ZP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVY7_LEIMU

TriTrypDb:

LmxM.22.1550

Length:

616

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVY7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	164	168	PF00656	0.502
CLV_NRD_NRD_1	534	536	PF00675	0.411
CLV_PCSK_SKI1_1	132	136	PF00082	0.434
CLV_PCSK_SKI1_1	333	337	PF00082	0.507
CLV_PCSK_SKI1_1	40	44	PF00082	0.342
CLV_PCSK_SKI1_1	65	69	PF00082	0.496
DEG_APCC_DBOX_1	458	466	PF00400	0.650
DEG_APCC_DBOX_1	546	554	PF00400	0.372
DOC_CYCLIN_yCln2_LP_2	433	439	PF00134	0.554
DOC_MAPK_DCC_7	105	114	PF00069	0.375
DOC_MAPK_FxFP_2	209	212	PF00069	0.300
DOC_MAPK_gen_1	128	137	PF00069	0.540
DOC_MAPK_gen_1	372	380	PF00069	0.503
DOC_MAPK_HePTP_8	102	114	PF00069	0.454
DOC_MAPK_JIP1_4	297	303	PF00069	0.274
DOC_MAPK_MEF2A_6	105	114	PF00069	0.465
DOC_MAPK_MEF2A_6	131	139	PF00069	0.494
DOC_MAPK_MEF2A_6	284	292	PF00069	0.364
DOC_MAPK_MEF2A_6	297	306	PF00069	0.378
DOC_MAPK_MEF2A_6	381	389	PF00069	0.577
DOC_MAPK_NFAT4_5	132	140	PF00069	0.487
DOC_PP1_RVXF_1	266	272	PF00149	0.362
DOC_PP1_RVXF_1	33	40	PF00149	0.378
DOC_PP4_FxxP_1	209	212	PF00568	0.300
DOC_PP4_FxxP_1	88	91	PF00568	0.538
DOC_USP7_MATH_1	11	15	PF00917	0.665
DOC_USP7_MATH_1	24	28	PF00917	0.455
DOC_USP7_MATH_1	245	249	PF00917	0.483
DOC_USP7_MATH_1	311	315	PF00917	0.426
DOC_USP7_MATH_1	412	416	PF00917	0.485
DOC_USP7_MATH_1	455	459	PF00917	0.684
DOC_USP7_MATH_1	5	9	PF00917	0.723
DOC_USP7_MATH_1	522	526	PF00917	0.416
DOC_USP7_MATH_1	91	95	PF00917	0.609
DOC_USP7_UBL2_3	31	35	PF12436	0.392
DOC_WW_Pin1_4	184	189	PF00397	0.619
DOC_WW_Pin1_4	190	195	PF00397	0.554
DOC_WW_Pin1_4	432	437	PF00397	0.752
DOC_WW_Pin1_4	490	495	PF00397	0.446
DOC_WW_Pin1_4	558	563	PF00397	0.446
LIG_14-3-3_CanoR_1	203	208	PF00244	0.298
LIG_14-3-3_CanoR_1	268	277	PF00244	0.348
LIG_14-3-3_CanoR_1	401	409	PF00244	0.507
LIG_14-3-3_CanoR_1	547	555	PF00244	0.418
LIG_14-3-3_CanoR_1	575	584	PF00244	0.481
LIG_Actin_WH2_2	415	430	PF00022	0.439
LIG_BIR_II_1	1	5	PF00653	0.652
LIG_BRCT_BRCA1_1	492	496	PF00533	0.409
LIG_BRCT_BRCA1_1	541	545	PF00533	0.481
LIG_BRCT_BRCA1_1	582	586	PF00533	0.493
LIG_BRCT_BRCA1_1	71	75	PF00533	0.527
LIG_Clathr_ClatBox_1	41	45	PF01394	0.346
LIG_EH_1	453	457	PF12763	0.683
LIG_FHA_1	154	160	PF00498	0.505
LIG_FHA_1	199	205	PF00498	0.417
LIG_FHA_1	272	278	PF00498	0.328
LIG_FHA_1	325	331	PF00498	0.363
LIG_FHA_1	471	477	PF00498	0.380
LIG_FHA_1	487	493	PF00498	0.574
LIG_FHA_1	589	595	PF00498	0.433
LIG_FHA_2	162	168	PF00498	0.393
LIG_FHA_2	191	197	PF00498	0.504
LIG_FHA_2	44	50	PF00498	0.406
LIG_FHA_2	499	505	PF00498	0.383
LIG_LIR_Apic_2	206	212	PF02991	0.304
LIG_LIR_Gen_1	234	244	PF02991	0.428
LIG_LIR_Gen_1	542	553	PF02991	0.432
LIG_LIR_Gen_1	593	603	PF02991	0.419
LIG_LIR_Nem_3	189	195	PF02991	0.453
LIG_LIR_Nem_3	196	202	PF02991	0.328
LIG_LIR_Nem_3	208	214	PF02991	0.386
LIG_LIR_Nem_3	234	239	PF02991	0.447
LIG_LIR_Nem_3	32	37	PF02991	0.385
LIG_LIR_Nem_3	542	548	PF02991	0.444
LIG_LIR_Nem_3	583	589	PF02991	0.381
LIG_LIR_Nem_3	590	595	PF02991	0.401
LIG_Pex14_2	271	275	PF04695	0.296
LIG_SH2_CRK	199	203	PF00017	0.469
LIG_SH2_CRK	351	355	PF00017	0.559
LIG_SH2_CRK	595	599	PF00017	0.474
LIG_SH2_STAT5	152	155	PF00017	0.379
LIG_SH2_STAT5	222	225	PF00017	0.353
LIG_SH2_STAT5	252	255	PF00017	0.349
LIG_SH2_STAT5	270	273	PF00017	0.312
LIG_SH2_STAT5	577	580	PF00017	0.550
LIG_SH2_STAT5	587	590	PF00017	0.384
LIG_SH3_3	27	33	PF00018	0.570
LIG_SH3_3	449	455	PF00018	0.669
LIG_SUMO_SIM_anti_2	299	305	PF11976	0.267
LIG_SUMO_SIM_anti_2	499	504	PF11976	0.410
LIG_SUMO_SIM_par_1	115	123	PF11976	0.377
LIG_SUMO_SIM_par_1	40	46	PF11976	0.467
LIG_SUMO_SIM_par_1	566	572	PF11976	0.453
LIG_TRAF2_1	337	340	PF00917	0.564
LIG_UBA3_1	462	468	PF00899	0.617
LIG_WRC_WIRS_1	211	216	PF05994	0.339
MOD_CK1_1	14	20	PF00069	0.562
MOD_CK1_1	248	254	PF00069	0.474
MOD_CK1_1	314	320	PF00069	0.453
MOD_CK1_1	4	10	PF00069	0.653
MOD_CK1_1	417	423	PF00069	0.544
MOD_CK1_1	431	437	PF00069	0.535
MOD_CK1_1	466	472	PF00069	0.497
MOD_CK1_1	51	57	PF00069	0.577
MOD_CK1_1	518	524	PF00069	0.455
MOD_CK1_1	569	575	PF00069	0.495
MOD_CK1_1	80	86	PF00069	0.606
MOD_CK2_1	190	196	PF00069	0.524
MOD_CK2_1	417	423	PF00069	0.627
MOD_CK2_1	97	103	PF00069	0.581
MOD_Cter_Amidation	129	132	PF01082	0.460
MOD_GlcNHglycan	14	17	PF01048	0.523
MOD_GlcNHglycan	180	183	PF01048	0.423
MOD_GlcNHglycan	247	250	PF01048	0.478
MOD_GlcNHglycan	271	274	PF01048	0.390
MOD_GlcNHglycan	298	301	PF01048	0.391
MOD_GlcNHglycan	3	6	PF01048	0.651
MOD_GlcNHglycan	313	316	PF01048	0.537
MOD_GlcNHglycan	356	359	PF01048	0.627
MOD_GlcNHglycan	414	417	PF01048	0.616
MOD_GlcNHglycan	520	523	PF01048	0.428
MOD_GlcNHglycan	99	102	PF01048	0.474
MOD_GSK3_1	1	8	PF00069	0.668
MOD_GSK3_1	14	21	PF00069	0.538
MOD_GSK3_1	198	205	PF00069	0.337
MOD_GSK3_1	210	217	PF00069	0.383
MOD_GSK3_1	231	238	PF00069	0.458
MOD_GSK3_1	248	255	PF00069	0.443
MOD_GSK3_1	292	299	PF00069	0.425
MOD_GSK3_1	310	317	PF00069	0.537
MOD_GSK3_1	324	331	PF00069	0.337
MOD_GSK3_1	417	424	PF00069	0.610
MOD_GSK3_1	428	435	PF00069	0.732
MOD_GSK3_1	466	473	PF00069	0.437
MOD_GSK3_1	48	55	PF00069	0.434
MOD_GSK3_1	486	493	PF00069	0.328
MOD_GSK3_1	518	525	PF00069	0.418
MOD_N-GLC_1	190	195	PF02516	0.559
MOD_N-GLC_1	231	236	PF02516	0.346
MOD_N-GLC_1	292	297	PF02516	0.431
MOD_N-GLC_1	325	330	PF02516	0.380
MOD_N-GLC_1	360	365	PF02516	0.624
MOD_N-GLC_1	441	446	PF02516	0.610
MOD_N-GLC_1	463	468	PF02516	0.558
MOD_N-GLC_1	548	553	PF02516	0.396
MOD_N-GLC_1	598	603	PF02516	0.537
MOD_NEK2_1	1	6	PF00069	0.615
MOD_NEK2_1	18	23	PF00069	0.452
MOD_NEK2_1	214	219	PF00069	0.428
MOD_NEK2_1	271	276	PF00069	0.306
MOD_NEK2_1	392	397	PF00069	0.604
MOD_NEK2_1	463	468	PF00069	0.567
MOD_NEK2_1	496	501	PF00069	0.341
MOD_NEK2_1	598	603	PF00069	0.417
MOD_NEK2_1	67	72	PF00069	0.408
MOD_NEK2_2	522	527	PF00069	0.444
MOD_PIKK_1	139	145	PF00454	0.554
MOD_PIKK_1	255	261	PF00454	0.468
MOD_PIKK_1	292	298	PF00454	0.421
MOD_PIKK_1	335	341	PF00454	0.426
MOD_PIKK_1	400	406	PF00454	0.695
MOD_PIKK_1	463	469	PF00454	0.544
MOD_PIKK_1	48	54	PF00454	0.529
MOD_PIKK_1	539	545	PF00454	0.534
MOD_PIKK_1	575	581	PF00454	0.508
MOD_PIKK_1	80	86	PF00454	0.407
MOD_PIKK_1	91	97	PF00454	0.503
MOD_PKA_2	104	110	PF00069	0.414
MOD_PKA_2	202	208	PF00069	0.297
MOD_PKA_2	400	406	PF00069	0.539
MOD_PKA_2	447	453	PF00069	0.662
MOD_Plk_1	234	240	PF00069	0.380
MOD_Plk_1	325	331	PF00069	0.357
MOD_Plk_1	441	447	PF00069	0.588
MOD_Plk_1	48	54	PF00069	0.403
MOD_Plk_1	598	604	PF00069	0.516
MOD_Plk_2-3	590	596	PF00069	0.431
MOD_Plk_4	141	147	PF00069	0.457
MOD_Plk_4	210	216	PF00069	0.374
MOD_Plk_4	248	254	PF00069	0.489
MOD_Plk_4	441	447	PF00069	0.593
MOD_Plk_4	498	504	PF00069	0.462
MOD_Plk_4	590	596	PF00069	0.431
MOD_Plk_4	599	605	PF00069	0.390
MOD_ProDKin_1	184	190	PF00069	0.623
MOD_ProDKin_1	432	438	PF00069	0.751
MOD_ProDKin_1	490	496	PF00069	0.435
MOD_ProDKin_1	558	564	PF00069	0.437
MOD_SUMO_rev_2	420	430	PF00179	0.438
TRG_DiLeu_BaEn_1	32	37	PF01217	0.412
TRG_DiLeu_BaLyEn_6	339	344	PF01217	0.460
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.666
TRG_ENDOCYTIC_2	152	155	PF00928	0.415
TRG_ENDOCYTIC_2	199	202	PF00928	0.466
TRG_ENDOCYTIC_2	211	214	PF00928	0.456
TRG_ENDOCYTIC_2	351	354	PF00928	0.554
TRG_ENDOCYTIC_2	595	598	PF00928	0.462
TRG_ER_diArg_1	553	556	PF00400	0.473
TRG_ER_FFAT_2	514	525	PF00635	0.537
TRG_NES_CRM1_1	221	235	PF08389	0.401

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HRF1	Leptomonas seymouri	77%	100%
A0A0S4J7N2	Bodo saltans	29%	74%
A0A1X0NTT4	Trypanosomatidae	51%	100%
A0A3Q8ICD1	Leishmania donovani	97%	100%
A0A3R7K4C8	Trypanosoma rangeli	53%	100%
A4HCJ4	Leishmania braziliensis	87%	100%
A4I014	Leishmania infantum	97%	100%
C9ZQ83	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
Q4QBJ2	Leishmania major	94%	100%
V5BGJ4	Trypanosoma cruzi	52%	100%