Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVZ8_LEIMU

TriTrypDb:

LmxM.22.1660

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVZ8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVZ8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.576
CLV_C14_Caspase3-7	281	285	PF00656	0.571
CLV_C14_Caspase3-7	513	517	PF00656	0.444
CLV_C14_Caspase3-7	567	571	PF00656	0.487
CLV_NRD_NRD_1	385	387	PF00675	0.507
CLV_NRD_NRD_1	416	418	PF00675	0.388
CLV_NRD_NRD_1	435	437	PF00675	0.336
CLV_NRD_NRD_1	527	529	PF00675	0.392
CLV_PCSK_KEX2_1	385	387	PF00082	0.507
CLV_PCSK_KEX2_1	416	418	PF00082	0.358
CLV_PCSK_KEX2_1	435	437	PF00082	0.336
CLV_PCSK_KEX2_1	527	529	PF00082	0.392
CLV_PCSK_KEX2_1	603	605	PF00082	0.495
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.394
CLV_PCSK_SKI1_1	217	221	PF00082	0.433
CLV_PCSK_SKI1_1	386	390	PF00082	0.579
CLV_PCSK_SKI1_1	416	420	PF00082	0.443
CLV_PCSK_SKI1_1	451	455	PF00082	0.421
DEG_APCC_DBOX_1	415	423	PF00400	0.428
DEG_SPOP_SBC_1	186	190	PF00917	0.615
DOC_CKS1_1	540	545	PF01111	0.475
DOC_CYCLIN_RxL_1	214	221	PF00134	0.394
DOC_CYCLIN_RxL_1	230	240	PF00134	0.273
DOC_CYCLIN_RxL_1	413	421	PF00134	0.433
DOC_MAPK_gen_1	320	329	PF00069	0.444
DOC_MAPK_gen_1	342	352	PF00069	0.364
DOC_MAPK_gen_1	416	424	PF00069	0.344
DOC_MAPK_MEF2A_6	320	329	PF00069	0.444
DOC_MAPK_MEF2A_6	345	352	PF00069	0.416
DOC_PP1_RVXF_1	231	238	PF00149	0.391
DOC_PP2B_LxvP_1	126	129	PF13499	0.527
DOC_USP7_MATH_1	139	143	PF00917	0.548
DOC_USP7_MATH_1	177	181	PF00917	0.575
DOC_USP7_MATH_1	186	190	PF00917	0.616
DOC_USP7_MATH_1	222	226	PF00917	0.482
DOC_USP7_MATH_1	461	465	PF00917	0.540
DOC_USP7_MATH_1	498	502	PF00917	0.616
DOC_USP7_MATH_1	526	530	PF00917	0.398
DOC_USP7_MATH_1	93	97	PF00917	0.427
DOC_WW_Pin1_4	135	140	PF00397	0.443
DOC_WW_Pin1_4	218	223	PF00397	0.477
DOC_WW_Pin1_4	502	507	PF00397	0.619
DOC_WW_Pin1_4	539	544	PF00397	0.456
DOC_WW_Pin1_4	588	593	PF00397	0.485
DOC_WW_Pin1_4	72	77	PF00397	0.531
LIG_14-3-3_CanoR_1	179	184	PF00244	0.641
LIG_14-3-3_CanoR_1	37	45	PF00244	0.651
LIG_14-3-3_CanoR_1	385	389	PF00244	0.527
LIG_14-3-3_CanoR_1	395	399	PF00244	0.431
LIG_14-3-3_CanoR_1	417	423	PF00244	0.406
LIG_14-3-3_CanoR_1	435	439	PF00244	0.417
LIG_Actin_WH2_2	411	428	PF00022	0.365
LIG_APCC_ABBA_1	22	27	PF00400	0.501
LIG_APCC_ABBA_1	303	308	PF00400	0.393
LIG_BRCT_BRCA1_1	179	183	PF00533	0.447
LIG_CaM_IQ_9	259	274	PF13499	0.418
LIG_DLG_GKlike_1	179	187	PF00625	0.555
LIG_EH1_1	575	583	PF00400	0.411
LIG_eIF4E_1	576	582	PF01652	0.414
LIG_FHA_1	139	145	PF00498	0.470
LIG_FHA_1	189	195	PF00498	0.538
LIG_FHA_1	299	305	PF00498	0.439
LIG_FHA_1	400	406	PF00498	0.474
LIG_FHA_1	535	541	PF00498	0.411
LIG_FHA_1	563	569	PF00498	0.327
LIG_IBAR_NPY_1	23	25	PF08397	0.509
LIG_LIR_Gen_1	160	170	PF02991	0.394
LIG_LIR_Gen_1	323	332	PF02991	0.377
LIG_LIR_Gen_1	428	433	PF02991	0.396
LIG_LIR_Gen_1	559	569	PF02991	0.460
LIG_LIR_Nem_3	160	165	PF02991	0.389
LIG_LIR_Nem_3	323	327	PF02991	0.396
LIG_LIR_Nem_3	397	401	PF02991	0.462
LIG_LIR_Nem_3	428	432	PF02991	0.438
LIG_LIR_Nem_3	464	468	PF02991	0.403
LIG_LIR_Nem_3	559	564	PF02991	0.339
LIG_NRBOX	418	424	PF00104	0.450
LIG_PCNA_yPIPBox_3	342	356	PF02747	0.352
LIG_PDZ_Class_2	611	616	PF00595	0.479
LIG_Pex14_1	384	388	PF04695	0.477
LIG_SH2_PTP2	162	165	PF00017	0.388
LIG_SH2_PTP2	324	327	PF00017	0.425
LIG_SH2_SRC	98	101	PF00017	0.381
LIG_SH2_STAP1	364	368	PF00017	0.213
LIG_SH2_STAP1	401	405	PF00017	0.399
LIG_SH2_STAT5	162	165	PF00017	0.417
LIG_SH2_STAT5	168	171	PF00017	0.426
LIG_SH2_STAT5	324	327	PF00017	0.457
LIG_SH2_STAT5	401	404	PF00017	0.358
LIG_SH2_STAT5	576	579	PF00017	0.497
LIG_SH2_STAT5	601	604	PF00017	0.378
LIG_SH2_STAT5	98	101	PF00017	0.454
LIG_SH3_3	169	175	PF00018	0.406
LIG_SH3_3	224	230	PF00018	0.365
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.413
LIG_UBA3_1	442	451	PF00899	0.278
LIG_WRC_WIRS_1	254	259	PF05994	0.357
MOD_CDK_SPxxK_3	588	595	PF00069	0.483
MOD_CDK_SPxxK_3	72	79	PF00069	0.541
MOD_CK1_1	118	124	PF00069	0.586
MOD_CK1_1	138	144	PF00069	0.498
MOD_CK1_1	188	194	PF00069	0.602
MOD_CK1_1	316	322	PF00069	0.599
MOD_CK1_1	464	470	PF00069	0.417
MOD_CK1_1	501	507	PF00069	0.622
MOD_CK1_1	75	81	PF00069	0.769
MOD_CK1_1	82	88	PF00069	0.656
MOD_CK2_1	3	9	PF00069	0.533
MOD_CK2_1	425	431	PF00069	0.383
MOD_CK2_1	507	513	PF00069	0.574
MOD_GlcNHglycan	109	113	PF01048	0.531
MOD_GlcNHglycan	120	123	PF01048	0.742
MOD_GlcNHglycan	141	144	PF01048	0.437
MOD_GlcNHglycan	159	162	PF01048	0.466
MOD_GlcNHglycan	213	216	PF01048	0.325
MOD_GlcNHglycan	298	301	PF01048	0.381
MOD_GlcNHglycan	315	318	PF01048	0.463
MOD_GlcNHglycan	337	340	PF01048	0.471
MOD_GlcNHglycan	501	504	PF01048	0.732
MOD_GlcNHglycan	528	531	PF01048	0.440
MOD_GlcNHglycan	570	573	PF01048	0.457
MOD_GlcNHglycan	68	71	PF01048	0.507
MOD_GlcNHglycan	95	98	PF01048	0.522
MOD_GSK3_1	135	142	PF00069	0.445
MOD_GSK3_1	153	160	PF00069	0.613
MOD_GSK3_1	175	182	PF00069	0.593
MOD_GSK3_1	184	191	PF00069	0.594
MOD_GSK3_1	218	225	PF00069	0.512
MOD_GSK3_1	23	30	PF00069	0.589
MOD_GSK3_1	492	499	PF00069	0.524
MOD_GSK3_1	501	508	PF00069	0.629
MOD_GSK3_1	62	69	PF00069	0.542
MOD_GSK3_1	75	82	PF00069	0.733
MOD_GSK3_1	89	96	PF00069	0.470
MOD_N-GLC_1	118	123	PF02516	0.477
MOD_N-GLC_1	588	593	PF02516	0.441
MOD_NEK2_1	110	115	PF00069	0.445
MOD_NEK2_1	144	149	PF00069	0.649
MOD_NEK2_1	185	190	PF00069	0.504
MOD_NEK2_1	2	7	PF00069	0.716
MOD_NEK2_1	237	242	PF00069	0.374
MOD_NEK2_1	289	294	PF00069	0.491
MOD_NEK2_1	298	303	PF00069	0.265
MOD_NEK2_1	418	423	PF00069	0.424
MOD_NEK2_1	425	430	PF00069	0.445
MOD_NEK2_1	492	497	PF00069	0.491
MOD_NEK2_1	599	604	PF00069	0.576
MOD_NEK2_1	91	96	PF00069	0.404
MOD_NEK2_2	3	8	PF00069	0.595
MOD_NEK2_2	401	406	PF00069	0.368
MOD_PIKK_1	291	297	PF00454	0.407
MOD_PIKK_1	79	85	PF00454	0.688
MOD_PKA_2	178	184	PF00069	0.659
MOD_PKA_2	344	350	PF00069	0.350
MOD_PKA_2	384	390	PF00069	0.533
MOD_PKA_2	394	400	PF00069	0.508
MOD_PKA_2	425	431	PF00069	0.509
MOD_PKA_2	434	440	PF00069	0.536
MOD_PKA_2	492	498	PF00069	0.487
MOD_PKA_2	526	532	PF00069	0.415
MOD_Plk_1	153	159	PF00069	0.310
MOD_Plk_1	18	24	PF00069	0.533
MOD_Plk_1	8	14	PF00069	0.663
MOD_Plk_4	153	159	PF00069	0.365
MOD_Plk_4	199	205	PF00069	0.600
MOD_Plk_4	223	229	PF00069	0.491
MOD_Plk_4	27	33	PF00069	0.502
MOD_Plk_4	418	424	PF00069	0.359
MOD_Plk_4	464	470	PF00069	0.522
MOD_Plk_4	8	14	PF00069	0.678
MOD_ProDKin_1	135	141	PF00069	0.442
MOD_ProDKin_1	218	224	PF00069	0.475
MOD_ProDKin_1	502	508	PF00069	0.611
MOD_ProDKin_1	539	545	PF00069	0.468
MOD_ProDKin_1	588	594	PF00069	0.486
MOD_ProDKin_1	72	78	PF00069	0.538
TRG_DiLeu_BaEn_4	358	364	PF01217	0.399
TRG_DiLeu_BaEn_4	559	565	PF01217	0.275
TRG_DiLeu_BaLyEn_6	285	290	PF01217	0.362
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.422
TRG_ENDOCYTIC_2	162	165	PF00928	0.417
TRG_ENDOCYTIC_2	25	28	PF00928	0.500
TRG_ENDOCYTIC_2	324	327	PF00928	0.403
TRG_ER_diArg_1	384	386	PF00400	0.516
TRG_ER_diArg_1	416	418	PF00400	0.346
TRG_ER_diArg_1	434	436	PF00400	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDK4	Leptomonas seymouri	47%	99%
A0A1X0NU19	Trypanosomatidae	28%	100%
A0A3R7K6E0	Trypanosoma rangeli	29%	100%
A0A3S5H7B4	Leishmania donovani	91%	100%
A4HCK7	Leishmania braziliensis	77%	100%
A4I025	Leishmania infantum	91%	100%
Q4QBI1	Leishmania major	90%	100%