	372	378	PF00069	0.293
MOD_CK2_1	483	489	PF00069	0.455
MOD_CK2_1	599	605	PF00069	0.465
MOD_CK2_1	858	864	PF00069	0.540
MOD_CK2_1	873	879	PF00069	0.488
MOD_GlcNHglycan	285	288	PF01048	0.584
MOD_GlcNHglycan	333	336	PF01048	0.536
MOD_GlcNHglycan	416	419	PF01048	0.502
MOD_GlcNHglycan	485	488	PF01048	0.560
MOD_GlcNHglycan	534	537	PF01048	0.542
MOD_GlcNHglycan	570	573	PF01048	0.320
MOD_GlcNHglycan	61	64	PF01048	0.660
MOD_GlcNHglycan	765	768	PF01048	0.601
MOD_GlcNHglycan	847	850	PF01048	0.501
MOD_GlcNHglycan	860	863	PF01048	0.615
MOD_GlcNHglycan	97	100	PF01048	0.692
MOD_GSK3_1	14	21	PF00069	0.726
MOD_GSK3_1	163	170	PF00069	0.372
MOD_GSK3_1	171	178	PF00069	0.560
MOD_GSK3_1	33	40	PF00069	0.672
MOD_GSK3_1	41	48	PF00069	0.593
MOD_GSK3_1	49	56	PF00069	0.656
MOD_GSK3_1	551	558	PF00069	0.542
MOD_GSK3_1	568	575	PF00069	0.543
MOD_GSK3_1	643	650	PF00069	0.539
MOD_GSK3_1	707	714	PF00069	0.522
MOD_GSK3_1	741	748	PF00069	0.580
MOD_GSK3_1	754	761	PF00069	0.480
MOD_GSK3_1	789	796	PF00069	0.565
MOD_LATS_1	179	185	PF00433	0.546
MOD_N-GLC_1	167	172	PF02516	0.377
MOD_N-GLC_1	261	266	PF02516	0.606
MOD_N-GLC_1	572	577	PF02516	0.559
MOD_N-GLC_1	643	648	PF02516	0.492
MOD_NEK2_1	14	19	PF00069	0.733
MOD_NEK2_1	161	166	PF00069	0.512
MOD_NEK2_1	205	210	PF00069	0.505
MOD_NEK2_1	323	328	PF00069	0.520
MOD_NEK2_1	427	432	PF00069	0.461
MOD_NEK2_1	51	56	PF00069	0.725
MOD_NEK2_1	532	537	PF00069	0.588
MOD_NEK2_1	582	587	PF00069	0.319
MOD_NEK2_1	643	648	PF00069	0.492
MOD_NEK2_1	663	668	PF00069	0.598
MOD_NEK2_1	711	716	PF00069	0.573
MOD_NEK2_1	784	789	PF00069	0.480
MOD_NEK2_1	900	905	PF00069	0.495
MOD_NEK2_2	704	709	PF00069	0.550
MOD_NEK2_2	754	759	PF00069	0.537
MOD_NEK2_2	765	770	PF00069	0.576
MOD_OFUCOSY	552	559	PF10250	0.538
MOD_PIKK_1	422	428	PF00454	0.552
MOD_PIKK_1	551	557	PF00454	0.515
MOD_PK_1	759	765	PF00069	0.643
MOD_PKA_2	25	31	PF00069	0.734
MOD_PKA_2	270	276	PF00069	0.548
MOD_PKA_2	45	51	PF00069	0.562
MOD_PKA_2	532	538	PF00069	0.572
MOD_PKA_2	663	669	PF00069	0.597
MOD_PKA_2	681	687	PF00069	0.438
MOD_PKA_2	704	710	PF00069	0.512
MOD_PKB_1	481	489	PF00069	0.625
MOD_PKB_1	856	864	PF00069	0.603
MOD_Plk_1	167	173	PF00069	0.453
MOD_Plk_1	181	187	PF00069	0.606
MOD_Plk_1	236	242	PF00069	0.519
MOD_Plk_1	261	267	PF00069	0.582
MOD_Plk_1	436	442	PF00069	0.516
MOD_Plk_1	572	578	PF00069	0.467
MOD_Plk_1	600	606	PF00069	0.492
MOD_Plk_1	643	649	PF00069	0.469
MOD_Plk_4	167	173	PF00069	0.411
MOD_Plk_4	187	193	PF00069	0.562
MOD_Plk_4	242	248	PF00069	0.537
MOD_Plk_4	271	277	PF00069	0.551
MOD_Plk_4	310	316	PF00069	0.388
MOD_Plk_4	430	436	PF00069	0.448
MOD_Plk_4	439	445	PF00069	0.419
MOD_Plk_4	449	455	PF00069	0.243
MOD_Plk_4	535	541	PF00069	0.568
MOD_Plk_4	643	649	PF00069	0.529
MOD_Plk_4	663	669	PF00069	0.593
MOD_Plk_4	765	771	PF00069	0.589
MOD_Plk_4	79	85	PF00069	0.608
MOD_Plk_4	88	94	PF00069	0.503
MOD_ProDKin_1	163	169	PF00069	0.600
MOD_ProDKin_1	18	24	PF00069	0.672
MOD_ProDKin_1	33	39	PF00069	0.758
MOD_ProDKin_1	372	378	PF00069	0.293
MOD_ProDKin_1	741	747	PF00069	0.533
MOD_SUMO_rev_2	301	311	PF00179	0.320
TRG_DiLeu_BaEn_1	468	473	PF01217	0.533
TRG_DiLeu_BaEn_1	809	814	PF01217	0.549
TRG_DiLeu_BaLyEn_6	314	319	PF01217	0.441
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.452
TRG_ENDOCYTIC_2	315	318	PF00928	0.480
TRG_ENDOCYTIC_2	697	700	PF00928	0.523
TRG_ENDOCYTIC_2	791	794	PF00928	0.576
TRG_ER_diArg_1	255	257	PF00400	0.421
TRG_ER_diArg_1	658	660	PF00400	0.540
TRG_ER_diArg_1	8	11	PF00400	0.667
TRG_ER_diArg_1	855	858	PF00400	0.544
TRG_Pf-PMV_PEXEL_1	150	154	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	181	186	PF00026	0.608
TRG_Pf-PMV_PEXEL_1	477	482	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	829	833	PF00026	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBG1	Leptomonas seymouri	54%	97%
A0A0S4JKR3	Bodo saltans	28%	81%
A0A1X0P744	Trypanosomatidae	32%	100%
A0A3Q8ICH8	Leishmania donovani	92%	100%
A4HCK8	Leishmania braziliensis	83%	100%
A4I026	Leishmania infantum	92%	100%
D0A544	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4QBI0	Leishmania major	90%	100%