RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVX6_LEIMU

TriTrypDb:

LmxM.22.1440

Length:

506

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVX6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	439	443	PF00656	0.552
CLV_NRD_NRD_1	281	283	PF00675	0.565
CLV_NRD_NRD_1	310	312	PF00675	0.702
CLV_PCSK_KEX2_1	281	283	PF00082	0.579
CLV_PCSK_KEX2_1	310	312	PF00082	0.666
CLV_PCSK_KEX2_1	333	335	PF00082	0.677
CLV_PCSK_KEX2_1	458	460	PF00082	0.621
CLV_PCSK_KEX2_1	50	52	PF00082	0.542
CLV_PCSK_KEX2_1	7	9	PF00082	0.464
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.677
CLV_PCSK_PC1ET2_1	458	460	PF00082	0.621
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.584
CLV_PCSK_PC1ET2_1	7	9	PF00082	0.503
CLV_PCSK_SKI1_1	274	278	PF00082	0.613
CLV_PCSK_SKI1_1	333	337	PF00082	0.617
CLV_PCSK_SKI1_1	341	345	PF00082	0.520
CLV_PCSK_SKI1_1	4	8	PF00082	0.617
CLV_PCSK_SKI1_1	50	54	PF00082	0.566
DEG_APCC_DBOX_1	273	281	PF00400	0.464
DOC_CKS1_1	388	393	PF01111	0.454
DOC_PP1_RVXF_1	339	345	PF00149	0.360
DOC_PP2B_LxvP_1	157	160	PF13499	0.521
DOC_SPAK_OSR1_1	493	497	PF12202	0.370
DOC_USP7_MATH_1	160	164	PF00917	0.504
DOC_USP7_MATH_1	247	251	PF00917	0.305
DOC_USP7_MATH_1	303	307	PF00917	0.465
DOC_USP7_MATH_1	363	367	PF00917	0.445
DOC_USP7_MATH_1	404	408	PF00917	0.551
DOC_USP7_MATH_1	435	439	PF00917	0.610
DOC_USP7_MATH_1	45	49	PF00917	0.743
DOC_WW_Pin1_4	239	244	PF00397	0.512
DOC_WW_Pin1_4	387	392	PF00397	0.411
DOC_WW_Pin1_4	447	452	PF00397	0.533
LIG_14-3-3_CanoR_1	152	160	PF00244	0.548
LIG_14-3-3_CanoR_1	203	207	PF00244	0.376
LIG_14-3-3_CanoR_1	8	14	PF00244	0.669
LIG_Actin_RPEL_3	486	505	PF02755	0.486
LIG_BRCT_BRCA1_1	135	139	PF00533	0.618
LIG_BRCT_BRCA1_1	391	395	PF00533	0.553
LIG_BRCT_BRCA1_1	432	436	PF00533	0.396
LIG_BRCT_BRCA1_1	87	91	PF00533	0.603
LIG_Clathr_ClatBox_1	304	308	PF01394	0.422
LIG_deltaCOP1_diTrp_1	171	180	PF00928	0.480
LIG_EVH1_2	453	457	PF00568	0.453
LIG_FHA_1	281	287	PF00498	0.444
LIG_FHA_1	299	305	PF00498	0.264
LIG_FHA_1	383	389	PF00498	0.388
LIG_FHA_1	68	74	PF00498	0.478
LIG_FHA_1	80	86	PF00498	0.485
LIG_FHA_2	10	16	PF00498	0.770
LIG_FHA_2	323	329	PF00498	0.385
LIG_FHA_2	466	472	PF00498	0.618
LIG_IBAR_NPY_1	500	502	PF08397	0.551
LIG_LIR_Apic_2	242	247	PF02991	0.490
LIG_LIR_Apic_2	351	357	PF02991	0.365
LIG_LIR_Gen_1	171	182	PF02991	0.476
LIG_LIR_Gen_1	193	202	PF02991	0.288
LIG_LIR_Gen_1	490	499	PF02991	0.457
LIG_LIR_Nem_3	171	177	PF02991	0.461
LIG_LIR_Nem_3	193	198	PF02991	0.299
LIG_LIR_Nem_3	470	475	PF02991	0.605
LIG_LIR_Nem_3	480	484	PF02991	0.472
LIG_LIR_Nem_3	490	494	PF02991	0.376
LIG_PCNA_yPIPBox_3	329	341	PF02747	0.263
LIG_PDZ_Class_2	501	506	PF00595	0.418
LIG_Pex14_1	174	178	PF04695	0.465
LIG_PTB_Apo_2	291	298	PF02174	0.362
LIG_SH2_CRK	484	488	PF00017	0.582
LIG_SH2_CRK	502	506	PF00017	0.364
LIG_SH2_GRB2like	28	31	PF00017	0.601
LIG_SH2_NCK_1	108	112	PF00017	0.596
LIG_SH2_NCK_1	28	32	PF00017	0.600
LIG_SH2_NCK_1	432	436	PF00017	0.548
LIG_SH2_NCK_1	475	479	PF00017	0.500
LIG_SH2_NCK_1	484	488	PF00017	0.463
LIG_SH2_STAP1	432	436	PF00017	0.396
LIG_SH2_STAP1	502	506	PF00017	0.526
LIG_SH2_STAT5	472	475	PF00017	0.461
LIG_SH2_STAT5	502	505	PF00017	0.503
LIG_SH3_3	385	391	PF00018	0.385
LIG_SH3_3	394	400	PF00018	0.495
LIG_SH3_3	448	454	PF00018	0.526
LIG_SUMO_SIM_anti_2	56	61	PF11976	0.440
LIG_SUMO_SIM_par_1	303	308	PF11976	0.423
LIG_SUMO_SIM_par_1	384	390	PF11976	0.384
LIG_TRAF2_1	415	418	PF00917	0.543
LIG_TRFH_1	497	501	PF08558	0.550
LIG_WRC_WIRS_1	177	182	PF05994	0.414
MOD_CK1_1	101	107	PF00069	0.590
MOD_CK1_1	109	115	PF00069	0.560
MOD_CK1_1	127	133	PF00069	0.398
MOD_CK1_1	155	161	PF00069	0.579
MOD_CK1_1	23	29	PF00069	0.803
MOD_CK1_1	366	372	PF00069	0.459
MOD_CK1_1	438	444	PF00069	0.608
MOD_CK1_1	78	84	PF00069	0.536
MOD_CK2_1	165	171	PF00069	0.534
MOD_CK2_1	26	32	PF00069	0.775
MOD_CK2_1	465	471	PF00069	0.503
MOD_CK2_1	9	15	PF00069	0.770
MOD_GlcNHglycan	109	112	PF01048	0.775
MOD_GlcNHglycan	270	273	PF01048	0.654
MOD_GlcNHglycan	373	376	PF01048	0.587
MOD_GlcNHglycan	391	394	PF01048	0.750
MOD_GlcNHglycan	406	409	PF01048	0.696
MOD_GlcNHglycan	425	428	PF01048	0.787
MOD_GlcNHglycan	432	435	PF01048	0.772
MOD_GlcNHglycan	9	12	PF01048	0.462
MOD_GSK3_1	106	113	PF00069	0.534
MOD_GSK3_1	120	127	PF00069	0.485
MOD_GSK3_1	20	27	PF00069	0.717
MOD_GSK3_1	436	443	PF00069	0.555
MOD_GSK3_1	75	82	PF00069	0.532
MOD_GSK3_1	98	105	PF00069	0.557
MOD_N-GLC_1	297	302	PF02516	0.643
MOD_N-GLC_1	98	103	PF02516	0.811
MOD_NEK2_1	103	108	PF00069	0.400
MOD_NEK2_1	197	202	PF00069	0.403
MOD_NEK2_1	280	285	PF00069	0.408
MOD_NEK2_1	297	302	PF00069	0.292
MOD_NEK2_1	335	340	PF00069	0.384
MOD_NEK2_1	343	348	PF00069	0.392
MOD_NEK2_1	430	435	PF00069	0.584
MOD_NEK2_1	436	441	PF00069	0.513
MOD_NEK2_2	2	7	PF00069	0.755
MOD_NEK2_2	247	252	PF00069	0.281
MOD_PIKK_1	152	158	PF00454	0.561
MOD_PIKK_1	312	318	PF00454	0.514
MOD_PKA_1	310	316	PF00069	0.516
MOD_PKA_1	7	13	PF00069	0.621
MOD_PKA_2	202	208	PF00069	0.423
MOD_PKA_2	280	286	PF00069	0.446
MOD_PKA_2	310	316	PF00069	0.460
MOD_PKA_2	382	388	PF00069	0.440
MOD_PKA_2	46	52	PF00069	0.740
MOD_PKA_2	7	13	PF00069	0.620
MOD_PKA_2	93	99	PF00069	0.610
MOD_PKB_1	423	431	PF00069	0.485
MOD_Plk_1	366	372	PF00069	0.502
MOD_Plk_1	441	447	PF00069	0.556
MOD_Plk_1	55	61	PF00069	0.607
MOD_Plk_1	98	104	PF00069	0.394
MOD_Plk_4	103	109	PF00069	0.605
MOD_Plk_4	247	253	PF00069	0.336
MOD_Plk_4	382	388	PF00069	0.376
MOD_Plk_4	477	483	PF00069	0.552
MOD_Plk_4	500	506	PF00069	0.567
MOD_Plk_4	75	81	PF00069	0.528
MOD_Plk_4	9	15	PF00069	0.819
MOD_ProDKin_1	239	245	PF00069	0.510
MOD_ProDKin_1	387	393	PF00069	0.419
MOD_ProDKin_1	447	453	PF00069	0.533
MOD_SUMO_for_1	457	460	PF00179	0.421
MOD_SUMO_for_1	97	100	PF00179	0.605
TRG_DiLeu_BaEn_1	351	356	PF01217	0.397
TRG_DiLeu_BaEn_1	56	61	PF01217	0.430
TRG_ENDOCYTIC_2	502	505	PF00928	0.573
TRG_ER_diArg_1	280	282	PF00400	0.358
TRG_ER_diArg_1	91	94	PF00400	0.619
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.559

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NV61	Trypanosomatidae	39%	100%
A0A3Q8ICC1	Leishmania donovani	91%	100%
A4HCI4	Leishmania braziliensis	82%	100%
A4I003	Leishmania infantum	91%	100%
Q4QBK3	Leishmania major	89%	100%
V5ANV0	Trypanosoma cruzi	36%	100%