I/6 autoantigen-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

i/6 autoantigen-like protein

Species:

Leishmania mexicana

UniProt:

E9AVX8_LEIMU

TriTrypDb:

LmxM.22.1460

Length:

204

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVX8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVX8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	10
GO:0005509	calcium ion binding	5	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.294
CLV_C14_Caspase3-7	121	125	PF00656	0.278
CLV_C14_Caspase3-7	4	8	PF00656	0.430
CLV_NRD_NRD_1	12	14	PF00675	0.371
CLV_NRD_NRD_1	152	154	PF00675	0.420
CLV_NRD_NRD_1	162	164	PF00675	0.461
CLV_NRD_NRD_1	94	96	PF00675	0.484
CLV_PCSK_KEX2_1	11	13	PF00082	0.443
CLV_PCSK_KEX2_1	152	154	PF00082	0.465
CLV_PCSK_KEX2_1	161	163	PF00082	0.498
CLV_PCSK_KEX2_1	94	96	PF00082	0.484
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.443
CLV_PCSK_PC1ET2_1	161	163	PF00082	0.593
CLV_PCSK_SKI1_1	108	112	PF00082	0.344
CLV_PCSK_SKI1_1	12	16	PF00082	0.420
CLV_PCSK_SKI1_1	6	10	PF00082	0.449
DEG_APCC_DBOX_1	151	159	PF00400	0.392
DEG_APCC_DBOX_1	93	101	PF00400	0.399
DEG_Nend_Nbox_1	1	3	PF02207	0.504
DOC_MAPK_gen_1	11	22	PF00069	0.325
DOC_USP7_UBL2_3	103	107	PF12436	0.454
DOC_USP7_UBL2_3	185	189	PF12436	0.752
DOC_USP7_UBL2_3	193	197	PF12436	0.810
DOC_WW_Pin1_4	184	189	PF00397	0.612
DOC_WW_Pin1_4	38	43	PF00397	0.552
LIG_14-3-3_CanoR_1	25	31	PF00244	0.492
LIG_14-3-3_CanoR_1	70	74	PF00244	0.463
LIG_14-3-3_CanoR_1	94	98	PF00244	0.317
LIG_FHA_2	13	19	PF00498	0.518
LIG_FHA_2	130	136	PF00498	0.492
LIG_FHA_2	41	47	PF00498	0.459
LIG_FHA_2	56	62	PF00498	0.324
LIG_LIR_Gen_1	117	125	PF02991	0.321
LIG_LIR_Gen_1	61	68	PF02991	0.456
LIG_LIR_Nem_3	117	123	PF02991	0.321
LIG_LIR_Nem_3	61	65	PF02991	0.559
LIG_SH2_STAT3	53	56	PF00017	0.548
LIG_SH2_STAT5	37	40	PF00017	0.521
LIG_SH3_3	82	88	PF00018	0.441
LIG_SH3_4	189	196	PF00018	0.511
LIG_SUMO_SIM_anti_2	17	24	PF11976	0.515
LIG_TRAF2_1	112	115	PF00917	0.321
LIG_TRAF2_1	96	99	PF00917	0.321
LIG_UBA3_1	119	128	PF00899	0.344
MOD_CDK_SPK_2	184	189	PF00069	0.519
MOD_CK1_1	49	55	PF00069	0.522
MOD_CK1_1	72	78	PF00069	0.470
MOD_CK2_1	109	115	PF00069	0.380
MOD_CK2_1	180	186	PF00069	0.505
MOD_CK2_1	40	46	PF00069	0.465
MOD_CK2_1	55	61	PF00069	0.381
MOD_CK2_1	93	99	PF00069	0.327
MOD_GlcNHglycan	200	203	PF01048	0.545
MOD_GlcNHglycan	74	77	PF01048	0.568
MOD_GSK3_1	180	187	PF00069	0.547
MOD_GSK3_1	68	75	PF00069	0.554
MOD_N-GLC_1	68	73	PF02516	0.561
MOD_NEK2_1	1	6	PF00069	0.447
MOD_PKA_1	12	18	PF00069	0.335
MOD_PKA_1	198	204	PF00069	0.515
MOD_PKA_2	12	18	PF00069	0.425
MOD_PKA_2	69	75	PF00069	0.469
MOD_PKA_2	93	99	PF00069	0.367
MOD_Plk_1	68	74	PF00069	0.514
MOD_Plk_2-3	109	115	PF00069	0.341
MOD_Plk_4	69	75	PF00069	0.569
MOD_ProDKin_1	184	190	PF00069	0.609
MOD_ProDKin_1	38	44	PF00069	0.546
MOD_SUMO_rev_2	121	130	PF00179	0.525
MOD_SUMO_rev_2	174	182	PF00179	0.589
TRG_ER_diArg_1	12	14	PF00400	0.321
TRG_NLS_Bipartite_1	179	201	PF00514	0.502
TRG_NLS_MonoCore_2	195	200	PF00514	0.495
TRG_NLS_MonoExtN_4	193	200	PF00514	0.704
TRG_Pf-PMV_PEXEL_1	138	143	PF00026	0.493
TRG_Pf-PMV_PEXEL_1	95	99	PF00026	0.342

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2S4	Leptomonas seymouri	65%	91%
A0A1X0NTK1	Trypanosomatidae	43%	92%
A0A3Q8IAT1	Leishmania donovani	84%	99%
A0A422N4A4	Trypanosoma rangeli	40%	100%
A4HCI3	Leishmania braziliensis	56%	99%
A4I005	Leishmania infantum	84%	99%
C9ZSQ6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	84%
C9ZSQ7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q26768	Trypanosoma brucei brucei	37%	84%
Q4QBK1	Leishmania major	80%	100%