Calpain-like cysteine peptidase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9AVY3_LEIMU

TriTrypDb:

LmxM.22.1510

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVY3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVY3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	366	370	PF00656	0.478
CLV_C14_Caspase3-7	419	423	PF00656	0.496
CLV_NRD_NRD_1	222	224	PF00675	0.797
CLV_NRD_NRD_1	4	6	PF00675	0.631
CLV_PCSK_KEX2_1	383	385	PF00082	0.646
CLV_PCSK_KEX2_1	424	426	PF00082	0.479
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.646
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.479
CLV_PCSK_SKI1_1	176	180	PF00082	0.768
CLV_PCSK_SKI1_1	240	244	PF00082	0.519
CLV_PCSK_SKI1_1	392	396	PF00082	0.574
CLV_PCSK_SKI1_1	6	10	PF00082	0.654
DEG_MDM2_SWIB_1	404	411	PF02201	0.616
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DEG_SCF_FBW7_1	114	120	PF00400	0.564
DEG_SPOP_SBC_1	117	121	PF00917	0.562
DOC_CKS1_1	114	119	PF01111	0.602
DOC_CKS1_1	326	331	PF01111	0.662
DOC_CYCLIN_RxL_1	2	11	PF00134	0.636
DOC_MAPK_FxFP_2	343	346	PF00069	0.535
DOC_MAPK_gen_1	424	432	PF00069	0.414
DOC_MAPK_MEF2A_6	425	434	PF00069	0.414
DOC_PP2B_LxvP_1	127	130	PF13499	0.547
DOC_PP2B_LxvP_1	282	285	PF13499	0.349
DOC_PP4_FxxP_1	343	346	PF00568	0.535
DOC_PP4_FxxP_1	376	379	PF00568	0.598
DOC_USP7_MATH_1	159	163	PF00917	0.764
DOC_USP7_MATH_1	196	200	PF00917	0.644
DOC_USP7_MATH_1	268	272	PF00917	0.638
DOC_USP7_MATH_1	319	323	PF00917	0.595
DOC_USP7_MATH_1	59	63	PF00917	0.782
DOC_USP7_MATH_1	93	97	PF00917	0.778
DOC_USP7_UBL2_3	176	180	PF12436	0.791
DOC_USP7_UBL2_3	392	396	PF12436	0.617
DOC_WW_Pin1_4	110	115	PF00397	0.737
DOC_WW_Pin1_4	216	221	PF00397	0.662
DOC_WW_Pin1_4	228	233	PF00397	0.633
DOC_WW_Pin1_4	270	275	PF00397	0.560
DOC_WW_Pin1_4	325	330	PF00397	0.612
DOC_WW_Pin1_4	409	414	PF00397	0.667
DOC_WW_Pin1_4	84	89	PF00397	0.694
LIG_14-3-3_CanoR_1	401	411	PF00244	0.492
LIG_14-3-3_CanoR_1	425	433	PF00244	0.425
LIG_CtBP_PxDLS_1	490	494	PF00389	0.630
LIG_DCNL_PONY_1	1	4	PF03556	0.584
LIG_FHA_1	306	312	PF00498	0.552
LIG_FHA_1	357	363	PF00498	0.521
LIG_FHA_1	405	411	PF00498	0.521
LIG_FHA_1	493	499	PF00498	0.752
LIG_FHA_2	286	292	PF00498	0.673
LIG_FHA_2	417	423	PF00498	0.493
LIG_FHA_2	46	52	PF00498	0.721
LIG_IRF3_LxIS_1	485	492	PF10401	0.610
LIG_LIR_Apic_2	340	346	PF02991	0.528
LIG_LIR_Apic_2	375	379	PF02991	0.597
LIG_LIR_Gen_1	121	131	PF02991	0.553
LIG_LIR_Gen_1	301	306	PF02991	0.486
LIG_LIR_Gen_1	405	415	PF02991	0.583
LIG_LIR_Nem_3	121	127	PF02991	0.563
LIG_LIR_Nem_3	301	305	PF02991	0.485
LIG_LIR_Nem_3	405	411	PF02991	0.543
LIG_PCNA_yPIPBox_3	240	251	PF02747	0.336
LIG_Pex14_1	68	72	PF04695	0.812
LIG_Pex14_2	345	349	PF04695	0.664
LIG_Pex14_2	404	408	PF04695	0.506
LIG_SH2_CRK	279	283	PF00017	0.547
LIG_SH2_SRC	140	143	PF00017	0.825
LIG_SH2_STAP1	279	283	PF00017	0.547
LIG_SH2_STAT5	344	347	PF00017	0.625
LIG_SH2_STAT5	356	359	PF00017	0.452
LIG_SH2_STAT5	403	406	PF00017	0.559
LIG_SH2_STAT5	414	417	PF00017	0.571
LIG_SH3_2	77	82	PF14604	0.692
LIG_SH3_3	104	110	PF00018	0.824
LIG_SH3_3	111	117	PF00018	0.807
LIG_SH3_3	146	152	PF00018	0.778
LIG_SH3_3	407	413	PF00018	0.642
LIG_SH3_3	446	452	PF00018	0.689
LIG_SH3_3	49	55	PF00018	0.764
LIG_SH3_3	74	80	PF00018	0.716
LIG_SH3_3	85	91	PF00018	0.567
LIG_SUMO_SIM_anti_2	445	451	PF11976	0.589
LIG_SUMO_SIM_par_1	231	237	PF11976	0.468
LIG_SUMO_SIM_par_1	489	495	PF11976	0.626
LIG_TRAF2_1	73	76	PF00917	0.814
LIG_TRAF2_1	83	86	PF00917	0.636
LIG_UBA3_1	1	6	PF00899	0.604
MOD_CDK_SPxK_1	325	331	PF00069	0.669
MOD_CDK_SPxxK_3	216	223	PF00069	0.519
MOD_CK1_1	113	119	PF00069	0.856
MOD_CK1_1	162	168	PF00069	0.769
MOD_CK1_1	198	204	PF00069	0.733
MOD_CK1_1	228	234	PF00069	0.616
MOD_CK1_1	292	298	PF00069	0.637
MOD_CK1_1	339	345	PF00069	0.487
MOD_CK1_1	368	374	PF00069	0.520
MOD_CK1_1	423	429	PF00069	0.624
MOD_CK1_1	492	498	PF00069	0.761
MOD_CK2_1	196	202	PF00069	0.650
MOD_CK2_1	231	237	PF00069	0.468
MOD_CK2_1	261	267	PF00069	0.684
MOD_CK2_1	285	291	PF00069	0.663
MOD_CK2_1	84	90	PF00069	0.764
MOD_CK2_1	93	99	PF00069	0.765
MOD_GlcNHglycan	144	147	PF01048	0.778
MOD_GlcNHglycan	171	174	PF01048	0.600
MOD_GlcNHglycan	216	219	PF01048	0.703
MOD_GlcNHglycan	227	230	PF01048	0.652
MOD_GlcNHglycan	269	273	PF01048	0.673
MOD_GlcNHglycan	291	294	PF01048	0.679
MOD_GlcNHglycan	319	322	PF01048	0.534
MOD_GlcNHglycan	350	353	PF01048	0.562
MOD_GlcNHglycan	426	429	PF01048	0.701
MOD_GSK3_1	113	120	PF00069	0.706
MOD_GSK3_1	165	172	PF00069	0.832
MOD_GSK3_1	183	190	PF00069	0.609
MOD_GSK3_1	198	205	PF00069	0.707
MOD_GSK3_1	246	253	PF00069	0.516
MOD_GSK3_1	285	292	PF00069	0.608
MOD_GSK3_1	306	313	PF00069	0.516
MOD_GSK3_1	332	339	PF00069	0.494
MOD_GSK3_1	344	351	PF00069	0.560
MOD_GSK3_1	416	423	PF00069	0.710
MOD_GSK3_1	60	67	PF00069	0.776
MOD_GSK3_1	89	96	PF00069	0.577
MOD_N-GLC_1	125	130	PF02516	0.698
MOD_N-GLC_1	473	478	PF02516	0.618
MOD_N-GLC_2	475	477	PF02516	0.695
MOD_NEK2_1	300	305	PF00069	0.490
MOD_NEK2_1	317	322	PF00069	0.567
MOD_NEK2_1	45	50	PF00069	0.575
MOD_PKA_1	424	430	PF00069	0.437
MOD_PKA_2	225	231	PF00069	0.617
MOD_PKA_2	424	430	PF00069	0.465
MOD_Plk_1	162	168	PF00069	0.735
MOD_Plk_1	300	306	PF00069	0.489
MOD_Plk_1	368	374	PF00069	0.520
MOD_Plk_4	14	20	PF00069	0.690
MOD_Plk_4	183	189	PF00069	0.809
MOD_Plk_4	261	267	PF00069	0.684
MOD_Plk_4	310	316	PF00069	0.633
MOD_Plk_4	339	345	PF00069	0.624
MOD_Plk_4	64	70	PF00069	0.690
MOD_ProDKin_1	110	116	PF00069	0.740
MOD_ProDKin_1	216	222	PF00069	0.661
MOD_ProDKin_1	228	234	PF00069	0.626
MOD_ProDKin_1	270	276	PF00069	0.551
MOD_ProDKin_1	325	331	PF00069	0.609
MOD_ProDKin_1	409	415	PF00069	0.673
MOD_ProDKin_1	84	90	PF00069	0.695
MOD_SUMO_rev_2	375	385	PF00179	0.627
TRG_ENDOCYTIC_2	279	282	PF00928	0.557
TRG_ENDOCYTIC_2	29	32	PF00928	0.686
TRG_ENDOCYTIC_2	323	326	PF00928	0.688
TRG_ENDOCYTIC_2	463	466	PF00928	0.689
TRG_NES_CRM1_1	246	259	PF08389	0.337
TRG_NLS_MonoCore_2	222	227	PF00514	0.647
TRG_NLS_MonoExtN_4	220	227	PF00514	0.645

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC61	Leptomonas seymouri	41%	91%
A0A3Q8IBJ7	Leishmania donovani	88%	100%
A4I010	Leishmania infantum	88%	100%
Q4QBJ6	Leishmania major	89%	100%