Putative ser/thr protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ser/thr protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AVZ2_LEIMU

TriTrypDb:

LmxM.22.1600

Length:

808

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0010494	cytoplasmic stress granule	5	1
GO:0035770	ribonucleoprotein granule	3	1
GO:0036464	cytoplasmic ribonucleoprotein granule	4	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0051286	cell tip	3	1
GO:0060187	cell pole	2	1
GO:0099080	supramolecular complex	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AVZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVZ2

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	1
GO:0006793	phosphorus metabolic process	3	1
GO:0006797	polyphosphate metabolic process	4	1
GO:0006798	polyphosphate catabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009987	cellular process	1	1
GO:0043436	oxoacid metabolic process	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0016787	hydrolase activity	2	7
GO:0000298	endopolyphosphatase activity	6	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0042578	phosphoric ester hydrolase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	316	320	PF00656	0.448
CLV_NRD_NRD_1	254	256	PF00675	0.702
CLV_NRD_NRD_1	411	413	PF00675	0.304
CLV_NRD_NRD_1	477	479	PF00675	0.388
CLV_NRD_NRD_1	75	77	PF00675	0.715
CLV_NRD_NRD_1	774	776	PF00675	0.405
CLV_PCSK_FUR_1	408	412	PF00082	0.304
CLV_PCSK_KEX2_1	410	412	PF00082	0.304
CLV_PCSK_KEX2_1	424	426	PF00082	0.304
CLV_PCSK_KEX2_1	477	479	PF00082	0.388
CLV_PCSK_KEX2_1	75	77	PF00082	0.715
CLV_PCSK_KEX2_1	796	798	PF00082	0.411
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.304
CLV_PCSK_PC1ET2_1	796	798	PF00082	0.408
CLV_PCSK_PC7_1	420	426	PF00082	0.304
CLV_PCSK_SKI1_1	358	362	PF00082	0.369
CLV_PCSK_SKI1_1	412	416	PF00082	0.304
CLV_PCSK_SKI1_1	6	10	PF00082	0.670
CLV_PCSK_SKI1_1	608	612	PF00082	0.565
CLV_PCSK_SKI1_1	736	740	PF00082	0.358
CLV_PCSK_SKI1_1	782	786	PF00082	0.517
CLV_PCSK_SKI1_1	797	801	PF00082	0.298
CLV_Separin_Metazoa	330	334	PF03568	0.487
DEG_APCC_DBOX_1	5	13	PF00400	0.670
DEG_APCC_DBOX_1	684	692	PF00400	0.400
DEG_Nend_UBRbox_2	1	3	PF02207	0.685
DEG_SCF_FBW7_1	650	656	PF00400	0.580
DEG_SCF_FBW7_1	661	667	PF00400	0.510
DEG_SPOP_SBC_1	153	157	PF00917	0.611
DEG_SPOP_SBC_1	172	176	PF00917	0.636
DEG_SPOP_SBC_1	264	268	PF00917	0.647
DEG_SPOP_SBC_1	290	294	PF00917	0.598
DEG_SPOP_SBC_1	45	49	PF00917	0.639
DEG_SPOP_SBC_1	629	633	PF00917	0.515
DEG_SPOP_SBC_1	653	657	PF00917	0.639
DOC_CDC14_PxL_1	554	562	PF14671	0.403
DOC_CKS1_1	413	418	PF01111	0.304
DOC_CKS1_1	650	655	PF01111	0.615
DOC_CKS1_1	661	666	PF01111	0.613
DOC_CYCLIN_RxL_1	3	13	PF00134	0.669
DOC_CYCLIN_yClb5_NLxxxL_5	4	12	PF00134	0.605
DOC_CYCLIN_yCln2_LP_2	612	618	PF00134	0.597
DOC_MAPK_gen_1	358	368	PF00069	0.369
DOC_MAPK_gen_1	446	455	PF00069	0.304
DOC_MAPK_gen_1	796	807	PF00069	0.385
DOC_MAPK_MEF2A_6	695	704	PF00069	0.382
DOC_PP2B_LxvP_1	570	573	PF13499	0.452
DOC_PP2B_LxvP_1	612	615	PF13499	0.595
DOC_PP2B_LxvP_1	704	707	PF13499	0.624
DOC_PP2B_PxIxI_1	322	328	PF00149	0.340
DOC_PP4_FxxP_1	555	558	PF00568	0.396
DOC_PP4_FxxP_1	730	733	PF00568	0.362
DOC_USP7_MATH_1	116	120	PF00917	0.646
DOC_USP7_MATH_1	153	157	PF00917	0.600
DOC_USP7_MATH_1	172	176	PF00917	0.777
DOC_USP7_MATH_1	205	209	PF00917	0.768
DOC_USP7_MATH_1	221	225	PF00917	0.510
DOC_USP7_MATH_1	236	240	PF00917	0.621
DOC_USP7_MATH_1	264	268	PF00917	0.651
DOC_USP7_MATH_1	278	282	PF00917	0.623
DOC_USP7_MATH_1	290	294	PF00917	0.633
DOC_USP7_MATH_1	57	61	PF00917	0.621
DOC_USP7_MATH_1	92	96	PF00917	0.732
DOC_USP7_UBL2_3	490	494	PF12436	0.405
DOC_USP7_UBL2_3	796	800	PF12436	0.397
DOC_WW_Pin1_4	141	146	PF00397	0.659
DOC_WW_Pin1_4	158	163	PF00397	0.649
DOC_WW_Pin1_4	193	198	PF00397	0.672
DOC_WW_Pin1_4	29	34	PF00397	0.604
DOC_WW_Pin1_4	41	46	PF00397	0.676
DOC_WW_Pin1_4	412	417	PF00397	0.304
DOC_WW_Pin1_4	546	551	PF00397	0.475
DOC_WW_Pin1_4	594	599	PF00397	0.597
DOC_WW_Pin1_4	649	654	PF00397	0.616
DOC_WW_Pin1_4	660	665	PF00397	0.616
DOC_WW_Pin1_4	788	793	PF00397	0.481
DOC_WW_Pin1_4	88	93	PF00397	0.680
LIG_14-3-3_CanoR_1	16	23	PF00244	0.563
LIG_14-3-3_CanoR_1	6	15	PF00244	0.686
LIG_14-3-3_CanoR_1	660	664	PF00244	0.563
LIG_14-3-3_CanoR_1	685	689	PF00244	0.453
LIG_14-3-3_CanoR_1	695	704	PF00244	0.413
LIG_BIR_III_4	310	314	PF00653	0.405
LIG_deltaCOP1_diTrp_1	499	505	PF00928	0.351
LIG_deltaCOP1_diTrp_1	728	734	PF00928	0.440
LIG_FHA_1	129	135	PF00498	0.534
LIG_FHA_1	175	181	PF00498	0.763
LIG_FHA_1	232	238	PF00498	0.640
LIG_FHA_1	319	325	PF00498	0.388
LIG_FHA_1	530	536	PF00498	0.338
LIG_FHA_1	539	545	PF00498	0.340
LIG_FHA_1	61	67	PF00498	0.623
LIG_FHA_1	630	636	PF00498	0.561
LIG_FHA_1	645	651	PF00498	0.644
LIG_FHA_1	654	660	PF00498	0.714
LIG_FHA_1	673	679	PF00498	0.543
LIG_FHA_1	692	698	PF00498	0.296
LIG_FHA_1	733	739	PF00498	0.380
LIG_FHA_1	91	97	PF00498	0.593
LIG_FHA_2	413	419	PF00498	0.335
LIG_FHA_2	665	671	PF00498	0.504
LIG_LIR_Apic_2	553	558	PF02991	0.398
LIG_LIR_Apic_2	728	733	PF02991	0.487
LIG_LIR_Gen_1	334	343	PF02991	0.317
LIG_LIR_Gen_1	399	407	PF02991	0.304
LIG_LIR_Gen_1	499	508	PF02991	0.401
LIG_LIR_Gen_1	732	742	PF02991	0.418
LIG_LIR_Nem_3	310	315	PF02991	0.398
LIG_LIR_Nem_3	334	340	PF02991	0.317
LIG_LIR_Nem_3	399	403	PF02991	0.304
LIG_LIR_Nem_3	499	504	PF02991	0.357
LIG_LIR_Nem_3	516	521	PF02991	0.485
LIG_LIR_Nem_3	553	557	PF02991	0.394
LIG_LIR_Nem_3	728	734	PF02991	0.462
LIG_MYND_1	145	149	PF01753	0.674
LIG_MYND_3	560	564	PF01753	0.432
LIG_PCNA_PIPBox_1	778	787	PF02747	0.388
LIG_PCNA_yPIPBox_3	210	219	PF02747	0.628
LIG_PCNA_yPIPBox_3	467	478	PF02747	0.445
LIG_PCNA_yPIPBox_3	775	785	PF02747	0.398
LIG_PDZ_Class_2	803	808	PF00595	0.402
LIG_Pex14_2	730	734	PF04695	0.355
LIG_PTB_Apo_2	394	401	PF02174	0.304
LIG_PTB_Phospho_1	394	400	PF10480	0.304
LIG_REV1ctd_RIR_1	214	223	PF16727	0.648
LIG_SH2_CRK	392	396	PF00017	0.304
LIG_SH2_CRK	400	404	PF00017	0.304
LIG_SH2_GRB2like	372	375	PF00017	0.369
LIG_SH2_PTP2	337	340	PF00017	0.304
LIG_SH2_SRC	337	340	PF00017	0.304
LIG_SH2_STAP1	709	713	PF00017	0.477
LIG_SH2_STAT5	337	340	PF00017	0.340
LIG_SH2_STAT5	359	362	PF00017	0.328
LIG_SH2_STAT5	372	375	PF00017	0.304
LIG_SH2_STAT5	400	403	PF00017	0.307
LIG_SH2_STAT5	437	440	PF00017	0.304
LIG_SH3_1	326	332	PF00018	0.469
LIG_SH3_1	410	416	PF00018	0.304
LIG_SH3_3	175	181	PF00018	0.618
LIG_SH3_3	223	229	PF00018	0.678
LIG_SH3_3	326	332	PF00018	0.469
LIG_SH3_3	410	416	PF00018	0.304
LIG_SH3_3	442	448	PF00018	0.304
LIG_SH3_3	480	486	PF00018	0.437
LIG_SH3_3	555	561	PF00018	0.499
LIG_SH3_3	647	653	PF00018	0.635
LIG_Sin3_3	699	706	PF02671	0.455
LIG_SUMO_SIM_anti_2	698	704	PF11976	0.383
LIG_SUMO_SIM_anti_2	735	741	PF11976	0.352
LIG_SUMO_SIM_par_1	687	692	PF11976	0.394
LIG_UBA3_1	488	494	PF00899	0.472
MOD_CDC14_SPxK_1	657	660	PF00782	0.599
MOD_CDK_SPK_2	145	150	PF00069	0.513
MOD_CDK_SPxK_1	654	660	PF00069	0.601
MOD_CK1_1	10	16	PF00069	0.631
MOD_CK1_1	119	125	PF00069	0.743
MOD_CK1_1	132	138	PF00069	0.702
MOD_CK1_1	156	162	PF00069	0.640
MOD_CK1_1	171	177	PF00069	0.683
MOD_CK1_1	18	24	PF00069	0.629
MOD_CK1_1	193	199	PF00069	0.529
MOD_CK1_1	266	272	PF00069	0.672
MOD_CK1_1	29	35	PF00069	0.775
MOD_CK1_1	291	297	PF00069	0.675
MOD_CK1_1	37	43	PF00069	0.826
MOD_CK1_1	60	66	PF00069	0.585
MOD_CK1_1	630	636	PF00069	0.556
MOD_CK1_1	646	652	PF00069	0.585
MOD_CK1_1	662	668	PF00069	0.565
MOD_CK1_1	91	97	PF00069	0.578
MOD_CK2_1	664	670	PF00069	0.505
MOD_CK2_1	718	724	PF00069	0.594
MOD_Cter_Amidation	253	256	PF01082	0.656
MOD_Cter_Amidation	773	776	PF01082	0.394
MOD_DYRK1A_RPxSP_1	412	416	PF00069	0.304
MOD_GlcNHglycan	113	116	PF01048	0.779
MOD_GlcNHglycan	118	121	PF01048	0.697
MOD_GlcNHglycan	12	15	PF01048	0.629
MOD_GlcNHglycan	170	173	PF01048	0.574
MOD_GlcNHglycan	192	195	PF01048	0.667
MOD_GlcNHglycan	238	241	PF01048	0.662
MOD_GlcNHglycan	268	271	PF01048	0.637
MOD_GlcNHglycan	273	276	PF01048	0.602
MOD_GlcNHglycan	28	31	PF01048	0.618
MOD_GlcNHglycan	285	288	PF01048	0.651
MOD_GlcNHglycan	36	39	PF01048	0.626
MOD_GlcNHglycan	55	58	PF01048	0.554
MOD_GlcNHglycan	603	606	PF01048	0.650
MOD_GlcNHglycan	622	627	PF01048	0.578
MOD_GlcNHglycan	691	694	PF01048	0.423
MOD_GlcNHglycan	697	700	PF01048	0.429
MOD_GlcNHglycan	720	723	PF01048	0.590
MOD_GSK3_1	107	114	PF00069	0.817
MOD_GSK3_1	128	135	PF00069	0.786
MOD_GSK3_1	141	148	PF00069	0.763
MOD_GSK3_1	152	159	PF00069	0.661
MOD_GSK3_1	160	167	PF00069	0.774
MOD_GSK3_1	168	175	PF00069	0.557
MOD_GSK3_1	182	189	PF00069	0.770
MOD_GSK3_1	264	271	PF00069	0.667
MOD_GSK3_1	279	286	PF00069	0.633
MOD_GSK3_1	297	304	PF00069	0.423
MOD_GSK3_1	34	41	PF00069	0.789
MOD_GSK3_1	44	51	PF00069	0.621
MOD_GSK3_1	53	60	PF00069	0.536
MOD_GSK3_1	590	597	PF00069	0.607
MOD_GSK3_1	627	634	PF00069	0.612
MOD_GSK3_1	640	647	PF00069	0.621
MOD_GSK3_1	649	656	PF00069	0.641
MOD_GSK3_1	660	667	PF00069	0.528
MOD_GSK3_1	691	698	PF00069	0.548
MOD_GSK3_1	788	795	PF00069	0.570
MOD_GSK3_1	88	95	PF00069	0.681
MOD_N-GLC_1	601	606	PF02516	0.675
MOD_N-GLC_1	66	71	PF02516	0.664
MOD_NEK2_1	111	116	PF00069	0.690
MOD_NEK2_1	192	197	PF00069	0.590
MOD_NEK2_1	318	323	PF00069	0.412
MOD_NEK2_1	640	645	PF00069	0.640
MOD_NEK2_1	659	664	PF00069	0.637
MOD_NEK2_1	66	71	PF00069	0.664
MOD_NEK2_1	672	677	PF00069	0.584
MOD_NEK2_1	689	694	PF00069	0.395
MOD_PIKK_1	7	13	PF00454	0.606
MOD_PIKK_1	723	729	PF00454	0.537
MOD_PK_1	182	188	PF00069	0.690
MOD_PKA_2	15	21	PF00069	0.602
MOD_PKA_2	297	303	PF00069	0.548
MOD_PKA_2	590	596	PF00069	0.583
MOD_PKA_2	659	665	PF00069	0.563
MOD_PKA_2	684	690	PF00069	0.412
MOD_Plk_1	398	404	PF00069	0.304
MOD_Plk_1	622	628	PF00069	0.645
MOD_Plk_4	129	135	PF00069	0.618
MOD_Plk_4	18	24	PF00069	0.601
MOD_Plk_4	398	404	PF00069	0.304
MOD_Plk_4	646	652	PF00069	0.550
MOD_Plk_4	684	690	PF00069	0.412
MOD_ProDKin_1	141	147	PF00069	0.663
MOD_ProDKin_1	158	164	PF00069	0.647
MOD_ProDKin_1	193	199	PF00069	0.672
MOD_ProDKin_1	29	35	PF00069	0.605
MOD_ProDKin_1	41	47	PF00069	0.675
MOD_ProDKin_1	412	418	PF00069	0.304
MOD_ProDKin_1	546	552	PF00069	0.470
MOD_ProDKin_1	594	600	PF00069	0.600
MOD_ProDKin_1	649	655	PF00069	0.616
MOD_ProDKin_1	660	666	PF00069	0.615
MOD_ProDKin_1	788	794	PF00069	0.474
MOD_ProDKin_1	88	94	PF00069	0.672
MOD_SUMO_for_1	561	564	PF00179	0.446
MOD_SUMO_rev_2	564	570	PF00179	0.450
TRG_DiLeu_BaEn_2	779	785	PF01217	0.385
TRG_DiLeu_BaEn_4	471	477	PF01217	0.372
TRG_DiLeu_BaLyEn_6	733	738	PF01217	0.418
TRG_DiLeu_BaLyEn_6	99	104	PF01217	0.561
TRG_ENDOCYTIC_2	337	340	PF00928	0.352
TRG_ENDOCYTIC_2	392	395	PF00928	0.304
TRG_ENDOCYTIC_2	400	403	PF00928	0.304
TRG_ENDOCYTIC_2	518	521	PF00928	0.452
TRG_ER_diArg_1	408	411	PF00400	0.303
TRG_ER_diArg_1	476	478	PF00400	0.390
TRG_NES_CRM1_1	696	710	PF08389	0.461
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	6	11	PF00026	0.670
TRG_Pf-PMV_PEXEL_1	775	780	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Q2	Leptomonas seymouri	63%	100%
A0A3Q8IBC4	Leishmania donovani	92%	100%
A4HCK0	Leishmania braziliensis	82%	100%
A4I019	Leishmania infantum	92%	100%
Q4QBI7	Leishmania major	92%	100%