Putative Serine-threonin protein phosphatase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Serine-threonin protein phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9AVY1_LEIMU

TriTrypDb:

LmxM.22.1490

Length:

362

Annotations

LeishMANIAdb annotations

A metalloenzyme with the catalytic domain facing outwards. Related to plant Shewanella-like protein phosphatases. Kinetoplastids have multiple copies of these genes but probably from a very ancient gene duplication.. The cluster might merge two separate, very distantly related groups.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 16, no: 11
NetGPI	no	yes: 0, no: 27

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

E9AVY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	28
GO:0016787	hydrolase activity	2	28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	237	239	PF00675	0.292
CLV_NRD_NRD_1	31	33	PF00675	0.547
CLV_PCSK_SKI1_1	216	220	PF00082	0.228
CLV_PCSK_SKI1_1	253	257	PF00082	0.272
DEG_APCC_DBOX_1	252	260	PF00400	0.507
DEG_APCC_DBOX_1	92	100	PF00400	0.261
DEG_Nend_UBRbox_1	1	4	PF02207	0.608
DOC_MAPK_MEF2A_6	298	306	PF00069	0.415
DOC_USP7_MATH_1	270	274	PF00917	0.528
DOC_WW_Pin1_4	82	87	PF00397	0.135
LIG_14-3-3_CanoR_1	225	229	PF00244	0.555
LIG_14-3-3_CanoR_1	79	85	PF00244	0.331
LIG_14-3-3_CanoR_1	93	97	PF00244	0.198
LIG_Actin_WH2_2	204	222	PF00022	0.451
LIG_BRCT_BRCA1_1	317	321	PF00533	0.588
LIG_FHA_1	260	266	PF00498	0.468
LIG_FHA_1	308	314	PF00498	0.478
LIG_FHA_1	92	98	PF00498	0.241
LIG_FHA_2	267	273	PF00498	0.503
LIG_FHA_2	334	340	PF00498	0.398
LIG_LIR_Gen_1	18	28	PF02991	0.424
LIG_LIR_Gen_1	357	362	PF02991	0.545
LIG_LIR_Gen_1	51	60	PF02991	0.309
LIG_LIR_Nem_3	172	178	PF02991	0.231
LIG_LIR_Nem_3	18	23	PF02991	0.474
LIG_LIR_Nem_3	303	309	PF02991	0.528
LIG_LIR_Nem_3	357	362	PF02991	0.496
LIG_LIR_Nem_3	51	56	PF02991	0.257
LIG_PDZ_Class_3	357	362	PF00595	0.494
LIG_SH2_CRK	12	16	PF00017	0.597
LIG_SH2_CRK	148	152	PF00017	0.285
LIG_SH2_CRK	296	300	PF00017	0.453
LIG_SH2_GRB2like	150	153	PF00017	0.318
LIG_SH2_NCK_1	296	300	PF00017	0.409
LIG_SH2_STAP1	296	300	PF00017	0.584
LIG_SH2_STAP1	309	313	PF00017	0.600
LIG_SH2_STAT5	150	153	PF00017	0.230
LIG_SH2_STAT5	178	181	PF00017	0.222
LIG_SH2_STAT5	20	23	PF00017	0.517
LIG_SH2_STAT5	309	312	PF00017	0.481
LIG_SUMO_SIM_anti_2	130	137	PF11976	0.243
LIG_SUMO_SIM_par_1	20	25	PF11976	0.407
LIG_SUMO_SIM_par_1	283	288	PF11976	0.452
LIG_SUMO_SIM_par_1	39	45	PF11976	0.244
LIG_TRAF2_1	118	121	PF00917	0.318
LIG_TRAF2_1	269	272	PF00917	0.586
LIG_TRAF2_1	352	355	PF00917	0.521
LIG_WRC_WIRS_1	16	21	PF05994	0.545
LIG_WW_3	76	80	PF00397	0.185
MOD_CK1_1	307	313	PF00069	0.586
MOD_CK2_1	115	121	PF00069	0.285
MOD_CK2_1	125	131	PF00069	0.285
MOD_CK2_1	266	272	PF00069	0.557
MOD_CK2_1	333	339	PF00069	0.387
MOD_CK2_1	349	355	PF00069	0.498
MOD_GlcNHglycan	125	128	PF01048	0.517
MOD_GlcNHglycan	231	234	PF01048	0.270
MOD_GlcNHglycan	245	248	PF01048	0.324
MOD_GlcNHglycan	272	275	PF01048	0.360
MOD_GlcNHglycan	317	320	PF01048	0.372
MOD_GlcNHglycan	330	333	PF01048	0.406
MOD_GlcNHglycan	70	73	PF01048	0.545
MOD_GSK3_1	224	231	PF00069	0.436
MOD_GSK3_1	243	250	PF00069	0.512
MOD_GSK3_1	266	273	PF00069	0.412
MOD_GSK3_1	307	314	PF00069	0.591
MOD_GSK3_1	80	87	PF00069	0.274
MOD_N-GLC_1	259	264	PF02516	0.291
MOD_N-GLC_1	311	316	PF02516	0.389
MOD_N-GLC_1	87	92	PF02516	0.482
MOD_NEK2_1	15	20	PF00069	0.509
MOD_NEK2_1	169	174	PF00069	0.264
MOD_NEK2_1	22	27	PF00069	0.503
MOD_NEK2_1	224	229	PF00069	0.490
MOD_NEK2_1	259	264	PF00069	0.447
MOD_NEK2_1	304	309	PF00069	0.507
MOD_NEK2_1	333	338	PF00069	0.317
MOD_NEK2_1	344	349	PF00069	0.391
MOD_PIKK_1	125	131	PF00454	0.311
MOD_PKA_2	169	175	PF00069	0.196
MOD_PKA_2	224	230	PF00069	0.498
MOD_PKA_2	92	98	PF00069	0.239
MOD_Plk_1	199	205	PF00069	0.372
MOD_Plk_1	259	265	PF00069	0.483
MOD_Plk_1	63	69	PF00069	0.286
MOD_Plk_4	15	21	PF00069	0.495
MOD_Plk_4	224	230	PF00069	0.540
MOD_Plk_4	317	323	PF00069	0.636
MOD_Plk_4	92	98	PF00069	0.205
MOD_ProDKin_1	82	88	PF00069	0.135
MOD_SUMO_rev_2	25	35	PF00179	0.349
TRG_DiLeu_BaEn_1	131	136	PF01217	0.201
TRG_DiLeu_BaEn_2	189	195	PF01217	0.387
TRG_DiLeu_BaEn_4	339	345	PF01217	0.334
TRG_ENDOCYTIC_2	12	15	PF00928	0.579
TRG_ENDOCYTIC_2	148	151	PF00928	0.261
TRG_ENDOCYTIC_2	156	159	PF00928	0.276
TRG_ENDOCYTIC_2	20	23	PF00928	0.544
TRG_ENDOCYTIC_2	296	299	PF00928	0.500
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	324	328	PF00026	0.382

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V2	Leptomonas seymouri	29%	97%
A0A0N1P9R1	Leptomonas seymouri	55%	100%
A0A0S4JBT9	Bodo saltans	41%	93%
A0A0S4JMN0	Bodo saltans	33%	89%
A0A0S4KJG1	Bodo saltans	28%	97%
A0A1X0NU01	Trypanosomatidae	43%	97%
A0A1X0NZX7	Trypanosomatidae	31%	81%
A0A1X0P2G6	Trypanosomatidae	29%	98%
A0A3Q8IBB4	Leishmania donovani	92%	100%
A0A3Q8IIK0	Leishmania donovani	28%	96%
A0A3R7NTC0	Trypanosoma rangeli	29%	98%
A0A3S5IRW3	Trypanosoma rangeli	29%	88%
A0A3S7X3U9	Leishmania donovani	27%	98%
A4HCJ2	Leishmania braziliensis	79%	100%
A4HH45	Leishmania braziliensis	28%	100%
A4HIR7	Leishmania braziliensis	29%	100%
A4I008	Leishmania infantum	92%	100%
A4I498	Leishmania infantum	28%	96%
A4I612	Leishmania infantum	27%	98%
C9ZQ86	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	97%
C9ZRD7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	82%
E9ADP5	Leishmania major	29%	100%
E9AM35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B1A3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	98%
O74480	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q4Q6W1	Leishmania major	27%	100%
Q4QBJ8	Leishmania major	91%	100%
Q8L774	Arabidopsis thaliana	25%	93%
Q944L7	Arabidopsis thaliana	26%	93%
V5ARZ9	Trypanosoma cruzi	47%	96%
V5BPY7	Trypanosoma cruzi	32%	82%
V5BX32	Trypanosoma cruzi	29%	99%