Palmitoyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AVW7_LEIMU

TriTrypDb:

LmxM.22.1350

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0005783	endoplasmic reticulum	5	2
GO:0005794	Golgi apparatus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2

Expansion

Sequence features

E9AVW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AVW7

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	2
GO:0006605	protein targeting	5	2
GO:0006612	protein targeting to membrane	5	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006810	transport	3	2
GO:0006886	intracellular protein transport	4	2
GO:0006897	endocytosis	5	2
GO:0008104	protein localization	4	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016192	vesicle-mediated transport	4	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018198	peptidyl-cysteine modification	6	2
GO:0018230	peptidyl-L-cysteine S-palmitoylation	7	2
GO:0018231	peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine	7	2
GO:0018345	protein palmitoylation	6	2
GO:0019538	protein metabolic process	3	2
GO:0033036	macromolecule localization	2	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071704	organic substance metabolic process	2	2
GO:0071705	nitrogen compound transport	4	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0016409	palmitoyltransferase activity	5	13
GO:0016417	S-acyltransferase activity	5	13
GO:0016740	transferase activity	2	13
GO:0016746	acyltransferase activity	3	13
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	13
GO:0019706	protein-cysteine S-palmitoyltransferase activity	4	13
GO:0019707	protein-cysteine S-acyltransferase activity	3	13
GO:0140096	catalytic activity, acting on a protein	2	13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.257
CLV_NRD_NRD_1	198	200	PF00675	0.391
CLV_NRD_NRD_1	257	259	PF00675	0.382
CLV_NRD_NRD_1	26	28	PF00675	0.316
CLV_NRD_NRD_1	285	287	PF00675	0.428
CLV_NRD_NRD_1	288	290	PF00675	0.405
CLV_NRD_NRD_1	352	354	PF00675	0.577
CLV_NRD_NRD_1	362	364	PF00675	0.542
CLV_PCSK_FUR_1	24	28	PF00082	0.323
CLV_PCSK_FUR_1	286	290	PF00082	0.438
CLV_PCSK_KEX2_1	125	127	PF00082	0.258
CLV_PCSK_KEX2_1	197	199	PF00082	0.492
CLV_PCSK_KEX2_1	256	258	PF00082	0.372
CLV_PCSK_KEX2_1	26	28	PF00082	0.316
CLV_PCSK_KEX2_1	261	263	PF00082	0.380
CLV_PCSK_KEX2_1	287	289	PF00082	0.410
CLV_PCSK_KEX2_1	292	294	PF00082	0.430
CLV_PCSK_KEX2_1	354	356	PF00082	0.563
CLV_PCSK_KEX2_1	362	364	PF00082	0.541
CLV_PCSK_PC1ET2_1	197	199	PF00082	0.537
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.367
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.371
CLV_PCSK_PC1ET2_1	287	289	PF00082	0.418
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.443
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.362
CLV_PCSK_PC7_1	257	263	PF00082	0.442
CLV_PCSK_PC7_1	288	294	PF00082	0.452
CLV_PCSK_SKI1_1	261	265	PF00082	0.421
CLV_PCSK_SKI1_1	289	293	PF00082	0.480
CLV_PCSK_SKI1_1	83	87	PF00082	0.322
DEG_APCC_DBOX_1	97	105	PF00400	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.681
DOC_MAPK_gen_1	362	369	PF00069	0.579
DOC_PP1_RVXF_1	233	240	PF00149	0.373
DOC_USP7_MATH_1	114	118	PF00917	0.611
DOC_USP7_MATH_1	25	29	PF00917	0.534
DOC_USP7_MATH_1	315	319	PF00917	0.776
DOC_USP7_MATH_1	357	361	PF00917	0.772
DOC_USP7_UBL2_3	256	260	PF12436	0.529
DOC_WW_Pin1_4	204	209	PF00397	0.314
LIG_14-3-3_CanoR_1	162	168	PF00244	0.514
LIG_14-3-3_CanoR_1	198	208	PF00244	0.267
LIG_14-3-3_CanoR_1	7	15	PF00244	0.642
LIG_APCC_ABBA_1	239	244	PF00400	0.514
LIG_BRCT_BRCA1_1	386	390	PF00533	0.707
LIG_BRCT_BRCA1_1	77	81	PF00533	0.406
LIG_BRCT_BRCA1_2	77	83	PF00533	0.246
LIG_CaM_IQ_9	183	199	PF13499	0.418
LIG_EH1_1	183	191	PF00400	0.386
LIG_EH1_1	63	71	PF00400	0.162
LIG_eIF4E_1	64	70	PF01652	0.162
LIG_FHA_1	183	189	PF00498	0.460
LIG_FHA_1	52	58	PF00498	0.171
LIG_FHA_1	75	81	PF00498	0.281
LIG_IRF3_LxIS_1	33	40	PF10401	0.520
LIG_IRF3_LxIS_1	65	72	PF10401	0.461
LIG_LIR_Apic_2	17	22	PF02991	0.545
LIG_LIR_Apic_2	202	208	PF02991	0.314
LIG_LIR_Apic_2	28	33	PF02991	0.501
LIG_LIR_Gen_1	249	255	PF02991	0.462
LIG_LIR_Gen_1	40	49	PF02991	0.435
LIG_LIR_Gen_1	78	89	PF02991	0.436
LIG_LIR_Nem_3	12	18	PF02991	0.566
LIG_LIR_Nem_3	166	170	PF02991	0.399
LIG_LIR_Nem_3	249	254	PF02991	0.513
LIG_LIR_Nem_3	387	393	PF02991	0.809
LIG_LIR_Nem_3	40	45	PF02991	0.403
LIG_LIR_Nem_3	78	84	PF02991	0.322
LIG_Pex14_1	15	19	PF04695	0.547
LIG_Pex14_2	123	127	PF04695	0.450
LIG_SH2_CRK	205	209	PF00017	0.314
LIG_SH2_CRK	358	362	PF00017	0.613
LIG_SH2_CRK	366	370	PF00017	0.597
LIG_SH2_SRC	242	245	PF00017	0.542
LIG_SH2_SRC	251	254	PF00017	0.490
LIG_SH2_SRC	30	33	PF00017	0.582
LIG_SH2_SRC	64	67	PF00017	0.162
LIG_SH2_STAP1	184	188	PF00017	0.378
LIG_SH2_STAP1	251	255	PF00017	0.481
LIG_SH2_STAT3	184	187	PF00017	0.418
LIG_SH2_STAT3	267	270	PF00017	0.644
LIG_SH2_STAT3	89	92	PF00017	0.554
LIG_SH2_STAT5	184	187	PF00017	0.301
LIG_SH2_STAT5	242	245	PF00017	0.469
LIG_SH2_STAT5	64	67	PF00017	0.408
LIG_SH3_1	19	25	PF00018	0.536
LIG_SH3_2	22	27	PF14604	0.517
LIG_SH3_2	322	327	PF14604	0.655
LIG_SH3_3	19	25	PF00018	0.532
LIG_SH3_3	316	322	PF00018	0.806
LIG_SH3_3	52	58	PF00018	0.305
LIG_SUMO_SIM_par_1	67	73	PF11976	0.329
LIG_WRC_WIRS_1	164	169	PF05994	0.397
MOD_CK1_1	182	188	PF00069	0.412
MOD_CK1_1	331	337	PF00069	0.799
MOD_CK1_1	341	347	PF00069	0.799
MOD_CK2_1	246	252	PF00069	0.505
MOD_CK2_1	25	31	PF00069	0.499
MOD_GlcNHglycan	112	115	PF01048	0.434
MOD_GlcNHglycan	27	30	PF01048	0.332
MOD_GlcNHglycan	331	334	PF01048	0.582
MOD_GlcNHglycan	344	347	PF01048	0.546
MOD_GlcNHglycan	377	380	PF01048	0.517
MOD_GlcNHglycan	39	42	PF01048	0.340
MOD_GlcNHglycan	9	12	PF01048	0.329
MOD_GSK3_1	110	117	PF00069	0.674
MOD_GSK3_1	243	250	PF00069	0.450
MOD_GSK3_1	338	345	PF00069	0.766
MOD_GSK3_1	375	382	PF00069	0.789
MOD_GSK3_1	47	54	PF00069	0.282
MOD_GSK3_1	70	77	PF00069	0.320
MOD_N-GLC_2	153	155	PF02516	0.265
MOD_NEK2_1	163	168	PF00069	0.330
MOD_NEK2_1	243	248	PF00069	0.462
MOD_NEK2_1	37	42	PF00069	0.524
MOD_NEK2_1	51	56	PF00069	0.249
MOD_NEK2_1	69	74	PF00069	0.361
MOD_NEK2_1	75	80	PF00069	0.303
MOD_NEK2_2	357	362	PF00069	0.562
MOD_OFUCOSY	149	155	PF10250	0.264
MOD_PIKK_1	199	205	PF00454	0.274
MOD_PIKK_1	266	272	PF00454	0.604
MOD_PIKK_1	338	344	PF00454	0.748
MOD_PK_1	133	139	PF00069	0.505
MOD_PKA_2	25	31	PF00069	0.499
MOD_Plk_1	315	321	PF00069	0.713
MOD_Plk_4	163	169	PF00069	0.428
MOD_Plk_4	179	185	PF00069	0.440
MOD_Plk_4	70	76	PF00069	0.388
MOD_ProDKin_1	204	210	PF00069	0.314
MOD_SUMO_rev_2	10	18	PF00179	0.638
MOD_SUMO_rev_2	269	279	PF00179	0.658
TRG_DiLeu_BaEn_1	61	66	PF01217	0.154
TRG_ENDOCYTIC_2	161	164	PF00928	0.465
TRG_ENDOCYTIC_2	242	245	PF00928	0.500
TRG_ENDOCYTIC_2	251	254	PF00928	0.431
TRG_ENDOCYTIC_2	358	361	PF00928	0.719
TRG_ENDOCYTIC_2	366	369	PF00928	0.734
TRG_ER_diArg_1	125	127	PF00400	0.465
TRG_ER_diArg_1	198	200	PF00400	0.191
TRG_ER_diArg_1	23	26	PF00400	0.521
TRG_ER_diArg_1	285	288	PF00400	0.622
TRG_ER_diArg_1	352	355	PF00400	0.773
TRG_ER_diArg_1	361	363	PF00400	0.733
TRG_NLS_MonoCore_2	285	290	PF00514	0.708
TRG_NLS_MonoExtN_4	286	291	PF00514	0.685
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3T7	Leptomonas seymouri	72%	98%
A0A1X0NUX2	Trypanosomatidae	50%	100%
A0A3Q8IIC8	Leishmania donovani	24%	100%
A0A3R7RC91	Trypanosoma rangeli	44%	100%
A0A3S5H6J6	Leishmania donovani	30%	100%
A0A3S7WX91	Leishmania donovani	89%	100%
A4HCH5	Leishmania braziliensis	74%	100%
A4IBG8	Leishmania infantum	25%	100%
B3DN87	Arabidopsis thaliana	24%	100%
C9ZSP6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E7EZI4	Danio rerio	28%	92%
E7F4Z4	Danio rerio	27%	69%
E9AF82	Leishmania major	26%	100%
E9AH03	Leishmania infantum	89%	100%
E9AWG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B6D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
P0C7U3	Homo sapiens	26%	100%
Q14AK4	Mus musculus	28%	100%
Q4QB09	Leishmania major	25%	100%
Q4QBL2	Leishmania major	88%	99%
Q4QGX1	Leishmania major	28%	100%
Q8WTX9	Homo sapiens	27%	82%
Q9H8X9	Homo sapiens	27%	96%
V5B8P9	Trypanosoma cruzi	47%	100%
V5BWI0	Trypanosoma cruzi	27%	100%