Mitochondrial glycoprotein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Mitochondrial glycoprotein, putative

Species:

Leishmania mexicana

UniProt:

E9AVY0_LEIMU

TriTrypDb:

LmxM.22.1480

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 18
NetGPI	no	yes: 0, no: 19

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	20
GO:0031974	membrane-enclosed lumen	2	20
GO:0043233	organelle lumen	3	20
GO:0070013	intracellular organelle lumen	4	20
GO:0110165	cellular anatomical entity	1	20

Expansion

Sequence features

E9AVY0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVY0

PDB structure(s): 1yqf_A , 1yqf_B , 1yqf_C , 1yqf_D , 1yqf_E , 1yqf_F

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.572
CLV_NRD_NRD_1	123	125	PF00675	0.343
CLV_NRD_NRD_1	186	188	PF00675	0.265
CLV_NRD_NRD_1	244	246	PF00675	0.358
CLV_NRD_NRD_1	30	32	PF00675	0.553
CLV_PCSK_FUR_1	124	128	PF00082	0.249
CLV_PCSK_KEX2_1	126	128	PF00082	0.369
CLV_PCSK_KEX2_1	186	188	PF00082	0.326
CLV_PCSK_KEX2_1	30	32	PF00082	0.552
CLV_PCSK_PC1ET2_1	126	128	PF00082	0.249
CLV_PCSK_PC7_1	26	32	PF00082	0.643
CLV_PCSK_SKI1_1	49	53	PF00082	0.488
DEG_APCC_DBOX_1	5	13	PF00400	0.427
DOC_PP4_FxxP_1	51	54	PF00568	0.481
DOC_USP7_MATH_1	157	161	PF00917	0.514
DOC_USP7_MATH_1	24	28	PF00917	0.667
DOC_USP7_MATH_1	67	71	PF00917	0.509
LIG_14-3-3_CterR_2	245	249	PF00244	0.558
LIG_BRCT_BRCA1_1	69	73	PF00533	0.424
LIG_eIF4E_1	116	122	PF01652	0.487
LIG_FHA_1	18	24	PF00498	0.518
LIG_FHA_2	136	142	PF00498	0.481
LIG_FHA_2	37	43	PF00498	0.467
LIG_FHA_2	91	97	PF00498	0.498
LIG_LIR_Apic_2	190	195	PF02991	0.480
LIG_LIR_Apic_2	50	54	PF02991	0.484
LIG_LIR_Gen_1	113	123	PF02991	0.467
LIG_LIR_Gen_1	70	81	PF02991	0.395
LIG_LIR_Nem_3	113	119	PF02991	0.495
LIG_LIR_Nem_3	70	76	PF02991	0.533
LIG_SH2_CRK	13	17	PF00017	0.547
LIG_SH2_CRK	192	196	PF00017	0.499
LIG_SH2_GRB2like	116	119	PF00017	0.558
LIG_SH2_GRB2like	237	240	PF00017	0.487
LIG_SH2_STAT5	116	119	PF00017	0.483
LIG_SH2_STAT5	211	214	PF00017	0.455
LIG_SH2_STAT5	237	240	PF00017	0.475
LIG_SH3_3	50	56	PF00018	0.468
LIG_SUMO_SIM_anti_2	141	147	PF11976	0.470
LIG_SUMO_SIM_par_1	90	97	PF11976	0.421
LIG_TRAF2_1	153	156	PF00917	0.558
LIG_WW_3	52	56	PF00397	0.385
MOD_CK1_1	136	142	PF00069	0.435
MOD_CK2_1	16	22	PF00069	0.519
MOD_CK2_1	36	42	PF00069	0.462
MOD_CK2_1	90	96	PF00069	0.454
MOD_GlcNHglycan	159	162	PF01048	0.308
MOD_GlcNHglycan	170	173	PF01048	0.309
MOD_GlcNHglycan	180	183	PF01048	0.396
MOD_GlcNHglycan	2	5	PF01048	0.624
MOD_GlcNHglycan	67	70	PF01048	0.558
MOD_GSK3_1	147	154	PF00069	0.574
MOD_GSK3_1	90	97	PF00069	0.530
MOD_LATS_1	185	191	PF00433	0.366
MOD_NEK2_1	133	138	PF00069	0.482
MOD_NEK2_1	16	21	PF00069	0.464
MOD_NEK2_1	177	182	PF00069	0.559
MOD_NEK2_1	94	99	PF00069	0.587
MOD_NEK2_2	36	41	PF00069	0.564
MOD_Plk_1	133	139	PF00069	0.526
MOD_Plk_2-3	202	208	PF00069	0.487
TRG_DiLeu_BaEn_4	112	118	PF01217	0.441
TRG_DiLeu_BaLyEn_6	239	244	PF01217	0.487
TRG_ENDOCYTIC_2	116	119	PF00928	0.482
TRG_ENDOCYTIC_2	13	16	PF00928	0.418
TRG_ER_diArg_1	30	33	PF00400	0.546
TRG_NES_CRM1_1	141	155	PF08389	0.528
TRG_NLS_MonoCore_2	123	128	PF00514	0.470
TRG_NLS_MonoExtC_3	124	129	PF00514	0.470
TRG_NLS_MonoExtN_4	124	129	PF00514	0.470
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P990	Leptomonas seymouri	27%	100%
A0A0N1HS24	Leptomonas seymouri	71%	98%
A0A0S4ITN8	Bodo saltans	31%	100%
A0A1X0NTH7	Trypanosomatidae	66%	95%
A0A1X0P207	Trypanosomatidae	30%	100%
A0A3Q8IBW7	Leishmania donovani	28%	100%
A0A3Q8IFM4	Leishmania donovani	92%	98%
A4HCI6	Leishmania braziliensis	81%	100%
A4HI52	Leishmania braziliensis	28%	89%
A4I007	Leishmania infantum	92%	98%
A4I5C8	Leishmania infantum	28%	100%
C9ZQR0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZSQ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	96%
C9ZU92	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	67%
E9B0M6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q7K6	Leishmania major	28%	91%
Q4QBJ9	Leishmania major	89%	100%
V5BDB3	Trypanosoma cruzi	65%	95%