Putative aquaporin

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Putative aquaporin

Gene product:

aquaporin, putative

Species:

Leishmania mexicana

UniProt:

E9AVX4_LEIMU

TriTrypDb:

LmxM.22.1420

Length:

294

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: antonio.jimenez@uah.es
Publication title: A functional BH3 domain in an aquaporin from Leishmania infantum
Publication 1st author(s): Genes
Publication Identifier(s): 27551533
Host organism: taxid:4932
Interaction detection method(s): two hybrid
Interaction type: physical association
Identification method participant A: predetermined participant
Identification method participant B: predetermined participant
ID(s) interactor A: Q07817
ID(s) interactor B: A4I001
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: bait

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	33
GO:0110165	cellular anatomical entity	1	33
GO:0005886	plasma membrane	3	1

Expansion

Sequence features

E9AVX4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVX4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006833	water transport	5	2
GO:0042044	fluid transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	33
GO:0015267	channel activity	4	33
GO:0022803	passive transmembrane transporter activity	3	33
GO:0022857	transmembrane transporter activity	2	33
GO:0005372	water transmembrane transporter activity	4	2
GO:0015250	water channel activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.697
CLV_NRD_NRD_1	143	145	PF00675	0.264
CLV_PCSK_KEX2_1	142	144	PF00082	0.299
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.277
CLV_PCSK_SKI1_1	185	189	PF00082	0.451
CLV_PCSK_SKI1_1	250	254	PF00082	0.525
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_CKS1_1	242	247	PF01111	0.405
DOC_CYCLIN_RxL_1	247	257	PF00134	0.211
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.191
DOC_MAPK_gen_1	142	149	PF00069	0.485
DOC_MAPK_MEF2A_6	20	27	PF00069	0.566
DOC_PP2B_LxvP_1	83	86	PF13499	0.231
DOC_PP2B_PxIxI_1	244	250	PF00149	0.388
DOC_PP4_FxxP_1	171	174	PF00568	0.263
DOC_USP7_MATH_1	23	27	PF00917	0.726
DOC_USP7_MATH_1	262	266	PF00917	0.234
DOC_USP7_MATH_1	66	70	PF00917	0.450
DOC_WW_Pin1_4	241	246	PF00397	0.408
DOC_WW_Pin1_4	258	263	PF00397	0.157
LIG_14-3-3_CanoR_1	250	256	PF00244	0.250
LIG_BRCT_BRCA1_1	105	109	PF00533	0.302
LIG_BRCT_BRCA1_1	60	64	PF00533	0.625
LIG_BRCT_BRCA1_1	98	102	PF00533	0.321
LIG_FHA_1	122	128	PF00498	0.344
LIG_FHA_1	192	198	PF00498	0.276
LIG_FHA_1	22	28	PF00498	0.686
LIG_FHA_1	242	248	PF00498	0.299
LIG_FHA_1	76	82	PF00498	0.286
LIG_GBD_Chelix_1	72	80	PF00786	0.280
LIG_LIR_Apic_2	170	174	PF02991	0.262
LIG_LIR_Gen_1	135	145	PF02991	0.482
LIG_LIR_Gen_1	179	188	PF02991	0.268
LIG_LIR_Gen_1	190	201	PF02991	0.310
LIG_LIR_Gen_1	281	290	PF02991	0.383
LIG_LIR_Gen_1	61	72	PF02991	0.504
LIG_LIR_Gen_1	78	87	PF02991	0.247
LIG_LIR_Gen_1	99	109	PF02991	0.338
LIG_LIR_Nem_3	110	114	PF02991	0.281
LIG_LIR_Nem_3	135	140	PF02991	0.503
LIG_LIR_Nem_3	190	196	PF02991	0.274
LIG_LIR_Nem_3	281	287	PF02991	0.295
LIG_LIR_Nem_3	61	67	PF02991	0.524
LIG_LIR_Nem_3	78	82	PF02991	0.253
LIG_PCNA_yPIPBox_3	178	188	PF02747	0.314
LIG_PDZ_Class_3	289	294	PF00595	0.586
LIG_Pex14_2	217	221	PF04695	0.384
LIG_Pex14_2	75	79	PF04695	0.297
LIG_SH2_CRK	162	166	PF00017	0.158
LIG_SH2_STAT5	113	116	PF00017	0.447
LIG_SH2_STAT5	148	151	PF00017	0.297
LIG_SH2_STAT5	162	165	PF00017	0.286
LIG_SH2_STAT5	284	287	PF00017	0.502
LIG_SH3_3	234	240	PF00018	0.405
LIG_SH3_3	25	31	PF00018	0.543
LIG_SH3_3	7	13	PF00018	0.743
LIG_SUMO_SIM_anti_2	24	29	PF11976	0.518
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.298
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.304
LIG_SUMO_SIM_par_1	121	126	PF11976	0.383
LIG_SUMO_SIM_par_1	23	29	PF11976	0.555
LIG_SUMO_SIM_par_1	78	84	PF11976	0.291
LIG_SUMO_SIM_par_1	85	90	PF11976	0.279
LIG_TYR_ITIM	282	287	PF00017	0.309
LIG_WRC_WIRS_1	108	113	PF05994	0.241
LIG_WRC_WIRS_1	137	142	PF05994	0.457
LIG_WRC_WIRS_1	192	197	PF05994	0.276
LIG_WRC_WIRS_1	252	257	PF05994	0.242
LIG_WRC_WIRS_1	76	81	PF05994	0.277
MOD_CK1_1	191	197	PF00069	0.255
MOD_CK1_1	21	27	PF00069	0.694
MOD_CK1_1	258	264	PF00069	0.205
MOD_CK2_1	129	135	PF00069	0.373
MOD_CK2_1	251	257	PF00069	0.251
MOD_CMANNOS	267	270	PF00535	0.276
MOD_GlcNHglycan	114	117	PF01048	0.234
MOD_GlcNHglycan	14	17	PF01048	0.538
MOD_GlcNHglycan	166	169	PF01048	0.454
MOD_GlcNHglycan	20	23	PF01048	0.501
MOD_GlcNHglycan	233	236	PF01048	0.443
MOD_GlcNHglycan	257	260	PF01048	0.406
MOD_GlcNHglycan	38	42	PF01048	0.415
MOD_GlcNHglycan	68	71	PF01048	0.207
MOD_GSK3_1	103	110	PF00069	0.304
MOD_GSK3_1	251	258	PF00069	0.221
MOD_GSK3_1	54	61	PF00069	0.602
MOD_GSK3_1	81	88	PF00069	0.283
MOD_N-GLC_1	255	260	PF02516	0.383
MOD_NEK2_1	103	108	PF00069	0.261
MOD_NEK2_1	129	134	PF00069	0.464
MOD_NEK2_1	164	169	PF00069	0.240
MOD_NEK2_1	176	181	PF00069	0.267
MOD_NEK2_1	188	193	PF00069	0.251
MOD_NEK2_1	255	260	PF00069	0.191
MOD_NEK2_1	46	51	PF00069	0.489
MOD_NEK2_1	75	80	PF00069	0.285
MOD_NEK2_1	81	86	PF00069	0.289
MOD_NEK2_1	87	92	PF00069	0.272
MOD_NEK2_2	58	63	PF00069	0.652
MOD_OFUCOSY	225	230	PF10250	0.211
MOD_PIKK_1	204	210	PF00454	0.526
MOD_PIKK_1	87	93	PF00454	0.136
MOD_PKA_1	54	60	PF00069	0.483
MOD_Plk_4	103	109	PF00069	0.279
MOD_Plk_4	123	129	PF00069	0.131
MOD_Plk_4	188	194	PF00069	0.275
MOD_Plk_4	196	202	PF00069	0.274
MOD_Plk_4	23	29	PF00069	0.537
MOD_Plk_4	262	268	PF00069	0.254
MOD_Plk_4	278	284	PF00069	0.252
MOD_Plk_4	75	81	PF00069	0.283
MOD_ProDKin_1	241	247	PF00069	0.408
MOD_ProDKin_1	258	264	PF00069	0.157
TRG_DiLeu_BaLyEn_6	141	146	PF01217	0.525
TRG_DiLeu_BaLyEn_6	242	247	PF01217	0.347
TRG_DiLeu_BaLyEn_6	42	47	PF01217	0.490
TRG_ENDOCYTIC_2	137	140	PF00928	0.504
TRG_ENDOCYTIC_2	162	165	PF00928	0.283
TRG_ENDOCYTIC_2	284	287	PF00928	0.452
TRG_ER_diArg_1	143	145	PF00400	0.518

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1D2	Leptomonas seymouri	74%	100%
A0A0N1ILB4	Leptomonas seymouri	41%	100%
A0A0N1PB10	Leptomonas seymouri	39%	100%
A0A0S4IS36	Bodo saltans	33%	84%
A0A0S4IS78	Bodo saltans	39%	100%
A0A0S4JRP5	Bodo saltans	28%	88%
A0A0S4KLV5	Bodo saltans	41%	100%
A0A1X0ND19	Trypanosomatidae	42%	100%
A0A1X0NT73	Trypanosomatidae	38%	100%
A0A1X0NTY8	Trypanosomatidae	66%	100%
A0A3R7RFH0	Trypanosoma rangeli	39%	100%
A0A3S5H7B2	Leishmania donovani	94%	100%
A0A3S5H7S4	Leishmania donovani	37%	100%
A0A3S7X8F2	Leishmania donovani	41%	100%
A0A422N493	Trypanosoma rangeli	68%	100%
A0A422N886	Trypanosoma rangeli	37%	70%
A0A422NSX8	Trypanosoma rangeli	42%	100%
A0A6M3QG69	Musa acuminata	26%	100%
A0A804KTT0	Musa acuminata subsp. malaccensis	24%	100%
A4HBA6	Leishmania braziliensis	41%	100%
A4HCI0	Leishmania braziliensis	76%	100%
A4HKM8	Leishmania braziliensis	35%	100%
A4HKM9	Leishmania braziliensis	36%	73%
A4I001	Leishmania infantum	94%	100%
A4I859	Leishmania infantum	37%	100%
A4IAF4	Leishmania infantum	41%	100%
A4L9J0	Oryctolagus cuniculus	29%	100%
B1VB61	Citrobacter freundii	28%	100%
E9B316	Leishmania mexicana (strain MHOM/GT/2001/U1103)	38%	100%
E9B5H8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
F9UTW9	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	24%	100%
F9UUD2	Lactiplantibacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1)	27%	100%
G5CTG2	Milnesium tardigradum	26%	100%
O26206	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	26%	100%
O62735	Ovis aries	28%	100%
O68874	Shigella flexneri	27%	100%
O77750	Bos taurus	25%	91%
O82316	Arabidopsis thaliana	26%	100%
O94778	Homo sapiens	27%	100%
P06624	Bos taurus	29%	100%
P08995	Glycine max	27%	100%
P0AER0	Escherichia coli (strain K12)	26%	100%
P0AER1	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	26%	100%
P0AER2	Escherichia coli O157:H7	26%	100%
P0C112	Brucella abortus biovar 1 (strain 9-941)	28%	100%
P0CD91	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	96%
P0DO54	Musa acuminata	27%	100%
P25794	Pisum sativum	27%	100%
P25818	Arabidopsis thaliana	30%	100%
P29972	Homo sapiens	26%	100%
P29975	Rattus norvegicus	25%	100%
P30302	Arabidopsis thaliana	26%	100%
P31140	Shigella flexneri	26%	100%
P34080	Rattus norvegicus	28%	100%
P41181	Homo sapiens	28%	100%
P42767	Atriplex canescens	26%	100%
P43286	Arabidopsis thaliana	24%	100%
P43287	Arabidopsis thaliana	26%	100%
P47863	Rattus norvegicus	27%	91%
P47864	Rattus norvegicus	26%	100%
P47865	Bos taurus	27%	100%
P49173	Nicotiana alata	23%	100%
P50501	Pelophylax lessonae	25%	100%
P55064	Homo sapiens	26%	100%
P55087	Homo sapiens	26%	91%
P55088	Mus musculus	28%	91%
P56401	Ovis aries	26%	100%
P56402	Mus musculus	29%	100%
P56404	Mus musculus	25%	100%
P56405	Rattus norvegicus	27%	100%
P60844	Escherichia coli (strain K12)	27%	100%
P60845	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	27%	100%
P61837	Arabidopsis thaliana	25%	100%
P61838	Vicia faba	25%	100%
P73809	Synechocystis sp. (strain PCC 6803 / Kazusa)	27%	100%
P79099	Bos taurus	28%	100%
P93004	Arabidopsis thaliana	26%	100%
Q02013	Mus musculus	25%	100%
Q06611	Arabidopsis thaliana	25%	100%
Q08451	Solanum lycopersicum	24%	100%
Q08733	Arabidopsis thaliana	24%	100%
Q0DK16	Oryza sativa subsp. japonica	26%	100%
Q0IWF3	Oryza sativa subsp. japonica	27%	95%
Q19KC1	Zea mays	23%	100%
Q23808	Cicadella viridis	29%	100%
Q25074	Haematobia irritans exigua	28%	100%
Q2YR68	Brucella abortus (strain 2308)	28%	100%
Q39196	Arabidopsis thaliana	24%	100%
Q41963	Arabidopsis thaliana	31%	100%
Q4Q2F7	Leishmania major	41%	100%
Q4Q538	Leishmania major	37%	100%
Q4QBK5	Leishmania major	92%	100%
Q54WT8	Dictyostelium discoideum	27%	100%
Q5I4F8	Notomys alexis	27%	100%
Q5I4F9	Notomys alexis	27%	90%
Q5R819	Pongo abelii	26%	100%
Q5Z6F0	Oryza sativa subsp. japonica	27%	100%
Q5Z9E2	Oryza sativa subsp. japonica	30%	100%
Q651D5	Oryza sativa subsp. japonica	26%	100%
Q67WJ8	Oryza sativa subsp. japonica	25%	99%
Q6EU94	Oryza sativa subsp. japonica	25%	100%
Q6J8I9	Ovis aries	29%	100%
Q6K215	Oryza sativa subsp. japonica	26%	100%
Q6PQZ1	Sus scrofa	26%	100%
Q6Z2T3	Oryza sativa subsp. japonica	26%	99%
Q7EYH7	Oryza sativa subsp. japonica	26%	96%
Q7MIV9	Vibrio vulnificus (strain YJ016)	25%	100%
Q7N5C1	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	25%	100%
Q7NNP3	Gloeobacter violaceus (strain ATCC 29082 / PCC 7421)	29%	100%
Q7NU39	Chromobacterium violaceum (strain ATCC 12472 / DSM 30191 / JCM 1249 / NBRC 12614 / NCIMB 9131 / NCTC 9757)	26%	100%
Q7PWV1	Anopheles gambiae	28%	100%
Q7XLR1	Oryza sativa subsp. japonica	27%	100%
Q7XSQ9	Oryza sativa subsp. japonica	24%	100%
Q7XUA6	Oryza sativa subsp. japonica	26%	100%
Q7Y1E6	Oryza sativa subsp. japonica	28%	100%
Q84RL6	Zea mays	30%	100%
Q84RL7	Zea mays	26%	100%
Q84S07	Oryza sativa subsp. japonica	24%	100%
Q866S3	Ovis aries	26%	100%
Q87MQ5	Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)	26%	100%
Q88F17	Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440)	27%	100%
Q89EG9	Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110)	26%	100%
Q8DB17	Vibrio vulnificus (strain CMCP6)	25%	100%
Q8EHC1	Shewanella oneidensis (strain MR-1)	28%	100%
Q8FY85	Brucella suis biovar 1 (strain 1330)	28%	100%
Q8LAA6	Arabidopsis thaliana	24%	100%
Q8LAI1	Arabidopsis thaliana	25%	100%
Q8LFP7	Arabidopsis thaliana	28%	100%
Q8VZW1	Arabidopsis thaliana	28%	99%
Q8W036	Arabidopsis thaliana	23%	100%
Q8W037	Arabidopsis thaliana	24%	100%
Q8X6K6	Escherichia coli O157:H7	27%	100%
Q923J4	Dipodomys merriami	26%	91%
Q92NM3	Rhizobium meliloti (strain 1021)	27%	100%
Q9AQU5	Zea mays	25%	100%
Q9AR14	Zea mays	26%	100%
Q9AT74	Zea mays	25%	98%
Q9ATM4	Zea mays	27%	100%
Q9ATM5	Zea mays	26%	100%
Q9ATN1	Zea mays	27%	97%
Q9C4Z5	Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg)	25%	100%
Q9C6T0	Arabidopsis thaliana	27%	91%
Q9FF53	Arabidopsis thaliana	26%	100%
Q9FIZ9	Arabidopsis thaliana	24%	100%
Q9FY14	Medicago truncatula	26%	100%
Q9HWZ3	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	26%	100%
Q9L772	Brucella melitensis biotype 1 (strain 16M / ATCC 23456 / NCTC 10094)	29%	100%
Q9N2J4	Canis lupus familiaris	26%	100%
Q9NHW7	Aedes aegypti	27%	100%
Q9SAI4	Arabidopsis thaliana	27%	96%
Q9SV84	Arabidopsis thaliana	28%	97%
Q9SXF8	Oryza sativa subsp. japonica	25%	100%
Q9U8P7	Dictyostelium discoideum	27%	100%
Q9V5Z7	Drosophila melanogaster	26%	100%
Q9WTY4	Mus musculus	26%	100%
Q9XF58	Zea mays	26%	100%
Q9XF59	Zea mays	25%	100%
Q9ZVX8	Arabidopsis thaliana	26%	100%
S5ZH89	Musa acuminata	24%	100%
V5ANF5	Trypanosoma cruzi	39%	100%
V5B469	Trypanosoma cruzi	67%	100%
V5BW46	Trypanosoma cruzi	40%	100%