Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVY9_LEIMU

TriTrypDb:

LmxM.22.1570

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.715
CLV_NRD_NRD_1	121	123	PF00675	0.477
CLV_NRD_NRD_1	145	147	PF00675	0.540
CLV_NRD_NRD_1	187	189	PF00675	0.742
CLV_NRD_NRD_1	59	61	PF00675	0.658
CLV_NRD_NRD_1	74	76	PF00675	0.608
CLV_PCSK_FUR_1	143	147	PF00082	0.560
CLV_PCSK_KEX2_1	145	147	PF00082	0.540
CLV_PCSK_KEX2_1	177	179	PF00082	0.643
CLV_PCSK_KEX2_1	187	189	PF00082	0.720
CLV_PCSK_KEX2_1	59	61	PF00082	0.691
CLV_PCSK_KEX2_1	63	65	PF00082	0.696
CLV_PCSK_KEX2_1	74	76	PF00082	0.718
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.535
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.691
CLV_PCSK_PC1ET2_1	63	65	PF00082	0.696
CLV_PCSK_SKI1_1	145	149	PF00082	0.536
CLV_PCSK_SKI1_1	187	191	PF00082	0.579
CLV_PCSK_SKI1_1	258	262	PF00082	0.616
CLV_Separin_Metazoa	285	289	PF03568	0.553
DEG_COP1_1	261	270	PF00400	0.502
DEG_Nend_UBRbox_4	1	3	PF02207	0.531
DEG_SPOP_SBC_1	298	302	PF00917	0.650
DEG_SPOP_SBC_1	66	70	PF00917	0.475
DOC_CYCLIN_RxL_1	139	152	PF00134	0.491
DOC_CYCLIN_RxL_1	22	36	PF00134	0.733
DOC_MAPK_gen_1	122	129	PF00069	0.527
DOC_PP2B_LxvP_1	265	268	PF13499	0.616
DOC_USP7_MATH_1	211	215	PF00917	0.593
DOC_USP7_MATH_1	256	260	PF00917	0.655
DOC_USP7_MATH_1	326	330	PF00917	0.573
DOC_USP7_MATH_1	53	57	PF00917	0.739
DOC_USP7_MATH_1	78	82	PF00917	0.599
DOC_USP7_UBL2_3	59	63	PF12436	0.700
DOC_WW_Pin1_4	189	194	PF00397	0.706
DOC_WW_Pin1_4	20	25	PF00397	0.710
DOC_WW_Pin1_4	62	67	PF00397	0.619
DOC_WW_Pin1_4	68	73	PF00397	0.648
LIG_14-3-3_CanoR_1	18	22	PF00244	0.605
LIG_14-3-3_CanoR_1	187	192	PF00244	0.710
LIG_14-3-3_CanoR_1	280	287	PF00244	0.520
LIG_14-3-3_CanoR_1	42	49	PF00244	0.602
LIG_14-3-3_CanoR_1	97	105	PF00244	0.429
LIG_BRCT_BRCA1_1	45	49	PF00533	0.668
LIG_Clathr_ClatBox_1	90	94	PF01394	0.342
LIG_FHA_1	262	268	PF00498	0.550
LIG_FHA_2	97	103	PF00498	0.476
LIG_IBAR_NPY_1	179	181	PF08397	0.525
LIG_LIR_Gen_1	113	121	PF02991	0.445
LIG_LIR_Gen_1	229	237	PF02991	0.547
LIG_LIR_Nem_3	113	118	PF02991	0.476
LIG_LIR_Nem_3	197	201	PF02991	0.435
LIG_LIR_Nem_3	229	235	PF02991	0.547
LIG_MAD2	6	14	PF02301	0.406
LIG_PDZ_Class_2	357	362	PF00595	0.654
LIG_SH2_NCK_1	348	352	PF00017	0.551
LIG_SH2_STAP1	232	236	PF00017	0.588
LIG_SH2_STAP1	348	352	PF00017	0.631
LIG_SH2_STAT5	348	351	PF00017	0.649
LIG_SUMO_SIM_par_1	263	269	PF11976	0.502
LIG_TRAF2_1	135	138	PF00917	0.498
LIG_TRAF2_1	92	95	PF00917	0.550
LIG_UBA3_1	169	177	PF00899	0.568
LIG_WRC_WIRS_1	232	237	PF05994	0.592
MOD_CDC14_SPxK_1	71	74	PF00782	0.524
MOD_CDK_SPxK_1	68	74	PF00069	0.527
MOD_CDK_SPxxK_3	68	75	PF00069	0.666
MOD_CK1_1	113	119	PF00069	0.557
MOD_CK1_1	301	307	PF00069	0.683
MOD_CK1_1	45	51	PF00069	0.624
MOD_CK1_1	52	58	PF00069	0.658
MOD_CK1_1	65	71	PF00069	0.477
MOD_CK1_1	73	79	PF00069	0.608
MOD_CK2_1	225	231	PF00069	0.649
MOD_CK2_1	244	250	PF00069	0.615
MOD_CK2_1	301	307	PF00069	0.502
MOD_CK2_1	79	85	PF00069	0.663
MOD_GlcNHglycan	213	216	PF01048	0.676
MOD_GlcNHglycan	238	241	PF01048	0.549
MOD_GlcNHglycan	258	261	PF01048	0.560
MOD_GlcNHglycan	326	329	PF01048	0.556
MOD_GlcNHglycan	51	54	PF01048	0.574
MOD_GlcNHglycan	55	58	PF01048	0.572
MOD_GSK3_1	106	113	PF00069	0.462
MOD_GSK3_1	183	190	PF00069	0.699
MOD_GSK3_1	236	243	PF00069	0.665
MOD_GSK3_1	26	33	PF00069	0.652
MOD_GSK3_1	297	304	PF00069	0.563
MOD_GSK3_1	320	327	PF00069	0.671
MOD_GSK3_1	45	52	PF00069	0.626
MOD_GSK3_1	62	69	PF00069	0.619
MOD_GSK3_1	9	16	PF00069	0.613
MOD_LATS_1	26	32	PF00433	0.580
MOD_N-GLC_1	194	199	PF02516	0.408
MOD_NEK2_1	110	115	PF00069	0.537
MOD_NEK2_1	206	211	PF00069	0.605
MOD_NEK2_1	236	241	PF00069	0.639
MOD_NEK2_1	30	35	PF00069	0.668
MOD_NEK2_1	49	54	PF00069	0.691
MOD_NEK2_2	268	273	PF00069	0.640
MOD_NEK2_2	34	39	PF00069	0.563
MOD_PIKK_1	13	19	PF00454	0.537
MOD_PIKK_1	206	212	PF00454	0.608
MOD_PKA_1	187	193	PF00069	0.714
MOD_PKA_2	17	23	PF00069	0.589
MOD_PKA_2	187	193	PF00069	0.659
MOD_PKA_2	324	330	PF00069	0.539
MOD_PKA_2	49	55	PF00069	0.682
MOD_PKA_2	73	79	PF00069	0.689
MOD_PKA_2	96	102	PF00069	0.433
MOD_Plk_1	151	157	PF00069	0.550
MOD_Plk_1	194	200	PF00069	0.427
MOD_Plk_1	268	274	PF00069	0.484
MOD_Plk_1	292	298	PF00069	0.473
MOD_Plk_1	346	352	PF00069	0.598
MOD_Plk_2-3	225	231	PF00069	0.582
MOD_Plk_4	231	237	PF00069	0.613
MOD_Plk_4	268	274	PF00069	0.581
MOD_ProDKin_1	189	195	PF00069	0.704
MOD_ProDKin_1	20	26	PF00069	0.711
MOD_ProDKin_1	62	68	PF00069	0.621
MOD_SUMO_rev_2	132	141	PF00179	0.377
MOD_SUMO_rev_2	81	88	PF00179	0.391
TRG_DiLeu_BaEn_2	230	236	PF01217	0.485
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.597
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.511
TRG_DiLeu_BaLyEn_6	168	173	PF01217	0.643
TRG_ENDOCYTIC_2	232	235	PF00928	0.533
TRG_ER_diArg_1	143	146	PF00400	0.495
TRG_NLS_MonoExtC_3	58	63	PF00514	0.726
TRG_NLS_MonoExtN_4	59	64	PF00514	0.737
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.570
TRG_Pf-PMV_PEXEL_1	156	161	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4X3	Leptomonas seymouri	42%	96%
A0A1X0NTI1	Trypanosomatidae	32%	100%
A0A3Q8IAT9	Leishmania donovani	89%	100%
A0A422N4X5	Trypanosoma rangeli	31%	100%
A4HCJ6	Leishmania braziliensis	73%	100%
A4I016	Leishmania infantum	89%	100%
C9ZQ77	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
Q4QBJ0	Leishmania major	88%	100%
V5ARZ4	Trypanosoma cruzi	30%	100%