cobW domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CobW/HypB/UreG, nucleotide-binding domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9AVZ7_LEIMU

TriTrypDb:

LmxM.22.1650

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.393
CLV_NRD_NRD_1	283	285	PF00675	0.588
CLV_NRD_NRD_1	330	332	PF00675	0.656
CLV_PCSK_KEX2_1	190	192	PF00082	0.393
CLV_PCSK_KEX2_1	283	285	PF00082	0.588
CLV_PCSK_PC7_1	186	192	PF00082	0.393
CLV_PCSK_SKI1_1	149	153	PF00082	0.199
CLV_PCSK_SKI1_1	190	194	PF00082	0.373
CLV_PCSK_SKI1_1	283	287	PF00082	0.584
CLV_PCSK_SKI1_1	357	361	PF00082	0.458
DEG_APCC_DBOX_1	148	156	PF00400	0.385
DEG_Nend_Nbox_1	1	3	PF02207	0.577
DOC_CDC14_PxL_1	117	125	PF14671	0.593
DOC_CYCLIN_RxL_1	281	290	PF00134	0.576
DOC_MAPK_gen_1	261	267	PF00069	0.543
DOC_MAPK_gen_1	32	40	PF00069	0.593
DOC_MAPK_MEF2A_6	32	40	PF00069	0.593
DOC_MAPK_MEF2A_6	7	14	PF00069	0.468
DOC_PP1_RVXF_1	318	325	PF00149	0.623
DOC_PP1_RVXF_1	355	361	PF00149	0.453
DOC_USP7_MATH_1	137	141	PF00917	0.593
DOC_USP7_MATH_1	151	155	PF00917	0.428
DOC_USP7_MATH_1	196	200	PF00917	0.604
DOC_USP7_MATH_1	214	218	PF00917	0.533
DOC_USP7_MATH_1	379	383	PF00917	0.529
DOC_USP7_MATH_1	58	62	PF00917	0.576
DOC_WW_Pin1_4	285	290	PF00397	0.574
LIG_14-3-3_CanoR_1	325	330	PF00244	0.600
LIG_14-3-3_CanoR_1	98	102	PF00244	0.385
LIG_Actin_WH2_2	269	285	PF00022	0.565
LIG_Clathr_ClatBox_1	267	271	PF01394	0.493
LIG_FHA_1	175	181	PF00498	0.529
LIG_FHA_1	18	24	PF00498	0.458
LIG_FHA_1	267	273	PF00498	0.554
LIG_FHA_1	277	283	PF00498	0.497
LIG_FHA_1	3	9	PF00498	0.493
LIG_FHA_2	143	149	PF00498	0.593
LIG_FHA_2	250	256	PF00498	0.467
LIG_FXI_DFP_1	361	365	PF00024	0.580
LIG_LIR_Nem_3	210	215	PF02991	0.497
LIG_LIR_Nem_3	334	338	PF02991	0.505
LIG_PCNA_yPIPBox_3	292	302	PF02747	0.281
LIG_Pex14_2	360	364	PF04695	0.570
LIG_SH2_NCK_1	238	242	PF00017	0.610
LIG_SH2_NCK_1	99	103	PF00017	0.538
LIG_SH2_PTP2	342	345	PF00017	0.614
LIG_SH2_STAT5	206	209	PF00017	0.488
LIG_SH2_STAT5	212	215	PF00017	0.443
LIG_SH2_STAT5	304	307	PF00017	0.549
LIG_SH2_STAT5	342	345	PF00017	0.614
LIG_SH3_1	25	31	PF00018	0.538
LIG_SH3_3	25	31	PF00018	0.538
LIG_SH3_3	335	341	PF00018	0.531
LIG_SUMO_SIM_anti_2	153	159	PF11976	0.587
LIG_SUMO_SIM_par_1	139	146	PF11976	0.572
LIG_SUMO_SIM_par_1	68	73	PF11976	0.524
LIG_TRAF2_1	253	256	PF00917	0.714
LIG_TRAF2_1	31	34	PF00917	0.593
LIG_TYR_ITIM	333	338	PF00017	0.604
LIG_UBA3_1	26	35	PF00899	0.488
LIG_UBA3_1	267	275	PF00899	0.493
LIG_WRC_WIRS_1	230	235	PF05994	0.484
MOD_CK1_1	140	146	PF00069	0.390
MOD_CK1_1	17	23	PF00069	0.488
MOD_CK1_1	316	322	PF00069	0.459
MOD_CK1_1	56	62	PF00069	0.488
MOD_CK2_1	249	255	PF00069	0.474
MOD_CK2_1	315	321	PF00069	0.600
MOD_CK2_1	97	103	PF00069	0.410
MOD_GlcNHglycan	16	19	PF01048	0.488
MOD_GlcNHglycan	305	308	PF01048	0.558
MOD_GlcNHglycan	349	352	PF01048	0.564
MOD_GlcNHglycan	365	369	PF01048	0.452
MOD_GlcNHglycan	377	380	PF01048	0.505
MOD_GlcNHglycan	55	58	PF01048	0.484
MOD_GlcNHglycan	62	65	PF01048	0.376
MOD_GlcNHglycan	72	75	PF01048	0.210
MOD_GlcNHglycan	90	93	PF01048	0.190
MOD_GSK3_1	136	143	PF00069	0.410
MOD_GSK3_1	14	21	PF00069	0.488
MOD_GSK3_1	375	382	PF00069	0.577
MOD_GSK3_1	56	63	PF00069	0.472
MOD_N-GLC_1	59	64	PF02516	0.410
MOD_NEK2_1	14	19	PF00069	0.488
MOD_NEK2_1	142	147	PF00069	0.474
MOD_NEK2_1	364	369	PF00069	0.458
MOD_PIKK_1	276	282	PF00454	0.481
MOD_PKA_2	347	353	PF00069	0.636
MOD_PKA_2	97	103	PF00069	0.196
MOD_Plk_4	137	143	PF00069	0.488
MOD_Plk_4	18	24	PF00069	0.488
MOD_Plk_4	214	220	PF00069	0.519
MOD_Plk_4	229	235	PF00069	0.456
MOD_Plk_4	97	103	PF00069	0.410
MOD_ProDKin_1	285	291	PF00069	0.567
MOD_SUMO_rev_2	175	185	PF00179	0.196
MOD_SUMO_rev_2	255	263	PF00179	0.586
TRG_DiLeu_BaEn_1	290	295	PF01217	0.266
TRG_DiLeu_BaEn_3	33	39	PF01217	0.488
TRG_DiLeu_BaLyEn_6	22	27	PF01217	0.410
TRG_ENDOCYTIC_2	212	215	PF00928	0.450
TRG_ENDOCYTIC_2	335	338	PF00928	0.498
TRG_ENDOCYTIC_2	342	345	PF00928	0.512
TRG_ENDOCYTIC_2	99	102	PF00928	0.386
TRG_ER_diArg_1	189	191	PF00400	0.488
TRG_ER_diArg_1	282	284	PF00400	0.579
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J8A6	Bodo saltans	27%	100%
A0A3Q8ILT9	Leishmania donovani	91%	100%
A4HCK6	Leishmania braziliensis	83%	100%
A4I024	Leishmania infantum	91%	100%
P31521	Pseudomonas chlororaphis	26%	92%
P94400	Bacillus subtilis (strain 168)	26%	97%
Q4QBI2	Leishmania major	92%	100%