Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVZ3_LEIMU

TriTrypDb:

LmxM.22.1610

Length:

730

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVZ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVZ3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	503	507	PF00656	0.472
CLV_C14_Caspase3-7	97	101	PF00656	0.497
CLV_NRD_NRD_1	210	212	PF00675	0.381
CLV_NRD_NRD_1	27	29	PF00675	0.499
CLV_NRD_NRD_1	399	401	PF00675	0.632
CLV_NRD_NRD_1	406	408	PF00675	0.578
CLV_NRD_NRD_1	417	419	PF00675	0.530
CLV_NRD_NRD_1	538	540	PF00675	0.544
CLV_NRD_NRD_1	641	643	PF00675	0.609
CLV_NRD_NRD_1	75	77	PF00675	0.420
CLV_PCSK_FUR_1	536	540	PF00082	0.473
CLV_PCSK_KEX2_1	210	212	PF00082	0.381
CLV_PCSK_KEX2_1	363	365	PF00082	0.483
CLV_PCSK_KEX2_1	538	540	PF00082	0.640
CLV_PCSK_KEX2_1	599	601	PF00082	0.413
CLV_PCSK_KEX2_1	640	642	PF00082	0.600
CLV_PCSK_PC1ET2_1	363	365	PF00082	0.483
CLV_PCSK_PC1ET2_1	599	601	PF00082	0.413
CLV_PCSK_SKI1_1	128	132	PF00082	0.480
CLV_PCSK_SKI1_1	321	325	PF00082	0.476
CLV_PCSK_SKI1_1	610	614	PF00082	0.450
CLV_PCSK_SKI1_1	622	626	PF00082	0.338
CLV_Separin_Metazoa	533	537	PF03568	0.416
DOC_ANK_TNKS_1	640	647	PF00023	0.455
DOC_CKS1_1	433	438	PF01111	0.651
DOC_CYCLIN_RxL_1	619	626	PF00134	0.333
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.606
DOC_MAPK_gen_1	238	247	PF00069	0.435
DOC_MAPK_MEF2A_6	158	167	PF00069	0.530
DOC_MAPK_MEF2A_6	241	249	PF00069	0.430
DOC_PP1_RVXF_1	129	136	PF00149	0.490
DOC_PP1_RVXF_1	620	626	PF00149	0.410
DOC_PP4_FxxP_1	262	265	PF00568	0.501
DOC_USP7_MATH_1	140	144	PF00917	0.483
DOC_USP7_MATH_1	224	228	PF00917	0.466
DOC_USP7_MATH_1	420	424	PF00917	0.661
DOC_USP7_MATH_1	553	557	PF00917	0.531
DOC_USP7_MATH_1	576	580	PF00917	0.419
DOC_USP7_MATH_1	612	616	PF00917	0.415
DOC_USP7_MATH_1	678	682	PF00917	0.537
DOC_USP7_MATH_1	726	730	PF00917	0.632
DOC_WW_Pin1_4	138	143	PF00397	0.525
DOC_WW_Pin1_4	168	173	PF00397	0.539
DOC_WW_Pin1_4	219	224	PF00397	0.507
DOC_WW_Pin1_4	273	278	PF00397	0.597
DOC_WW_Pin1_4	324	329	PF00397	0.409
DOC_WW_Pin1_4	383	388	PF00397	0.672
DOC_WW_Pin1_4	423	428	PF00397	0.586
DOC_WW_Pin1_4	432	437	PF00397	0.637
DOC_WW_Pin1_4	46	51	PF00397	0.526
DOC_WW_Pin1_4	95	100	PF00397	0.646
LIG_14-3-3_CanoR_1	210	218	PF00244	0.410
LIG_14-3-3_CanoR_1	425	433	PF00244	0.656
LIG_14-3-3_CanoR_1	516	526	PF00244	0.349
LIG_14-3-3_CanoR_1	538	547	PF00244	0.447
LIG_14-3-3_CanoR_1	622	628	PF00244	0.424
LIG_14-3-3_CanoR_1	630	635	PF00244	0.429
LIG_Actin_WH2_2	117	133	PF00022	0.410
LIG_BIR_II_1	1	5	PF00653	0.365
LIG_BRCT_BRCA1_1	348	352	PF00533	0.451
LIG_BRCT_BRCA1_1	578	582	PF00533	0.416
LIG_BRCT_BRCA1_1	588	592	PF00533	0.516
LIG_CSL_BTD_1	58	61	PF09270	0.346
LIG_EH1_1	528	536	PF00400	0.394
LIG_eIF4E_1	529	535	PF01652	0.391
LIG_FHA_1	11	17	PF00498	0.499
LIG_FHA_1	180	186	PF00498	0.409
LIG_FHA_1	327	333	PF00498	0.474
LIG_FHA_1	476	482	PF00498	0.454
LIG_FHA_1	492	498	PF00498	0.325
LIG_FHA_1	591	597	PF00498	0.475
LIG_FHA_2	38	44	PF00498	0.430
LIG_FHA_2	4	10	PF00498	0.287
LIG_FHA_2	528	534	PF00498	0.396
LIG_FHA_2	555	561	PF00498	0.436
LIG_FHA_2	658	664	PF00498	0.436
LIG_FHA_2	95	101	PF00498	0.599
LIG_Integrin_RGD_1	37	39	PF01839	0.496
LIG_LIR_Apic_2	259	265	PF02991	0.475
LIG_LIR_Apic_2	272	277	PF02991	0.390
LIG_LIR_Gen_1	468	479	PF02991	0.453
LIG_LIR_Gen_1	9	18	PF02991	0.328
LIG_LIR_Nem_3	468	474	PF02991	0.466
LIG_LIR_Nem_3	9	15	PF02991	0.336
LIG_MYND_1	58	62	PF01753	0.395
LIG_SH2_CRK	121	125	PF00017	0.402
LIG_SH2_CRK	519	523	PF00017	0.438
LIG_SH2_NCK_1	519	523	PF00017	0.332
LIG_SH2_STAP1	12	16	PF00017	0.397
LIG_SH2_STAP1	519	523	PF00017	0.365
LIG_SH2_STAP1	81	85	PF00017	0.370
LIG_SH2_STAT5	12	15	PF00017	0.454
LIG_SH2_STAT5	17	20	PF00017	0.399
LIG_SH2_STAT5	480	483	PF00017	0.446
LIG_SH2_STAT5	529	532	PF00017	0.388
LIG_SH2_STAT5	601	604	PF00017	0.408
LIG_SH2_STAT5	671	674	PF00017	0.504
LIG_SH3_3	157	163	PF00018	0.520
LIG_SH3_3	195	201	PF00018	0.563
LIG_SH3_3	433	439	PF00018	0.643
LIG_SH3_3	55	61	PF00018	0.358
LIG_SH3_3	686	692	PF00018	0.599
LIG_SH3_4	561	568	PF00018	0.449
LIG_SUMO_SIM_anti_2	530	536	PF11976	0.395
LIG_SUMO_SIM_anti_2	663	670	PF11976	0.480
LIG_SUMO_SIM_par_1	123	129	PF11976	0.390
LIG_SUMO_SIM_par_1	165	171	PF11976	0.594
LIG_SUMO_SIM_par_1	550	557	PF11976	0.413
LIG_TRAF2_1	276	279	PF00917	0.561
LIG_TRFH_1	136	140	PF08558	0.392
LIG_TRFH_1	261	265	PF08558	0.490
LIG_TYR_ITIM	119	124	PF00017	0.408
LIG_TYR_ITIM	517	522	PF00017	0.374
LIG_UBA3_1	244	251	PF00899	0.265
MOD_CK1_1	143	149	PF00069	0.517
MOD_CK1_1	202	208	PF00069	0.461
MOD_CK1_1	222	228	PF00069	0.369
MOD_CK1_1	285	291	PF00069	0.501
MOD_CK1_1	337	343	PF00069	0.579
MOD_CK1_1	355	361	PF00069	0.366
MOD_CK1_1	373	379	PF00069	0.533
MOD_CK1_1	382	388	PF00069	0.653
MOD_CK1_1	423	429	PF00069	0.700
MOD_CK1_1	469	475	PF00069	0.410
MOD_CK1_1	486	492	PF00069	0.494
MOD_CK2_1	273	279	PF00069	0.557
MOD_CK2_1	3	9	PF00069	0.288
MOD_CK2_1	324	330	PF00069	0.407
MOD_CK2_1	408	414	PF00069	0.620
MOD_CK2_1	527	533	PF00069	0.450
MOD_CK2_1	538	544	PF00069	0.449
MOD_CK2_1	554	560	PF00069	0.276
MOD_CK2_1	591	597	PF00069	0.474
MOD_CK2_1	657	663	PF00069	0.448
MOD_CK2_1	667	673	PF00069	0.539
MOD_GlcNHglycan	142	145	PF01048	0.487
MOD_GlcNHglycan	202	205	PF01048	0.441
MOD_GlcNHglycan	214	217	PF01048	0.368
MOD_GlcNHglycan	226	229	PF01048	0.577
MOD_GlcNHglycan	284	287	PF01048	0.561
MOD_GlcNHglycan	335	339	PF01048	0.458
MOD_GlcNHglycan	348	351	PF01048	0.416
MOD_GlcNHglycan	354	357	PF01048	0.324
MOD_GlcNHglycan	372	375	PF01048	0.578
MOD_GlcNHglycan	382	385	PF01048	0.645
MOD_GlcNHglycan	388	391	PF01048	0.592
MOD_GlcNHglycan	409	413	PF01048	0.620
MOD_GlcNHglycan	428	431	PF01048	0.528
MOD_GlcNHglycan	452	455	PF01048	0.522
MOD_GlcNHglycan	483	486	PF01048	0.651
MOD_GlcNHglycan	488	491	PF01048	0.560
MOD_GlcNHglycan	498	501	PF01048	0.297
MOD_GlcNHglycan	519	522	PF01048	0.401
MOD_GlcNHglycan	541	544	PF01048	0.489
MOD_GlcNHglycan	578	581	PF01048	0.405
MOD_GlcNHglycan	588	591	PF01048	0.537
MOD_GlcNHglycan	614	617	PF01048	0.485
MOD_GlcNHglycan	685	688	PF01048	0.551
MOD_GSK3_1	134	141	PF00069	0.444
MOD_GSK3_1	218	225	PF00069	0.619
MOD_GSK3_1	269	276	PF00069	0.616
MOD_GSK3_1	309	316	PF00069	0.502
MOD_GSK3_1	322	329	PF00069	0.397
MOD_GSK3_1	333	340	PF00069	0.640
MOD_GSK3_1	358	365	PF00069	0.490
MOD_GSK3_1	368	375	PF00069	0.766
MOD_GSK3_1	376	383	PF00069	0.528
MOD_GSK3_1	408	415	PF00069	0.747
MOD_GSK3_1	465	472	PF00069	0.439
MOD_GSK3_1	481	488	PF00069	0.600
MOD_GSK3_1	582	589	PF00069	0.491
MOD_GSK3_1	591	598	PF00069	0.372
MOD_GSK3_1	663	670	PF00069	0.553
MOD_GSK3_1	672	679	PF00069	0.541
MOD_GSK3_1	90	97	PF00069	0.626
MOD_N-GLC_1	10	15	PF02516	0.490
MOD_N-GLC_1	396	401	PF02516	0.625
MOD_NEK2_1	120	125	PF00069	0.342
MOD_NEK2_1	194	199	PF00069	0.405
MOD_NEK2_1	218	223	PF00069	0.615
MOD_NEK2_1	247	252	PF00069	0.299
MOD_NEK2_1	309	314	PF00069	0.419
MOD_NEK2_1	333	338	PF00069	0.516
MOD_NEK2_1	352	357	PF00069	0.334
MOD_NEK2_1	465	470	PF00069	0.545
MOD_NEK2_1	582	587	PF00069	0.533
MOD_NEK2_1	623	628	PF00069	0.267
MOD_NEK2_1	667	672	PF00069	0.490
MOD_NEK2_1	676	681	PF00069	0.587
MOD_NEK2_1	708	713	PF00069	0.689
MOD_NEK2_1	720	725	PF00069	0.604
MOD_NEK2_2	126	131	PF00069	0.412
MOD_NEK2_2	466	471	PF00069	0.386
MOD_PKA_1	407	413	PF00069	0.672
MOD_PKA_1	538	544	PF00069	0.397
MOD_PKA_2	209	215	PF00069	0.411
MOD_PKA_2	256	262	PF00069	0.452
MOD_PKA_2	475	481	PF00069	0.425
MOD_PKA_2	517	523	PF00069	0.269
MOD_PKA_2	538	544	PF00069	0.408
MOD_PKA_2	590	596	PF00069	0.368
MOD_PKB_1	405	413	PF00069	0.566
MOD_PKB_1	536	544	PF00069	0.380
MOD_Plk_1	10	16	PF00069	0.466
MOD_Plk_1	179	185	PF00069	0.446
MOD_Plk_1	321	327	PF00069	0.367
MOD_Plk_1	43	49	PF00069	0.417
MOD_Plk_1	657	663	PF00069	0.437
MOD_Plk_1	672	678	PF00069	0.538
MOD_Plk_4	120	126	PF00069	0.347
MOD_Plk_4	194	200	PF00069	0.458
MOD_Plk_4	227	233	PF00069	0.316
MOD_Plk_4	314	320	PF00069	0.463
MOD_Plk_4	355	361	PF00069	0.422
MOD_Plk_4	466	472	PF00069	0.490
MOD_Plk_4	475	481	PF00069	0.407
MOD_Plk_4	527	533	PF00069	0.333
MOD_Plk_4	630	636	PF00069	0.451
MOD_ProDKin_1	138	144	PF00069	0.525
MOD_ProDKin_1	168	174	PF00069	0.538
MOD_ProDKin_1	219	225	PF00069	0.513
MOD_ProDKin_1	273	279	PF00069	0.602
MOD_ProDKin_1	324	330	PF00069	0.407
MOD_ProDKin_1	383	389	PF00069	0.672
MOD_ProDKin_1	423	429	PF00069	0.586
MOD_ProDKin_1	432	438	PF00069	0.636
MOD_ProDKin_1	46	52	PF00069	0.529
MOD_ProDKin_1	95	101	PF00069	0.640
MOD_SUMO_rev_2	21	31	PF00179	0.423
TRG_DiLeu_BaEn_1	663	668	PF01217	0.472
TRG_DiLeu_BaLyEn_6	619	624	PF01217	0.422
TRG_ENDOCYTIC_2	12	15	PF00928	0.396
TRG_ENDOCYTIC_2	121	124	PF00928	0.409
TRG_ENDOCYTIC_2	519	522	PF00928	0.383
TRG_ENDOCYTIC_2	529	532	PF00928	0.389
TRG_ENDOCYTIC_2	81	84	PF00928	0.368
TRG_ER_diArg_1	209	211	PF00400	0.404
TRG_ER_diArg_1	516	519	PF00400	0.495
TRG_ER_diArg_1	537	539	PF00400	0.625
TRG_ER_diArg_1	640	642	PF00400	0.562
TRG_ER_diLys_1	727	730	PF00400	0.536
TRG_Pf-PMV_PEXEL_1	128	132	PF00026	0.264

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJC5	Leptomonas seymouri	47%	100%
A0A3S7WXI7	Leishmania donovani	89%	100%
A0A422N4V7	Trypanosoma rangeli	25%	100%
A4HCK2	Leishmania braziliensis	76%	100%
A4I020	Leishmania infantum	89%	100%
Q4QBI6	Leishmania major	88%	99%