MORN repeat-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVX2_LEIMU

TriTrypDb:

LmxM.22.1400

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 24
NetGPI	no	yes: 0, no: 24

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	2
GO:0031514	motile cilium	5	2
GO:0042995	cell projection	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0110165	cellular anatomical entity	1	4
GO:0120025	plasma membrane bounded cell projection	3	2
GO:0005815	microtubule organizing center	2	1
GO:0005816	spindle pole body	3	1
GO:0036064	ciliary basal body	3	1
GO:0044732	mitotic spindle pole body	4	1
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AVX2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVX2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	346	350	PF00656	0.258
CLV_C14_Caspase3-7	392	396	PF00656	0.608
CLV_NRD_NRD_1	118	120	PF00675	0.483
CLV_NRD_NRD_1	381	383	PF00675	0.662
CLV_NRD_NRD_1	52	54	PF00675	0.369
CLV_PCSK_KEX2_1	118	120	PF00082	0.418
CLV_PCSK_KEX2_1	315	317	PF00082	0.418
CLV_PCSK_KEX2_1	325	327	PF00082	0.313
CLV_PCSK_KEX2_1	52	54	PF00082	0.369
CLV_PCSK_PC1ET2_1	315	317	PF00082	0.418
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.313
CLV_PCSK_SKI1_1	22	26	PF00082	0.701
CLV_PCSK_SKI1_1	9	13	PF00082	0.615
DEG_APCC_DBOX_1	78	86	PF00400	0.545
DEG_APCC_DBOX_1	8	16	PF00400	0.617
DEG_Nend_UBRbox_2	1	3	PF02207	0.356
DOC_CYCLIN_RxL_1	5	16	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	11	17	PF00134	0.615
DOC_MAPK_FxFP_2	93	96	PF00069	0.523
DOC_MAPK_gen_1	234	243	PF00069	0.201
DOC_PP1_RVXF_1	20	26	PF00149	0.424
DOC_PP4_FxxP_1	93	96	PF00568	0.523
DOC_USP7_MATH_1	285	289	PF00917	0.317
DOC_USP7_MATH_1	57	61	PF00917	0.474
DOC_USP7_MATH_1	62	66	PF00917	0.492
DOC_USP7_UBL2_3	159	163	PF12436	0.394
LIG_14-3-3_CanoR_1	118	122	PF00244	0.363
LIG_14-3-3_CanoR_1	81	86	PF00244	0.552
LIG_deltaCOP1_diTrp_1	293	299	PF00928	0.381
LIG_deltaCOP1_diTrp_1	31	37	PF00928	0.311
LIG_FHA_1	302	308	PF00498	0.490
LIG_FHA_1	397	403	PF00498	0.670
LIG_FHA_2	215	221	PF00498	0.256
LIG_Integrin_RGDW_4	197	200	PF00362	0.377
LIG_LIR_Apic_2	210	214	PF02991	0.381
LIG_LIR_Apic_2	304	308	PF02991	0.462
LIG_LIR_Apic_2	92	96	PF02991	0.526
LIG_LIR_Gen_1	88	96	PF02991	0.444
LIG_LIR_Nem_3	144	150	PF02991	0.445
LIG_LIR_Nem_3	88	93	PF02991	0.426
LIG_SH2_CRK	147	151	PF00017	0.498
LIG_SH2_CRK	273	277	PF00017	0.396
LIG_SH2_GRB2like	321	324	PF00017	0.258
LIG_SH2_SRC	211	214	PF00017	0.369
LIG_SH2_SRC	321	324	PF00017	0.258
LIG_SH2_STAT3	127	130	PF00017	0.355
LIG_SH2_STAT5	173	176	PF00017	0.297
LIG_SH2_STAT5	188	191	PF00017	0.363
LIG_SH2_STAT5	211	214	PF00017	0.274
LIG_SH2_STAT5	242	245	PF00017	0.313
LIG_SH2_STAT5	290	293	PF00017	0.343
LIG_SH2_STAT5	317	320	PF00017	0.411
LIG_SH2_STAT5	339	342	PF00017	0.314
LIG_SH2_STAT5	377	380	PF00017	0.511
LIG_SH2_STAT6	89	93	PF00017	0.518
LIG_SUMO_SIM_par_1	65	73	PF11976	0.481
LIG_WRC_WIRS_1	90	95	PF05994	0.499
MOD_CK1_1	256	262	PF00069	0.438
MOD_CK1_1	335	341	PF00069	0.521
MOD_CK2_1	214	220	PF00069	0.237
MOD_Cter_Amidation	323	326	PF01082	0.348
MOD_GlcNHglycan	143	146	PF01048	0.420
MOD_GlcNHglycan	201	204	PF01048	0.357
MOD_GlcNHglycan	214	217	PF01048	0.323
MOD_GlcNHglycan	258	261	PF01048	0.285
MOD_GlcNHglycan	59	62	PF01048	0.339
MOD_GSK3_1	255	262	PF00069	0.452
MOD_GSK3_1	331	338	PF00069	0.524
MOD_N-GLC_1	207	212	PF02516	0.407
MOD_NEK2_1	117	122	PF00069	0.505
MOD_NEK2_2	272	277	PF00069	0.278
MOD_PIKK_1	117	123	PF00454	0.343
MOD_PKA_1	315	321	PF00069	0.264
MOD_PKA_2	117	123	PF00069	0.496
MOD_PKA_2	230	236	PF00069	0.318
MOD_PKA_2	265	271	PF00069	0.512
MOD_PKA_2	301	307	PF00069	0.481
MOD_PKA_2	315	321	PF00069	0.346
MOD_PKA_2	80	86	PF00069	0.502
MOD_PKB_1	79	87	PF00069	0.550
MOD_Plk_1	178	184	PF00069	0.387
MOD_Plk_1	5	11	PF00069	0.609
MOD_Plk_4	151	157	PF00069	0.320
MOD_Plk_4	207	213	PF00069	0.313
MOD_SUMO_rev_2	144	150	PF00179	0.411
MOD_SUMO_rev_2	154	160	PF00179	0.354
TRG_DiLeu_BaLyEn_6	410	415	PF01217	0.559
TRG_DiLeu_BaLyEn_6	6	11	PF01217	0.616
TRG_ENDOCYTIC_2	147	150	PF00928	0.478
TRG_ENDOCYTIC_2	273	276	PF00928	0.425
TRG_ENDOCYTIC_2	90	93	PF00928	0.434
TRG_ER_diArg_1	117	119	PF00400	0.377
TRG_ER_diArg_1	224	227	PF00400	0.258
TRG_ER_diArg_1	296	299	PF00400	0.419
TRG_LysEnd_GGAAcLL_1	411	417	PF00790	0.494
TRG_NES_CRM1_1	66	80	PF08389	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIF6	Leptomonas seymouri	77%	73%
A0A0N1IIK8	Leptomonas seymouri	36%	100%
A0A0S4J443	Bodo saltans	26%	94%
A0A0S4JES9	Bodo saltans	30%	82%
A0A0S4KIY0	Bodo saltans	35%	100%
A0A0S4KKM9	Bodo saltans	30%	78%
A0A1X0NTG8	Trypanosomatidae	43%	95%
A0A1X0P1A5	Trypanosomatidae	37%	100%
A0A3R7NAK8	Trypanosoma rangeli	45%	100%
A0A3S7WXA1	Leishmania donovani	93%	79%
A0A3S7X3U7	Leishmania donovani	36%	100%
A0A422P0W0	Trypanosoma rangeli	35%	100%
A4HCH7	Leishmania braziliensis	88%	100%
A4HIR9	Leishmania braziliensis	36%	100%
A4HZZ9	Leishmania infantum	93%	79%
A4I615	Leishmania infantum	36%	100%
C9ZRE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZSQ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	95%
E9ATG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9B1A6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
Q4Q137	Leishmania major	24%	100%
Q4Q6V8	Leishmania major	36%	100%
Q4QBK7	Leishmania major	92%	100%