TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVX1_LEIMU

TriTrypDb:

LmxM.22.1390

Length:

258

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AVX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVX1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	175	179	PF00656	0.409
CLV_C14_Caspase3-7	41	45	PF00656	0.609
CLV_PCSK_KEX2_1	69	71	PF00082	0.331
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.331
CLV_PCSK_SKI1_1	158	162	PF00082	0.373
CLV_PCSK_SKI1_1	197	201	PF00082	0.326
CLV_PCSK_SKI1_1	212	216	PF00082	0.299
CLV_Separin_Metazoa	10	14	PF03568	0.581
DOC_CYCLIN_RxL_1	192	203	PF00134	0.403
DOC_MAPK_MEF2A_6	197	206	PF00069	0.270
DOC_PP2B_LxvP_1	249	252	PF13499	0.402
DOC_USP7_MATH_1	186	190	PF00917	0.481
DOC_USP7_MATH_1	40	44	PF00917	0.731
DOC_USP7_UBL2_3	82	86	PF12436	0.451
DOC_WW_Pin1_4	45	50	PF00397	0.563
LIG_14-3-3_CanoR_1	158	164	PF00244	0.312
LIG_14-3-3_CanoR_1	17	22	PF00244	0.538
LIG_14-3-3_CanoR_1	212	220	PF00244	0.301
LIG_14-3-3_CanoR_1	56	60	PF00244	0.435
LIG_APCC_ABBA_1	145	150	PF00400	0.389
LIG_APCC_ABBA_1	220	225	PF00400	0.332
LIG_APCC_ABBAyCdc20_2	219	225	PF00400	0.333
LIG_BIR_III_4	225	229	PF00653	0.320
LIG_FHA_1	160	166	PF00498	0.382
LIG_FHA_1	201	207	PF00498	0.281
LIG_FHA_1	213	219	PF00498	0.302
LIG_LIR_Nem_3	225	230	PF02991	0.441
LIG_PDZ_Class_3	253	258	PF00595	0.510
LIG_REV1ctd_RIR_1	81	90	PF16727	0.330
LIG_SH2_SRC	108	111	PF00017	0.323
LIG_SH2_STAP1	108	112	PF00017	0.315
LIG_SH2_STAP1	79	83	PF00017	0.388
LIG_SH2_STAT5	135	138	PF00017	0.498
LIG_SUMO_SIM_anti_2	198	203	PF11976	0.334
LIG_SUMO_SIM_par_1	198	203	PF11976	0.334
LIG_TRAF2_1	48	51	PF00917	0.558
LIG_UBA3_1	199	207	PF00899	0.325
LIG_WRC_WIRS_1	18	23	PF05994	0.520
MOD_CK1_1	20	26	PF00069	0.631
MOD_CK2_1	35	41	PF00069	0.566
MOD_CK2_1	4	10	PF00069	0.624
MOD_CK2_1	45	51	PF00069	0.534
MOD_Cter_Amidation	67	70	PF01082	0.354
MOD_GlcNHglycan	23	26	PF01048	0.626
MOD_GlcNHglycan	5	9	PF01048	0.522
MOD_GSK3_1	13	20	PF00069	0.558
MOD_GSK3_1	191	198	PF00069	0.404
MOD_GSK3_1	28	35	PF00069	0.413
MOD_GSK3_1	36	43	PF00069	0.601
MOD_NEK2_1	200	205	PF00069	0.246
MOD_NEK2_1	21	26	PF00069	0.614
MOD_PKA_2	176	182	PF00069	0.574
MOD_PKA_2	28	34	PF00069	0.662
MOD_PKA_2	55	61	PF00069	0.444
MOD_Plk_1	108	114	PF00069	0.308
MOD_ProDKin_1	45	51	PF00069	0.559
MOD_SUMO_rev_2	174	183	PF00179	0.593
TRG_Pf-PMV_PEXEL_1	237	242	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4J7D9	Bodo saltans	49%	76%
A0A1X0NU43	Trypanosomatidae	39%	72%
A0A422N2C4	Trypanosoma rangeli	40%	74%
A4HCH6	Leishmania braziliensis	78%	100%
C9ZSQ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	68%
E9AH07	Leishmania infantum	95%	100%
Q4QBK8	Leishmania major	94%	100%
V5D4J4	Trypanosoma cruzi	39%	75%